Abstract：
BACKGROUND:Endometrial adenocarcinoma is a frequently occurring cancer in women, accounting for 42,000 deaths every year. Despite treatment with standard therapy, occurrence of remote metastases and local recurrences is high. Through help of RT-qPCR minimal residual disease could be detected and characterized, facilitating therapeutic decision making. MATERIALS AND METHODS:A number of marker genes were first tested in model systems and genes that performed best, were consequently used for the examination of 13 blood samples from endometrial carcinoma patients. RESULTS:Cytokeratin 19 and MIG7 were chosen for the analysis in patient samples. Both genes were found up-regulated in small tumours and in one large tumour, but no statistical correlations could be revealed between expression levels of these two genes and tumour characteristics. CONCLUSION:There seems to be a coherence between gene expression and the stage of tumorigenesis, but the number of samples is still too small, to be able to obtain statistical significant differences.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kölbl AC,Wellens R,Koch J,Rack B,Hutter S,Friese K,Jeschke U,Andergassen Usubject
Has Abstractpub_date
2016-06-01 00:00:00pages
3205-9issue
6eissn
0250-7005issn
1791-7530pii
36/6/3205journal_volume
36pub_type
杂志文章abstract：:The in vitro antitumor activity of a new platinum complex, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolan e] platinum(II) (SKI 2053R, NSC D644591), cisplatin (CDDP) and carboplatin (CBDCA) was determined against two human lung cancer (PC-9 and PC-14) and two human stomach cancer (MKN-45 and KATO II...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:Hypoxia, a condition of reduced oxygen concentration, is observed in many physiological and pathophysiological states. However, there is rather limited information regarding hypoxic effects in the processes of immortalization and senescence of human cells. Here, the effects of hypoxia induced by either 1.5% O2, or by ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:This study was performed to determine whether drug action on breast tumours could also be analysed using a cell turnover index (CTI), a composite measurement of both proliferation and apoptosis. MATERIALS AND METHODS:Data were obtained from a randomized, placebo-controlled trial comparing three single doses...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：
更新日期：2002-07-01 00:00:00
abstract：:Radiation therapy is essential for local tumor control for many types of cancer histologies. Technological advancements in recent years have allowed for precise irradiation of target tissues while minimizing the dose to non-target tissues. To enhance radiation damage to cancer cells and further limit the radiation eff...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:Incidence of brain metastases (BM) from breast cancer (BC) is increasing. However, prognostic evaluation and treatment strategies are still a matter of debate. AIM:To describe the clinical outcome of BM from BC treated by neurosurgical resection and to identify the actual prognostic factors in this specific...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-05-01 00:00:00
abstract：:Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in o...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2007-03-01 00:00:00
abstract：:The effect of retinoid induced suppression of in vitro invasive ability of A549 human lung carcinoma cells on sialyltransferase activity and sialic acid content was investigated. Inhibition by retinol acetate of cell invasive potential was accompanied by a significant decrease in the enzyme activity of intact cells as...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Reduction of E-cadherin in most common epithelial tumors relates to metastasis, which results from the silence of E-cadherin by CpG methylation. MATERIALS AND METHODS:We examined the E-cadherin expression by immunohistochemical staining and detected methylation by methylation-specific polymerase chain react...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND/AIM:Identifying useful biomarkers is central to selecting optimal therapeutic strategies for esophageal squamous cell carcinoma (ESCC). Serum p53 antibody (S-p53Ab), squamous cell carcinoma antigen (SCC-Ag), and carcinoembryonic antigen (CEA) were investigated to evaluate the significance of single and combi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12419
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND/AIM:This study aimed to identify the prognostic factors and outcomes of osteosarcoma (OS) located in proximal versus distal extremity long bones. PATIENTS AND METHODS:A nationwide cohort comprising all Norwegian high-grade OSs in extremity long bones between 1982 and 2009 was investigated. RESULTS:The univ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13365
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:The tumor microenvironment is an emerging source of novel therapeutic targets in cancer. The glycosaminoglycan hyaluronan (HA) accumulates in 20-30% of tumors and is often associated with poor prognosis. MATERIALS AND METHODS:We developed a digitized, semiquantitative scoring system for tumor-associated HA ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：:The question remains as to whether metastatic cells (cancer seed) that eventually colonize a particular organ (cancer soil) have specific properties that distinguish them from the other cells of the primary tumor. However until recently there have not been model systems in which this question could be fully answered. ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：:The purpose of this study was to determine whether the degree of anchorage-independent growth of rodent or human cells in increasing concentrations of agarose correlated with successful transfection of the cells with an activated c-Ha-ras oncogene and tumorigenicity in nude mice. NIH 3T3 cells, C3H 10T1/2 fibroblasts,...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Cancer stem cells (CSCs) have a high tumorigenic ability to form patient-derived tumor xenografts (PDXs). PDXs are an attractive pre-clinical model, but gene expression and biological behavior of cancer cells in the tumor will change during establishment and passage of PDXs. MATERIALS AND METHODS:Human colo...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-07-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a deadly malignant disease with extremely poor prognosis. Many therapeutic modalities have been proposed, but considerable uncertainty still remains about their effectiveness. Inositol hexaphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has novel anti-cancer fu...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND/AIM:Typical carcinoids (TC) and atypical carcinoids (AC) are rare diseases. A paucity of randomized studies and disagreements among various guidelines makes the management challenging. PATIENTS AND METHODS:Using codes for TC (8240) and AC (8249) in the National Cancer Database (NCDB), all surgically resecte...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13900
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:Cancer of the oesophagus is the most common gastrointestinal malignancy in South African blacks. The aim of this study was to determine the reversible and irreversible lipid peroxidation in cancer of the oesophagus; a feature that has not been assessed before in this or other cancer tissue. METHODS:Biopsies...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-03-01 00:00:00
abstract：BACKGROUND:DMXAA (5,6-dimethylxanthenone-4-acetic acid; AS1404), a vascular disrupting agent currently in clinical trials, induces tumour endothelial cell apoptosis in vivo in mice and in cancer patients. DMXAA activates NF-kappaB in many different cell types. In this study, whether DMXAA-induced endothelial cell apopt...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:VP-16 and ICRF-193 are different types of antitumor topoisomerase II inhibitors, being cleavable and non-cleavable complex-stabilizing types, respectively. To examine the possibility of enhancing the efficacy of combination chemotherapy, we carried out simultaneous and sequencial treatment of cells with the two drugs....
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:Consumption of dietary fat has been linked to the high incidence of certain cancers. However, recent research has stimulated interest in conjugated linoleic acid (CLA), a newly recognized anticarcinogenic fatty acid. Human MCF-7 breast cancer cells were incubated for 12 d in culture medium supplemented with various co...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：BACKGROUND/AIM:Although reckoned necessary for survival benefit, neoadjuvant chemotherapy (NAC) of gastric cancer (GC) patients has so far provided questionable results. Consequently, searching for new and clearer systems of response to NAC, post-NAC re-evaluation and prognostic prediction appears essential. The purpos...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13208
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:We have recently demonstrated that Thymax, a gross thymic extract, induces an apoptotic effect against human breast cancer cells. In this study, the ability of Thymax to activate human dendritic cells (DCs) and the DC-directed T-cell response was examined in an in vitro culture model of peripheral blood mono...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-11-01 00:00:00
abstract：:Transferrin was covalently conjugated to adriamycin (Trf-adr) by the formation of a schiff base. This conjugate was found to bind to cell membrane trf receptors in a variety of human tumor cell lines. The Trf-adr conjugate was found to be active against sensitive and resistant cell lines e.g. Lovo, HL-60, H-meso and H...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：:The experimental techniques, methods of evaluation, and environmental implications of the findings of chemical carcinogenesis studies and related subject areas are herein critically reviewed. It is concluded that firstly, certain presently used procedures provide the best possibilities for the study of the hazardous n...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1985-09-01 00:00:00
abstract：BACKGROUND/AIM:Occult cancers' reported rates vary from 2-12% and serous tubal intraepithelial carcinomas (STICs) have been identified in 3-12% of the prophylactically removed tubes of women carrying a BRCA mutation. The aim of this study was to evaluate the incidence of tubal minor epithelial atypia (STIL), STIC, and ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11948
更新日期：2017-09-01 00:00:00
abstract：:Because of its poor prognosis, new modalities to treat pancreatic cancer are highly welcome. Gammalinolenate (GLA) has been shown to possess antitumor activity on various human cancer cell lines in vitro and some evidence has been found of its modulative activity on tubulin active agents, such as vinca alkaloids. GLA ...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Alteration of T-cell-associated signal transduction molecules has recently been implicated in immune suppression in tumour-bearing hosts. Here we report the immunoregulatory effects of human lactoferrin (LF) on zeta-chain expression in peripheral blood T lymphocytes from cervical cancer patients and healthy donors. By...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:The use of lysozyme preparations in the treatment of tumor diseases is based on more than 30 years' experience, using different methodologies and showing various results from which suggestions on the mechanism of action were derived. Lysozymes have no established place in the treatment of human tumors in spite of some...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1989-05-01 00:00:00
abstract：:Chronic treatment with Sasa Health, extract of bamboo grass leaves obtained by alkaline hydrolysis, in drinking water at the concentration of 0.044%-0.088% Fe-Chlorophyllin Na resulted in the significant inhibition of both development and growth of spontaneous mammary tumours in a high mammary tumour strain of SHN vir...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：BACKGROUND:Human herpesviruses types 4 and 6 (EBV, HHV-6) are frequently found in Hodgkin 's disease (HD) and--to a certain extent--in Kikuchi-Fujimoto's disease (KFD). Both viruses are apparently related to proliferative and/or apoptotic processes as represented by HD or KFD respectively. OBJECTIVE:To correlate frequ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
