2-triazenoindoles: synthesis and biological activity.

Abstract:

:A series of 2-triazenoindole derivatives was prepared in moderate to good yields by coupling 2-diazoindoles with secondary amines. Only 3-ethoxycarbonyl-2-(3.3-tetramethylenetriazenyl)-indole, tested against a panel of 60 human tumor cell lines, showed moderate activity on breast, ovarian and CNS cancer with GI50 in the range 23-36 microM.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Barraja P,Diana P,Lauria A,Montalbano A,Almerico AM,Dattolo G,Cirrincione G

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

837-40

issue

2A

eissn

0250-7005

issn

1791-7530

journal_volume

22

pub_type

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