Fungal Pneumonia in Patients with Hematologic Malignancy and Hematopoietic Stem Cell Transplantation.

Abstract:

:Fungal pneumonias cause unacceptable morbidity among patients with hematologic malignancies (HM) and recipients of hematopoietic stem cell transplantation (HSCT). The high incidence of fungal pneumonias in HM/HSCT populations arises from their frequently severe, complex, and persistent immune dysfunction caused by the underlying disease and its treatment. The cytopenias, treatment toxicities, and other immune derangements that make patients susceptible to fungal pneumonia frequently complicate its diagnosis and increase the intensity and duration of antifungal therapy. This article addresses the host factors that contribute to susceptibility, summarizes diagnostic recommendations, and reviews current guidelines for management of fungal pneumonia in patients with HM/HSCT.

journal_name

Clin Chest Med

authors

Young AY,Leiva Juarez MM,Evans SE

doi

10.1016/j.ccm.2017.04.009

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

479-491

issue

3

eissn

0272-5231

issn

1557-8216

pii

S0272-5231(17)30044-8

journal_volume

38

pub_type

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