A Case of Vanishing Brain Metastasis in a Melanoma Patient on Nivolumab.

Abstract:

BACKGROUND:Melanoma is among the top three cancers to present with brain metastasis. The risk of brain metastases in advanced melanoma increases with disease duration. Cytotoxic chemotherapy does not have a significant role in the management of melanoma patients with brain metastases, neither alone nor in conjunction with radiation therapy. PATIENTS AND METHODS:We herein discuss a case of a 66-year-old male diagnosed initially with stage III-B melanoma and underwent a wide local excision with a split thickness graft and sentinel lymph node biopsy, followed by adjuvant treatment with high-dose interferon. RESULTS:On subsequent follow up he was found to have a brain lesion, which later on resolved after starting ipilumumab. Five to twenty percent of patients with melanoma of any stage develop cerebral metastases. CONCLUSION:Immunotherapy modalities, ipilimumab has been shown to have activity against brain metastases.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Basnet A,Saad N,Benjamin S

doi

10.21873/anticanres.11038

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

4795-8

issue

9

eissn

0250-7005

issn

1791-7530

pii

36/9/4795

journal_volume

36

pub_type

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