Abstract:
BACKGROUND:Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism. A common C677T polymorphism in the gene for MTHFR leads to an enzyme with decreased activity. MTHFR polymorphisms have been studied in various cancers but not in primary brain tumors. The purpose of this case-control study was to explore a possible association between MTHFR C677T polymorphism and primary brain tumors. MATERIALS AND METHODS:The MTHFR C677T genotype was determined in 74 patients with histologically-verified primary brain tumors and 98 cancer-free control subjects. RESULTS:The MTHFR 677T variant genotype was observed in 49% of cases and 46% of controls. Although the difference was not significant (p =0. 194), the homozygous TT genotype was found at a higher frequency in high-grade glioma (HGG) patients compared to controls (15.4% and 7.1%, respectively). The MTHFR genotype was not associated with meningioma patients. Defining patients with the CC genotype as reference, the relative risk of HGG for subjects with the T allele (CT+ TT genotype) was 1.17. CONCLUSION:In spite of the established effect of the MTHFR 677 TT genotype on DNA hypomethylation with concomitant inadequate folate levels, the MTHFR 677 TT genotype is not associated with individual susceptibility to HGG.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kafadar AM,Yilmaz H,Kafadar D,Ergen A,Zeybek U,Bozkurt N,Kuday C,Isbir Tsubject
Has Abstractpub_date
2006-05-01 00:00:00pages
2445-9issue
3Beissn
0250-7005issn
1791-7530journal_volume
26pub_type
杂志文章abstract:BACKGROUND:The purpose of the present study was to correlate the nuclear expression of p53 and p21 with response to paclitaxel and carboplatin, progression-free survival (PFS) as well as overall survival (OS), in patients with urothelial metastatic transitional-cell carcinoma (TCC). PATIENTS AND METHODS:Histological s...
journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:2002-03-01 00:00:00
abstract::Adjuvant radioimmunotherapy (RIT) for human colonic cancer was performed in a nude rat model of experimental liver metastases. Thirty-three rats were injected intraportally through a mesenteric vein with 5 x 10(6) cells from the human colonic cancer cell line LS174T. Within half an hour, 20 MBq (n = 2), 75 MBq (n = 5)...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:10.21873/anticanres.12648
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pub_type: 杂志文章
doi:
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:
更新日期:2012-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.13739
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journal_title:Anticancer research
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doi:
更新日期:2013-08-01 00:00:00
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doi:
更新日期:2009-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2015-10-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2016-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2009-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2014-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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