Genetics of drug resistance in tuberculosis.

abstract：:Lung cancer remains the most common fatal malignancy, so even modest therapeutic advances are potentially beneficial to large numbers of patients. For patients with regional nodal metastases identified at thoracotomy, adjuvant chemotherapy may be of benefit and additional clinical trials are in progress. Locally advan...

journal_title：Clinics in chest medicine

authors： Murren JR,Buzaid AC

更新日期：1993-03-01 00:00:00

abstract：:Smoking is overwhelmingly the major cause of chronic bronchitis and emphysema worldwide. Additional risk factors for developing COPD are presented, along with the variables that govern cigarette smoke deposition in the lung. Major paradigms for the pathogenesis of COPD, including the protease-antiprotease and oxidant-...

journal_title：Clinics in chest medicine

authors： Sethi JM,Rochester CL

更新日期：2000-03-01 00:00:00

abstract：:Recent progress in medical therapies has diminished the role of transplantation in the management of PPH during the past decade. Drug therapy is not effective in some patients, responses to therapy are not sustained over time in others, and drug side effects eventually limit the benefits of treatment in a few more. Lu...

journal_title：Clinics in chest medicine

authors： Trulock EP

更新日期：2001-09-01 00:00:00

abstract：:In the United States, trauma is the leading cause of death in people under 40 years of age. Chest trauma is a relatively common but potentially lethal injury and requires a high level of suspicion, rapid diagnosis, and appropriate therapy. Methods for the assessment, diagnosis, and treatment of chest trauma are discus...

journal_title：Clinics in chest medicine

authors： Kshettry VR,Bolman RM 3rd

更新日期：1994-03-01 00:00:00

abstract：:The features characterizing pneumonia due to Mycoplasma pneumoniae are described. Typical cases, along with chest radiographs of laboratory-documented cases, are presented. ...

journal_title：Clinics in chest medicine

authors： Luby JP

更新日期：1991-06-01 00:00:00

abstract：:In summary, bacterial organisms are clinically relevant contributors to asthma exacerbations, and have received much less attention than viruses in this process. Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis have been linked to asthma exacerbations, particularly when sinusitis is present. ...

journal_title：Clinics in chest medicine

authors： Kraft M

更新日期：2000-06-01 00:00:00

abstract：:Inhaled particles are cleared from the airways by ciliary transport of a discontinuous mucous layer. The effectiveness of this process depends on the viscoelastic properties of the secretion, which in turn depend on the composition and interaction of the glycoprotein constituents. In human airways, two major cell type...

journal_title：Clinics in chest medicine

authors： Basbaum CB

更新日期：1986-06-01 00:00:00

abstract：:Non-small cell lung cancer with very limited extent of metastatic spread commonly is termed, oligometastatic disease (OMD), and typically described as no more than 3 to 5 lesions. Definitive local therapy potentially leads to significant improvement in progression-free survival and overall survival. OMD may occur de n...

journal_title：Clinics in chest medicine

authors： West H

更新日期：2020-06-01 00:00:00

abstract：:The specialty has the knowledge and technology to change the outcome of lung cancer. Lung cancer, diagnosed in early stages, is as curable as all other cancers. Sputum cytology is the initial step in diagnosing roentgenographically occult lung cancer. Sputum cytology is complementary to CT scanning. Sputum cytology id...

journal_title：Clinics in chest medicine

authors： Petty TL,Tockman MS,Palcic B

更新日期：2002-03-01 00:00:00

abstract：:Management of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) is largely supportive, with the use of mechanical ventilation being a central feature. Recent advances in the understanding of ALI/ARDS and mechanical ventilation have revealed that lung-protective ventilation strategies may atten...

journal_title：Clinics in chest medicine

authors： Fan E,Stewart TE

更新日期：2006-12-01 00:00:00

abstract：:This article summarizes the health effects of indoor air pollutants and the modalities available to control them. The pollutants discussed include active and passive exposure to tobacco smoke; combustion products of carbon monoxide; nitrogen dioxide; products of biofuels, including wood and coal; biologic agents leadi...

journal_title：Clinics in chest medicine

authors： Gold DR

更新日期：1992-06-01 00:00:00

abstract：:Our ability to define appropriate molecular targets for preclinical development and develop better methods needs to be improved, to determine the clinical value of novel acute respiratory distress syndrome (ARDS) agents. Clinical trials must have realistic sample sizes and meaningful end points and use the available o...

journal_title：Clinics in chest medicine

authors： Curley GF,McAuley DF

更新日期：2014-12-01 00:00:00

abstract：:This article discusses refeeding in relation to respiratory skeletal muscle function and the subsequent function of the respiratory system as a whole. The characteristic alterations in malnourished skeletal muscle and the response to refeeding are outlined. Following this, a simple energetic model is used to explore f...

journal_title：Clinics in chest medicine

authors： Fraser IM

更新日期：1986-03-01 00:00:00

abstract：:Inhaled corticosteroids (ICS) have led to improved asthma control and reduced asthma mortality in the Western world. ICS are effective in combating T-helper type 2-driven inflammation featuring mast cell and eosinophilic airway infiltration. Their effect on innate immunity-driven neutrophilic inflammation is poor and ...

journal_title：Clinics in chest medicine

authors： Louis R,Schleich F,Barnes PJ

更新日期：2012-09-01 00:00:00

abstract：:Cellular dysfunction is a commonplace sequelum of sepsis and other systemic inflammatory conditions. Impaired energy production (related to mitochondrial inhibition, damage, and reduced protein turnover) appears to be a core mechanism underlying the development of organ dysfunction. The reduction in energy availabilit...

journal_title：Clinics in chest medicine

authors： Singer M

更新日期：2008-12-01 00:00:00

abstract：:Flexible fiberoptic bronchoscopy is the most useful invasive technique for diagnosing lung cancer. This article details the use and efficacy of bronchoscopy with such established techniques as forceps biopsy, brush biopsy, and bronchial washing in the diagnosis and staging of bronchoscopically visible central lung can...

journal_title：Clinics in chest medicine

authors： Arroliga AC,Matthay RA

更新日期：1993-03-01 00:00:00

abstract：:The host response to microbial invasion in the lung must be sufficiently vigorous to allow for microbial eradication but appropriately controlled to prevent spillover of the response into the systemic circulation. Although inflammatory responses in pneumonia are generally compartmentalized, microbial and host factors ...

journal_title：Clinics in chest medicine

authors： Deng JC,Standiford TJ

更新日期：2005-03-01 00:00:00

abstract：:Lung cancer can be diagnosed based on histologic biopsy or cytologic specimens. The 2015 World Health Organization Classification of Lung Tumors addressed the diagnosis of lung cancer in resection specimens and in small biopsies and cytology specimens. For these small specimens, diagnostic terms and criteria are recom...

journal_title：Clinics in chest medicine

authors： Travis WD

更新日期：2020-03-01 00:00:00

abstract：:This article concentrates on those factors that are particularly important for performing and interpreting lung function tests in children. Specifically, technical considerations such as equipment, personnel, test performance, and bronchoprovocation procedures are discussed. Changes in lung function with growth and ap...

journal_title：Clinics in chest medicine

authors： Eisenberg JD,Wall MA

更新日期：1987-12-01 00:00:00

abstract：:Massive hemoptysis is a rare, but life-threatening event. Death from massive hemoptysis is usually due to aspiration of blood. Thus, the initial evaluation should occur simultaneously with efforts to control the patient's airway and respiratory status. Therapeutic interventions can be directed with an understanding of...

journal_title：Clinics in chest medicine

authors： Thompson AB,Teschler H,Rennard SI

更新日期：1992-03-01 00:00:00

abstract：:Delirium is a frequent complication in older patients in the ICU and often persists beyond their ICU stay. Delirium in older persons in the ICU is a dynamic and complex process. There is a high prevalence of pre-existing cognitive impairment in patients who are admitted to the medical ICU. This pre-existing cognitive ...

journal_title：Clinics in chest medicine

authors： Pisani MA,McNicoll L,Inouye SK

更新日期：2003-12-01 00:00:00

abstract：:Polymerase chain reaction-based diagnosis has become the standard for viral pneumonia and other respiratory tract infections. Expansion of respiratory viral panels (RVPs) outside of influenza and, possibly, respiratory syncytial virus has led to the ability to diagnose viral infections for which no approved specific a...

journal_title：Clinics in chest medicine

authors： Wunderink RG

更新日期：2017-03-01 00:00:00

abstract：:In therapy for ventilator-associated pneumonia, it is essential to get initial empiric therapy correct; this is challenging because many patients are infected with multidrug-resistant pathogens. The need for achieving appropriate therapy can lead to broad-spectrum empiric therapy, which can represent antibiotic overus...

journal_title：Clinics in chest medicine

authors： Niederman MS,Soulountsi V

更新日期：2011-09-01 00:00:00

abstract：:Controversy over the use of inhaled beta-agonists has dated almost from their introduction as a treatment for asthma. Their effectiveness as bronchodilators is not disputed, but there is concern that they may worsen asthma control if used regularly and that excessive use may increase the risk of death from asthma. Fiv...

journal_title：Clinics in chest medicine

authors： Fahy JV,Boushey HA

更新日期：1995-12-01 00:00:00

abstract：:Many different therapeutic compounds are associated with pulmonary toxicity. Although the mechanism of injury for many of these compounds is poorly defined, several compounds are believed to produce alterations in normal lung biochemistry. These mechanisms of injury in both clinical and experimental models are discuss...

journal_title：Clinics in chest medicine

authors： Duncan CA

更新日期：1989-03-01 00:00:00

abstract：:Endobronchial ablative therapies, such as mechanical debulking, laser therapy, electrocautery, argon plasma coagulation, cryotherapy, brachytherapy, photodynamic therapy, microdebrider bronchoscopy, resector balloon deobstruction, and intratumoral chemotherapy, are performed through a rigid or flexible bronchoscope in...

journal_title：Clinics in chest medicine

authors： Bilaçeroğlu S

更新日期：2018-03-01 00:00:00

abstract：:It has been proposed that invasive carcinoma of the bronchus develops through a transition from preinvasive lesions to overt malignancy. Newer diagnostic technologies have provided a more sensitive way to diagnose preinvasive lesions and a better understanding of the prevalence of such lesions. The natural history of ...

journal_title：Clinics in chest medicine

authors： Rivera MP

更新日期：2011-12-01 00:00:00

abstract：:Each year, a vast number of individuals are infected with the endemic fungi. An expanding population, along with further land development in endemic areas, will likely continue to place individuals at risk for exposure to these organisms. A high index of suspicion may be required to diagnose histoplasmosis, blastomyco...

journal_title：Clinics in chest medicine

authors： Goldman M,Johnson PC,Sarosi GA

更新日期：1999-09-01 00:00:00

abstract：:Selected occupational populations are at the highest risk of lung cancer, because they smoke at increased rates and are concurrently exposed to workplace lung carcinogens. Low-dose computed tomography (CT)-based lung cancer screening has an enormous potential to reduce lung cancer mortality in these populations, as sh...

journal_title：Clinics in chest medicine

authors： Markowitz SB,Dickens B

更新日期：2020-12-01 00:00:00

abstract：:This article provides a systematic review of the literature on the application of noninvasive ventilation in various forms of hypercapnic and hypoxemic respiratory failures. A description of the underlying pathophysiology is followed by a review of physiologic data explaining the mechanisms of action of noninvasive ve...

journal_title：Clinics in chest medicine

authors： Meduri GU

更新日期：1996-09-01 00:00:00