Developing a decision-making model based on an interdisciplinary oncological care group for the management of colorectal cancer.

Abstract:

AIM:To report our experience on implementation and preliminary results of a decision-making model based on the recommendations of an Interdisciplinary Oncological Care Group developed for the management of colorectal cancer. PATIENTS AND METHODS:The multidisciplinary team identified a reference guideline using appraisal of guidelines for research and evaluation (AGREE) tool based on a sequential assessment of the guideline quality. Thereafter, internal guidelines with diagnostic and therapeutic management for early, locally advanced and metastatic colonic and rectal cancer were drafted; organizational aspects, responsibility matrices, protocol actions for each area of specialty involved and indicators for performing audits were also defined. RESULTS:The National Institute for Health and Care Excellence (NICE) UK guideline was the reference for drafting the internal guideline document; from February to November 2013, 125 patients with colorectal cancer were discussed by and taken under the care of the Interdisciplinary Oncological Care Group. The first audit performed in December 2013 revealed optimal adherence to the internal guideline, mainly in terms of uniformity and accuracy of perioperative staging, coordination and timing of multi-modal therapies. To date, all patients under observation are within the diagnostic and therapeutic course, no patient came out from the multidisciplinary "path" and only in 14% of cases have the first recommendations proposed been changed. The selected indicators appear effective and reliable, while at the moment, it is not yet possible to assess the impact of the multidisciplinary team on clinical outcome. CONCLUSION:Although having a short observation period, our model seems capable of determining optimal uniformity of diagnostic and therapeutic management, to a high degree of patient satisfaction. A longer observation period is necessary in order to confirm these observations and for assessing the impact on clinical outcome.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Genovesi D,Mazzilli L,Trignani M,DI Tommaso M,Nuzzo A,Biondi E,Tinari N,Martino MT,Innocenti P,DI Sebastiano P,Mazzola L,Lanci C,Neri M,Laterza F,Marino M,Ferrini G,Spadaccini A,Filippone A,DI Giandomenico E,Marulli

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

2525-31

issue

5

eissn

0250-7005

issn

1791-7530

pii

34/5/2525

journal_volume

34

pub_type

杂志文章
  • A Case of 15-Year Recurrence-free Survival After Microwave Coagulation Therapy for Liver Metastasis from Gastric Cancer.

    abstract::A 70-year-old man with a growing liver tumor had undergone subtotal gastrectomy with pancreaticoduodenectomy for gastric cancer (T4b P0 H0 N1, Stage IIIB) 30 months before admission to our hospital. Enhanced computed tomography revealed two hypervascular nodules in segments 4 and 8. After histological diagnosis of sma...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12389

    authors: Kinoshita K,Beppu T,Miyata T,Kuramoto K,Yoshida Y,Umesaki N,Kitano Y,Nakagawa S,Okabe H,Nitta H,Imai K,Hayashi H,Yamashita YI,Komori H,Horino K,Misumi A,Baba H

    更新日期:2018-03-01 00:00:00

  • Prophylactic antiangiogenic tumor treatment.

    abstract::Complementary antitumor treatments are required to increase the cure rate achieved by surgery and/or radiotherapy by avoiding future recurrences and metastases. The growth of most solid tumors, particularly carcinomas, depends upon the simultaneous development of internal tumor vasculature to allow the proliferation o...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Madarnas P,Benrezzak O,Nigam VN

    更新日期:1989-07-01 00:00:00

  • Transformation of rat fibroblasts by TGF-beta and EGF induces sensitivity for intercellular induction of apoptosis.

    abstract::During intercellular induction of apoptosis, TGF-beta-treated nontransformed fibroblasts induce apoptosis specifically in transformed fibroblasts. To test whether sensitivity to intercellular induction of apoptosis is causally related to the expression of the transformed phenotype, NRK 536 cells were reversibly transf...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Häufel T,Bauer G

    更新日期:2001-07-01 00:00:00

  • The effect of a biological response modifier, PSK, on the intestinal immune system in tumor-bearing mice.

    abstract::We have previously shown that oral administration of PSK not only exerts antitumor activity, but also restores immune response in tumor-bearing mice. In order to analyze the immunomodulative effect of PSK, we investigated the effects of oral PSK on the intestinal immune systems in ICR mice bearing sarcoma 180. Oral ad...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Matsunaga K,Morita I,Oguchi Y,Fujii T,Yoshikumi C,Nomoto K

    更新日期:1987-05-01 00:00:00

  • Gastric Cancer Mortality Trends in China (2006-2013) Reveal Increasing Mortality in Young Subjects.

    abstract:BACKGROUND/AIM:Although the advent of Helicobacter pylori eradication and global societal changes are widely assumed to impact on gastric cancer (GC)-related mortality, there is remarkable little quantitative and qualitative insight into the nature of its effects. Here, we exploited a nationwide reporting system to inv...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11871

    authors: Yin J,Song JN,Bai ZG,Cai J,Zhang J,Zheng Z,Wu HW,Ye PP,Gao X,Zhang ZT

    更新日期:2017-08-01 00:00:00

  • Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men.

    abstract:BACKGROUND/AIM:Several studies have revealed an association between single nucleotide polymorphisms (SNPs) in the VDR gene and prostate cancer (PCa) risk in European and Asian populations. To investigate whether VDR SNPs are associated with PCa risk in African-American (AA) men, nine VDR SNPs were analyzed in a case-co...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Jingwi EY,Abbas M,Ricks-Santi L,Winchester D,Beyene D,Day A,Naab TJ,Kassim OO,Dunston GM,Copeland RL Jr,Kanaan YM

    更新日期:2015-03-01 00:00:00

  • Influence of two prostaglandin synthesis inhibitors on the intratumor distribution of blood flow and vascular volume in a transplantable rat fibrosarcoma.

    abstract::The intratumor and intramuscle distribution of blood flow and plasma volume was studied via isotope techniques in a transplantable rat fibrosarcoma. Administration of two prostaglandin synthesis inhibitors, indomethacin and diclofenac-sodium, had different effects. Indomethacin changed muscle plasma volume significant...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Karlsson L,Alpsten M,Peterson HI

    更新日期:1984-05-01 00:00:00

  • Prognostic Influence of the Extent of Lymph Node Dissection and Perioperative Comorbidities in Patients with Gastric Cancer.

    abstract:BACKGROUND:The proportion of geriatric gastric cancer (GC) patients with comorbidities has been increasing in Japan. This study was designed to evaluate the prognostic influence of the extent of lymph node dissection (END) and perioperative morbidities in patients with GC. PATIENTS AND METHODS:Between 2008 and 2013, t...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kawaguchi T,Komatsu S,Ichikawa D,Kimura YU,Komiyama S,Konishi H,Kin S,Kawakami S,Kosuga T,Okamoto K,Otsuji E

    更新日期:2016-04-01 00:00:00

  • Treatment Strategy for Rectal Cancer Patients With Inguinal Lymph Node Metastasis.

    abstract:BACKGROUND/AIM:To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS:Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13779

    authors: Ueta K,Matsuda T,Yamashita K,Hasegawa H,Mukohyama J,Yamamoto M,Matsuda Y,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

    更新日期:2019-10-01 00:00:00

  • High levels of Wilms' tumor 1 (WT1) expression were associated with aggressive clinical features in ovarian cancer.

    abstract:AIM:The aim of the present study was to evaluate the correlation between WT1 expression levels and clinical features, to investigate the prognostic value of WT1 expression and to use lentiviral constructs to examine whether overexpression of WT1 affects cell proliferation and invasion in ovarian cancer patients. MATER...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Liu Z,Yamanouchi K,Ohtao T,Matsumura S,Seino M,Shridhar V,Takahashi T,Takahashi K,Kurachi H

    更新日期:2014-05-01 00:00:00

  • Improved survival after gross total resection of malignant gliomas in pediatric patients from the HIT-GBM studies.

    abstract::The present study was performed to investigate the prognostic impact of tumor resection on survival in children and adolescents with malignant gliomas. From the HIT-GBM data base of the Gesellschaft für Paediatrische Onkologie und Haematologie (GPOH), 85 pediatric patients with malignant non-pontine gliomas were analy...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kramm CM,Wagner S,Van Gool S,Schmid H,Sträter R,Gnekow A,Rutkowski S,Wolff JE

    更新日期:2006-09-01 00:00:00

  • DNA damage, repair, replication, and tumor incidence in the BDIV rat strain following administration of N-ethyl-N-nitrosourea.

    abstract::Berlin-Druckrey (BD-IV) rats were used to evaluate the level of neoplastic transformation, initiation of DNA damage and repair following treatment with N-ethyl-N-nitrosourea (ENU). ENU, a potent neurocarcinogen in the Sprague-Dawley (CD) and BDIX rat strains, was a less potent neurocarcinogen when administered to 30 d...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: D'Ambrosio SM,Su C,Chang MJ,Oravec C,Stoica G,Koestner A

    更新日期:1986-01-01 00:00:00

  • Identification of up- and down-regulated proteins in gemcitabine-resistant pancreatic cancer cells using two-dimensional gel electrophoresis and mass spectrometry.

    abstract::The prognosis of patients with pancreatic cancer is very poor because of late diagnosis and the lack of response to various therapies. Pancreatic cancer is generally resistant to chemotherapy and is highly fatal. Gemcitabine (GEM) appears to be the only effective agent for treatment of pancreatic cancer. However, a hi...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kuramitsu Y,Taba K,Ryozawa S,Yoshida K,Zhang X,Tanaka T,Maehara S,Maehara Y,Sakaida I,Nakamura K

    更新日期:2010-09-01 00:00:00

  • Modification of membrane permeability measured by Texas-Red during cell cycle progression and differentiation.

    abstract::Membrane permeability is a critical parameter which must be assessed in the course of new potential anticancer drug studies. Flow cytometry allows us to monitor the permeability status of living cells through the measurement of fluorochrome retention; conventionally this is done using fluorescein diacetate or Hoechst3...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Leonce S,Cudennec CA

    更新日期:1990-03-01 00:00:00

  • Pancreatic resection for metastatic melanoma originating from the nasal cavity: a case report and literature review.

    abstract::Metastatic pancreatic malignant melanoma is considered to be a highly aggressive neoplasm, and only few metastasectomies for lesions originating from the skin or the ocular region have been reported. We report a case of resection of pancreatic metastasis of malignant melanoma originating from the nasal cavity. An isol...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Sugimoto M,Gotohda N,Kato Y,Takahashi S,Kinoshita T,Shibasaki H,Kojima M,Ochiai A,Zenda S,Akimoto T,Konishi M

    更新日期:2013-02-01 00:00:00

  • The Use of Complementary and Alternative Medicine in Scandinavia.

    abstract:BACKGROUND:Complementary alternative medicine (CAM) is widely used among patients with cancer. This usage may have potentially harmful effects, especially when combined with anticancer drugs. However, some complementary methods may benefit patients. This review investigated the prevalence of CAM use among patients with...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Nilsson J,Källman M,Östlund U,Holgersson G,Bergqvist M,Bergström S

    更新日期:2016-07-01 00:00:00

  • 5-year results of cisplatin-epirubicin-vinorelbine (PEV) combination as primary chemotherapy in T2-3, N0-2 breast cancer patients: a multicentre phase II study.

    abstract:UNLABELLED:The aim this study was to assess the efficacy of cisplatin-epirubicin-vinorelbine, as primary chemotherapy, in reducing the tumour burden in T2-3 N0-2 breast carcinomas. Breast conservative surgery (BCS) rate, clinical and pathological complete response (pCR), toxicity and 5-year disease-free survival (DFS) ...

    journal_title:Anticancer research

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Barni S,Visini M,Piazza E,Ionta MT,Ardizzoia A,Arnoldi E,Fava S,Pinotti G,Torretta F,Corradini G,Villa S,Nosenzo AM,Massidda B,Cazzaniga ME

    更新日期:2007-07-01 00:00:00

  • Acetabular osteosarcoma treated by irradiation-vascularized hybrid bone graft.

    abstract:BACKGROUND:Periacetabular reconstruction after malignant bone tumor resection to preserve limb function is extremely challenging. The optimal reconstruction method has not yet received consensus and the functional outcomes still remain unsatisfactory. CASE REPORT:A thirteen-year-old girl who was suffering from acetabu...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kubo T,Sugita T,Shimose S,Tanaka H,Nobuto H,Tanaka K,Ochi M

    更新日期:2004-05-01 00:00:00

  • Biomarkers of anticancer activity of R115777 (Tipifarnib, Zarnestra) in human breast cancer models in vitro.

    abstract:BACKGROUND:Farnesyltransferase inhibitor R115777 (Tipifamib, Zarnestra) is active in breast cancer, but its efficacy in drug combinations has not been extensively investigated. MATERIALS AND METHODS:The activity of R115777 and paclitaxel, alone and in combination, was studied in the human breast cancer cell lines, BT-...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Izbicka E,Campos D,Carrizales G,Patnaik A

    更新日期:2005-09-01 00:00:00

  • Long-term stability of circulating nucleosomes in serum.

    abstract:BACKGROUND:Circulating nucleosomes, complexes of DNA and histones, are recognized as a potential new diagnostic tool for therapy monitoring of cancer disease and as prognostic marker in other acute diseases. Because many studies are carried out retrospectively on serum samples collected earlier, we tested the stability...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Holdenrieder S,Von Pawel J,Nagel D,Stieber P

    更新日期:2010-05-01 00:00:00

  • Radical external beam radiotherapy for clinically localized prostate cancer in Japan: changing trends in the patterns of care process survey between 1996-1998 and 1999-2001.

    abstract:BACKGROUND:This report presents results of a study delineating changing trends in radical external beam radiotherapy usage for prostate cancer between the 1996-1998 and 1999-2001 Patterns of Care Study (PCS) survey periods in Japan. MATERIALS AND METHODS:Out of the 694 patients comprising the 1996-1998 and 1999-2001 P...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ogawa K,Nakamura K,Onishi H,Sasaki T,Koizumi M,Shioyama Y,Komiyama T,Miyabe Y,Teshima T,Japanese Patterns of Care Study Working Subgroup of Prostate Cancer.

    更新日期:2005-09-01 00:00:00

  • Ovarian cancer-associated ascites demonstrates altered immune environment: implications for antitumor immunity.

    abstract:BACKGROUND:To identify immunosuppressive elements present in ovarian cancer associated ascites. PATIENTS AND METHODS:Ascites and plasma were obtained from ovarian, primary peritoneal or fallopian tube cancer patients. Surface markers were identified by fluorescence-activated cell sorting (FACS). Cytokine and chemokine...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Giuntoli RL 2nd,Webb TJ,Zoso A,Rogers O,Diaz-Montes TP,Bristow RE,Oelke M

    更新日期:2009-08-01 00:00:00

  • A phase II study of neuroimmunotherapy with subcutaneous low-dose IL-2 plus the pineal hormone melatonin in untreatable advanced hematologic malignancies.

    abstract::Interleukin-2 (IL-2) has proven to be able to generate an effective anticancer immunity against both solid and hematologic malignancies. Moreover, recent advances in the knowledge of psychoneuroimmunology have demonstrated that anticancer immunity is under neuroendocrine control and that the pineal hormone melatonin (...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Lissoni P,Bolis S,Brivio F,Fumagalli L

    更新日期:2000-05-01 00:00:00

  • Feasibility Technique of Low-passage In Vitro Drug Sensitivity Testing of Malignant Pleural Effusion from Advanced-stage Non-small Cell Lung Cancer for Prediction of Clinical Outcome.

    abstract:BACKGROUND/AIM:Individualized proper chemotherapy using in vitro drug sensitivity testing has been proposed as a novel therapeutic modality and shown to have better efficacy than empiric chemotherapy. However, issues around establishing a patient-derived cell culture or xenograft, the timing of the testing obtained, an...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13920

    authors: Vinayanuwattikun C,Prakhongcheep O,Tungsukruthai S,Petsri K,Thirasastr P,Leelayuwatanakul N,Chanvorachote P

    更新日期:2019-12-01 00:00:00

  • Randomised double blind placebo control study of adjuvant treatment with the metalloproteinase inhibitor, Marimastat in patients with inoperable colorectal hepatic metastases: significant survival advantage in patients with musculoskeletal side-effects.

    abstract:BACKGROUND:A double blind placebo RCT of adjuvant treatment of the matrix metalloproteinase inhibitor, Marimastat, in patients with unresectable colorectal liver metastases showed no significant effect on survival. There was a statistically significant survival advantage for the marimastat-treated patients with musculo...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: King J,Zhao J,Clingan P,Morris D

    更新日期:2003-01-01 00:00:00

  • Lobarstin enhances chemosensitivity in human glioblastoma T98G cells.

    abstract:BACKGROUND/AIM:Lobarstin is a metabolite occurring from the Antarctic lichen Stereocaulon alpnum. Human glioblastoma is highly resistant to chemotherapy with temozolomide. Lobarstin was examined for its effect on glioblastoma. MATERIALS AND METHODS:Temozolomide-resistant T98G cells were subjected to toxicity test with...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kim S,Jo S,Lee H,Kim TU,Kim IC,Yim JH,Chung H

    更新日期:2013-12-01 00:00:00

  • BDNF: An Oncogene or Tumor Suppressor?

    abstract::Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:10.21873/anticanres.11783

    authors: Radin DP,Patel P

    更新日期:2017-08-01 00:00:00

  • Vitamin D3 up-regulated protein 1 (VDUP1) expression in gastrointestinal cancer and its relation to stage of disease.

    abstract::Decreased expression of VDUP1, which is an interesting stress response gene, has been shown in rat mammary tumors and has been discussed in relation to the development of the tumor. However, VDUP1 expression in clinical specimens of human cancer remains unclear. We employed TaqMan RT-PCR assay to investigate VDUP1 exp...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ikarashi M,Takahashi Y,Ishii Y,Nagata T,Asai S,Ishikawa K

    更新日期:2002-11-01 00:00:00

  • Molecular Mechanisms of Breast Cancer Metastasis and Potential Anti-metastatic Compounds.

    abstract::Throughout the world, breast cancer is among the major causes of cancer-related death and is the most common cancer found in women. The development of cancer molecular knowledge has surpassed the novel concept of cancer biology and unraveled principle targets for anticancer drug developments and treatment strategies. ...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:10.21873/anticanres.12502

    authors: Tungsukruthai S,Petpiroon N,Chanvorachote P

    更新日期:2018-05-01 00:00:00

  • Serologic angiogenesis factors and microvascular density in renal cell carcinoma: two independent parameters.

    abstract::Renal Cell Carcinoma (RCC) is characterized by high intratumoral microvascular density (iMVD) and significantly elevated serologic titers of angiogenesis factors, basic fibroblast growth factor (bFGF), vascular endothelial growth factor (vEGF) and angiogenin (Ag). The goal of the present study was to find whether a co...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Wechsel HW,Feil G,Bichler KH,Beiter T,Gleichmann R

    更新日期:2000-11-01 00:00:00