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Usefulness of current risk groups in the treatment of surgically staged endometrial carcinomas; a population-based study from Western Sweden.

Abstract：

BACKGROUND:Endometrial carcinoma is the most common malignancy of the female genital tract and its incidence is increasing. However, treatment results have not improved during the last decades. PATIENTS AND METHODS:Our regional quality register was used to evaluate treatment results for the period between January 1995 and December 2003. This study includes 2211 consecutive patients, of which 1993 surgically staged patients were evaluated in detail. Of these, 831 (53%) were at low risk and were given no further treatment after primary surgery. Patients with moderate- and high-risk tumors were postoperatively treated according to the respective protocols of one Swedish and one international study. Postoperative vaginal brachytherapy +/- external radiation was given to 486 (31%) patients at moderate risk, while 234 (15%) had high-risk disease and were randomized to external radiation + brachytherapy or external radiation + brachyterapy + chemotherapy. RESULTS:Overall cause-specific 5- and 10-year survival was 83.9% and 81.3%, respectively, for all included patients. The corresponding figures for surgically staged patients were 87.4% and 84.9%, respectively. One important observation was that there was no significant difference in survival between patients at low and moderate risk. CONCLUSION:The results strongly suggest that the risk groups used during this study period were not optimal. It is recommended to use smaller, better specified groups defined by more prognostic factors for enhanced individualization of treatment.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Paulsson G,Genell A,Jakobsen AM,Horvath G

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

1585-90

issue

5

eissn

0250-7005

issn

1791-7530

pii

29/5/1585

journal_volume

29

pub_type

杂志文章

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