Cellular dysfunction in sepsis.


:Cellular dysfunction is a commonplace sequelum of sepsis and other systemic inflammatory conditions. Impaired energy production (related to mitochondrial inhibition, damage, and reduced protein turnover) appears to be a core mechanism underlying the development of organ dysfunction. The reduction in energy availability appears to trigger a metabolic shutdown that impairs normal functioning of the cell. This may well represent an adaptive mechanism analogous to hibernation that prevents a massive degree of cell death and thus enables eventual recovery in survivors.


Clin Chest Med


Singer M




Has Abstract


2008-12-01 00:00:00


655-60, viii-ix












  • Chronic thromboembolic pulmonary hypertension.

    abstract::The description of organized thrombus in major pulmonary arteries can be found in autopsy reports dating back to the late nineteenth and early twentieth centuries. Not until the 1950s was the antemortem diagnosis and clinical syndrome of chronic thrombotic obstruction of the major pulmonary arteries better characteriz...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Auger WR,Kim NH,Kerr KM,Test VJ,Fedullo PF

    更新日期:2007-03-01 00:00:00

  • Intra-abdominal hypertension: evolving concepts.

    abstract::This article focuses primarily on the recent literature on abdominal compartment syndrome (ACS) and the definitions and recommendations published by the World Society for the Abdominal Compartment Syndrome. The definitions regarding increased intra-abdominal pressure (IAP) are listed and are followed by an overview of...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Malbrain ML,De laet IE

    更新日期:2009-03-01 00:00:00

  • Barriers and Challenges to the Successful Implementation of an Intensive Care Unit Mobility Program: Understanding Systems and Human Factors in Search for Practical Solutions.

    abstract::ICU-acquired weakness is a common problem and carries significant morbidity. Despite evidence that early mobility can mitigate this, implementation outside of the research setting is lagging. Understanding barriers at the systems as well as individual level is a crucial step in successful implementation of an ICU mobi...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Honiden S,Connors GR

    更新日期:2015-09-01 00:00:00

  • A decade of advances in treatment for advanced non-small cell lung cancer.

    abstract::The last decade has heralded a paradigm shift in the evaluation and treatment of advanced non-small cell lung cancer (NSCLC). No longer are patients with NSCLC considered a homogeneous population treated in the same way; rather, clinical characteristics, histology, and an expanding array of molecular markers are incre...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Gettinger S,Lynch T

    更新日期:2011-12-01 00:00:00

  • Role of bronchoscopy in massive hemoptysis.

    abstract::Massive hemoptysis accounts for a minority of all patients with hemoptysis but poses a major challenge for the acute and long-term treatment. Massive hemoptysis can lead to asphyxiation and airway obstruction, shock, and exsanguination. Bronchoscopy plays an integral part in managing massive hemoptysis in diagnosis an...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Dweik RA,Stoller JK

    更新日期:1999-03-01 00:00:00

  • Obesity Hypoventilation Syndrome.

    abstract::Obesity hypoventilation syndrome has been noted for centuries, yet we still are trying to uncover the exact mechanisms behind the disease and best treatment modalities for patients afflicted by the condition. The syndrome, which results in symptoms based on a diverse spectrum of interactions between obesity, ventilato...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Iftikhar IH,Roland J

    更新日期:2018-06-01 00:00:00

  • Asthma in Hispanics in the United States.

    abstract::The Hispanic population in the United States is diverse in many respects. Although there is marked variation in the prevalence, morbidity, and mortality of asthma among Hispanic subgroups in the United States, these differences are poorly understood. Future stu-dies of asthma should include large samples of Hispanic s...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Cohen RT,Celedón JC

    更新日期:2006-09-01 00:00:00

  • Interventional chest procedures in pregnancy.

    abstract::Interventional pulmonology encompasses diagnostic and therapeutic bronchoscopic procedures, and pleural interventions. In the last 10 years older techniques have been refined and exciting new technologies have extended the reach and application of the instruments used. The main areas within pulmonary medicine for whic...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Morgan RK,Ernst A

    更新日期:2011-03-01 00:00:00

  • New modalities of mechanical ventilation: high-frequency oscillatory ventilation and airway pressure release ventilation.

    abstract::Management of acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) is largely supportive, with the use of mechanical ventilation being a central feature. Recent advances in the understanding of ALI/ARDS and mechanical ventilation have revealed that lung-protective ventilation strategies may atten...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Fan E,Stewart TE

    更新日期:2006-12-01 00:00:00

  • Inflammation and Pneumonia: Why Are Some More Susceptible than Others?

    abstract::Pneumonia is an important cause of morbidity and mortality. However, pneumonia is an unusual outcome of respiratory infection. Most of the time, microbes in the lung can be controlled by a combination of constitutive and recruited defense mechanisms. Inflammation is a key component of recruited defenses. Variations in...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Mizgerd JP

    更新日期:2018-12-01 00:00:00

  • Host defense impairments that may lead to respiratory infections.

    abstract::Host defense mechanisms spaced along the respiratory tree and in the alveolar spaces effectively remove or contend with micro-organisms that enter the airways, so serious lung infections occur rarely in healthy people. Special circumstances, such as virgin exposure to a virulent microbe or a large innoculum of a patho...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Reynolds HY

    更新日期:1987-09-01 00:00:00

  • Pulmonary function testing and extreme environments.

    abstract::Millions of people worldwide engage in leisure or occupational activities in extreme environments. These environments entail health risks even for normal subjects. The presence of lung disease, or other conditions, further predisposes to illness or injury. Patients who have lung conditions should, but often do not, co...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Dillard TA,Khosla S,Ewald FW Jr,Kaleem MA

    更新日期:2005-09-01 00:00:00

  • Universal directly observed therapy. A treatment strategy for tuberculosis.

    abstract::Patient adherence to prescribed tuberculosis regimens must be assured to prevent relapse, acquired resistance, and transmission. Directly observed therapy (DOT), an outpatient management strategy designed to ensure adherence, is not widely used because it is perceived to be inordinately expensive. The primary focus of...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Weis SE

    更新日期:1997-03-01 00:00:00

  • Chronic bronchitis.

    abstract::Our understanding of chronic bronchitis has been hampered by the fact that the diagnosis is based upon historical evidence of recurrent cough and sputum without any requirement that certain physiologic or microscopic criteria be met. Despite the fact that epidemiological studies have implicated viruses, bacteria, and ...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Sachs FL

    更新日期:1981-01-01 00:00:00

  • Bronchoscopic Therapies for Peripheral Lung Malignancies.

    abstract::Current advances in guided bronchoscopy methods permit minimally invasive access to essentially any area of the lungs. This provides a potential means to treat patients with localized lung malignancies who might not otherwise tolerate conventional treatment, which commonly relies on surgical resection. Ablation method...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Hsia DW,Musani AI

    更新日期:2018-03-01 00:00:00

  • Screening for Occupational Lung Cancer: An Unprecedented Opportunity.

    abstract::Selected occupational populations are at the highest risk of lung cancer, because they smoke at increased rates and are concurrently exposed to workplace lung carcinogens. Low-dose computed tomography (CT)-based lung cancer screening has an enormous potential to reduce lung cancer mortality in these populations, as sh...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Markowitz SB,Dickens B

    更新日期:2020-12-01 00:00:00

  • Sleep-disordered breathing in neurologic conditions.

    abstract::Sleep-related breathing disorder or sleep-disordered breathing (SDB) encompasses central sleep apnea (CSA), obstructive sleep apnea (OSA), and sleep-related hypoventilation or hypoxemic syndromes. SDB is common in neurologic conditions that affect the central and/or peripheral nervous systems. Patients with neurologic...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Deak MC,Kirsch DB

    更新日期:2014-09-01 00:00:00

  • Imaging of small airways disease and chronic obstructive pulmonary disease.

    abstract::CT is a useful tool for identification of small airways diseases, and it can be used to classify these entities into inflammatory and constrictive bronchiolitis. Inflammatory forms of bronchiolitis include cellular bronchiolitis (usually caused by infection or aspiration), respiratory bronchiolitis, panbronchiolitis, ...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Lynch DA

    更新日期:2008-03-01 00:00:00

  • Viral Pneumonia in Patients with Hematopoietic Cell Transplantation and Hematologic Malignancies.

    abstract::Viral pneumonia is a common complication for patients with hematologic malignancies and after hematopoietic cell transplantation causing significant morbidity, and often mortality. Infections are predominantly caused by herpes viruses, either by reactivation of latent infection, or less commonly primary infection, or ...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Green ML

    更新日期:2017-06-01 00:00:00

  • Predictors of mortality in chronic obstructive pulmonary disease.

    abstract::Chronic obstructive pulmonary disease (COPD) has become a major and growing health problem, with a mortality rate that continues to increase. Several factors, have been identified as individual predictors of mortality in COPD. This article reviews individual predictors for mortality. It also discusses the ability of a...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Cote CG,Celli BR

    更新日期:2007-09-01 00:00:00

  • Etiology of ventilator-associated pneumonia.

    abstract::This review focuses on the top ten causes of ventilator-associated pneumonia (VAP), updating an earlier study. These pathogens have specific risk factors, different patterns of clinical resolution, and a wide range of attributable mortality. The discussion herein analyzes these aspects, placing particular emphasis on ...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Rello J,Díaz E,Rodríguez A

    更新日期:2005-03-01 00:00:00

  • Pulmonary arterial hypertension associated with congenital heart disease.

    abstract::In the past decade, there have been more patients with congenital heart disease (CHD) surviving to adulthood; whether due to late repair, or complex underlying CHD, many of these patients will be faced with pulmonary arterial hypertension (PAH) associated with CHD (APAH-CHD). In this review, the authors discuss the mo...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Krishnan U,Rosenzweig EB

    更新日期:2013-12-01 00:00:00

  • Control of breathing in asthma.

    abstract::The hyperventilation seen in asthma is due to an increase in respiratory drive. This may be reflected by increased neural output to the respiratory muscles and probably by alterations in the respiratory pattern. This increased respiratory drive is most likely in response to irritant receptor stimulation in the lung. O...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Schiff M

    更新日期:1980-01-01 00:00:00

  • Diet and Metabolism in the Evolution of Asthma and Obesity.

    abstract::Obesity is a major risk factor for asthma. This association appears related to altered dietary composition and metabolic factors that can directly affect airway reactivity and airway inflammation. This article discusses how specific changes in the western diet and metabolic changes associated with the obese state affe...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Dixon AE,Holguin F

    更新日期:2019-03-01 00:00:00

  • Pleural effusions and pulmonary edema.

    abstract::Pleural effusions are a common clinical problem, yet the mechanisms of pleural fluid formation have only recently been investigated. In this article, the anatomy and physiology of the normal pleural space is discussed, as well as the pathophysiology of pleural effusion formation. ...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Wiener-Kronish JP,Berthiaume Y,Albertine KH

    更新日期:1985-09-01 00:00:00

  • Hyper-IgE Syndromes and the Lung.

    abstract::Elevated serum IgE has many etiologies including parasitic infection, allergy and asthma, malignancy, and immune dysregulation. The hyper-IgE syndromes caused by mutations in STAT3, DOCK8, and PGM3 are monogenic primary immunodeficiencies associated with high IgE, eczema, and recurrent infections. These primary immuno...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Freeman AF,Olivier KN

    更新日期:2016-09-01 00:00:00

  • Lung Function Testing in Chronic Obstructive Pulmonary Disease.

    abstract::Lung function testing has undisputed value in the comprehensive assessment and individualized management of chronic obstructive pulmonary disease, a pathologic condition in which a functional abnormality, poorly reversible expiratory airway obstruction, is at the core of its definition. After an overview of the physio...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Neder JA,de-Torres JP,Milne KM,O'Donnell DE

    更新日期:2020-09-01 00:00:00

  • Pulmonary scintigraphy and the diagnosis of pulmonary embolism. A perspective.

    abstract::The authors attempt to demonstrate those circumstances for which perfusion scintigraphy, by itself, or in combination with ventilation scintiscanning, offers the best adjunctive information in excluding or confirming the presence of pulmonary embolism. They then identify those circumstances in which scintiscanning doe...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Polak JF,McNeil BJ

    更新日期:1984-09-01 00:00:00

  • Thoracoscopy: a real-life perspective.

    abstract::This article focuses on thoracoscopy for pleural procedures, both diagnostic and therapeutic, and discusses whether there is a difference between pleuroscopy and thoracoscopy or video-assisted thoracic surgery. How thinking should be structured regarding the management of pleural disease in the modern context of avail...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Detterbeck FC

    更新日期:2013-03-01 00:00:00

  • Respiratory disability. The uncoupling of oxygen consumption and disability.

    abstract::In the past it was believed that respiratory disability could be objectively assessed by comparing the measured O2 consumption requirement of the job with the subjects' measured or estimated maximal oxygen consumption. More recently, it has become clear that this "classic" paradigm does not completely apply to all sit...

    journal_title:Clinics in chest medicine

    pub_type: 杂志文章,评审


    authors: Harber P

    更新日期:1992-06-01 00:00:00