Abstract:
:Fungal pneumonias cause unacceptable morbidity among patients with hematologic malignancies (HM) and recipients of hematopoietic stem cell transplantation (HSCT). The high incidence of fungal pneumonias in HM/HSCT populations arises from their frequently severe, complex, and persistent immune dysfunction caused by the underlying disease and its treatment. The cytopenias, treatment toxicities, and other immune derangements that make patients susceptible to fungal pneumonia frequently complicate its diagnosis and increase the intensity and duration of antifungal therapy. This article addresses the host factors that contribute to susceptibility, summarizes diagnostic recommendations, and reviews current guidelines for management of fungal pneumonia in patients with HM/HSCT.
journal_name
Clin Chest Medjournal_title
Clinics in chest medicineauthors
Young AY,Leiva Juarez MM,Evans SEdoi
10.1016/j.ccm.2017.04.009subject
Has Abstractpub_date
2017-09-01 00:00:00pages
479-491issue
3eissn
0272-5231issn
1557-8216pii
S0272-5231(17)30044-8journal_volume
38pub_type
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journal_title:Clinics in chest medicine
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