Abstract：
BACKGROUND/AIM:In addition to its cytocidal effects as a microtubule dynamics inhibitor, eribulin mesylate (eribulin) regulates the tumour microenvironment. We examined the clinical significance of tumour infiltrating lymphocytes (TILs) and transforming growth factor-β (TGF-β), which are local markers of host immunity, and of the neutrophil-lymphocyte ratio (NLR) and absolute lymphocyte count (ALC), which are systemic markers. PATIENTS AND METHODS:We administered eribulin chemotherapy to 106 patients with locally advanced or metastatic breast cancer. Of these, 21 had their lesions resected. RESULTS:The response to eribulin was significantly associated with ALC (p=0.007). The expression of pSmad2 (an indicator of activation of TGF-β downstream signaling) was significantly decreased before and after eribulin chemotherapy (p<0.001). Moreover, a baseline ALC ≥ 1,500 /μl was observed in a significantly high number of patients with pSmad2 negative conversion (p<0.001). CONCLUSION:Eribulin improved the tumour immune microenvironment by decreasing TGF-β expression. This demonstrated that local change can be evaluated based on ALC.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kashiwagi S,Asano Y,Goto W,Takada K,Morisaki T,Kouhashi R,Yabumoto A,Tanaka S,Takashima T,Ohsawa M,Hirakawa K,Ohira Mdoi
10.21873/anticanres.14317subject
Has Abstractpub_date
2020-06-01 00:00:00pages
3345-3354issue
6eissn
0250-7005issn
1791-7530pii
40/6/3345journal_volume
40pub_type
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pub_type： 杂志文章,多中心研究
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doi：
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doi：
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doi：
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