Tyr1009 and Tyr1021 in the platelet-derived growth factor beta-receptor mediate agonist triggered calcium signalling.

abstract：AIM:Human papillomavirus (HPV) is a risk factor for oropharyngeal squamous cell carcinoma (OPSCC), with an increasing incidence. The present study aimed to determine the changing incidence of HPV in patients with OPSCC in the period 1980-2009 and its influence on survival. PATIENTS AND METHODS:We randomly sampled 158 ...

journal_title：Anticancer research

authors： Henneman R,Van Monsjou HS,Verhagen CV,Van Velthuysen ML,Ter Haar NT,Osse EM,Lopez-Yurda MI,Balm AJ,Van Den Brekel MW

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Patients with type 2 diabetes mellitus (T2DM) as well as patients with obesity have increased cancer mortality. In a previous paper we suggested that there was a trend for decreased mortality in obese individuals with T2DM. The aim of the new analyses was to investigate the same relationship after increasing...

journal_title：Anticancer research

authors： Landman GW,Van Hateren KJ,Kleefstra N,Bilo HJ

更新日期：2010-02-01 00:00:00

abstract：:The effects induced by a low dose cyclophosphamide treatment (CPA) along with an attempt of estradiol-17-beta (E2) cell recruitment, on the bioenergetics and the phosphomonoesters/phosphodiesters (PME/PDE) ratio in the transplantable MXT mouse mammary tumor have been studied by 31P-NMR spectroscopy in vivo. Our result...

journal_title：Anticancer research

authors： Scheiber C,Kiss R,De Launoit Y,Frühling J

更新日期：1988-05-01 00:00:00

abstract：:The chromosomes were studied by an in vitro technique in four parametrial and one gastric leiomyomas. The findings in parametrial myomas (the present four cases and one published earlier) differed from the observations in uterine cases by the absence of normal stemlines and the absence of 1p,6p and 7q changes. As has ...

journal_title：Anticancer research

authors： Havel G,Dahlenfors R,Wedell B,Hogström L,Mark J

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The tumor microenvironment is an emerging source of novel therapeutic targets in cancer. The glycosaminoglycan hyaluronan (HA) accumulates in 20-30% of tumors and is often associated with poor prognosis. MATERIALS AND METHODS:We developed a digitized, semiquantitative scoring system for tumor-associated HA ...

journal_title：Anticancer research

authors： Jiang P,Li X,Thompson CB,Huang Z,Araiza F,Osgood R,Wei G,Feldmann M,Frost GI,Shepard HM

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Canine lymphoma has lately drawn focus as a model of human non-Hodgkin's lymphoma due to its spontaneous occurrence and similar biological behavior. Cells with stem cell-like characteristics are believed to play a key role in therapeutic failure. Thus, an initial characterization and the possibility of speci...

journal_title：Anticancer research

authors： Liu W,Selçuk F,Rütgen BC,Moulay M,Willenbrock S,Hammer SE,Sterenczak KA,Junghanss C,Hewicker-Trautwein M,Nolte I,Murua Escobar H

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND/AIM:Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS:Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180....

journal_title：Anticancer research

authors： Glei M,Fischer S,Lamberty J,Ludwig D,Lorkowski S,Schlörmann W

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the efficacy of a combination of gemcitabine and sirolimus in a mouse model of invasive bladder cancer. MATERIALS AND METHODS:Gemcitabine (50 mg/kg) and sirolimus (1.5 mg/kg) were administered to animals previously exposed to N-butyl-N-4(hydroxybutyl)nitrosamine in...

journal_title：Anticancer research

authors： Vasconcelos-Nóbrega C,Colaço A,Santos L,Vala H,Palomino LF,Lopes C,Oliveira PA

更新日期：2011-05-01 00:00:00

abstract：:The interleukins (IL)-6 and -10 and heat shock proteins (HSP) have an important role in the host-tumor interaction and in tumor bulk. HSP-90 may have a regulatory role in cytokine biosynthesis and prognostic value in some tumors. To define the role of IL-6, IL-10 and HSP-90 in prostate cancer progression the immunohis...

journal_title：Anticancer research

authors： Cardillo MR,Ippoliti F

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Pathological examination of sentinel lymph nodes (SLNs) and non-SLNs in colon cancer is frequently not performed to the same extent. We examined whether non-SLNs were truly negative in tumors with tumor-negative SLNs using reverse transcriptase-polymerase chain reaction (RT-PCR). PATIENTS AND METHODS:RT-PCR...

journal_title：Anticancer research

authors： Kelder W,Braat A,van den Berg A,Platteel I,Hollema H,Groen H,Plukker J

更新日期：2007-07-01 00:00:00

abstract：:To evaluate the effects of dietary fats on breast cancer growth and metastasis, KPL-1 human breast carcinoma cells which have a propensity for axillary lymph node metastasis when inoculated into the thoracic mammary fat pad of female nude mice were examined. The mice were fed one of three semipurified diets containing...

journal_title：Anticancer research

authors： Senzaki H,Iwamoto S,Ogura E,Kiyozuka Y,Arita S,Kurebayashi J,Takada H,Hioki K,Tsubura A

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen and predominant target for cancer immunotherapy. Its detection is only established based on gene expression. In this study, we established a monoclonal antibody against KK-LC-1 to detect its protein expression in formalin-fixed samples. ...

journal_title：Anticancer research

authors： Kondo Y,Fukuyama T,Yamamura R,Futawatari N,Ichiki Y,Tanaka Y,Nishi Y,Takahashi Y,Yamazaki H,Kobayashi N,Watanabe M

更新日期：2018-10-01 00:00:00

abstract：:Metastatic renal cell carcinoma (RCC) has a poor response to anticancer chemotherapy and radiotherapy. While immunotherapy and molecular targeted drugs have been used as first-line therapy for RCC metastasis, the response rate to these agents is low. We report the case of a patient with lung and bone metastases of RCC...

journal_title：Anticancer research

authors： Nishida H,Shirai T,Hayashi K,Takeuchi A,Tanzawa Y,Mizokami A,Namiki M,Tsuchiya H

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIM:Androgen-androgen receptor (AR) signal is known as a powerful driver of prostate cancer progression. We previously reported the limitation of prostate-specific antigen (PSA) at diagnosis as a prognostic biomarker of prostate cancer. Although serum total testosterone (TT) level has been reported as a prog...

journal_title：Anticancer research

authors： Izumi K,Shigehara K,Nohara T,Narimoto K,Kadono Y,Mizokami A

更新日期：2017-10-01 00:00:00

abstract：AIM:We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. PATIENTS AND METHODS:The study retrospectively analyzed 160 patients with stage II/III gastric cancer w...

journal_title：Anticancer research

authors： Hara K,Aoyama T,Yamada T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Hayashi T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-03-01 00:00:00

abstract：:The purpose of this analysis was to study the association between the quantity of free circulating DNA and clinical variables in 99 advanced non-small cell lung cancer patients (NSCLC). The quantification in the serum of the gene of the catalytic fraction of telomerase (hTERT) by RT-PCR was used as a reference of the ...

journal_title：Anticancer research

authors： Camps C,Sirera R,Bremnes RM,Ródenas V,Blasco A,Safont MJ,Garde J,Juarez A,Caballero C,Sanchez JJ,Taron M,Rosell R

更新日期：2006-11-01 00:00:00

abstract：:We have examined the effects of irradiation on the cytokine secretion from genetically modified human esophageal and gastric carcinomas. Both cell lines were transduced retrovirally to secrete interleukin-2, interleukin-6 and granulocyte-macrophage colony-stimulating factor, respectively. The metabolism of all the tra...

journal_title：Anticancer research

authors： Matsubara H,Tagawa M,Gunji Y,Takenaga K,Sugaya M,Urashima T,Koide Y,Suzuki T,Asano T,Ochiai T,Isono K,Kageyama H,Nakamura Y,Sakiyama S

更新日期：1996-03-01 00:00:00

abstract：:The time course and characteristics of the tumor marker CASA (Cancer Associated Serum Antigen) during the menstrual cycle were analysed. We investigated whether hormonal influences in women and the score of this tumor marker ought to be considered in diagnosis. It could be demonstrated that CASA is not influenced by p...

journal_title：Anticancer research

authors： Meisel M,Römer T,Straube W

更新日期：1997-07-01 00:00:00

abstract：:The effect of selenite on mitochondrial morphology, selenoprotein synthesis, membrane potential, phosphorylating respiration, P/O ratio and respiratory control index were evaluated relative to selenite inhibition of DNA synthesis in murine mammary epithelial cell lines. No inhibition of mitochondrial function was note...

journal_title：Anticancer research

authors： Morrison DG,Pauly DF,Berdan RC,Dishart MK,Turner DS,Oborn CJ,Medina D

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:Vinflunine is a novel Vinca alkaloid currently undergoing Phase II clinical trials, which have previously demonstrated anti-vascular effects in a transplantable murine colon adenocarcinoma model. Previous studies with compounds showing similar effects in combination with standard anti-cancer agents have demo...

journal_title：Anticancer research

authors： Shnyder SD,Cooper PA,Gyselinck N,Hill BT,Double JA,Bibby MC

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Sixteen 3-styryl-2H-chromenes were subjected to quantitative structure-activity relationship analysis based on their cytotoxicity, tumor selectivity and anti-HIV activity, in order to find their new biological activities. MATERIALS AND METHODS:Cytotoxicity against four human oral squamous cell carcinoma (OS...

journal_title：Anticancer research

authors： Uesawa Y,Sakagami H,Ishihara M,Kagaya H,Kanamoto T,Terakubo S,Nakashima H,Yahagi H,Takao K,Sugita Y

更新日期：2015-10-01 00:00:00

abstract：:Eight patients with metastatic hypernephroma were treated with constant infusion recombinant Interleukin-2 (rIL-2), changes in renal and hepatic function and protein levels were monitored during 2 cycles of treatment. The rIL-2 infusion caused a reversible fall in ures and a non-reversible rise in creatinine. Liver fu...

journal_title：Anticancer research

authors： Ubhi SS,Horsburgh T,Veitch PS,Bell PR

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND/AIM:We undertook a case-control and a case-case study to examine the possible association of p53 codon72 polymorphism with the breast cancer risk and resistance to anthracycline-based chemotherapy. PATIENTS AND METHODS:Case-control study: This study enrolled 175 patients with breast cancer treated at the Sa...

journal_title：Anticancer research

authors： Arfaoui A,Douik H,Kablouti G,Chaaben AB,Handiri N,Zid Z,Ouni N,Zouiouch F,Ayari F,Mamoughli T,Bouassida J,Abazza H,Harzallaha L,Guemira F

更新日期：2015-03-01 00:00:00

abstract：AIM:The American thyroid association (ATA) recommends that additional imaging procedures supplement cervical ultrasonography (US) in any patient with a basal calcitonin value above 150 pg/ml in the follow-up of medullary thyroid carcinoma (MTC). The aim of the present study was to reaffirm or challenge this cut-off for...

journal_title：Anticancer research

authors： Sesti A,Mayerhoefer M,Weber M,Anner P,Wadsak W,Dudczak R,Haug A,Karanikas G

更新日期：2014-11-01 00:00:00

abstract：AIM:The aim of this study was to investigate the effects of medium-chain triglycerides (MCTs) on chemically-induced hepatic carcinogenesis (HCC) in mice. MATERIALS AND METHODS:In a first set of experiments, mice were treated with diethylnitrosoamine intraperitoneally at two weeks of age. They were fed chow containing ...

journal_title：Anticancer research

authors： Wakana H,Kono H,Fukushima H,Nakata Y,Akazawa Y,Maruyama S,Hagio K,Fujii H,Ichikawa D

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The optimal treatment for locoregionally recurrent rectal cancer after curative surgery has not yet been defined. The definition of prognostic factors could lead to the selection of an aggressive therapeutic approach in patients with favourable prognosis alone. PATIENTS AND METHODS:The records of thirty-nin...

journal_title：Anticancer research

authors： Pergolizzi S,Settineri N,Santacaterina A,Maisano R,Frosina P,Loria F,Nardella G,Garufi G,Sansotta G,De Renzis C

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Zoledronate (Zol), an anti-osteoclastic and anticancer drug, is used to control bone metastasis in several cancer types, including non-small cell lung cancer (NSCLC). However, the mechanisms behind Zol resistance in NSCLC are unclear. MATERIALS AND METHODS:Zol-resistant cell lines were developed by repeated...

journal_title：Anticancer research

authors： Aoyagi T,Morii T,Ohtsuka K,Ohnishi H,Tajima T,Yoshiyama A,Mochizuki K,Satomi K,Ichimura S

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIM:The clinical significance of surgery for secondary small intestinal non-Hodgkin's lymphomas (NHL) remains unknown. This study aimed to investigate the efficacy of resection for both primary and secondary small intestinal NHL. PATIENTS AND METHODS:Twenty patients with small intestinal lymphoma who underw...

journal_title：Anticancer research

authors： Iida T,Nozawa H,Sonoda H,Toyama K,Kawai K,Hata K,Tanaka T,Nishikawa T,Sasaki K,Shuno Y,Kaneko M,Murono K,Emoto S,Ishii H,Kurokawa M,Ishihara S

更新日期：2020-04-01 00:00:00

abstract：:The in vitro antitumor activity of a new platinum complex, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolan e] platinum(II) (SKI 2053R, NSC D644591), cisplatin (CDDP) and carboplatin (CBDCA) was determined against two human lung cancer (PC-9 and PC-14) and two human stomach cancer (MKN-45 and KATO II...

journal_title：Anticancer research

authors： Hong WS,Kim HT,Kim KH,Kim DK

更新日期：1995-01-01 00:00:00

abstract：:We have previously shown biopsies from human malignant melanoma, as well as a cell line (MELUR) derived from human malignant melanoma cells, to contain dexamethasone (DEX) - and medroxyprogesterone acetate (MPA) - binding macromolecules exhibiting properties of glucocorticoid receptors from well-known target organs. I...

journal_title：Anticancer research

authors： Bojar H,Fabry W

更新日期：1985-03-01 00:00:00