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Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results.

Abstract：

BACKGROUND/AIM:Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented. PATIENTS AND METHODS:In 64 patients, the impact of tumor cell expression of erythropoietin (EPO) and erythropoietin-receptor (EPO-R) and ten additional factors (age, gender, performance status, tumor length, tumor stage (T-stage), nodes (N-stage), histology/grading, hemoglobin levels during radiotherapy, surgery) on survival and loco-regional control was evaluated up to 10 years following radio-chemotherapy. RESULTS:On multivariate analysis, improved survival was associated with low EPO-R expression (p=0.034) and hemoglobin levels during radiotherapy ≥ 12 g/dl (p=0.026). Low EPO expression was associated with survival on univariate (p=0.010) but not on multivariate analysis (p=0.42). On multivariate analysis, improved loco-regional control was significantly associated with hemoglobin levels during radiotherapy ≥ 12 g/dl (p<0.001). CONCLUSION:The long-term results confirm that hemoglobin levels during radiotherapy and tumor cell expression of EPO-R are significant prognostic factors in patients with locally advanced esophageal cancer.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Rades D,Bajrovic A,Schild SE,Thorns C,Kilic E

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

4351-5

issue

8

eissn

0250-7005

issn

1791-7530

pii

34/8/4351

journal_volume

34

pub_type

杂志文章

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