Abstract：
:Corticosteroids are the most effective treatment for asthma; inhaled corticosteroids (ICSs) are the first-line treatment for children and adults with persistent symptoms. ICSs are associated with significant improvements in lung function. The anti-inflammatory effects of corticosteroids are mediated by both genomic and nongenomic factors. Variation in the response to corticosteroids has been observed. Patient characteristics, biomarkers, and genetic features may be used to predict response to ICSs. The existence of multiple mechanisms underlying glucocorticoid insensitivity raises the possibility that this might indeed reflect different diseases with a common phenotype.
journal_name
Clin Chest Medjournal_title
Clinics in chest medicineauthors
Ramadan AA,Gaffin JM,Israel E,Phipatanakul Wdoi
10.1016/j.ccm.2018.10.010subject
Has Abstractpub_date
2019-03-01 00:00:00pages
163-177issue
1eissn
0272-5231issn
1557-8216pii
S0272-5231(18)30121-7journal_volume
40pub_type
杂志文章,评审abstract：:The pharmacologic treatment of the reversible elements of chronic obstructive pulmonary disease is discussed in this article. Discussion focuses on three classes of bronchodilator drugs--the sympathomimetic agents, the methylxanthines, and the anticholinergic agents. A section on corticosteroid use in patients with ch...
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
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journal_title：Clinics in chest medicine
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