Abstract：
UNLABELLED:The aim of this study wsa to evaluate the additive effect of valproic acid (VPA) to γδ T-cell cytotoxicity against bladder cancer cells. MATERIALS AND METHODS:Human bladder cancer cell lines TCCSUP and 253J were treated with VPA and mRNA expression of natural killer group 2D (NKG2D) ligands was determined. The antitumour effect of expanded γδ T-cells against zoledronic acid (ZOL) and VPA pre-treated cancer cells was subsequently determined. RESULTS:VPA increased mRNA expression of NKG2D ligands on both cancer cell types. A blocking study revealed that 253J cells were recognised through NKG2D, while TCCSUP cells were mainly recognised through γδ T-cell receptor. VPA pre-treatment increased sensitivity to cytolysis by γδ T-cells for both cancer cell types, whereas ZOL pre-treatment was only effective against TCCSUP. CONCLUSION:Induction of NKG2D ligands by VPA increased the susceptibility of cancer cells that are recognised by NKG2D to cytolysis by γδ T-cells.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Suzuki T,Terao S,Acharya B,Naoe M,Yamamoto S,Okamura H,Gotoh Asubject
Has Abstractpub_date
2010-11-01 00:00:00pages
4509-13issue
11eissn
0250-7005issn
1791-7530pii
30/11/4509journal_volume
30pub_type
杂志文章abstract：:We investigated the in vitro effects of heparin on the growth and interaction of SW480 colon adenocarcinoma cells with the extracellular matrix proteins laminin, fibronectin and collagen IV. Cell adhesion assays were performed in wells precoated with the proteins mentioned. Tumor cell migration and invasiveness were a...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1995-07-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
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更新日期：2016-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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doi：
更新日期：2003-05-01 00:00:00
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doi：
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
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doi：
更新日期：2004-09-01 00:00:00
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doi：
更新日期：2008-05-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2008-05-01 00:00:00
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doi：
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doi：
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doi：
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doi：
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journal_title：Anticancer research
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doi：
更新日期：2005-11-01 00:00:00
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doi：
更新日期：2004-05-01 00:00:00
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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doi：
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