New modalities of mechanical ventilation: high-frequency oscillatory ventilation and airway pressure release ventilation.

abstract：:Lung diffusing capacity for carbon monoxide (Dlco) remains the only noninvasive pulmonary function test to provide an integrated picture of gas exchange efficiency in human lungs. Due to its critical dependence on the accessible "alveolar" volume (Va), there remains substantial misunderstanding on the interpretation o...

journal_title：Clinics in chest medicine

authors： Neder JA,Berton DC,Muller PT,O'Donnell DE

更新日期：2019-06-01 00:00:00

abstract：:Pneumonia, acute bronchitis, and sinusitis are common infections encountered by the pulmonary specialist. Such conditions are usually treated with antibiotics, and their use requires an understanding of their pharmacokinetic properties as well as their antimicrobial spectrum and adverse side effects. ...

journal_title：Clinics in chest medicine

authors： Segreti J,Trenholme GM

更新日期：1986-09-01 00:00:00

abstract：:This article provides a systematic review of the literature on the application of noninvasive ventilation in various forms of hypercapnic and hypoxemic respiratory failures. A description of the underlying pathophysiology is followed by a review of physiologic data explaining the mechanisms of action of noninvasive ve...

journal_title：Clinics in chest medicine

authors： Meduri GU

更新日期：1996-09-01 00:00:00

abstract：:Early detection and surgical resection are essential for the treatment of lung cancer. It would be ideal to be able to detect and treat preinvasive bronchial lesions, defined as dysplasia and carcinoma in situ before progressing to invasive cancer. Advanced airway-assessment techniques have opened an avenue for early ...

journal_title：Clinics in chest medicine

authors： Nakajima T,Yasufuku K

更新日期：2013-09-01 00:00:00

abstract：:This review focuses on the top ten causes of ventilator-associated pneumonia (VAP), updating an earlier study. These pathogens have specific risk factors, different patterns of clinical resolution, and a wide range of attributable mortality. The discussion herein analyzes these aspects, placing particular emphasis on ...

journal_title：Clinics in chest medicine

authors： Rello J,Díaz E,Rodríguez A

更新日期：2005-03-01 00:00:00

abstract：:Individualized management of asthma requires consideration of single or combined pharmacologic alternatives. This article reviews experimental and clinical data on the efficacy, safety, mode of action, and therapeutic indications for cromolyn and related inhalational compounds; ketotifen; alpha-adrenergic blockers; ca...

journal_title：Clinics in chest medicine

authors： Falliers CJ,Tinkelman DG

更新日期：1986-09-01 00:00:00

abstract：:Quantitative assessment of pulmonary metabolic function has been shown to be a novel and important approach to obtaining specific and subtle biochemical information regarding endothelial cell function in the normal and diseased lung. A primary consideration in this measurement of whole organ metabolism, whether it be ...

journal_title：Clinics in chest medicine

authors： Pitt BR,Lister G

更新日期：1989-03-01 00:00:00

abstract：:This article reviews the basic pathophysiologic mechanisms underlying the abnormal pulmonary gas exchange often seen in patients with cirrhosis. To summarize, the following keypoints seem appropriate: (1) Patients with cirrhosis have a low pulmonary vascular tone characterized by a poor or absent hypoxic pressor respo...

journal_title：Clinics in chest medicine

authors： Agusti AG,Roca J,Rodriguez-Roisin R

更新日期：1996-03-01 00:00:00

abstract：:The use of nuclear magnetic resonance to produce diagnostic images of the human chest has just become possible. These images are computer-reconstructed maps of the distribution in tissue of protons and of some of their magnetic characteristics. The images are high resolution and anatomically accurate, are capable of d...

journal_title：Clinics in chest medicine

authors： Newhouse JH

更新日期：1984-06-01 00:00:00

abstract：:Infections due to the rapidly growing mycobacteria are being identified with increasing frequency, especially in the southern coastal United States. Cutaneous disease, including both community-acquired infections and nosocomial diseases such as augmentation mammaplasty wound infections and sternal wound infections, ar...

journal_title：Clinics in chest medicine

authors： Wallace RJ Jr

更新日期：1989-09-01 00:00:00

abstract：:Prophylaxis for DVT unequivocally is beneficial in patients identified to be at high risk. Heparin prophylaxis with subcutaneous low-dose UFH is adequate in some clinical settings but less effective in others. LMWH preparations are effective and safe as prophylaxis in certain medical patients as well as in general sur...

journal_title：Clinics in chest medicine

authors： Tapson VF,Hull RD

更新日期：1995-06-01 00:00:00

abstract：:As recently as the 1992 Report of the American Thoracic Society Workshop on Lung Transplantation, no QOL facts were given and no knowledge gaps related to QOL outcomes were cited. Even at the present time, the information in that area is based on a relatively small set of preliminary reports. Current information indic...

journal_title：Clinics in chest medicine

authors： Gross CR,Raghu G

更新日期：1997-06-01 00:00:00

abstract：:This article reviews the basic principles of drug treatment of tuberculosis, individual pharmacologic agents, current treatment recommendations, and several special situations that clinicians are likely to encounter in medical practice. ...

journal_title：Clinics in chest medicine

authors： Sahbazian B,Weis SE

更新日期：2005-06-01 00:00:00

abstract：:Flexible fiberoptic bronchoscopy is the most useful invasive technique for diagnosing lung cancer. This article details the use and efficacy of bronchoscopy with such established techniques as forceps biopsy, brush biopsy, and bronchial washing in the diagnosis and staging of bronchoscopically visible central lung can...

journal_title：Clinics in chest medicine

authors： Arroliga AC,Matthay RA

更新日期：1993-03-01 00:00:00

abstract：:Anticholinergic agents are useful bronchodilators, the use of which should not be overlooked in patients with airways diseases. In patients with stable asthma, they are not first-line therapy but may be valuable as adjunctive therapy. In status asthmaticus they add to the bronchodilatation achieved by adrenergic thera...

journal_title：Clinics in chest medicine

authors： Gross NJ

更新日期：1988-12-01 00:00:00

abstract：:Smoking is overwhelmingly the major cause of chronic bronchitis and emphysema worldwide. Additional risk factors for developing COPD are presented, along with the variables that govern cigarette smoke deposition in the lung. Major paradigms for the pathogenesis of COPD, including the protease-antiprotease and oxidant-...

journal_title：Clinics in chest medicine

authors： Sethi JM,Rochester CL

更新日期：2000-03-01 00:00:00

abstract：:Pulmonary function testing (PFT) is used extensively by pulmonary specialists to address two common clinical questions: (1) What is the risk of a postoperative pulmonary complication in an individual with lung disease? and (2) Will the patient be able to tolerate lung resection surgery? Today, there are numerous tests...

journal_title：Clinics in chest medicine

authors： Powell CA,Caplan CE

更新日期：2001-12-01 00:00:00

abstract：:Bronchiectasis is a persistent and progressive condition characterized by inflammation and infection causing damage that potentiates impaired mucociliary clearance. The rationale for promoting airway clearance is so that purulent secretions are removed from the airways, ameliorating the inflammation and improving cont...

journal_title：Clinics in chest medicine

authors： Flude LJ,Agent P,Bilton D

更新日期：2012-06-01 00:00:00

abstract：:Sleep-related breathing disorders are strongly associated with increased risk of stroke independent of known risk factors. The direction of causation favors sleep-disordered breathing leading to stroke rather than the other way around, although definitive proof of this awaits the results of prospective cohort studies....

journal_title：Clinics in chest medicine

authors： Yaggi H,Mohsenin V

更新日期：2003-06-01 00:00:00

abstract：:The most common causes for undiagnosed transudative effusions are congestive heart failure and hepatic hydrothorax. Pleural fluid N terminal pro-brain natriuretic peptide levels higher than 1500 pg/mL are virtually diagnostic of congestive heart failure. The most common causes for undiagnosed exudative pleural effusio...

journal_title：Clinics in chest medicine

authors： Light RW

更新日期：2006-06-01 00:00:00

abstract：:Inhaled corticosteroids (ICS) have led to improved asthma control and reduced asthma mortality in the Western world. ICS are effective in combating T-helper type 2-driven inflammation featuring mast cell and eosinophilic airway infiltration. Their effect on innate immunity-driven neutrophilic inflammation is poor and ...

journal_title：Clinics in chest medicine

authors： Louis R,Schleich F,Barnes PJ

更新日期：2012-09-01 00:00:00

abstract：:A number of different imaging modalities can be used in the assessment of pleural disease. Although ultrasound has been the more traditional method, CT has found increasing utility for the assessment of the empyema and loculated pleural fluid collections prior to drainage and the evaluation of benign and malignant ple...

journal_title：Clinics in chest medicine

authors： McLoud TC

更新日期：1998-06-01 00:00:00

abstract：:Nonresolving pneumonia is a common and frequently misunderstood problem faced by the practicing pulmonologist. While radiographic resolution of most infections is relatively long and lags behind clinical signs of recovery, data suggest that a variety of host defense problems are a consequence of systemic illness and a...

journal_title：Clinics in chest medicine

authors： Fein AM,Feinsilver SH,Niederman MS,Fiel S,Pai PB

更新日期：1987-09-01 00:00:00

abstract：:Bullectomy for giant bullae, lung volume reduction surgery, and lung transplantation are three surgical therapies that may benefit highly selected patients with advanced chronic obstructive pulmonary disease. In this article, each procedure is reviewed, with an emphasis on guidelines for patient selection and clinical...

journal_title：Clinics in chest medicine

authors： Lederer DJ,Arcasoy SM

更新日期：2007-09-01 00:00:00

abstract：:The last decade has heralded a paradigm shift in the evaluation and treatment of advanced non-small cell lung cancer (NSCLC). No longer are patients with NSCLC considered a homogeneous population treated in the same way; rather, clinical characteristics, histology, and an expanding array of molecular markers are incre...

journal_title：Clinics in chest medicine

authors： Gettinger S,Lynch T

更新日期：2011-12-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is a potentially severe, frequently disabling autoimmune disease with multiorgan involvement and a typically waxing and waning course. SLE is often considered the prototypical autoimmune disease. Although SLE has the potential to affect any organ, the lungs are commonly involved late...

journal_title：Clinics in chest medicine

authors： Kamen DL,Strange C

更新日期：2010-09-01 00:00:00

abstract：:The authors attempt to demonstrate those circumstances for which perfusion scintigraphy, by itself, or in combination with ventilation scintiscanning, offers the best adjunctive information in excluding or confirming the presence of pulmonary embolism. They then identify those circumstances in which scintiscanning doe...

journal_title：Clinics in chest medicine

authors： Polak JF,McNeil BJ

更新日期：1984-09-01 00:00:00

abstract：:Available targeted therapies for pulmonary arterial hypertension are capable only of slowing progression of the disease and a cure remains elusive. However with the improved understanding of the pulmonary vascular remodeling that characterizes the disease, there is optimism that the disconnect between preclinical and ...

journal_title：Clinics in chest medicine

authors： O'Connell C,O'Callaghan DS,Humbert M

更新日期：2013-12-01 00:00:00

abstract：:This article focuses on thoracoscopy for pleural procedures, both diagnostic and therapeutic, and discusses whether there is a difference between pleuroscopy and thoracoscopy or video-assisted thoracic surgery. How thinking should be structured regarding the management of pleural disease in the modern context of avail...

journal_title：Clinics in chest medicine

authors： Detterbeck FC

更新日期：2013-03-01 00:00:00

abstract：:In summary, bacterial organisms are clinically relevant contributors to asthma exacerbations, and have received much less attention than viruses in this process. Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis have been linked to asthma exacerbations, particularly when sinusitis is present. ...

journal_title：Clinics in chest medicine

authors： Kraft M

更新日期：2000-06-01 00:00:00