Abstract:
BACKGROUND:The tumor microenvironment is an emerging source of novel therapeutic targets in cancer. The glycosaminoglycan hyaluronan (HA) accumulates in 20-30% of tumors and is often associated with poor prognosis. MATERIALS AND METHODS:We developed a digitized, semiquantitative scoring system for tumor-associated HA content, then grouped tumors (from animal models or patients) according to the degree of HA accumulation (HA+1,2,3). The antitumor response to HA-depletion by pegylated PH20 hyaluronidase (PEGPH20) was then characterized as a function of HA accumulation. RESULTS:Semiquantitative grouping of tumors demonstrated that HA accumulation predicts the response of tumors in animal models to PEGPH20. Prospective analysis of HA content was used to predict response to PEGPH20 of squamous cell-type explants from patients with non-small cell lung cancer in nude mice. CONCLUSION:Measurement of HA is a viable biomarker approach for predicting antitumor response in animal models to the HA-depleting agent, PEGPH20.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Jiang P,Li X,Thompson CB,Huang Z,Araiza F,Osgood R,Wei G,Feldmann M,Frost GI,Shepard HMsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
1203-12issue
4eissn
0250-7005issn
1791-7530pii
32/4/1203journal_volume
32pub_type
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journal_title:Anticancer research
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