Abstract:
:Smoking is overwhelmingly the major cause of chronic bronchitis and emphysema worldwide. Additional risk factors for developing COPD are presented, along with the variables that govern cigarette smoke deposition in the lung. Major paradigms for the pathogenesis of COPD, including the protease-antiprotease and oxidant-antioxidant theories are described, and evidence for impaired reparative mechanisms in the causation of emphysema is noted. A description of the natural history of declining lung function in smokers and in the susceptible subset of smokers that ultimately develop smoking-induced COPD is accompanied by a discussion of the effects of smoking cessation on preservation of lung health. The disordered ventilation and gas-exchange physiology in the cigarette smoke-damaged lung is explained on the basis of the observed morphological changes.
journal_name
Clin Chest Medjournal_title
Clinics in chest medicineauthors
Sethi JM,Rochester CLdoi
10.1016/s0272-5231(05)70008-3subject
Has Abstractpub_date
2000-03-01 00:00:00pages
67-86, viiiissue
1eissn
0272-5231issn
1557-8216pii
S0272-5231(05)70008-3journal_volume
21pub_type
杂志文章,评审abstract::Lung diffusing capacity for carbon monoxide (Dlco) remains the only noninvasive pulmonary function test to provide an integrated picture of gas exchange efficiency in human lungs. Due to its critical dependence on the accessible "alveolar" volume (Va), there remains substantial misunderstanding on the interpretation o...
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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journal_title:Clinics in chest medicine
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