Detection and clinical relevance of tumor cells in blood and bone marrow of patients with colorectal cancer.

abstract：OBJECTIVE:The extent of radiogenic damage in salivary gland (SG) tissue depends on the radiation dose (RD), the fractionation (FN) and the localization of SG in the radiation field (RF). While the functional restriction and the radiogenic SG tissue damage are well documented using histomorphological, electron-microscop...

journal_title：Anticancer research

authors： Bartel-Friedrich S,Friedrich RE,Lautenschläger C,Holzhausen HJ,Moll R

更新日期：2000-11-01 00:00:00

abstract：:In the presence study we demonstrated that hycanthone and chlorophenoxamine can modulate the resistance of multidrug resistant (MDR) murine L1210 leukemia tumor lines in vitro and in vivo. The circumvention of MDR by hycanthone and chlorophenoxamine in vitro was demonstrated by a short-term test using tritiated nuclei...

journal_title：Anticancer research

authors： Efferth T,Klett T,Mattern J,Osswald H,Pommerenke EW,Stöhr M,Volm M

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND/AIM:Lymphatic invasion (ly) may mainly reflect the selective affinity of breast cancer cells for lymph nodes. We conducted the present study to investigate whether the presence of lymphatic invasion is a predictor of sentinel lymph node (SLN) metastasis in clinically node-negative breast cancer. PATIENTS AN...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tatsuki H,Suto T,Morita H,Tsutsumi S,Kuwano H

更新日期：2015-06-01 00:00:00

abstract：:Clinical and hematological parameters, and three derived major staging systems were compared with DNA-cytometric parameters in 73 patients with newly diagnosed multiple myeloma (MM) and correlated in univariate analysis with survival to assess their predictive value. Regarding diagnostic validity, a multi-parameter sy...

journal_title：Anticancer research

authors： Kropff M,Leo E,Steinfurth G,Esselborn H,Adler CP,Böcking A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND/AIM:Invasive bladder cancer mortality remains high despite progresses made in early diagnosis and surgical procedures. Thus, there is a need to define new markers for bladder cancer. CLIC1 has not been previously studied in bladder cancer and thus, we aimed to assess its immunohistochemical expression in rel...

journal_title：Anticancer research

authors： Adelmann TG,Camerota TC,Ceausu AR,Cimpean AM,Mazzanti M,Raica M

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Long-acting sandostatin (S-LAR; octreotide acetate) is well tolerated and effective for symptom control and possibly disease control in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We undertook a retrospective analysis to study the efficacy and tolerability of higher doses (more than 20-30 mg/mon...

journal_title：Anticancer research

authors： Chadha MK,Lombardo J,Mashtare T,Wilding GE,Litwin A,Raczyk C,Gibbs JF,Kuvshinoff B,Javle MM,Iyer RV

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:The concentration of Des-gamma-carboxy-prothrombin (DCP) or PIVKA-II has been described to be increased in patients with hepatocellular cancer, along with its elevation in vitamin K deficient states by warfarin or dicoumarol treatment. The aim of the study was to investigate its clinical value in HCC in comp...

journal_title：Anticancer research

authors： Lamerz R,Runge M,Stieber P,Meissner E

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:The genetic basis of sinonasal inverted papilloma (SNIP)-derived squamous cell carcinoma (SCC) has not yet been well characterized. AIM:To characterize the genetic abnormalities of SNIP and SNIP-derived SCC and to uncover their differences. MATERIALS AND METHODS:Mutations of 409 genes were analyzed using a...

journal_title：Anticancer research

authors： Uchi R,Jiromaru R,Yasumatsu R,Yamamoto H,Hongo T,Manako T,Sato K,Hashimoto K,Wakasaki T,Matsuo M,Nakagawa T

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Human mesenchymal stem cells (MSCs) are thought to be multipotent cells which primarily reside in the bone marrow. Besides their well-known ability to replicate as undifferentiated cells and to differentiate into diverse lineages of mesenchymal tissues, they were recently suggested to also give rise to haema...

journal_title：Anticancer research

authors： Wöhrer S,Rabitsch W,Shehata M,Kondo R,Esterbauer H,Streubel B,Sillaber C,Raderer M,Jaeger U,Zielinski C,Valent P

更新日期：2007-11-01 00:00:00

abstract：:An important variable in determining in vitro cell survival is the time interval between treatment and assay. One manifestation of radiation damage is the introduction of a division delay in which the post-radiation division rate is less than the pre-radiation division rate. We have examined the influence of length of...

journal_title：Anticancer research

authors： Yohem KH,Bregman MD,Meyskens FL Jr

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Recently, we reported on the existence of activated protein kinase Cα (PKCα) in blood and the possibility for its use in cancer diagnosis. MATERIALS AND METHODS:In the present study, serum samples collected from patients with different lung cancer types (small-cell cancer, adenocarcinoma, and anaplastic can...

journal_title：Anticancer research

authors： Kang JH,Mori T,Kitazaki H,Niidome T,Takayama K,Nakanishi Y,Katayama Y

更新日期：2013-02-01 00:00:00

abstract：AIM:We aimed to retrospectively investigate the outcomes and pathological effects of retrograde superselective intra-arterial chemoradiotherapy (IACRT) combined with hyperthermia on metastatic lymph nodes of patients with oral squamous cell carcinoma. PATIENTS AND METHODS:Patients with lymph node metastasis from oral ...

journal_title：Anticancer research

authors： Nozato T,Koizumi T,Hayashi Y,Iida M,Iwai T,Oguri S,Hirota M,Kioi M,Koike I,Hata M,Tohnai I,Mitsudo K

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND/AIM:We retrospectively investigated the relationship between pathological complete response (pCR) and tumor volume (TV) reduction during neoadjuvant chemoradiation therapy (NACRT) in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We evaluated patients who received NACRT (50 Gy/25 fractions with pl...

journal_title：Anticancer research

authors： Takahashi S,Go T,Anada M,Kinoshita T,Nishide T,Yokomise H,Shibata T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Activating Gs a mutations have been identified in most instances of fibrous dysplasia (FD). This mutation leads to consistently elevated intracellular cyclic adenosine monophosphate (cAMP) levels, with various biological consequences. The development of secondary sarcoma in FD is a rare but well-established ...

journal_title：Anticancer research

authors： Gu W,Ogose A,Matsuba A,Kawashima H,Hotta T,Kudo N,Hoshino M,Kondo N,Mera H,Endo N

更新日期：2006-03-01 00:00:00

abstract：:Development and progression of tumours is generally driven by an accumulation of genetic alterations. In this study we correlated chromosome 17 aneuploidy to invasiveness of bladder cancer by the method of fluorescence in situ hybridisation (FISH) in urinary cytospins. We investigated the value of FISH compared to DNA...

journal_title：Anticancer research

authors： Krause FS,Feil G,Zumbrägel A,Bichler KH

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Tumour stage and the appropriate course of treatment in patients with breast cancer are primarily characterized by the state of metastasis in the axillary lymph nodes. In recent years, substantial research has focused on the prediction of lymph node status based on various pathological and molecular markers ...

journal_title：Anticancer research

authors： Mojarad S,Venturini B,Fulgenzi P,Papaleo R,Brisigotti M,Monti F,Canuti D,Ravaioli A,Woo L,Dlay S,Sherbet GV

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND/AIM:Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status...

journal_title：Anticancer research

authors： Krause R,Stange R,Roth HJ,Kaase H,Michalsen A,Holick MF

更新日期：2018-02-01 00:00:00

abstract：:In this study, a protein kinase C inhibitor, H-7, was found to potentiate the antiproliferative effects of difluoromethyl ornithine (DFMO), inhibitor of the polyamine biosynthesis, on NIH 3T3 and 3T3/SV40 cells in culture. Incubation of the cells with DFMO inhibited the cell growth, whereas the addition of polyamine s...

journal_title：Anticancer research

authors： Khan NA,Havouis R,Quemener V,Moulinoux JP

更新日期：1992-07-01 00:00:00

abstract：:Between 1981 and 1987, 533 patients from 9 institutions were entered in a randomized trial to assess the value of adjuvant perioperative portal infusion with Fluorouracil and Mitomycin as compared to radical surgery alone. Analysis of 469 evaluable patients at a median follow-up of 5.8 years revealed 110 recurrences i...

journal_title：Anticancer research

authors： Weber W,Laffer U,Metzger U

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND:High thymidine kinase (TK) activity in cancer cells could counteract adjuvant chemotherapy directed at the inhibition of de novo DNA synthesis. TK is an independent prognostic factor in breast cancer patients receiving adjuvant chemotherapy. MATERIAL AND METHODS:In this paper, we describe the effects of ext...

journal_title：Anticancer research

authors： Span P,Heuvel J,Romain S,Piffanelli A,Martin PM,Geurts-Moespot A,Sweep F

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Microparticles are known to be increased in various malignancies. In this prospective study, microparticle levels were evaluated in patients with benign and malignant ovarian lesions. PATIENTS AND METHODS:Microparticles from platelets/megakaryocytes, activated platelets and endothelial cells, tissue factor ...

journal_title：Anticancer research

authors： Rank A,Liebhardt S,Zwirner J,Burges A,Nieuwland R,Toth B

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Positron emission tomography-computed tomography (PET-CT) is currently not established in the management of recurrent ovarian cancer. Here, its value in diagnosis and therapy planning was evaluated. PATIENTS AND METHODS:Seventy patients received PET-CT for suspicion of recurrent ovarian cancer. PET-CT and s...

journal_title：Anticancer research

authors： Lenhard MS,Burges A,Johnson TR,Stieber P,Kümper C,Ditsch N,Linke R,Friese K

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation. MATERIALS AND METHODS:We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell line...

journal_title：Anticancer research

authors： Turner SD,Merz H,Yeung D,Alexander DR

更新日期：2006-09-01 00:00:00

abstract：:Berlin-Druckrey (BD-IV) rats were used to evaluate the level of neoplastic transformation, initiation of DNA damage and repair following treatment with N-ethyl-N-nitrosourea (ENU). ENU, a potent neurocarcinogen in the Sprague-Dawley (CD) and BDIX rat strains, was a less potent neurocarcinogen when administered to 30 d...

journal_title：Anticancer research

authors： D'Ambrosio SM,Su C,Chang MJ,Oravec C,Stoica G,Koestner A

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Immmunosuppression and infectious disease in cancer patients receiving chemotherapy is a serious problem. Immunopotentiating drugs may show a therapeutic efficacy. MATERIALS AND METHODS:The protective effect of Hochu-ekki-to (TJ-41), a Japanese traditional herbal medicine, on mitomycin C (MMC)-induced immun...

journal_title：Anticancer research

authors： Kido T,Mori K,Daikuhara H,Tsuchiya H,Ishige A,Sasaki H

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Intratumoural hypoxia is associated with chemoresistance in glioblastoma multiforme (GBM), a highly malignant brain tumour. Adaptive response to endoplasmic reticulum stress induced by temozolomide is a major obstacle in recurrent GBM. We investigated whether hyperoxia resensitizes temozolomide-resistant GBM...

journal_title：Anticancer research

authors： Lee D,Sun S,Ho AS,Kiang KM,Zhang XQ,Xu FF,Leung GK

更新日期：2014-06-01 00:00:00

abstract：:The model of human malignant tumors, heterotransplanted and passaged into athymic nude mice, proved to be a valuable tool for nutritional oncology. It showed that several human tumors proliferate in distinct dependence on the available vitamin B6. A surplus of the vitamin causes enhancement of growth. Proliferation is...

journal_title：Anticancer research

authors： Fortmeyer HP,Timm C,Blum U,Wenisch HJ,Förster H

更新日期：1988-07-01 00:00:00

abstract：:The expression of the protooncogene encoded proteins (c-erbB1, c-erb B2, c-myc, c-fos) and the suppressor gene product p53 was analyzed in 81 human squamous cell carcinomas of the lung and correlated with clinical parameters of the patients (patient survival, presence of metastases and tumor stage) and with biological...

journal_title：Anticancer research

authors： Volm M,Efferth T,Mattern J

更新日期：1992-01-01 00:00:00

abstract：:Para-aminobenzoic acid (PABA) has been previously reported as being an inhibitor of DDP toxicity, and its use did not result in any observable loss in antitumor activity of DDP. The following studies investigated the effect of PABA on the pharmacokinetics and urinary excretion of cis-diamminedichloroplatinum(II) (DDP)...

journal_title：Anticancer research

authors： Esposito M,Vannozzi M,Viale M,Pellecchia C,Civalleri D,Gogioso L

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

journal_title：Anticancer research

authors： Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

更新日期：2017-12-01 00:00:00