Abstract：
BACKGROUND/AIM:Individualized proper chemotherapy using in vitro drug sensitivity testing has been proposed as a novel therapeutic modality and shown to have better efficacy than empiric chemotherapy. However, issues around establishing a patient-derived cell culture or xenograft, the timing of the testing obtained, and the validity of testing represent major limitations to translating the use of such a technique to clinical practice. PATIENTS AND METHODS:In this study, we assessed the feasibility of an in vitro drug sensitivity technique for testing malignant pleural effusion from advanced-stage non-small cell lung cancer. RESULTS:Our technique was able to produce a turnaround time for in vitro drug sensitivity testing of less than 1 week, with a success rate of more than 90% of cases. Correlated with the individual clinical outcome, using the area under the dose response curve (AUC) could define the level of in vitro drug sensitivity as: responsive (AUC>0.25), intermediate response (0.1≤AUC≤0.25), or resistance (AUC<0.1). CONCLUSION:Data obtained from this method of drug testing were correlated with the clinical outcome. The present drug sensitivity evaluation may benefit the development of individual precision chemotherapy.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Vinayanuwattikun C,Prakhongcheep O,Tungsukruthai S,Petsri K,Thirasastr P,Leelayuwatanakul N,Chanvorachote Pdoi
10.21873/anticanres.13920subject
Has Abstractpub_date
2019-12-01 00:00:00pages
6981-6988issue
12eissn
0250-7005issn
1791-7530pii
39/12/6981journal_volume
39pub_type
杂志文章abstract：:Using gas chromatography, the fatty acid profile has been measured in subcutaneous fat obtained from women undergoing biopsy for benign and malignant breast conditions. There was a similar proportion of saturated and unsaturated fatty acids in both types or fat, suggesting that long-term differences in fatty acid cons...
journal_title：Anticancer research
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更新日期：1987-11-01 00:00:00
abstract：BACKGROUND:Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered. MATERIALS AND METHODS:Da...
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journal_title：Anticancer research
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更新日期：2003-05-01 00:00:00
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journal_title：Anticancer research
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更新日期：1999-01-01 00:00:00
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