Cellular dysfunction in sepsis.

Abstract:

:Cellular dysfunction is a commonplace sequelum of sepsis and other systemic inflammatory conditions. Impaired energy production (related to mitochondrial inhibition, damage, and reduced protein turnover) appears to be a core mechanism underlying the development of organ dysfunction. The reduction in energy availability appears to trigger a metabolic shutdown that impairs normal functioning of the cell. This may well represent an adaptive mechanism analogous to hibernation that prevents a massive degree of cell death and thus enables eventual recovery in survivors.

journal_name

Clin Chest Med

authors

Singer M

doi

10.1016/j.ccm.2008.06.003

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

655-60, viii-ix

issue

4

eissn

0272-5231

issn

1557-8216

pii

S0272-5231(08)00080-4

journal_volume

29

pub_type

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