Effect of hexafluoro-1,25-dihydroxyvitamin D3 and sodium butyrate combination on differentiation and proliferation of HL-60 leukemia cells.

abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...

journal_title：Anticancer research

authors： Kovacs CJ,Evans MJ,Daly BM

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Immunotherapy has become an attractive new strategy in the treatment of cancer. The laboratory and clinical study of cancer immunotherapy is rapidly advancing. However, in the clinical setting, the results of cancer immunotherapy are mixed. We therefore contend that cancer immunotherapy should be customized ...

journal_title：Anticancer research

authors： Inui T,Kuchiike D,Kubo K,Mette M,Uto Y,Hori H,Sakamoto N

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：:Cisplatin is the most active anticancer agent for lung cancer. It has been reported that intracellular accumulation of cisplatin is important in determining resistance to cisplatin, which may be modulated by Na+, K(+)-ATPase activity. On the other hand, it is well-known that sorbitol, a metabolite of glucose mediated ...

journal_title：Anticancer research

authors： Bando T,Fujimura M,Kasahara K,Shibata K,Shirasaki H,Heki U,Iwasa K,Ueda A,Tomikawa S,Matsuda T

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:We used non-linear kernel discriminant analysis (KDA) to predict the outcome of 134 axillary node-negative primary breast cancer patients not treated with adjuvant therapy in a non censored database. MATERIAL:Posterior probabilities of relapse at 5 years were estimated using probabilistic neural networks (P...

journal_title：Anticancer research

authors： Le Goff JM,Lavayssière L,Rouëssé J,Spyratos F

更新日期：2000-05-01 00:00:00

abstract：:The oxazaphosphorines cyclophosphamide (CP) and ifosfamide (IF) are alkylating agents that require bioactivation via cytochrome (CYP) P450 isoenzymes including CYP2C9 enzymes. The present study investigated CYP2C9 in regard to its allelic variants in 23 tumor samples (10 breast tumors, 1 breast tumor cell line, 5 brai...

journal_title：Anticancer research

authors： Knüpfer H,Stanitz D,Preiss R

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND/AIM:Neoplastic spindle cells (NSCs) are believed to play a role in cancer invasion and metastasis, as well as in poor prognosis. The clinicopathological characteristics and prognostic relevance of NSCs was investigated in gallbladder cancer. MATERIALS AND METHODS:Specimens were obtained from 62 patients wit...

journal_title：Anticancer research

authors： Midorikawa R,Hisaka T,Sakai H,Nomura Y,Goto Y,Sato T,Kawahara R,Ishikawa H,Fujita F,Yasunaga M,Tanigawa M,Naito Y,Akiba J,Yano H,Tanaka H,Akagi Y,Okuda K

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:We evaluated the effect of in vivo electrogene therapy (EGT), a newly-developed gene transfer method using electroporation on the induction of anti-cancer immunity. MATERIALS AND METHODS:The in vivo EGT was carried out by direct injection of plasmid DNAs encoding mouse interleukin-2 (IL-2) and granulocyte-m...

journal_title：Anticancer research

authors： Chi CH,Wang YS,Lai YS,Chi KH

更新日期：2003-01-01 00:00:00

abstract：:The expression of the protooncogene encoded proteins (c-erbB1, c-erb B2, c-myc, c-fos) and the suppressor gene product p53 was analyzed in 81 human squamous cell carcinomas of the lung and correlated with clinical parameters of the patients (patient survival, presence of metastases and tumor stage) and with biological...

journal_title：Anticancer research

authors： Volm M,Efferth T,Mattern J

更新日期：1992-01-01 00:00:00

abstract：:The E6 protein of the high-risk human papillomavirus (HPV) types 16 and 18 is capable of complexing with the wild-type p53 tumor suppressor gene product, leading to loss of the normal p53 function as an anti-oncogene, whereas the low-risk HPV types 6 and 11 lack this binding property. The malignant potential of HPV 16...

journal_title：Anticancer research

authors： Tervahauta AI,Syrjänen SM,Väyrynen M,Saastamoinen J,Syrjänen KJ

更新日期：1993-07-01 00:00:00

abstract：:Bone only metastasis in patients with estrogen receptor (ER) positive breast cancer reported to have favorable response to chemotherapy, favorable prognosis, and an "indolent" course. Therefore, we assessed the ability of MG-63 osteoblast-like human osteosarcoma cells (MG-63 cells) and MG-63 conditioned media (CM) to ...

journal_title：Anticancer research

authors： Choki I,Sourla A,Reyes-Moreno C,Koutsilieris M

更新日期：1998-11-01 00:00:00

abstract：:Endometrial cancer is the most common gynecologic malignancy. The mainstay of treatment for endometrial cancer is total hysterectomy with bilateral salpingo-oophorectomy. Radiation and chemotherapy accompanied with progestins can also play a significant role in treatment. Lower urinary tract symptoms (LUTS) following ...

journal_title：Anticancer research

authors： Koutras A,Peteinaris A,Davakis S,Kalinterakis G,Tsilikis I,Garmpis N,Zotos PA,Chionis A,Schizas D,Karavokyros I,Thomakos N,Kontomanolis E,Syllaios A

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that doxorubicin (DXR) showed much higher cytotoxicity against human oral squamous cell carcinoma cell lines compared to normal human mesenchymal normal oral cells (gingival fibroblast, periodontal ligament fibroblast, pulp cell), yielding high tumor-specificity. However, we u...

journal_title：Anticancer research

authors： Sakagami H,Okudaira N,Masuda Y,Amano O,Yokose S,Kanda Y,Suguro M,Natori T,Oizumi H,Oizumi T

更新日期：2017-03-01 00:00:00

abstract：AIM:This study aimed at exploring several brain metastatic prognostic scores in patients with renal cell carcinoma. PATIENTS AND METHODS:We retrospectively analyzed data of 93 metastatic renal cell carcinoma patients who were diagnosed with brain metastases between October 2005 and July 2016 who received targeted ther...

journal_title：Anticancer research

authors： El Ali Z,Rottey S,Barthelemy P,Kotecki N,VAN Paemel R,Devrient D,Awada A,Gil T,Pannier D,Ryckewaert T,Waisse W,Clavier JB,Penel N,Vermassen T

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:In order to decrease surgery-related morbidity, we evaluated the reliability of the evaluation of lymph node metastasis in patients with uterine corpus cancer by positron-emission tomography (PET) with 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) before surgical staging. MATERIALS AND METHODS:Patients with newly...

journal_title：Anticancer research

authors： Klar M,Meyer PT,Hancke K,Brink I,Orlowska-Volk M,Gitsch G,Denschlag D

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:DNA repair capacity may be an important factor in determining both individual susceptibility to cancer and the response to cancer therapy. The aim of this work was to compare DNA damage and the repair process in cells originating from healthy donors and cancer patients. MATERIALS AND METHODS:Using the micro...

journal_title：Anticancer research

authors： Palyvoda O,Mukalov I,Polanska J,Wygoda A,Drobot L,Widel M,Rzeszowska-Wolny J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND/AIM:It is generally believed that the plasma concentration of 5-fluorouracil (5-FU) is constant when 5-FU is continually administered for chemotherapy. The aim of the present study was to verify whether this is true. PATIENTS AND METHODS:Nine patients with colorectal cancer were enrolled in this study. All ...

journal_title：Anticancer research

authors： Matsumoto H,Okumura H,Murakami H,Kubota H,Higashida M,Tsuruta A,Tohyama K,Hirai T

更新日期：2015-11-01 00:00:00

abstract：:Adrenocortical Carcinoma (ACC) is rare with an annual incidence of 0.5-2 cases per million worldwide. Some ACC tumors over express N-cadherin, which correlates with metastatic potential. ADH-1 (Exherin™) is a competitive inhibitor of N-cadherin, resulting in rapid onset of tumor vascular angiolysis and apoptosis in pr...

journal_title：Anticancer research

authors： Yarom N,Stewart D,Avruch L,Malik R,Wells J,Jonker DJ

更新日期：2011-11-01 00:00:00

abstract：:In colorectal cancer, the predictive value of the currently used staging method is limited. Therefore, many parameters have been studied to improve the prediction of final clinical outcome, including several aspects of the primary tumor that are associated with its aggressiveness and the capacity of the host response....

journal_title：Anticancer research

authors： Vlems FA,Wobbes T,Punt CJ,Van Muijen GN

更新日期：2003-01-01 00:00:00

abstract：:Secreted pro-cathepsin B of HS-24 human lung-tumour cells, human alveolar macrophages and Wi-38 human lung-fibroblast cells was pre-purified by ion exchange chromatography and investigated by 2D gel electrophoresis. Four (Wi-38), six (HS-24) and ten (alveolar macrophages) polypeptides differing in charge, but with the...

journal_title：Anticancer research

authors： Werle B,Ebert W,Klein W,Spiess E

更新日期：1996-01-01 00:00:00

abstract：:We have previously reported the presence of human beta-defensin-2 (HBD-2), a peptide with antimicrobial and cytotoxic properties, in oral squamous cell carcinomas. The aim of the present study was to measure the concentration of HBD-2 in abnormal tissues such as oral squamous cell carcinomas. HBD-2 was extracted from ...

journal_title：Anticancer research

authors： Sawaki K,Mizukawa N,Yamaai T,Yoshimoto T,Nakano M,Sugahara T

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Recently, it has become obvious that the HMGB1 protein can act as a proinflammatory and proangiogenic mediator when actively secreted by macrophages or passively released from necrotic cells playing an important role in the pathogenesis of several diseases including cancer. MATERIALS AND METHODS:The absolut...

journal_title：Anticancer research

authors： Winter N,Meyer A,Richter A,Krisponeit D,Bullerdiek J

更新日期：2009-12-01 00:00:00

abstract：AIM:The current study reports the type of salvage chemotherapy following osimertinib and its treatment efficacy in patients with non-small-cell lung carcinoma (NSCLC) who acquire resistance to osimertinib. PATIENTS AND METHODS:In this retrospective cohort study, data from the medical charts of 40 patients with NSCLC t...

journal_title：Anticancer research

authors： Tone M,Inomata M,Awano N,Kuse N,Jo T,Yoshimura H,Minami J,Takada K,Miyamoto S,Izumo T

更新日期：2020-04-01 00:00:00

abstract：AIM:To assess the ability of ultrasound (US)-guided vacuum-assisted breast excision (VAE) to remove Breast Imaging Reporting and Data System (BI-RADS) ≥3 breast lesions in order to analyze US features most frequently associated with complete excision. MATERIALS AND METHODS:A total of 266 BI-RADS ≥3 lesions without mic...

journal_title：Anticancer research

authors： Perretta T,Lamacchia F,Ferrari D,Beninati E,DI Tosto F,DE Stasio V,Meucci R,DI Stefano C,Buonomo OC,Vanni G,Pistolese CA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukemia (CLL) is characterized by a clonal accumulation of neoplastic lymphocytes, indicating disruption of apoptosis. PATIENTS AND METHODS:Differential methylation hybridization analysis was performed to identify novel target genes silenced by CpG island methylation in patients with CL...

journal_title：Anticancer research

authors： Schmidt-Wolf IG,Plass C,Byrd JC,Frevel K,Pietsch T,Waha A

更新日期：2016-09-01 00:00:00

abstract：:Glycerophosphoinositols are metabolites formed by the sequential action of a phospholipase A2 specific for membrane phosphoinositides, and a lysolipase. Increased levels of these compounds characterize cell lines of different origin transformed by ras and other oncogenes. Thus, glycerophosphoinositols have been propos...

journal_title：Anticancer research

authors： Corda D,Falasca M

更新日期：1996-05-01 00:00:00

abstract：UNLABELLED:Concurrent chemoradiotherapy has become a standard therapy for locoregionally advanced inoperable nonsmall cell lung cancer (NSCLC). The purpose of this phase II trial was to evaluate the efficacy and toxicity of concurrent chemoradiotherapy following induction with non-platinum chemotherapy in patients with...

journal_title：Anticancer research

authors： Kosmidis P,Fountzilas G,Baka S,Samantas E,Dimopoulos AM,Gogas H,Skarlos D,Papacostas P,Boukovinas J,Bakogiannis Ch,Pantelakos P,Athanasiou H,Misailidou D,Tsekeris P,Pavlidis N

更新日期：2007-11-01 00:00:00

abstract：:This review focuses on the relationship between pre-treatment immune parameter values and outcome of immunotherapy of cancer patients. The evidence presented in this review suggests that there is a relationship between pre-treatment immune parameter values and survival of cancer patients treated with immunotherapy. Tu...

journal_title：Anticancer research

authors： Characiejus D,Jacobs JJ,Pašukonienė V,Kazlauskaitė N,Danilevičiūtė V,Mauricas M,Den Otter W

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical feasibility and surgical outcomes of robotic-assisted transperitoneal infrarenal para-aortic lymphadenectomy (TIPAL) in patients with gynecological malignancies. PATIENTS AND METHODS:The perioperative outcomes in 90 patients with gynecological malignancies who underwent laparos...

journal_title：Anticancer research

authors： Lee HJ,Lee YH,Chong GO,Hong DG,Lee YS

更新日期：2017-12-01 00:00:00

abstract：:Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been indicated as a novel cancer drug target, since it plays an important role in diverse oncogenic processes including survival, cell proliferation and migration. Emerging STAT3 inhibitors have demonstrated efficacy in cancer ce...

journal_title：Anticancer research

authors： Tian J,Xiao H,Wu R,Cao Y,Li C,Xu R,Pierson CR,Finlay JL,Yang F,Gu N,Lin J

更新日期：2017-02-01 00:00:00