Incorporating Lung Diffusing Capacity for Carbon Monoxide in Clinical Decision Making in Chest Medicine.

Abstract:

:Lung diffusing capacity for carbon monoxide (Dlco) remains the only noninvasive pulmonary function test to provide an integrated picture of gas exchange efficiency in human lungs. Due to its critical dependence on the accessible "alveolar" volume (Va), there remains substantial misunderstanding on the interpretation of Dlco and the diffusion coefficient (Dlco/Va ratio, Kco). This article presents the physiologic and methodologic foundations of Dlco measurement. A clinically friendly approach for Dlco interpretation that takes those caveats into consideration is outlined. The clinical scenarios in which Dlco can effectively assist the chest physician are discussed and illustrative clinical cases are presented.

journal_name

Clin Chest Med

authors

Neder JA,Berton DC,Muller PT,O'Donnell DE

doi

10.1016/j.ccm.2019.02.005

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

285-305

issue

2

eissn

0272-5231

issn

1557-8216

pii

S0272-5231(19)30005-X

journal_volume

40

pub_type

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