Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis.

Abstract:

BACKGROUND/AIM:Breast cancer is the most prevalent and devastating malignant disease among women worldwide. Green tea has been extensively studied for its anti-cancer effects, however, existing literature on the correlation of other types of tea with breast cancer is very limited. MATERIALS AND METHODS:We used six different breast cancer cell lines (ER+, PR+ or HER2+ and triple-negative), treated under different concentrations of green, oolong, black and dark tea extracts, and determined their biological effects. RESULTS:We determined cell viability, observed the changes of cell morphology, measured DNA damage and cleavage, and analyzed the effect on soft agar colony formation and growth. CONCLUSION:Oolong tea, same as green tea, can induce DNA damage and cleavage, play an inhibitory role in breast cancer cell growth, proliferation and tumorigenesis, and was a great potential as a chemo-preventive agent against breast cancer.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Shi H,Liu J,Tu Y,Freter CE,Huang C

doi

10.21873/anticanres.12976

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

6217-6223

issue

11

eissn

0250-7005

issn

1791-7530

pii

38/11/6217

journal_volume

38

pub_type

杂志文章
  • Modified arabinoxylan rice bran (MGN-3/Biobran) enhances yeast-induced apoptosis in human breast cancer cells in vitro.

    abstract::We have recently reported that phagocytosis of killed Saccharomyces cerevisiae, baker's yeast, induced apoptosis in human breast cancer cell lines MCF-7, ZR-75-1 and HCC70. In this study we have evaluated the effect of treatment with MGN-3, a modified arabinoxylan from rice bran, on phagocytosis and yeast-induced apop...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ghoneum M,Gollapudi S

    更新日期:2005-03-01 00:00:00

  • Paclitaxel-ifosfamide-cisplatin as salvage chemotherapy in ovarian cancer patients pretreated with platinum compounds and paclitaxel.

    abstract:BACKGROUND:The role of combination chemotherapy regimens in the management of ovarian cancer patients with tumors previously exposed to platinum compounds and paclitaxel has not yet been defined. The present phase II study evaluated the activity and toxicity of a paclitaxel-ifosfamide-cisplatin combination in the afore...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Polyzos A,Kosmas C,Tsavaris N,Toufexi H,Lagadas A,Gogas H,Giannakopoulos K,Kouraklis G,Griniatsos J,Felekouras E,Tsigris C,Nikiteas N,Papadopoulos O,Giannopoulos A

    更新日期:2007-05-01 00:00:00

  • The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: a phase I-II clinical study.

    abstract::Glutathione (GSH) concentration is high in most tumour cells and this may be an important factor in resistance to chemotherapy. Previous in-vitro and animal experiments have shown a differential response of tumour versus normal cells to various cysteine delivery systems. More specifically, an in-vitro assay showed tha...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kennedy RS,Konok GP,Bounous G,Baruchel S,Lee TD

    更新日期:1995-11-01 00:00:00

  • Fundamentals of chemo-differentiation therapy of myeloid leukemia.

    abstract::It has been shown recently that various myeloid leukemia cells can be induced by numerous compounds to differentiate terminally into non-growing mature cells. Furthermore, some of these compounds have been found to be clinically useful for the therapy of certain types of myeloid leukemia. To improve this new method of...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Hozumi M

    更新日期:1994-05-01 00:00:00

  • Immunocytochemical determination of estrogen and progesterone receptors and flow cytometric DNA analysis of breast cancer on fine needle aspirates.

    abstract::A prospective study was performed on a series of 42 patients with breast carcinoma. Immunocytochemical determination of receptors for estrogens (ER) and progesterone (PR) and flow cytometric DNA analysis (DNA-ploidy and the S-phase fraction) were performed on material obtained from fine-needle aspirates (FNA). The pat...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Marrazzo A,Russo A,Bazan V,Taormina P,Lupo F,Bazan P

    更新日期:1993-11-01 00:00:00

  • Transformation of rat fibroblasts by TGF-beta and EGF induces sensitivity for intercellular induction of apoptosis.

    abstract::During intercellular induction of apoptosis, TGF-beta-treated nontransformed fibroblasts induce apoptosis specifically in transformed fibroblasts. To test whether sensitivity to intercellular induction of apoptosis is causally related to the expression of the transformed phenotype, NRK 536 cells were reversibly transf...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Häufel T,Bauer G

    更新日期:2001-07-01 00:00:00

  • Epidermal growth factor receptor changes during breast cancer metastasis.

    abstract:BACKGROUND:Since the anti-HER2 monoclonal antibody trastuzumab made its triumphant advance into breast cancer therapy, new selective agents, including pan-HER inhibitors are entering clinical practice. MATERIALS AND METHODS:This study investigates the expression of the four HER-family members, HER1-4, in 48 primary br...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Fuchs IB,Siemer I,Bühler H,Schmider A,Henrich W,Lichtenegger W,Schaller G,Kuemmel S

    更新日期:2006-11-01 00:00:00

  • Expression of p53, Ki-67, E-cadherin, N-cadherin and TOP2A in triple-negative breast cancer.

    abstract:BACKGROUND:Elucidation of the biological features of triple negative breast cancer (TNBC) is important for deciding treatment strategies. The expression of a number of biomarkers in TNBC was analyzed to elucidate those features. PATIENTS AND METHODS:The subjects were 134 TNBC patients. Immunohistochemical staining was...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Nakagawa M,Bando Y,Nagao T,Morimoto M,Takai C,Ohnishi T,Honda J,Moriya T,Izumi K,Takahashi M,Sasa M,Tangoku A

    更新日期:2011-06-01 00:00:00

  • Induction of NK-like activity in T cells by IL-2/anti-CD3 is linked to expression of a new antitumour receptor with specificity for acetylated mannose.

    abstract::The generation of MHC-unrestricted cytotoxicity of highly enriched human CD3+ T cells (95-99%) by treatment with IL-2 and/or anti-CD3 antibodies was studied. T cells obtained by positive immunomagnetic sorting (anti-CD3) developed comparable specific cytotoxicities against K562 and Daudi cells when cultured with IL-2 ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Zollner TM,Zhu HG,Anderer FA

    更新日期:1993-07-01 00:00:00

  • Adjuvant portal liver infusion with 5-fluorouracil and mitomycin in colorectal cancer. SAKK.

    abstract::Between 1981 and 1987, 533 patients from 9 institutions were entered in a randomized trial to assess the value of adjuvant perioperative portal infusion with Fluorouracil and Mitomycin as compared to radical surgery alone. Analysis of 469 evaluable patients at a median follow-up of 5.8 years revealed 110 recurrences i...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Weber W,Laffer U,Metzger U

    更新日期:1993-09-01 00:00:00

  • Development of an animal model for prostate cancer cell metastasis to adult human bone.

    abstract:BACKGROUND:Prostate cancer metastases to bone are associated with significant morbidity and mortality. Presently, there is little known about the biological interaction between prostate cancer cells and bone. Development of an animal model using adult human bone will enhance our ability to study the biology of prostate...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tsingotjidou AS,Zotalis G,Jackson KR,Sawyers C,Puzas JE,Hicks DG,Reiter R,Lieberman JR

    更新日期:2001-03-01 00:00:00

  • Thymidine phosphorylase expression in gastric carcinoma as a marker for metastasis.

    abstract:BACKGROUND:Thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor (PD-ECCF) and has a function of angiogenesis in vitro and in several types of human carcinoma tissues. We have reported that expression of dThdPase was an independent prognostic factor in 116 gastric carcinomas...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Konno S,Takebayashi Y,Higashimoto M,Katsube T,Kanzaki A,Kawahara M,Takenoshita S,Aiba M,Ogawa K

    更新日期:2003-11-01 00:00:00

  • Benefits of complete polyamine deprivation in hormone responsive and hormone resistant MCF-7 human breast adenocarcinoma in vivo.

    abstract::Polyamines are ubiquitous cellular compounds which are required for estradiol induced proliferation in breast cancer. Complete polyamine deprivation, using 2 alpha-difluoromethyl-ornithine (DFMO, Eflornithine), a specific inactivator of ornithine decarboxylase (key-enzyme of the polyamine biosynthesis) combined with i...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Leveque J,Foucher F,Havouis R,Desury D,Grall JY,Moulinoux JP

    更新日期:2000-01-01 00:00:00

  • Inhibition of actin polymerization by cytochalasin B induces polyploidization and increases the number of nucleolar organizer regions in human megakaryocyte cell lines.

    abstract::Megakaryocyte polyploidization is an advantageous and regulated mechanism which leads to an increase in platelet production. In megakaryocyte cell lines, polyploidization can be obtained by using cytochalasin B, an inhibitor of the actin polymerization. The Nucleolar Organizer Regions (AgNORs) are parts of nucleolar D...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

    更新日期:1998-01-01 00:00:00

  • Cancer treatment-induced oral mucositis.

    abstract::Oral mucositis is one of the main complications in non-surgical cancer treatments. It represents the major dose-limiting toxicity for some chemotherapeutic agents, for radiotherapy of the head and neck region and for some radiochemotherapy combined treatments. Many reviews and clinical studies have been published in o...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Alterio D,Jereczek-Fossa BA,Fiore MR,Piperno G,Ansarin M,Orecchia R

    更新日期:2007-03-01 00:00:00

  • Inhibitory effect of dietary inulin or oligofructose on the development of cancer metastases.

    abstract::The possible influence of continuous dietary treatment with 15% inulin or oligofructose on the development of lung metastases of a transplantable liver tumor in young male C3H mice was investigated. Microscopical examination demonstrated a distinct inhibitory effect of this dietary treatment on the development of lung...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Taper HS,Roberfroid MB

    更新日期:2000-11-01 00:00:00

  • Antimetastatic activity induced by Clostridium butyricum and characterization of effector cells.

    abstract::The effects of a bacterial vaccine, heat-killed Clostridium butyricum MII 588 cells, on the metastasis of B16-F10 melanoma in BDF1 mice was investigated. The vaccine stimulated natural killer (NK) cell cytotoxic activity against YAC-1 target cells, which peaked at 72 hr after the pretreatment, whereas maximum macropha...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Chen HY,Wu SL,Yeh MY,Chen CF,Mikami Y,Wu JS

    更新日期:1993-01-01 00:00:00

  • High energy shock waves (HESW) for sonodynamic therapy: effects on HT-29 human colon cancer cells.

    abstract:BACKGROUND:Whether high energy shock waves (HESW), generated by a piezoelectric generator, were able to activate a sonosensitizer, 5-aminolevulinic acid (ALA) and induce inhibition of cell growth in HT-29 human colorectal cancer cells was investigated. MATERIALS AND METHODS:Cell survival and cell death pathways were i...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Canaparo R,Serpe L,Catalano MG,Bosco O,Zara GP,Berta L,Frairia R

    更新日期:2006-09-01 00:00:00

  • Stimulation by estrogen and progesterone of the in vivo growth of transformed murine Leydig cells only at the limited early phase of growth.

    abstract::B-1 F is a cell line established from estrogen-responsive murine Leydig cell tumor and maintained in vitro. We investigated the effects of steroid hormones on the growth of tumors produced by the inoculation of B-1 F cells into mice. When tumor tissues were transplanted into castrated male mice, injections of estradio...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yamamoto T,Li I,Uchida N,Nishizawa Y,Yamamoto R,Terada N,Taniguchi H,Matsumoto K,Sato B

    更新日期:1992-09-01 00:00:00

  • Secretory phospholipase A2 mediates human esophageal adenocarcinoma cell growth and proliferation via ERK 1/2 pathway.

    abstract:BACKGROUND/AIM:Secretory phospholipase-A2 (sPLA2) mediates growth and proliferation of human esophageal adenocarcinoma cells (HEAC). Two major molecular pathways of cancer growth regulation include extracellular signal-regulated kinase 1/2 (ERK 1/2) and protein kinase-B (AKT). Phospholipase enzymes have been demonstrat...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Sadaria MR,Yu JA,Meng X,Fullerton DA,Reece TB,Weyant MJ

    更新日期:2013-04-01 00:00:00

  • Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells.

    abstract::Despite the advances in the detection and treatment of lung cancer, the overall 5-year survival is only 10-20%. Accumulating evidence suggests that verapamil, a calcium channel antagonist, is a potential anticancer agent. Epidermal growth factor receptor (EGFR) is a key therapeutic target in many types of cancer, wher...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Zhang C,Lv F,Zhou L,Li X,Wu XX,Hoffman RM

    更新日期:2009-01-01 00:00:00

  • Neocarzinostatin in cancer chemotherapy (review).

    abstract::This article describes previous studies on a unique protein antitumor antibiotic, neocarzinostatin. Namely, its chemical nature, mode of action at molecular and cellular levels, toxicity and pharmacology, and recent results in clinical trials obtained primarily in Japan have been reviewed briefly. ...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Maeda H

    更新日期:1981-01-01 00:00:00

  • Mucoepidermoid carcinoma of the trachea with airway hyperresponsiveness.

    abstract::We report a case of mucoepidermoid carcinoma of the trachea in a 23-year-old pregnant female in her 39th week. The patient had cough and wheezing in the early morning for 9 months before admission. No abnormalities were detected on a chest roentgenogram. At Caesarean section, fiberscopy revealed a polypoid lesion narr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Watanabe M,Tomita K,Burioka N,Yajima H,Nakamura H,Ohgi S,Shimizu E

    更新日期:2000-05-01 00:00:00

  • Promoter Methylation Down-regulates B-cell Translocation Gene 1 Expression in Breast Carcinoma.

    abstract:BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13729

    authors: Woo HY,DO SI,Kim SH,Song SY,Kim HS

    更新日期:2019-10-01 00:00:00

  • Beta-adrenergic influences on doxorubicin-sensitive or -resistant P388 leukemia cells.

    abstract::Taking into account the possible regulatory influences of the beta-adrenergic system on lymphocyte proliferation as well as the proposed role of cyclic 3'-5'-adenosine monophosphate (cAMP) in the modulation of multidrug resistance (MDR) in tumour cells, we have tried to assess the status of the interactions between th...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: D'Amico C,Crescimanno M,Armata MG,Leonardi V,Palazzoadriano M,D'Alessandro N

    更新日期:1992-11-01 00:00:00

  • Inhibition of P-glycoprotein transport function by N-acylphenothiazines.

    abstract::Multidrug resistance (mdr) constitutes the major obstacle to successful cancer treatment. The ability of fifteen newly-synthesised N-acylphenothiazine derivatives to inhibit the transport activity of P-glycoprotein was studied by flow cytometry in a resistant mouse lymphoma cell line. A standard functional assay with ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Wesolowska O,Molnár J,Motohashi N,Michalak K

    更新日期:2002-09-01 00:00:00

  • Sedation in gynaecologic oncology day surgery.

    abstract::Gynaecologic oncology day surgery deals primarily with the diagnosis of endometrial, cervical, vulvar and vaginal tumors. Conscious sedation is an important technique used in gynaecologic oncology day surgery. It is often associated with regional anaesthesia. The goals of conscious sedation are to provide effective pa...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Pace MC,Palagiano A,Pace L,Passavanti MB,Iannotti M,Sorrentino R,Aurilio C

    更新日期:2004-11-01 00:00:00

  • Dehydroepiandrosterone sulfate estrogenic action at its physiological plasma concentration in human breast cancer cell lines.

    abstract::Estrogen receptor activation in hormone dependent cells (MCF-7 and T47D) and hormone independent cells (MDA-MB-231) was measured by bioluminescence in stably transfected human breast cancer MCF-7, T47D and MDA-MB-231 cell lines with a reporter gene which allows expression of the firefly luciferase enzyme under the con...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Le Bail JC,Allen K,Nicolas JC,Habrioux G

    更新日期:1998-05-01 00:00:00

  • Carcinoma of the axillary tail of Spence: a case series.

    abstract::There is sparse information about cancer in the axillary tail of Spence (CATS). Eight hundred and thirty-nine patients with breast cancer were retrospectively studied for the occurrence of CATS. Ten patients were identified based on detection by imaging studies. A tendency towards stage II or III disease, and estrogen...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ampil F,Caldito G,Henderson B,Li B,Kim RH,Burton G,Chu Q

    更新日期:2012-09-01 00:00:00

  • Expression of nitrotyrosine is associated with angiogenesis in esophageal squamous cell carcinoma.

    abstract:BACKGROUND:In our previous study, it was suggested that nitrotyrosine, a product of nitrogen species, found in esophageal squamous cell carcinoma (ESCC), may contribute to the progression of esophageal cancer. MATERIALS AND METHODS:To clarify whether nitrotyrosine expression is associated with apoptosis and/or angioge...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kato H,Miyazaki T,Yoshikawa M,Nakajima M,Fukai Y,Masuda N,Ojima H,Tsukada K,Nishida Y,Kuwano H

    更新日期:2001-09-01 00:00:00