Re-evaluation of prognostic mitotic figure counting in breast cancer: results of a prospective clinical follow-up study.

abstract：:Myc is an oncogenic transcription factor that promotes tumorigenesis. Recently, a dominant negative form of Myc (Omomyc) was shown to cause regression of lung tumors in a mouse model of lung cancer caused by KRAS mutation, suggesting that Myc might be a potential therapeutic target to treat the KRAS lung cancer. Howev...

journal_title：Anticancer research

authors： Fukazawa T,Maeda Y,Matsuoka J,Yamatsuji T,Shigemitsu K,Morita I,Faiola F,Durbin ML,Soucek L,Naomoto Y

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The feasibility and diagnostic reliability of sentinel lymph node biopsy of gastric carcinoma are still unclear and controversial. PATIENTS AND METHODS:To assess the applicability of the sentinel node concept to gastric carcinoma, we retrospectively analyzed the location of metastatic lymph nodes in patient...

journal_title：Anticancer research

authors： Moenig SP,Luebke T,Baldus SE,Schroeder W,Bollschweiler E,Schneider PM,Hoelscher AH

更新日期：2005-03-01 00:00:00

abstract：:Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by 'mistake'. In the la...

journal_title：Anticancer research

authors： Rappa F,Farina F,Zummo G,David S,Campanella C,Carini F,Tomasello G,Damiani P,Cappello F,DE Macario EC,Macario AJ

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:A critical step in the delivery of nanomedicines to tumour cells is transporting these particles through the extracellular matrix. Tumour-specific anticancer agents, such as encapsulated drugs, proteins, and genes, show low uptake in tumour tissue. It is not clear whether the collagen network or the glycosam...

journal_title：Anticancer research

authors： Eikenes L,Tufto I,Schnell EA,Bjørkøy A,De Lange Davies C

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Ribonucleotide reductase composed of the hRRM1 and hRRM2 subunits catalyzes the conversion of ribonucleotides to their corresponding deoxy forms for DNA replication. Anti-hRRM2 siRNA degrades hRRM2's mRNA and suppresses tumorigenesis. A Phase I clinical trial demonstrated its therapy potential. HN-1 represen...

journal_title：Anticancer research

authors： Un F,Zhou B,Yen Y

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Signaling between androgen receptor (AR) and mTOR may be crucial for prostate cancer cells to endure the low androgen and suboptimal nutrient conditions produced by androgen deprivation therapy. MATERIALS AND METHODS:AR and mTOR cross-talk was examined in LNCaP cells exposed to either high or low testostero...

journal_title：Anticancer research

authors： Wu Y,Chhipa RR,Cheng J,Zhang H,Mohler JL,Ip C

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:HER-2/neu onco-protein is increasingly being recognized as a target for therapy in solid tumors, but data on its role in malignant melanoma is currently limited. Our study objective was to determine a relationship, if any, between HER-2/neu overexpression and malignant melanoma. PATIENTS AND METHODS:Overexp...

journal_title：Anticancer research

authors： Potti A,Hille R,Koch M

更新日期：2003-09-01 00:00:00

abstract：:The in vitro antioxidative activity of benzylideneascorbate (SBA) and the in vivo effect on adriamycin (ADR)-induced cardiotoxicity in a mouse model were investigated. The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase an...

journal_title：Anticancer research

authors： Kojima S,Iizuka H,Yamaguchi H,Tanuma S,Kochi M,Ueno Y

更新日期：1994-09-01 00:00:00

abstract：:Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. ...

journal_title：Anticancer research

authors： Tungsukruthai S,Petpiroon N,Chanvorachote P

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND/AIM:FAM92A1-289 is recognized as one of the newly-discovered putative oncogenes. This study was performed to reveal its oncogenic functions in human cervical carcinoma cells. MATERIALS AND METHODS:The FAM92A1-289+ cell line was established with knock-in technique and selected by puromycin-resistance screeni...

journal_title：Anticancer research

authors： Gui H,Guo XR,Fang J,Ma SN,Wu G,Shen JH,Tu HJ,Li DS,Dai LJ,Ruan XZ

更新日期：2016-10-01 00:00:00

abstract：:Xenograft hyperacute rejection in humans occurs as a secondary response to a cellular glycosylation incompatibility with most non-human mammalian species. A key component of hyperacute rejection, alpha(1,3)galactosyl (agal) epitopes present on the surface of most non-human mammal cells, is bound by host anti-agal IgG ...

journal_title：Anticancer research

authors： Link CJ Jr,Seregina T,Atchison R,Hall A,Muldoon R,Levy JP

更新日期：1998-07-01 00:00:00

abstract：AIM:To comprehensively summarize the most important literature regarding the late effects of radiotherapy to the abdomen in childhood and adolescence. MATERIALS AND METHODS:Published trials, studies and series were identified using the PubMed database. The key words late effects, late sequelae, child, radiation, radio...

journal_title：Anticancer research

authors： Bölling T,Willich N,Ernst I

更新日期：2010-01-01 00:00:00

abstract：:P53 mutation, through defects in repairing DNA damages, is associated with genomic instability. In 24 adult patients with relapsed acute lymphoblastic leukemia (ALL), the status of the p53 gene at different stages was serially followed by cytogenetic and polymerase-chain reaction/single strand conformation polymorphis...

journal_title：Anticancer research

authors： Tang JL,Tien HF,Lin MT,Chen PJ,Chen YC

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND/AIM:The significance of microvascular invasion (MVI) of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA) is unknown. PATIENTS AND METHODS:We studied 149 patients with solitary small-sized HCC (≤3 cm) who underwent hepatectomy, and developed a predictive model of MVI using independent facto...

journal_title：Anticancer research

authors： Imai K,Yamashita YI,Yusa T,Nakao Y,Itoyama R,Nakagawa S,Okabe H,Chikamoto A,Ishiko T,Baba H

更新日期：2018-02-01 00:00:00

abstract：:Smokeless tobacco consumption is causally associated with oral cavity cancers; however, extensive cytogenetic studies have not been done. In the present study, individuals consuming dry snuff or tobacco with lime have been studied for frequency of micronucleated cells (MNC) in exfoliated buccal mucosa and chromosome a...

journal_title：Anticancer research

authors： Trivedi AH,Dave BJ,Adhvaryu SG

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Incidence of brain metastases (BM) from breast cancer (BC) is increasing. However, prognostic evaluation and treatment strategies are still a matter of debate. AIM:To describe the clinical outcome of BM from BC treated by neurosurgical resection and to identify the actual prognostic factors in this specific...

journal_title：Anticancer research

authors： Tabouret E,Metellus P,Tallet-Richard A,Figarella-Branger D,Charaffe-Jauffret E,Viens P,Gonçalves A

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND/AIM:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) plays an important role in the adhesion, invasion, and metastasis of tumor cells. Although emerging evidence suggests that IMP3 promotes tumor progression in several malignancies, the expression of IMP3 and its prognostic implication in adenocar...

journal_title：Anticancer research

authors： Kim HG,Park MS,Sung JY,Kim YW,Kim HS,Na K

更新日期：2019-09-01 00:00:00

abstract：:Approximately 85% of patients with advanced ovarian cancer will experience recurrence of the disease. In 311 patients CA125 serum levels were determined at follow up investigation in our department. A sensitivity of 92% and specificity of 89% were calculated. Reflecting the further course of disease, specificity could...

journal_title：Anticancer research

authors： Meier W,Baumgartner L,Stieber P,Hasholzner U,Fateh-Moghadam A

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND/AIM:Up-regulation of metallo-proteinase (MMP) proteins has been shown in various types of solid cancers and the genotype of MMP1 has been associated with the risk of solid cancers. The contribution of MMP1 genotype to lung cancer has been investigated in various countries, though, to our knowledge, not in Ta...

journal_title：Anticancer research

authors： Shen TC,Chang WS,Tsai CW,Chao CY,Lin YT,Hsiao CL,Hsu CL,Chen WC,Hsia TC,Bau DT

更新日期：2018-01-01 00:00:00

abstract：:We carried out a systematic review of new drugs active in non-small cell lung carcinoma (NSCLC). Fifty five phase II and III trials were reviewed (vinorelbine (19 trials), paclitaxel (15), gemcitabine (11), docetaxel (6), topotecan (2) or irinotecan (2)). The first four ones could be considered as active drugs when gi...

journal_title：Anticancer research

authors： Meert AP,Berghmans T,Branle F,Lemaître F,Mascaux C,Rubesova E,Vermylen P,Paesmans M,Sculier JP

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:The heterogeneity in prostate cancer is the reason for the difficult diagnosis and prognosis of this tumor. In this study, we looked for a correlation between prostate specific antigen (PSA), tumor staging and DNA cytophotometry. MATERIALS AND METHODS:Twenty-two prostates (pT1-T4) from patients with prostat...

journal_title：Anticancer research

authors： Krause FS,Feil G,Bichler KH,Schrott KM,Akcetin ZY,Engehausen DG

更新日期：2005-05-01 00:00:00

abstract：:Interleukin-10 (IL-10) is an immunosuppressive cytokine involved in carcinogenesis via immune escape. The present study aimed at evaluating the contribution of IL-10 promoter A-1082G (rs1800896), T-819C (rs3021097), A-592C (rs1800872) genetic polymorphisms to the risk of lung cancer in Taiwan. Associations of three IL...

journal_title：Anticancer research

authors： Hsia TC,Chang WS,Liang SJ,Chen WC,Tu CY,Chen HJ,Yang MD,Tsai CW,Hsu CM,Tsai CH,Bau DT

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/AIM:Rta, a transactivator of Epstein-Barr virus, is associated with progression of nasopharyngel carcinoma (NPC); however, its mechanism of contribution to the pathogenesis of NPC remains unclear. Interleukin-6 (IL-6), a tumor promoter, is detected in NPC. This in vitro study examined whether and how Rta pro...

journal_title：Anticancer research

authors： Tung KL,Wu YT,Liu C,Lin SC,Wu CH,Wu SY,Chang Y,Lan YY

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND/AIM:To validate the melanoma nomogram and improve its function in prediction of nodal dissemination by incorporating a molecular marker in the model. Microphthalmia transcription factor (MITF) is an important regulator of melanocyte homeostasis and differentiation. We have shown that the grade of MITF expres...

journal_title：Anticancer research

authors： Naffouje SA,Naffouje R,Chen J,Salti GI

更新日期：2016-12-01 00:00:00

abstract：:This report describes a precise molecular analysis of a rare case of Philadelphia chromosome (Ph) positive acute myeloid leukemia (AML) (FAB classification M2). Phenotypic markers were positive for cells of the myeloid lineage, but negative for B cell and T cell lineage. The leukemic cells carried a Philadelphia chrom...

journal_title：Anticancer research

authors： Yoshida A,Kishi S,Kita K,Kamada N,Nakamura T,Ueda T

更新日期：1997-01-01 00:00:00

abstract：:Sentinel lymph node biopsy (SLNB) is currently the suggested axillary staging procedure in patients with early-stage breast cancer (BC) and usually requires intraoperative frozen-section (FS) examination of the removed nodes. However, other techniques, such as touch imprint cytology (IC), real-time reverse transcripta...

journal_title：Anticancer research

authors： Lumachi F,Marino F,Zanella S,Chiara GB,Basso SM

更新日期：2012-08-01 00:00:00

abstract：:The influence of several oncogenes on drug resistance has recently been show by transfection studies. Therefore, we investigated the influence of transfection on adriamycin (ADR) in cell line transfected with several oncogenes accompanied with pSV2neo vector. There were differences in both the intracellular accumulati...

journal_title：Anticancer research

authors： Gaoi XS,Asaumi J,Kawasaki S,Nishikawa K,Kuroda M,Li H,Takeda Y,Hiraki Y,Ihara M,Ohnishi T

更新日期：1995-09-01 00:00:00

abstract：AIM:To report our experience on implementation and preliminary results of a decision-making model based on the recommendations of an Interdisciplinary Oncological Care Group developed for the management of colorectal cancer. PATIENTS AND METHODS:The multidisciplinary team identified a reference guideline using apprais...

journal_title：Anticancer research

authors： Genovesi D,Mazzilli L,Trignani M,DI Tommaso M,Nuzzo A,Biondi E,Tinari N,Martino MT,Innocenti P,DI Sebastiano P,Mazzola L,Lanci C,Neri M,Laterza F,Marino M,Ferrini G,Spadaccini A,Filippone A,DI Giandomenico E,Marulli

更新日期：2014-05-01 00:00:00

abstract：:This study was undertaken to investigate the role of the human ras family gene product [P21] in various benign, precancerous and malignant skin lesions. A streptavidin-biotin peroxidase method was performed using the monoclonal antibody (Mab)Y13259 in paraffin tissue sections of a total of 69 skin lesions (5 benign hy...

journal_title：Anticancer research

authors： Zioga C,Malamou-Mitsis VD,Kamina S,Agnantis NJ

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Antibodies against human epidermal growth factor receptor 2 (HER2) affect metastatic breast cancer cells and cardiac myocytes. Guidelines recommend evaluation of cardiac ejection fraction (EF) every 3 months despite little supporting evidence for this need. We assessed the impact of EF screening on clinical ...

journal_title：Anticancer research

authors： Mescher C,Ding C,Defor T,Konety S,Blaes A

更新日期：2017-07-01 00:00:00