Novel medical therapies for pulmonary arterial hypertension.

abstract：:Pleural effusions are a common clinical problem, yet the mechanisms of pleural fluid formation have only recently been investigated. In this article, the anatomy and physiology of the normal pleural space is discussed, as well as the pathophysiology of pleural effusion formation. ...

journal_title：Clinics in chest medicine

authors： Wiener-Kronish JP,Berthiaume Y,Albertine KH

更新日期：1985-09-01 00:00:00

abstract：:Obesity hypoventilation syndrome has been noted for centuries, yet we still are trying to uncover the exact mechanisms behind the disease and best treatment modalities for patients afflicted by the condition. The syndrome, which results in symptoms based on a diverse spectrum of interactions between obesity, ventilato...

journal_title：Clinics in chest medicine

authors： Iftikhar IH,Roland J

更新日期：2018-06-01 00:00:00

abstract：:Sleep-related breathing disorder or sleep-disordered breathing (SDB) encompasses central sleep apnea (CSA), obstructive sleep apnea (OSA), and sleep-related hypoventilation or hypoxemic syndromes. SDB is common in neurologic conditions that affect the central and/or peripheral nervous systems. Patients with neurologic...

journal_title：Clinics in chest medicine

authors： Deak MC,Kirsch DB

更新日期：2014-09-01 00:00:00

abstract：:The authors' data show a higher rate of pleural and meningeal involvement among extrapulmonary TB cases than expected by previous works. Special attention should be given to tuberculous meningitis cases among all extrapulmonary TB cases because of its high mortality rate. The most common extrapulmonary involvement is ...

journal_title：Clinics in chest medicine

authors： Ozbay B,Uzun K

更新日期：2002-06-01 00:00:00

abstract：:Airway inflammation due to exposure to a wide variety of agents encountered in the workplace is a major cause of occupational asthma. This article reviews major examples of occupational asthma linked to airway inflammation, including their epidemiology, pathophysiology, and clinical course. ...

journal_title：Clinics in chest medicine

authors： Fine JM,Balmes JR

更新日期：1988-12-01 00:00:00

abstract：:This article concentrates on those factors that are particularly important for performing and interpreting lung function tests in children. Specifically, technical considerations such as equipment, personnel, test performance, and bronchoprovocation procedures are discussed. Changes in lung function with growth and ap...

journal_title：Clinics in chest medicine

authors： Eisenberg JD,Wall MA

更新日期：1987-12-01 00:00:00

abstract：:An older smoker tends to be asked less often to quit although he or she has much to gain from achieving a nonsmoking status. Multiple barriers may interfere with attempting to quit including nicotine withdrawal, doubted self-efficacy, other smokers in one's environment, or misperceptions of little gain from quitting. ...

journal_title：Clinics in chest medicine

authors： Cox JL

更新日期：1993-09-01 00:00:00

abstract：:Controversy over the use of inhaled beta-agonists has dated almost from their introduction as a treatment for asthma. Their effectiveness as bronchodilators is not disputed, but there is concern that they may worsen asthma control if used regularly and that excessive use may increase the risk of death from asthma. Fiv...

journal_title：Clinics in chest medicine

authors： Fahy JV,Boushey HA

更新日期：1995-12-01 00:00:00

abstract：:Traditional tuberculosis (TB) infection control focuses on the known patient with TB, usually on appropriate treatment. A refocused, intensified TB infection control approach is presented. Combined with active case finding and rapid molecular diagnostics, an approach called FAST is described as a convenient way to cal...

journal_title：Clinics in chest medicine

authors： Nardell EA

更新日期：2019-12-01 00:00:00

abstract：:Chronic lung diseases, including chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), are unusually prevalent among persons infected with human immunodeficiency virus (HIV). Often these disease states are identified at younger ages than would be expected in the general population. Recent epide...

journal_title：Clinics in chest medicine

authors： Fitzpatrick M,Crothers K,Morris A

更新日期：2013-06-01 00:00:00

abstract：:In the last few years, there has been considerable progress in our understanding of the mechanisms of action and resistance to antimycobacterials. To date, there is information about 11 genes involved in resistance in M. tuberculosis. This has prompted the development of novel tests for the rapid identification of res...

journal_title：Clinics in chest medicine

authors： Telenti A

更新日期：1997-03-01 00:00:00

abstract：:Leptospirosis is a worldwide disease. In this time of globalization knowledge about leptospirosis is important. Although pulmonary involvement has an incidence varying from 20% to 70% and its exteriorization may vary from mild to severe, The severe form appears to be becoming more prevalent (at least in Brazil) and ma...

journal_title：Clinics in chest medicine

authors： Carvalho CR,Bethlem EP

更新日期：2002-06-01 00:00:00

abstract：:Inhaled corticosteroids (ICSs), when used in combination with long-acting bronchodilators, reduce the risk of exacerbations and improve health-related quality of life in patients with chronic obstructive pulmonary disease (COPD) compared with bronchodilator or ICS therapy alone. Potential side effects of ICSs include ...

journal_title：Clinics in chest medicine

authors： Mkorombindo T,Dransfield MT

更新日期：2020-09-01 00:00:00

abstract：:Obstructive sleep-disordered breathing consists of a spectrum ranging from the upper airway resistance syndrome to complete apnea. Although this disorder is relatively common, it is still under-recognized, resulting in a significant increase in morbidity and mortality. In this article, we describe the rationale for tr...

journal_title：Clinics in chest medicine

authors： Bahammam A,Kryger M

更新日期：1998-03-01 00:00:00

abstract：:The pharmacologic treatment of the reversible elements of chronic obstructive pulmonary disease is discussed in this article. Discussion focuses on three classes of bronchodilator drugs--the sympathomimetic agents, the methylxanthines, and the anticholinergic agents. A section on corticosteroid use in patients with ch...

journal_title：Clinics in chest medicine

authors： Theodore AC,Beer DJ

更新日期：1986-12-01 00:00:00

abstract：:Nasal CPAP is and should be the first-line treatment for OSA. Any physician who uses nasal CPAP undoubtedly recognizes that this treatment modality has limitations, however. The authors believe that surgery offers a viable alternative to nasal CPAP in patients who are intolerant of nasal CPAP. Potential risks and comp...

journal_title：Clinics in chest medicine

authors： Li KK

更新日期：2003-06-01 00:00:00

abstract：:Blood gas analyses are an essential part of modern patient care. Although all blood gas instruments have pH, PCO2, and PO2 electrodes based on the same principles, instruments in current use vary greatly in design, operator dependence, and accuracy. For the clinician to obtain accurate and timely results there must be...

journal_title：Clinics in chest medicine

authors： Hansen JE

更新日期：1989-06-01 00:00:00

abstract：:Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by the accumulation of surfactant in alveoli and terminal airways resulting in respiratory failure. PAP comprises part of a spectrum of disorders of surfactant homeostasis (clearance and production). The surfactant production disorders are caused by...

journal_title：Clinics in chest medicine

authors： Suzuki T,Trapnell BC

更新日期：2016-09-01 00:00:00

abstract：:After half a century of clinical experience and research, management of pulmonary arterial hypertension remains a challenge. Currently, data to support the use of standard therapies for pulmonary arterial hypertension (oxygen supplementation, diuretics, digoxin, anticoagulation, and calcium channel blockers) are mostl...

journal_title：Clinics in chest medicine

authors： Alam S,Palevsky HI

更新日期：2007-03-01 00:00:00

abstract：:In the past it was believed that respiratory disability could be objectively assessed by comparing the measured O2 consumption requirement of the job with the subjects' measured or estimated maximal oxygen consumption. More recently, it has become clear that this "classic" paradigm does not completely apply to all sit...

journal_title：Clinics in chest medicine

authors： Harber P

更新日期：1992-06-01 00:00:00

abstract：:The pathogenic importance of cytomegalovirus (CMV) infection in AIDS-associated pneumonitis is controversial. Uncertainty regarding the significance of CMV isolation from pulmonary secretions of AIDS patients results in part from the difficulty in distinguishing CMV infection from CMV disease and from the high frequen...

journal_title：Clinics in chest medicine

authors： Jacobson MA,Mills J

更新日期：1988-09-01 00:00:00

abstract：:In the past 3 years, lung volume reduction surgery has become the most controversial topic in the clinical management of patients with emphysema. Although literature has added to the understanding of the procedure, many important issues remain unclear. This article emphasizes functional and basic physiologic changes t...

journal_title：Clinics in chest medicine

authors： Sciurba FC

更新日期：1997-06-01 00:00:00

abstract：:Early detection and surgical resection are essential for the treatment of lung cancer. It would be ideal to be able to detect and treat preinvasive bronchial lesions, defined as dysplasia and carcinoma in situ before progressing to invasive cancer. Advanced airway-assessment techniques have opened an avenue for early ...

journal_title：Clinics in chest medicine

authors： Nakajima T,Yasufuku K

更新日期：2013-09-01 00:00:00

abstract：:With the increasing threat of pandemic influenza and catastrophic bioterrorism, it is important for intensive care providers to be prepared to meet the challenge of large-scale airborne epidemics causing mass casualty respiratory failure. The severe acute respiratory syndrome outbreak exposed the vulnerability of heal...

journal_title：Clinics in chest medicine

authors： Phua GC,Govert J

更新日期：2008-06-01 00:00:00

abstract：:The pathogenesis of O2 toxicity involves intracellular production of partially reduced O2 metabolites, which increases with O2 partial pressure. Cytotoxic O2 metabolites impair enzyme function and inhibit DNA, protein, and surfactant lipid biosynthesis. Compounds used clinically that increase O2 metabolism or that are...

journal_title：Clinics in chest medicine

authors： Jackson RM

更新日期：1990-03-01 00:00:00

abstract：:The features of cardiovascular and pulmonary disease in exercise testing are described. In general, ventilatory limitation is the most common factor in lung disease. An early anaerobic threshold and a decreased VO2 mix in the absence of ventilatory limitation is the usual feature of severe heart disease. ...

journal_title：Clinics in chest medicine

authors： Kanarek DJ,Hand RW

更新日期：1984-03-01 00:00:00

abstract：:Lung cancer remains the most common fatal malignancy, so even modest therapeutic advances are potentially beneficial to large numbers of patients. For patients with regional nodal metastases identified at thoracotomy, adjuvant chemotherapy may be of benefit and additional clinical trials are in progress. Locally advan...

journal_title：Clinics in chest medicine

authors： Murren JR,Buzaid AC

更新日期：1993-03-01 00:00:00

abstract：:The process of smoking cessation involves progression through five stages of change: precontemplation, contemplation, preparation, action, and maintenance. Most patients are not prepared to take action on their smoking, yet most smoking cessation programs are designed for smokers who are so prepared. Small percentages...

journal_title：Clinics in chest medicine

authors： Prochaska JO,Goldstein MG

更新日期：1991-12-01 00:00:00

abstract：:Pulmonary complications occur in 40% to 60% of recipients of bone marrow trans-plants, account for more than 90% of mortality, and develop during identifiable phases. Phase 1 (Days 1-30) includes pulmonary edema; diffuse alveolar hemorrhage; and various bacterial, fungal, and viral infections; Phase 2 (Days 31-100) us...

journal_title：Clinics in chest medicine

authors： Yen KT,Lee AS,Krowka MJ,Burger CD

更新日期：2004-03-01 00:00:00

abstract：:Occupational and environmental exposures contribute to the development and progression of most lung diseases, yet their impact is greatly under-recognized in clinical practice. Clinicians caring for patients with respiratory diseases should maintain a high index of suspicion for occupational and environmental contribu...

journal_title：Clinics in chest medicine

authors： James E,Linde B,Redlich CA

更新日期：2020-12-01 00:00:00