Shift of Keratin Expression Profile in End-stage Kidney Increases the Risk of Tumor Development.

abstract：BACKGROUND/AIM:4-methylumbelliferone (4-MU) has received considerable attention due to its potential for cancer treatment since it inhibits cell proliferation, migration and invasion. An increasing body of evidence suggests that extracellular matrix (e.g. hyaluronan) and nutrients (e.g. glucose) in the tumor microenvir...

journal_title：Anticancer research

authors： Wang R,Zhou W,Wang J,Liu Y,Chen Y,Jiang S,Luo X,Stupack DG,Luo N

更新日期：2015-09-01 00:00:00

abstract：:We report a case with unexpected toxicity after low-dose docetaxel chemotherapy. The patient had a history of clinically latent HCV-positive hepatic cirrhosis when she presented with inoperable pulmonary adenocarcinoma. She was recruited in a protocol combining standard radiotherapy (RT) with docetaxel (30 mg/m2 week)...

journal_title：Anticancer research

authors： Koukourakis MI,Kapsoritakis A,Maltezos E,Potamiano S,Mouzas I,Kouroumalis H

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:The correlation between telomerase activity and antitumor effects was investigated in cell lines of human gastric (MKN-28, MKN-45, and MKN-74) and breast (T-47D, MCF-7, ZR75-1) cancers to evaluate the possibility of utilizing this enzyme to predict tumor response to chemotherapy. MATERIALS AND METHODS:After...

journal_title：Anticancer research

authors： Terashima M,Takiyama I,Uesugi N,Sasaki N,Takagane A,Hayakawa Y,Abe K,Araya M,Nishizuka S,Shimooki O,Nakaya T,Irinoda T,Yonezawa H,Oyama K,Saito K

更新日期：2000-01-01 00:00:00

abstract：:Angiosarcoma of the breast is a malignant tumour of vascular endothelial cells. It is a rare and difficult tumour to treat. The authors report a case of cutaneous radiation-associated angiosarcoma treated with paclitaxel chemotherapy. A few days after drug administration, bleeding of skin lesions was observed and the ...

journal_title：Anticancer research

authors： Tomasello L,Gardin G,Boccardo F

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Although well-acknowledged in vivo, spontaneous death of cancer cells in vitro is less widely appreciated. MATERIALS AND METHODS:Colony formation was studied in untreated control plates of standard clonogenic assays and measurements of actual and potential doubling times performed in asynchronous cultures o...

journal_title：Anticancer research

authors： Warenius H,Kyritsi L,Grierson I,Howarth A,Seabra L,Jones M,Thomas C,Browning P,White R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIM:Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS:Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180....

journal_title：Anticancer research

authors： Glei M,Fischer S,Lamberty J,Ludwig D,Lorkowski S,Schlörmann W

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Glutathione-S-transferases (GSTs) and N-acetyltransferases (NATs) are involved in the metabolism of a wide range of carcinogenic chemicals. Allelic polymorphism of these enzymes is associated with variations in enzyme activity, hence it may affect the concentration of activated carcinogenic chemicals in the ...

journal_title：Anticancer research

authors： Kiss I,Németh A,Bogner B,Pajkos G,Orsós Z,Sándor J,Csejtey A,Faluhelyi Z,Rodler I,Ember I

更新日期：2004-11-01 00:00:00

abstract：AIM:To report our experience on implementation and preliminary results of a decision-making model based on the recommendations of an Interdisciplinary Oncological Care Group developed for the management of colorectal cancer. PATIENTS AND METHODS:The multidisciplinary team identified a reference guideline using apprais...

journal_title：Anticancer research

authors： Genovesi D,Mazzilli L,Trignani M,DI Tommaso M,Nuzzo A,Biondi E,Tinari N,Martino MT,Innocenti P,DI Sebastiano P,Mazzola L,Lanci C,Neri M,Laterza F,Marino M,Ferrini G,Spadaccini A,Filippone A,DI Giandomenico E,Marulli

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:During the progression from low-grade dysplastic nodule (DN) to progressed hepatocellular carcinoma (HCC), intranodular portal tracts gradually disappear, while unpaired arteries develop increasingly. Contrast-enhanced ultrasound (CEUS) is highly accurate in depicting intranodular vascularity. This study eva...

journal_title：Anticancer research

authors： Giorgio A,Calisti G,di Sarno A,Farella N,de Stefano G,Scognamiglio U,Giorgio V

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Disseminated tumor cells (DTCs) in bone marrow (BM) occur in 30-40% of primary breast cancer patients. An impaired bone microenvironment may lead to reduced bone density and osteoporosis affecting the BM as a homing site for DTCs. The bone mineral density (BMD) and its correlation to DTC in BM was evaluated....

journal_title：Anticancer research

authors： Kraemer B,Rothmund R,Banys M,Krawczyk N,Solomayer EF,Mack C,Wallwiener D,Fehm T

更新日期：2011-12-01 00:00:00

abstract：:Serially propagated fibroblast clones were treated with 25-mM methionine and a thioguanine resistance assay was performed at each passage to measure mutagenesis at the HGPRT locus. The spontaneous frequency of thioguanine resistant mutants before treatment was less than 5 X 10(-6) in four clones and 22 X 10(-6) in one...

journal_title：Anticancer research

authors： Hill M,Hillova J,Mariage-Samson R,Brada Z

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Canine lymphoma has lately drawn focus as a model of human non-Hodgkin's lymphoma due to its spontaneous occurrence and similar biological behavior. Cells with stem cell-like characteristics are believed to play a key role in therapeutic failure. Thus, an initial characterization and the possibility of speci...

journal_title：Anticancer research

authors： Liu W,Selçuk F,Rütgen BC,Moulay M,Willenbrock S,Hammer SE,Sterenczak KA,Junghanss C,Hewicker-Trautwein M,Nolte I,Murua Escobar H

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Incidence of brain metastases (BM) from breast cancer (BC) is increasing. However, prognostic evaluation and treatment strategies are still a matter of debate. AIM:To describe the clinical outcome of BM from BC treated by neurosurgical resection and to identify the actual prognostic factors in this specific...

journal_title：Anticancer research

authors： Tabouret E,Metellus P,Tallet-Richard A,Figarella-Branger D,Charaffe-Jauffret E,Viens P,Gonçalves A

更新日期：2013-05-01 00:00:00

abstract：:Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death, with features more ...

journal_title：Anticancer research

authors： Wazir U,Khanzada ZS,Jiang WG,Sharma AK,Kasem A,Mokbel K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Chagas disease patients with longstanding megaesophagus have a significantly increased risk for esophageal carcinoma. MATERIALS AND METHODS:PCR-SSCP analysis and DNA sequencing of esophageal mucosa from Chagas disease patients (with or without megaesophagus) in the exons of the TP53, CDKN2A and FHIT genes w...

journal_title：Anticancer research

authors： DA Silva Manoel-Caetano F,Silveira AF,Silva AE

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The area under the curve (AUC) of free carboplatin, is a major determinant of toxicity and response. A conventional pharmacokinetic study to determine AUC requires frequent blood sampling. One strategy for overcoming this problem is to apply a limited sampling model (LSM). MATERIALS AND METHODS:We developed...

journal_title：Anticancer research

authors： Miyazaki M,Fujiwara Y,Takahashi T,Isobe T,Ohune T,Tsuya T,Yamakido M

更新日期：1997-11-01 00:00:00

abstract：UNLABELLED:BACKGROUD/AIM: We previously demonstrated that high protein expression of excision repair cross-complementation group-1 (ERCC1) was associated with poor disease-free survival in patients who received adjuvant cisplatin-based chemotherapy or chemoradiotherapy with cisplatin, and was shown to be an independent...

journal_title：Anticancer research

authors： Torii Y,Kato R,Minami Y,Hasegawa K,Fujii T,Udagawa Y

更新日期：2014-01-01 00:00:00

abstract：:The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at...

journal_title：Anticancer research

authors： Suefuji H,Koto M,Demizu Y,Saitoh JI,Shioyama Y,Tsuji H,Okimoto T,Ohno T,Nemoto K,Nakano T,Kamada T

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Cyclin D1 is a key protein involved in cell cycle regulation. A common A870G single nucleotide polymorphism in exon 4 of the cyclin D1 gene (CCND1) has an effect on the transcription of two different cyclin D1 mRNAs. Association of the genetic polymorphism of A870G of CCND1 with several cancer risks has been...

journal_title：Anticancer research

authors： Koike H,Suzuki K,Satoh T,Ohtake N,Takei T,Nakata S,Yamanaka H

更新日期：2003-11-01 00:00:00

abstract：:CYFRA 21-1 was evaluated in 115 untreated patients with malignant pleural effusions (96 with primary lung cancer and 19 with non lung cancer) and 99 patients with benign pleural effusions. The levels of pleural fluid CYFRA 21-1 were from 1 to 385 times higher than those in serum, in all the examined patients. The mean...

journal_title：Anticancer research

authors： Toumbis M,Rasidakis A,Passalidou E,Kalomenidis J,Alchanatis M,Orphanidou D,Jordanoglou J

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:The recent availability of a monoclonal antibody against human telomerase reverse transcriptase (hTERT) has enabled us to investigate the telomerase activity of tissue specimens more easily than by classical TRAP assay. In this study, we studied teromerase activity in thyroid tumors using this antibody. MAT...

journal_title：Anticancer research

authors： Ito Y,Yoshida H,Tomoda C,Uruno T,Takamura Y,Miya A,Kobayashi K,Matsuzuka F,Kuma K,Miyauchi A

更新日期：2005-01-01 00:00:00

abstract：:Cell proliferation measurements using bromodeoxyuridine administration to patients and flow cytometry to measure Tpot in head and neck cancer are discussed. Several hundred patients have now been assessed and the majority of studies suggest that this group of tumours represent a relatively fast proliferating site with...

journal_title：Anticancer research

authors： Wilson GD

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Since tumor markers can be increased in the course of many benign diseases, the aim of this study was to verify if this also occurs in the course of rheumatic diseases. MATERIALS AND METHODS:We investigated the incidence and characteristics of Tumor M2-PK in the EDTA-plasma of 137 patients suffering from rh...

journal_title：Anticancer research

authors： Oremek GM,Müller R,Sapoutzis N,Wigand R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:The constant overexpression of glycolysis and active mitochondrial function are critical for productive energy required for the immortal proliferation of cancer cells. The genes related to glycolysis and mitochondrial respiration might have some function during stomach carcinogenesis. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Rho M,Kim J,Jee CD,Lee YM,Lee HE,Kim MA,Lee HS,Kim WH

更新日期：2007-01-01 00:00:00

abstract：:A copper complex with superoxide dismutase mimetic activity, Cu(II)2 (3,5-diisopropylsalicylate)4 (CuDIPS), was tested for activity against mammary cancer in female C3H/HeNCR mice. Initiation of treatment at 20 or at 30 weeks of age had a limited beneficial effect on survival rates. Further, a small, but not statistic...

journal_title：Anticancer research

authors： Crispens CG Jr,Sorenson JR

更新日期：1992-07-01 00:00:00

abstract：:Cytosol from immature rabbit uteri was classified into six groups according to range of molecular weights. The molecular sieve can be achieved by AMICON ultrafiltration using membranes of different pore sizes. The results revealed that almost 50% of the total activity of ER and PgR was confined to the largest fraction...

journal_title：Anticancer research

authors： Chen YM,Vaughn CB

更新日期：1990-11-01 00:00:00

abstract：:Over recent decades there has been debate over whether or not Swedish snuff is carcinogenic in humans. Animal studies and molecular biological and experimental studies have shown the carcinogenic potential of Swedish snuff, but this has not been proved in prospective randomized studies. We present a case series of pat...

journal_title：Anticancer research

authors： Hirsch JM,Wallström M,Carlsson AP,Sand L

更新日期：2012-08-01 00:00:00

abstract：:Amitriptyline, a tricyclic antidepressant, was able to reverse the multidrug resistance efflux pump of human colon cancer subline SW 620 and multidrug resistant (mdr) mouse lymphoma cells by decreasing rhodamine 123 efflux. The inhibitory effect of amitriptyline on the efflux pump was dose dependent. An investigation ...

journal_title：Anticancer research

authors： Varga A,Nugel H,Baehr R,Marx U,Hevér A,Nacsa J,Ocsovszky I,Molnar J

更新日期：1996-01-01 00:00:00

abstract：AIM:Combined cisplatin-topotecan therapy is standard care for advanced cervical cancer, however it is associated with haematotoxicity and nephrotoxicity. This trial was designed to assess the combination of carboplatin which is less nephrotoxic, and oral topotecan. PATIENTS AND METHODS:Patients with advanced/recurrent...

journal_title：Anticancer research

authors： Kurtz JE,Freyer G,Joly F,Gladieff L,Kaminski MC,Fabbro M,Floquet A,Hardy-Bessard AC,Raban N,Ray-Coquard I,Pujade-Lauraine E,GINECO Group, France.

更新日期：2012-03-01 00:00:00