Abstract:
AIM:To evaluate (18)F-fluorodihydroxyphenylalanine-positron emission tomography/ contrast-enhanced computed tomography ((18)F-DOPA PET/CT) for the detection of paragangliomas (PARA) without any patient selection, such as genetic predisposition for the development of these tumors, history of metastatic PARA or hormonal status. PATIENTS AND METHODS:In this retrospective study, 28 consecutive patients (15 women, 13 men; mean age=46.4 years; age range=19-73 years), who were referred to our PET/CT center for the detection of clinically suspected PARA, were included. Final diagnosis was confirmed by histological reports of surgically proven lesions and/or clinical follow-up (including laboratory results and/or PET/CT follow-up). RESULTS:On a per-lesion basis (45 lesions) analysis, there was a sensitivity of 64.3% for CT, 73.8% for PET, 100% for PET/CT and a positive predictive value (PPV) of 93.1% for CT, 96.9% for PET and 100% for PET/CT. On a per-patient basis analysis, the sensitivity, specificity and accuracy for CT was 86.7%, 84.6% and 85.7%, respectively, and, for PET 80%, 100% and 89.3%, respectively, and, for PET/CT 100%. CONCLUSION:Based on our data, (18)F-DOPA PET/CT is a "one-stop diagnostic modality" for the assessment of patients with suspected PARA.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
El-Rabadi K,Weber M,Mayerhofer M,Nakuz T,Scherer T,Mitterhauser M,Dudczak R,Hacker M,Karanikas Gsubject
Has Abstractpub_date
2016-08-01 00:00:00pages
4187-93issue
8eissn
0250-7005issn
1791-7530pii
36/8/4187journal_volume
36pub_type
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journal_title:Anticancer research
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