Abstract：
:An important variable in determining in vitro cell survival is the time interval between treatment and assay. One manifestation of radiation damage is the introduction of a division delay in which the post-radiation division rate is less than the pre-radiation division rate. We have examined the influence of length of incubation on radiosensitivity of murine and human melanoma cells in a soft-agar assay. In general, the longer the incubation period the larger was the median colony diameter within control or experimental groups. Hence apparent radiosensitivity decreased with increased length of incubation.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Yohem KH,Bregman MD,Meyskens FL Jrsubject
Has Abstractpub_date
1990-07-01 00:00:00pages
1079-82issue
4eissn
0250-7005issn
1791-7530journal_volume
10pub_type
杂志文章abstract：BACKGROUND/AIM:Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. MATERIALS AND METHODS:This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who wer...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13584
更新日期：2019-08-01 00:00:00
abstract：:K-ras-NIH3T3 cells were more invasive than NIH3T3 cells in a chemotactic invasion assay. Conophylline, a new vinca alkaloid isolated as a ras function inhibitor, inhibited the invasion of K-ras-NIH3T3 cells, while it showed no effect on NIH3T3 cells. Conophylline did not increase expression of fibronectin but induced ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:A possible influence of tamoxifen (TAM) treatment on the measurable content of some steroid hormone receptors (i.e. ER, PgR, AR) from primary breast cancers has been evaluated. In eleven postmenopausal women, two biopsies were taken from the same tumor, the first biopsy before starting endocrine treatment, and a secon...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
abstract：:The effect of the vitamins C, E-acetate and beta-carotene on the sanazole (AK-2123) efficiency was investigated in vitro (E. coli bacteria AB 1157) under the influence of gamma-rays. The vitamins were applied with sanazole individually or in appropriate mixtures in airfree media as well as in media saturated with nitr...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:Ras proteins must be isoprenylated at a conserved cysteine residue near the carboxyl terminus (Cys-186 in mammalian Ras p21 proteins) in order to extend their biological activity. Previous studies have indicate an intermediate in the mevalonate pathway, most likely farnesyl pyrophosphate, is the donor of this isopreny...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：:It has been shown recently that various myeloid leukemia cells can be induced by numerous compounds to differentiate terminally into non-growing mature cells. Furthermore, some of these compounds have been found to be clinically useful for the therapy of certain types of myeloid leukemia. To improve this new method of...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1994-05-01 00:00:00
abstract：AIM:Hepatic resection has become the standard treatment for patients with primary or metastatic liver malignancies. The aim of our study was to evaluate the clinical outcome of hepatic resection in patients with advanced ovarian cancer (AOC). PATIENTS AND METHODS:All patients undergoing hepatic resection for AOC in ou...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND/AIM:Amentoflavone has been shown to be effective against a variety of cancer cells, but its role in bladder cancer remains unclear. Thus, the aim of this study is to evaluate whether amentoflavone may induce toxicity effect of bladder cancer. MATERIALS AND METHODS:Herein, we evaluated amentoflavone effects ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13512
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:The objective of the present study was to investigate how oxidative status influences the effectiveness of cytotoxicity of artemisinin towards cancer cells. It is hypothesized that antioxidants would reduce, whereas pro-oxidants would enhance, cytotoxicity. MATERIALS AND METHODS:Molt-4 human leukemia cells ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-04-01 00:00:00
abstract：:Primary cultures from 30 human gliomas (26 high grade, 3 low grade, and one oligoastrocytoma) were studied to examine the mixture of cells that make up the outgrowth, and their interactions. GFAP + ve Fibronectin - ve cells had a predominantly process forming (PF) morphology and formed complex networks around explants...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：BACKGROUND:S-1, an oral 5-fluorouracil (5-FU)-based medicine that combines tegafur, gimeracil and oteracil potassium is commonly used as an adjuvant chemotherapeutic drug for the treatment of colorectal cancer. PATIENTS AND METHODS:We enrolled 53 patients who underwent curative resection for colorectal cancer and live...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:PSMA expression varies among prostate cell lines. We examined the role of CpG methylation and histone deacetylation in PSMA transcriptional repression in prostate cell lines. MATERIALS AND METHODS:The methylation status of a PSMA CpG island was investigated in LNCaP, DU145 and PC3 prostate cell lines. Cells...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：AIM:To investigate frequent quantitative alterations of intestinal-type gastric adenocarcinoma. MATERIALS AND METHODS:We analyzed genome-wide DNA copy numbers of 22 samples and using CytoScan® HD Array. RESULTS:We identified 22 gene alterations that to the best of our knowledge have not been described for gastric can...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-11-01 00:00:00
abstract：:The antioxidative activity and antimutagenic effects of the water-soluble beta-(1-3)-D-glucan derivatives from biotechnologically important species, in particular carboxymethyl-glucan (CM-G) and sulfoethyl-glucan (SE-G) both from the baker's yeast Saccharomyces cerevisiae, and carboxymethyl-chitin-glucan (CM-CG) from ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：AIM:Neoadjuvant epirubicin/docetaxel (ET) combination chemotherapy was administered to breast cancer patients in order to investigate their clinical and pathological response. Moreover, the breast-conserving surgery (BCS) rate, disease-free (DFS) and overall survival (OS), safety profile and the correlation of biologic...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：AIM:The aim of the study was to evaluate the long-term oncology outcomes of prostate cancer patients receiving robotic-assisted radical prostatectomy (RARP). PATIENTS AND METHODS:We retrospectively evaluated 111 patients with clinically-localized prostate cancer receiving RARP with a mean follow-up of 103.43 months. ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11803
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:The overexpression of syndecan-1 in breast carcinomas correlates with poorer prognosis and an aggressive phenotype. The effect of syndecan-1 expression on tumor response to neoadjuvant chemotherapy was determined in locally advanced breast cancer. PATIENTS AND METHODS:Semi-quantitative syndecan-1 immunohist...
journal_title：Anticancer research
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The standard treatment of epithelial ovarian cancer is tumor debulking by surgery, followed by six cycles of chemotherapy consisting of cisplatinum and paclitaxel. However, this therapy protocol is not satisfactory, since about 50% of the treated patients eventually experience recurrence within a few years o...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：:Calcium signalling was studied in porcine aortic endothelial cells stably transfected with wild type or mutants of the human platelet-derived growth factor (PDGF) beta-receptor and fibroblast growth factor (FGF) receptor-1 (FGFR1). Phospholipase C-gamma (PLC-gamma) has a consensus binding site at phosphorylated Tyr102...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：PURPOSE:Despite more than four decades of fluoro-pyrimidine treatment in different cancers, the optimal schedule is still not known. The plasma half-life of 5-fluorouracil (5-FU) is extremely short and continuous infusion has gained popularity. In this study we explored whether repeated bolus 5-FU injections could impr...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Mechanisms of tumor growth are concerned with the possibility that neoplasms are disturbed in their response to growth factors. Interleukin 2 (IL 2) is secreted by activated T-cells and is required for autocrine T-cell growth. Controversy exists as to the functional capacity of T-lymphocytes in patients with B-cell ch...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:The effect of various physiological fluids on the radical intensity of sodium ascorbate and sodium 5,6-benzylidene-L-ascorbate (SBA) was investigated using ESR spectroscopy. Blood from various animals did not significantly affect the radical intensity of both ascorbates, whereas the corresponding plasma fractions sign...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND:Chemotherapy sensitivity of soft-tissue sarcomas (STS) is limited, which may be due to multidrug resistance (MDR). MDR is associated with expression of P-glycoprotein (P-gp), Multidrug Resistance-associated Protein 1 (MRP1) and Lung Resistance-related Protein (LRP). It is unknown whether in STS metastasis is...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:The objective of this study was to discover whether the peptides LRMK and LRMK-Ava linked to the N-terminus of peptides HER-2 (774-788) and HER-2 (776-788), respectively, help differentiation of E75-TCR(+)CD8(+) cells. Activation was quantified in terms of proliferation of E75-TCR(+)CD8(+) cells expressing high, mediu...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:Gross cystic disease (GCD) represents an advanced form of fibrocystic disease of the breast. Bearers of macrocysts have been reported to be at risk of developing breast cancer. Natural killer (NK) cells are a lymphocyte subset deeply involved in immunosurveillance against neoplasia. We investigated whether breast cyst...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2016-04-01 00:00:00
abstract：:Several signaling pathways have been recognized in normal c-kit-mediated signal transduction following stem cell factor (SCF) stimulation including Janus kinase (JAK)/signal transducer and activator of transcription (STAT), mitogen-activated protein kinase (MAPK) and phosphoinositol 3-kinase (PI-3 K) pathways. In gast...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:During the last 50 years median survival for metastatic breast cancer has not varied and remains 2-3.5 years. To assess the clinical benefit of salvage systemic therapy a retrospective analysis of metastatic breast cancer patients all homogeneously treated with a commonly used first-line anthacycline-containing cytoto...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：:Intracellular accumulation of adriamycin (ADR) has been reported to be influenced by cell membrane potential. We first evaluated intracellular accumulation of ADR and 3,3'-(di-n-hexyl)-2,2'-oxacarbocyanine iodide (NK-2280), an indicator of cell membrane potential, and found a good correlation between ADR and NK-2280 i...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：UNLABELLED:Magnetic drug targeting (MDT) is a new locoregional chemotherapy method that increases the drug dose in the tumour region, while simultaneously reducing the overall dose through the application of chemotherapeutic-bound superparamagnetic nanoparticles, which are focused by an external magnetic field to the d...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
