Abstract：
:Inhaled corticosteroids (ICSs), when used in combination with long-acting bronchodilators, reduce the risk of exacerbations and improve health-related quality of life in patients with chronic obstructive pulmonary disease (COPD) compared with bronchodilator or ICS therapy alone. Potential side effects of ICSs include adverse effects on glycemic control, bone density, cataract formation, skin changes, oral candidiasis, and pulmonary infections. Pneumonia is observed at increased rates in COPD patients, in particular those with greater airflow limitation, low body mass index, advanced age, and male gender, and ICSs may increase this risk. Risk assessment is essential in selecting appropriate patients for ICS-containing therapy.
journal_name
Clin Chest Medjournal_title
Clinics in chest medicineauthors
Mkorombindo T,Dransfield MTdoi
10.1016/j.ccm.2020.05.006subject
Has Abstractpub_date
2020-09-01 00:00:00pages
475-484issue
3eissn
0272-5231issn
1557-8216pii
S0272-5231(20)30032-0journal_volume
41pub_type
杂志文章,评审abstract：:Elevated serum IgE has many etiologies including parasitic infection, allergy and asthma, malignancy, and immune dysregulation. The hyper-IgE syndromes caused by mutations in STAT3, DOCK8, and PGM3 are monogenic primary immunodeficiencies associated with high IgE, eczema, and recurrent infections. These primary immuno...
journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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abstract：:Hemodynamic monitoring is a diagnostic tool. Because hemodynamic monitoring often requires invasive procedures, it can be associated with an increased incidence of untoward events. Like any diagnostic tool, its ability to improve outcome will be primarily related to the survival benefit enjoyed by specific therapies t...
journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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更新日期：2007-03-01 00:00:00
abstract：:The pathogenesis of O2 toxicity involves intracellular production of partially reduced O2 metabolites, which increases with O2 partial pressure. Cytotoxic O2 metabolites impair enzyme function and inhibit DNA, protein, and surfactant lipid biosynthesis. Compounds used clinically that increase O2 metabolism or that are...
journal_title：Clinics in chest medicine
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doi：
更新日期：1990-03-01 00:00:00
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：10.1016/j.ccm.2005.10.002
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journal_title：Clinics in chest medicine
pub_type： 杂志文章
doi：
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：
更新日期：1988-03-01 00:00:00
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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更新日期：2011-06-01 00:00:00
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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更新日期：2001-03-01 00:00:00
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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更新日期：2013-09-01 00:00:00
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：
更新日期：1995-12-01 00:00:00
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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journal_title：Clinics in chest medicine
pub_type： 杂志文章
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：
更新日期：1992-12-01 00:00:00
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：
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journal_title：Clinics in chest medicine
pub_type： 杂志文章,评审
doi：
更新日期：1989-03-01 00:00:00
