Abstract：
BACKGROUND:Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen and predominant target for cancer immunotherapy. Its detection is only established based on gene expression. In this study, we established a monoclonal antibody against KK-LC-1 to detect its protein expression in formalin-fixed samples. MATERIALS AND METHODS:The monoclonal antibody against KK-LC-1 was evaluated and the detection of KK-LC-1 between gene expression and protein expression was compared in patients with breast cancer. The monoclonal antibody clone 34B3, which we established, stained testicular germ cells positively. RESULTS:The rates of detection of KK-LC-1 gene and protein expression were 11.8% and 52.9%, respectively. Protein expression was detected in all triple-negative breast cancer cases studied (n=8). Furthermore, KK-LC-1 was detected in all tumours without oestrogen receptor expression. CONCLUSION:This study indicated that KK-LC-1 expression was detected in breast cancer, especially in oestrogen receptor-negative subtypes.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kondo Y,Fukuyama T,Yamamura R,Futawatari N,Ichiki Y,Tanaka Y,Nishi Y,Takahashi Y,Yamazaki H,Kobayashi N,Watanabe Mdoi
10.21873/anticanres.12937subject
Has Abstractpub_date
2018-10-01 00:00:00pages
5923-5928issue
10eissn
0250-7005issn
1791-7530pii
38/10/5923journal_volume
38pub_type
杂志文章abstract：:Simultaneous administration of medroxyprogesterone acetate (MPA) and tamoxifen markedly elevated the serum alanine and aspartate aminotransferase activities in 4 out of 30 patients with endometrial or ovarian carcinoma; and also slightly increased the activities of gamma-glutamyl transferase in 2 of the patients. Thes...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1984-05-01 00:00:00
abstract：BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11582
更新日期：2017-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11490
更新日期：2017-04-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14792
更新日期：2021-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-05-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2014-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2013-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2016-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：1997-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1994-05-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2002-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：1986-03-01 00:00:00
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doi：
更新日期：2012-07-01 00:00:00
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doi：
更新日期：2013-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1998-05-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2009-11-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2013-08-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2010-05-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2010-07-01 00:00:00
