Expression of MAGE-1, MAGE-2 and MAGE-3 genes in human gastric carcinomas; lack of evidence for cytotoxic effects in cases with simultaneous expression of MAGE-3 and HLA-A2.

abstract：:The question remains as to whether metastatic cells (cancer seed) that eventually colonize a particular organ (cancer soil) have specific properties that distinguish them from the other cells of the primary tumor. However until recently there have not been model systems in which this question could be fully answered. ...

journal_title：Anticancer research

authors： Togo S,Wang X,Shimada H,Moossa AR,Hoffman RM

更新日期：1995-05-01 00:00:00

abstract：:In lung cancer patients tumor markers are used for disease monitoring. The goal of this study was to improve diagnostic efficiency in the detection of tumor progression in lung cancer patients by using fuzzy logic modeling in combination with a tumor marker panel (Tumor M2-PK, CYFRA 21-1, CEA, NSE and SCC). Thirty-thr...

journal_title：Anticancer research

authors： Schneider J,Peltri G,Bitterlich N,Neu K,Velcovsky HG,Morr H,Katz N,Eigenbrodt E

更新日期：2003-03-01 00:00:00

abstract：:The in vivo investigation of onco/suppressor gene effects may provide new information on chemical-environmental carcinogenesis. We previously described the elevation of onco/suppressor gene expression due to CHOP and COPP chemotherapeutical protocols in a CBA/Ca mouse model. Below we describe the results of the onco/s...

journal_title：Anticancer research

authors： Ember I,Kiss I,Ghodratollah N,Raposa T

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Monoclonal Antibody (MAb) 29-13 reacts with the human sarcoma-associated antigen (SAA) p200. We report here engineering and primary characterization of a single chain antibody (scFV2913). MATERIALS AND METHODS:The scFV2913 recombinant gene, consisting of VH-linker-VK, was constructed with RT-PCR. This gene ...

journal_title：Anticancer research

authors： Chen H,Wang P,Stastny JJ,Shilkaitis A,Liao X,Das Gupta TK

更新日期：1996-11-01 00:00:00

abstract：:Colchicine is an alkaloid widely used for the treatment of inflammatory diseases, such as gout. It suppresses cell division by inhibiting mitosis. We investigated the anticancer effects of colchicine on human hypopharyngeal cancer cells and the mechanisms underlying its anticancer effects. XTT cell proliferation assay...

journal_title：Anticancer research

authors： Cho JH,Joo YH,Shin EY,Park EJ,Kim MS

更新日期：2017-11-01 00:00:00

abstract：:BK virus was isolated by Gardner et al in 1971 from the urine of an immunosuppressed patient with a kidney allograft. Antibodies to this virus are ubiquitous in the general populations worldwide, but the oncogenic capacity of BKV in humans had not been reported. The virus transformed in vitro permissive human and non-...

journal_title：Anticancer research

authors： Sekiguchi M,Miyazaki S,Fujikawa K,Shiroko Y,Asanuma K

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Cancer-related acute disseminated intravascular coagulation (DIC) is uncommon, but it is a severe complication resulting in a very dismal prognosis. Choosing the appropriate chemotherapy agents to treat the underlying cancer and stop the acute DIC process effectively, while avoiding chemotherapy-induced myel...

journal_title：Anticancer research

authors： Lin PH,Lu YS,Lin CH,Chang DY,Huang CS,Cheng AL,Yeh KH

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND/AIM:Intrapelvic bleeding after extended pelvic surgery is fatal, but few reports have addressed this serious situation. The objective of the present study was to evaluate the short-term clinical outcome of this complication. PATIENTS AND METHODS:This study was a retrospective medical chart review of 130 pat...

journal_title：Anticancer research

authors： Ogawa H,Mizushima T,Takemasa I,Yamamoto H,Doki Y,Mori M

更新日期：2014-06-01 00:00:00

abstract：AIM:We aimed to clarify the prognostic significance of HER2 positivity in advanced gastric cancer. PATIENTS AND METHODS:The cohort included patients with initially metastatic or recurrent gastric cancer treated with first-line modified FOLFOX-6. The HER2 status was analyzed according to modified scoring criteria speci...

journal_title：Anticancer research

authors： Kim JW,Im SA,Kim M,Cha Y,Lee KH,Keam B,Kim MA,Han SW,Oh DY,Kim TY,Kim WH,Bang YJ

更新日期：2012-04-01 00:00:00

abstract：:p63 expression was evaluated in a tissue microarray of prostate tissues including benign glands, prostatic intraepithelial neoplasia and prostatic carcinoma. Immunostaining with anti-p63 antibody was restricted to basal cell nuclei. Detectable p63 was found in immortalized and early passage cell cultures, but not in s...

journal_title：Anticancer research

authors： Davis LD,Zhang W,Merseburger A,Young D,Xu L,Rhim JS,Moul JW,Srivastava S,Sesterhenn IA

更新日期：2002-11-01 00:00:00

abstract：:The growth and amino acid utilization of a mouse macrophage-like cell line J774.1 was investigated in two different culture media supplemented with 10% fetal bovine serum (FBS). The J774.1 cells grew faster, and consumed glutamine and serine at higher rates in DMEM than in RPMI1640 medium. The consumption of other ami...

journal_title：Anticancer research

authors： Thet MM,Yokote Y,Chu Q,Wang QT,Kishino K,Tamura N,Shimada J,Amano O,Kanda Y,Kunii S,Takekawa F,Hatano H,Shimada C,Hasegawa H,Sakagami H

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND/AIM:Although insulin-like growth factor-1 (IGF-1) is well-implicated in cancer biology, the potential roles of IGF-1 variants in different types of cancer are largely unknown. The aim of the present study was to in vitro characterize several human cancers for their IGF-1 variant expression patterns. MATERIA...

journal_title：Anticancer research

authors： Christopoulos PF,Philippou A,Koutsilieris M

更新日期：2015-01-01 00:00:00

abstract：:Sirolimus, and its antiproliferative capacity, was studied in vivo in three different syngenic rat tumours in the liver. Sirolimus is an inhibitor of the cytosolic mTOR-kinase, associated with the phosphoinositide-3-kinase/Akt pathway. After one week of daily sirolimus treatment, initiated on the day of tumour-cell in...

journal_title：Anticancer research

authors： Rizell M,Lindner P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:The use of prophylactic cranial irradiation (PCI) to treat brain metastases (BM) in non-small cell lung cancer (NSCLC) is restricted due to the potential associated toxicity and lack of survival benefit. BM can have a negative impact on neurocognitive function (NF) and quality of life (QOL). The aim of this ...

journal_title：Anticancer research

authors： Precival C,Landy M,Poole C,Mullaney L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND/AIM:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy due to its selective ability to induce apoptosis of cancer cells. However, some cancer cells are resistant to TRAIL. Here, we demonstrated that treatment with TRAIL, in combination with equol, sens...

journal_title：Anticancer research

authors： Kim EY,Kim AK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Investigation of transcription regulators in carcinoma can contribute greatly to clarifying the biological character of the carcinoma. In this study, we examined the expression of ets-1 and ets-2, prominent transcription regulators belonging to the ets family, in various colonic tissues. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Ito Y,Takeda T,Okada M,Matsuura N

更新日期：2002-05-01 00:00:00

abstract：:The effects of a bacterial vaccine, heat-killed Clostridium butyricum MII 588 cells, on the metastasis of B16-F10 melanoma in BDF1 mice was investigated. The vaccine stimulated natural killer (NK) cell cytotoxic activity against YAC-1 target cells, which peaked at 72 hr after the pretreatment, whereas maximum macropha...

journal_title：Anticancer research

authors： Chen HY,Wu SL,Yeh MY,Chen CF,Mikami Y,Wu JS

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIM:The prognosis of pancreatic cancer has not improved due to its migratory feature and refractory potential to chemo-resistance with absence of effective diagnosis. Despite continuous efforts, its underlying mechanisms of malignant nature remain ambiguous. The objective of this study was to investigate del...

journal_title：Anticancer research

authors： Lee J,Lee J,Kim DH,Kim JH

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/AIM:Lymphatic invasion (ly) may mainly reflect the selective affinity of breast cancer cells for lymph nodes. We conducted the present study to investigate whether the presence of lymphatic invasion is a predictor of sentinel lymph node (SLN) metastasis in clinically node-negative breast cancer. PATIENTS AN...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tatsuki H,Suto T,Morita H,Tsutsumi S,Kuwano H

更新日期：2015-06-01 00:00:00

abstract：:The antitumor activity of (2''R)-4'-O-tetrahydropyranyl adriamycin (pirarubicin; THP) was assessed using human gastric cancer cell lines in vitro and in vivo. The cytotoxicity of THP on MKN-28 and MKN-45 was superior to that of adriamycin (ADM) as detected by a growth assay with an MTT colorimetric endpoint. When the ...

journal_title：Anticancer research

authors： Saikawa Y,Kubota T,Kuo TH,Furukawa T,Kase S,Tanino H,Ishibiki K,Kitajima M,Hoffman RM

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND/AIM:Since androgens affect urothelial bladder cancer (UBC), we examined whether 5α-reductases (5-AR) have genomic alterations in UBC and whether 5α-reductase inhibitors (5-ARI) affect UBC. MATERIALS AND METHODS:The cBioPortal was used to analyze genomic alternations of 5-ARs in UBC cancer genomic datasets. ...

journal_title：Anticancer research

authors： Chen CC,Huang CP,Tsai YT,Hseih TF,Shyr CR

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:The transforming growth factor beta (TGF-beta) superfamily regulates cell growth in various cells. Previous studies have shown that altered expression of TGF-beta receptors, Smad2 and Smad4, as mediators of TGF-beta superfamily signaling, contributes to tumor progression in esophageal squamous cell carcinoma...

journal_title：Anticancer research

authors： Osawa H,Nakajima M,Kato H,Fukuchi M,Kuwano H

更新日期：2004-11-01 00:00:00

abstract：:The poor response of pancreatic adenocarcinoma to conventional chemotherapy has prompted us to search for innovative treatment approaches. Verapamil, a calcium channel blocker, has been reported to increase the doxorubicin sensitivity of several tumor models with acquired resistance, often in association with decrease...

journal_title：Anticancer research

authors： Chang BK,Brenner DE,Gutman R

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Resistance to multiple chemotherapeutic agents results from a variety of factors including a lack of apoptosis in tumor cells. To induce apoptosis in two types of tumor cells, RPMI-8226 and MG-63, a combination of chemotherapeutic agents and retroviral transduction of TRAIL was employed. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Suzuki H,Hotta T,Koyama T,Komagata M,Imakiire A,Yanase N,Yoshimoto T,Mizuguchi J

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Pulmonary complications (PCs) after esophagectomy for patients with esophageal cancer have been correlated with prolonged hospital stays and in-hospital mortality. Previous studies have shown that minimally-invasive esophagectomy (MIE) is associated with a lower rate of PCs compared to conventional open surg...

journal_title：Anticancer research

authors： Kubo N,Ohira M,Yamashita Y,Sakurai K,Toyokawa T,Tanaka H,Muguruma K,Shibutani M,Yamazoe S,Kimura K,Nagahara H,Amano R,Ohtani H,Yashiro M,Maeda K,Hirakawa K

更新日期：2014-05-01 00:00:00

abstract：:Cervical cancer is not considered a hormone-responsive tumor in spite of the presence of estrogen receptors (ER) and progesterone receptors (PgR) in some of them. Endocrine treatments have not achieved clinical responses, however, tamoxifen has been reported to induce PgR and to inhibit cell growth of many cervical ca...

journal_title：Anticancer research

authors： Vargas Roig LM,Lotfi H,Olcese JE,Lo Castro G,Ciocca DR

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Copper transporters (CTR) also regulate the cellular transport of platinum drugs, but their role in platinum resistance of ovarian cancer has not been elucidated. MATERIALS AND METHODS:CTR expression in ovarian cancer tissues resected from patients treated by platinum-based chemotherapy was evaluated immuno...

journal_title：Anticancer research

authors： Yoshida H,Teramae M,Yamauchi M,Fukuda T,Yasui T,Sumi T,Honda K,Ishiko O

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors are uncommon intra-abdominal tumors. In fewer than 5% of cases, they originate primarily from the mesentery, omentum or peritoneum and these extra-gastrointestinal stromal tumors tend to have characteristics similar to gastrointestinal stromal. CASE REPORT:We report a case of...

journal_title：Anticancer research

authors： Rediti M,Pellegrini E,Molinara E,Cerullo C,Fonte C,Lunghi A,Iori A,Neri B

更新日期：2014-02-01 00:00:00

abstract：:EGF/TGF-alpha and progesterone were measured in the urine of 74 ovarian carcinoma patients, 21 postmenopausal women with non-gynecological disseminated cancer, 20 premenopausal and 20 postmenopausal controls. Radically operated women excreted significantly less EGF/TGF-alpha into urine than women with residual tumour ...

journal_title：Anticancer research

authors： Ridderheim M,Cajander S,Tavelin B,Stendahl U,Bäckström T

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIM:Individualized proper chemotherapy using in vitro drug sensitivity testing has been proposed as a novel therapeutic modality and shown to have better efficacy than empiric chemotherapy. However, issues around establishing a patient-derived cell culture or xenograft, the timing of the testing obtained, an...

journal_title：Anticancer research

authors： Vinayanuwattikun C,Prakhongcheep O,Tungsukruthai S,Petsri K,Thirasastr P,Leelayuwatanakul N,Chanvorachote P

更新日期：2019-12-01 00:00:00