Serum Asunaprevir and Daclatasvir Concentrations and Outcomes in Patients with Recurrent Hepatitis C Who Have Undergone Living Donor Liver Transplantation.

abstract：:The cyclin-dependent kinase inhibitor (CDK1) p27(kip1) is a negative regulator of cell cycling and has antitumor effects. In our previous study, the recombinant adenovirus expressing wild-type p27(kip1) (Adp27-wt) induced cell cycle arrest and apoptosis, and proved that p27 is a tumor suppressor gene like p53. Another...

journal_title：Anticancer research

authors： Shiraso S,Katayose Y,Yamamoto K,Mizuma M,Yabuuchi S,Oda A,Rikiyama T,Onogawa T,Yoshida H,Hayashi H,Ohtsuka H,Motoi F,Egawa S,Kato J,Unno M

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia (CLL) is characterized by a clonal accumulation of neoplastic lymphocytes, indicating disruption of apoptosis. PATIENTS AND METHODS:Differential methylation hybridization analysis was performed to identify novel target genes silenced by CpG island methylation in patients with CL...

journal_title：Anticancer research

authors： Schmidt-Wolf IG,Plass C,Byrd JC,Frevel K,Pietsch T,Waha A

更新日期：2016-09-01 00:00:00

abstract：:The influence of cytostatically active alkyllysophospholipid analogs with different chemical structure on IP3 (inositol-1,4,5-trisphosphate) formation and intracellular Ca++ concentration was studied in human mammary epithelial cells before and after transfection with v-erb B oncogene DNA. Transformed cells showed an ...

journal_title：Anticancer research

authors： Junghahn I,Bergmann J,Langen P,Thun I,Vollgraf C,Brachwitz H

更新日期：1995-03-01 00:00:00

abstract：:Rats were inoculated subcutaneously into both flanks with a transplantable adenocarcinoma of the colon. They were treated intravenously with either 5-FUrd (5-fluorouridine) or 5-FdUrd (5-fluoro-2'-deoxyuridine) with or without addition of dipyridamole 20 and 30 min later, respectively, for 3 consecutive days. Dipyrida...

journal_title：Anticancer research

authors： el Hag IA,Roos G,Jönsson PE,Stenram U

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Protein kinase C (PKC) activity is increased and gap junctional intercellular communication (GJIC) is decreased frequently in Ras-transformed cells. We investigated the roles of Ras and PKC in the deficient gap junctional intercellular communication (GJIC) of K-ras-transformed E9 mouse lung carcinoma cells. ...

journal_title：Anticancer research

authors： Cesen-Cummings K,Warner KA,Ruch RJ

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND/AIM:Our original hypothesis was that the rectus sheath block (RSB) analgesia could enhance patient satisfaction and decrease pain following midline laparotomy. PATIENTS AND METHODS:Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and con...

journal_title：Anticancer research

authors： Kuosmanen V,Ruottinen M,Rahkola D,Saimanen I,Kaaronen V,Selander T,Purdy M,Kokki H,Kokki M,Eskelinen M

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The molecular mechanisms of genistein's proliferative effects on breast cancer cells are largely unknown. This study aimed to examine estrogen-receptor (ER)-related signaling molecules involved in genistein-associated cell proliferation and survival (ERK1/2, p90RSK, JNK, Akt and NFκB) and to correlate these ...

journal_title：Anticancer research

authors： Gwin J,Drews N,Ali S,Stamschror J,Sorenson M,Rajah TT

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) remains the most aggressive and frequently occurring brain neoplasm. Members of the Rho family of small GTP-binding proteins, including Rho, Rac, and Cdc42, have been shown to participate in cell growth differentiation and motility. The mitogen-activated protein kinase (MAPK) pa...

journal_title：Anticancer research

authors： Zohrabian VM,Forzani B,Chau Z,Murali R,Jhanwar-Uniyal M

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:The present project studied the implications of using the irregular surface compensator (ISC) technique in comparison to three-dimensional conformal radiation therapy (3D-CRT) for breast cancer treatment. ISC is an electronic compensation algorithm that modulates the fluence across the radiation fields to compe...

journal_title：Anticancer research

authors： Flejmer AM,Josefsson D,Nilsson M,Stenmarker M,Dasu A

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND/AIM:3,4',7-O-trimethylquercetin (34'7TMQ), a derivative of quercetin, inhibited ovarian cancer cell migration and invasion without affecting proliferation. In this study, the apoptotic effect of 34'7TMQ on three cancer cell lines (CRL-1978, CRL-11731, SK-OV-3) was evaluated. MATERIALS AND METHODS:Expression...

journal_title：Anticancer research

authors： Ashraf AHMZ,Afroze SH,Yamauchi K,Zawieja DC,Keuhl TJ,Erlandson LW,Uddin MN

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:The authors report their experience in patients with adjuvant systemic 2-interferon with the aim of defining the effectiveness, side-effects, indications and limitations of this treatment. MATERIALS AND METHODS:From January 1989 to December 1996, 123 patients with genital, anorectal and perineal HPV lesions ...

journal_title：Anticancer research

authors： Scala M,Bonelli G,Gipponi M,Margarino G,Muzza A

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Apolipoprotein E (APOE), a lipid transport protein that has a key role in the lipoprotein metabolism, is expressed by macrophages under the control of the transcription factor Liver X Receptor (LXR), an oxysterol-activated transcriptional factor involved in cholesterol metabolism. Recent work has shown that ...

journal_title：Anticancer research

authors： El Roz A,Bard JM,Valin S,Huvelin JM,Nazih H

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The number of patients with second malignancies is growing and they represent about one in six out of all new cancers. Second malignancies can be categorized into three major groups according to the predominant etiological factor(s): (i) treatment-related, (ii) part of a syndrome and (iii) those due to share...

journal_title：Anticancer research

authors： Mahmood S,Vu K,Tai P,Joseph K,Koul R,Dubey A,Yu E

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:A critical step in the delivery of nanomedicines to tumour cells is transporting these particles through the extracellular matrix. Tumour-specific anticancer agents, such as encapsulated drugs, proteins, and genes, show low uptake in tumour tissue. It is not clear whether the collagen network or the glycosam...

journal_title：Anticancer research

authors： Eikenes L,Tufto I,Schnell EA,Bjørkøy A,De Lange Davies C

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) alone for Stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS:Data of 65 patients (median age=73 years) with Stage III NSCLC who underwent CIRT alone in the QST Hospital, Chiba, Japan, between 1997 and 2015 were retros...

journal_title：Anticancer research

authors： Anzai M,Yamamoto N,Hayashi K,Nakajima M,Nomoto A,Ogawa K,Tsuji H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:In our previous study, it was suggested that nitrotyrosine, a product of nitrogen species, found in esophageal squamous cell carcinoma (ESCC), may contribute to the progression of esophageal cancer. MATERIALS AND METHODS:To clarify whether nitrotyrosine expression is associated with apoptosis and/or angioge...

journal_title：Anticancer research

authors： Kato H,Miyazaki T,Yoshikawa M,Nakajima M,Fukai Y,Masuda N,Ojima H,Tsukada K,Nishida Y,Kuwano H

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis. PATIENTS AND METHODS:A case-control study was conducted to investigate the role of these polymorph...

journal_title：Anticancer research

authors： Delort L,Chalabi N,Satih S,Rabiau N,Kwiatkowski F,Bignon YJ,Bernard-Gallon DJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Biodegradable loaded systems are promising devices for controlled and sustained release of anticancer drugs to brain tumours. We investigated the influence of drug-release profiles of 5-fluorouracil-loaded microspheres designed for the treatment of malignant gliomas. MATERIALS AND METHODS:2.5 mg 5-FU delive...

journal_title：Anticancer research

authors： Roullin VG,Lemaire L,Venier-Julienne MC,Faisant N,Franconi F,Benoit JP

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) encapsulated in sterically-stabilized PEGylated STEALTH liposomes (SL) can better and more safely augment the efficacy of other treatment modalities than free TNF-alpha. The aim of this study was to examine the effects of SL-TNF-alpha i...

journal_title：Anticancer research

authors： Kim DW,Andres ML,Kajioka EH,Dutta-Roy R,Miller GM,Seynhaeve AL,ten Hagen TL,Gridley DS

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The phase II NEJ001 trial suggested that gefitinib was active against advanced non-small cell lung cancer (NSCLC) even in patients with poor performance status (PS). Clinical response among the patients harboring epidermal growth factor receptor (EGFR) mutation with poor PS is fair; however, gefitinib does n...

journal_title：Anticancer research

authors： Okuma Y,Hosomi Y,Nagamata M,Yamada Y,Sekihara K,Kato K,Hishima T,Okamura T

更新日期：2013-11-01 00:00:00

abstract：:Metastatic spread of malignancy is the primary cause of treatment failure and subsequent death in cancer patients. All cancers have the capability to metastasize, however, there are notable exceptions which rarely if ever metastasize. These include basal cell carcinoma, or cancers which are primarily locally invasive ...

journal_title：Anticancer research

authors： Kohn EC

更新日期：1993-11-01 00:00:00

abstract：:In experimental and clinical phase II trials GnRH agonists were shown to possess antitumor activity in ovarian cancer. The outcome of prostatic cancer was also improved experimentally by a combination of cytostatic chemotherapy and GnRH analogs. Encouraged by these results, we administered micro-encapsulated triptorel...

journal_title：Anticancer research

authors： Medl M,Peters-Engel C,Fuchs G,Leodolter S

更新日期：1993-11-01 00:00:00

abstract：:MicroRNAs (miRNA) are a class of small noncoding RNAs that regulate the expression of their target genes. The aim of the present study was to explore the effects of miR-206 on laryngeal suamous cell carcinoma (LSCC) cells. The expression level of miR-206 was quantified by qRT-PCR in primary LSCC tissues and correspond...

journal_title：Anticancer research

authors： Zhang T,Liu M,Wang C,Lin C,Sun Y,Jin D

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND/AIM:To identify the clinical and dosimetric predictors of severe acute radiation esophagitis (RE) in patients with non-small cell lung cancer (NSCLC) treated with accelerated hyperfractionated concurrent chemoradiotherapy (AH-CCRT) with concomitant boost technique. PATIENTS AND METHODS:A total of 159 patien...

journal_title：Anticancer research

authors： Wada K,Kishi N,Kanayama N,Hirata T,Ueda Y,Kawaguchi Y,Morimoto M,Konishi K,Imamura F,Ogawa K,Teshima T

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem. Immunopotentiating drugs may show a therapeutic efficacy. MATERIALS AND METHODS:The protective effect of Hochu-ekki-to (TJ-41), a Japanese traditional herbal medicine, on mitomycin C (MMC)-induced immun...

journal_title：Anticancer research

authors： Kido T,Mori K,Daikuhara H,Tsuchiya H,Ishige A,Sasaki H

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIM:Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis and tumorigenicity. We previously assessed the role of cytokine gene polymorphisms in gastric cancer risk in Chile. In the present study, we aimed to analyze whether these polym...

journal_title：Anticancer research

authors： Gonzalez-Hormazabal P,Romero S,Musleh M,Bustamante M,Stambuk J,Pisano R,Lanzarini E,Chiong H,Rojas J,Castro VG,Jara L,Berger Z

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Dendritic cell (DC) mono-immunotherapy has not been successful so far in ovarian cancer. The addition of a toll-like receptor (TLR) agonist has the potential to boost the innate immune system, in addition to the adoptive immune response initiated by DCs. MATERIALS AND METHODS:ID8-fLuc C57BL/6 mice were inje...

journal_title：Anticancer research

authors： Vindevogel E,Baert T,VAN Hoylandt A,Verbist G,Vande Velde G,Garg AD,Agostinis P,Vergote I,Coosemans AN

更新日期：2016-11-01 00:00:00

abstract：:The use of gene-modified dendritic cells (DC) is a powerful tool to enhance antitumor immune responses stimulated by these cells in cancer immunotherapy. Cationized gelatin is preferably incorporated via phagocytosis and is gradually degraded by proteolysis while buffering lysosomal activity. This may be appropriate f...

journal_title：Anticancer research

authors： Inada S,Fujiwara H,Atsuji K,Takashima K,Araki Y,Kubota T,Tabata Y,Yamagishi H

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations. MATERIALS AND METHODS:We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archi...

journal_title：Anticancer research

authors： Irabor DO,Oluwasola OA,Ogunbiyi OJ,Ogun OG,Okolo CA,Melas M,Gruber SB,Shi C,Raskin L

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Despite having disseminated cancer, not all patients are eligible for palliative chemotherapy or targeted therapies. AIM:To study reasons for withholding palliative chemotherapy, to survey which alternatives were offered and to study survival outcomes. MATERIALS AND METHODS:Medical records of 346 patients ...

journal_title：Anticancer research

authors： Randén M,Runesdotter S,Strang P

更新日期：2013-12-01 00:00:00