Abstract:
BACKGROUND:We herein report a comparison of the radiolabels 177Lu and 125I bound to the monoclonal antibody HH1 that targets the CD37 antigen expressed on non-Hodgkin B-cell lymphomas. MATERIALS AND METHODS:Mixtures of 177Lu and 125I-labeled HH1 antibody were co-injected into nude mice carrying Ramos xenografts and the biodistribution using the paired label format allowing tracer comparisons in each individual mouse. RESULTS:Products of the two radionuclides had very similar immunoractivity in vitro but showed different properties in vivo. Both products had relevant stability in blood and most normal tissues in nude mice carrying subcutaneous Ramos xenografts. However, both the tumor uptake and retention were significantly higher for 177Lu vs. 125I labeled HH1. The tumor to normal tissue ratios were several-fold improved for 177Lu compared to radioiodine labeled antibodies. CONCLUSION:The data presented herein support the evaluation of CD37 as a target for clinical 177Lu-based radioimmunotherapy against b-cell malignancies.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Repetto-Llamazares A,Abbas N,Bruland ØS,Dahle J,Larsen RHsubject
Has Abstractpub_date
2014-07-01 00:00:00pages
3263-9issue
7eissn
0250-7005issn
1791-7530pii
34/7/3263journal_volume
34pub_type
杂志文章abstract::The effect of treatment schedule on the antitumor activity of a new platinum derivative, glycolate-0,0'-diammineplatinum (II) (254S) compared with cis- diamminedichloroplatinum (II) (CDDP) was investigated using ascites L1210 leukemia and solid Lewis lung carcinoma. The drugs were given i.p. by three treatments: as a ...
journal_title:Anticancer research
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更新日期:2001-01-01 00:00:00
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doi:
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pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
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doi:
更新日期:2005-07-01 00:00:00
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更新日期:1997-09-01 00:00:00
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更新日期:1998-07-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2010-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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doi:
更新日期:1999-07-01 00:00:00
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更新日期:2009-12-01 00:00:00
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更新日期:2013-01-01 00:00:00
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doi:
更新日期:2009-02-01 00:00:00
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