Clinical trial design in prevention and treatment of acute respiratory distress syndrome.

abstract：:Two recent major guidelines on diagnosis and treatment of ventilator-associated pneumonia (VAP) recommend consideration of local antibiotic resistance patterns and individual patient risks for resistant pathogens when formulating an initial empiric antibiotic regimen. One recommends against invasive diagnostic techniq...

journal_title：Clinics in chest medicine

authors： Metersky ML,Kalil AC

更新日期：2018-12-01 00:00:00

abstract：:Each year, a vast number of individuals are infected with the endemic fungi. An expanding population, along with further land development in endemic areas, will likely continue to place individuals at risk for exposure to these organisms. A high index of suspicion may be required to diagnose histoplasmosis, blastomyco...

journal_title：Clinics in chest medicine

authors： Goldman M,Johnson PC,Sarosi GA

更新日期：1999-09-01 00:00:00

abstract：:The features characterizing pneumonia due to Mycoplasma pneumoniae are described. Typical cases, along with chest radiographs of laboratory-documented cases, are presented. ...

journal_title：Clinics in chest medicine

authors： Luby JP

更新日期：1991-06-01 00:00:00

abstract：:Lung cancer remains the most common fatal malignancy, so even modest therapeutic advances are potentially beneficial to large numbers of patients. For patients with regional nodal metastases identified at thoracotomy, adjuvant chemotherapy may be of benefit and additional clinical trials are in progress. Locally advan...

journal_title：Clinics in chest medicine

authors： Murren JR,Buzaid AC

更新日期：1993-03-01 00:00:00

abstract：:Pathologic conditions affecting the abdomen are a significant cause of morbidity and mortality in the intensive care unit, but their importance is not widely recognized. This article presents several aspects of abdominal pathology that can occur in intensive care unit patients. This pathology may have a considerable i...

journal_title：Clinics in chest medicine

authors： Liolios A,Oropello JM,Benjamin E

更新日期：1999-06-01 00:00:00

abstract：:Pregnancy induces significant physiologic stresses on the pulmonary and cardiovascular systems that may precipitate respiratory compromise. In addition, certain disease states that are unique to the pregnant woman, such as amniotic fluid emboli syndrome, may be associated with respiratory failure. The physiologic chan...

journal_title：Clinics in chest medicine

authors： Pereira A,Krieger BP

更新日期：2004-06-01 00:00:00

abstract：:Hypersensitivity pneumonitis (HP) represents a group of immunologically mediated lung disorders provoked by recurrent exposure to various environmental agents. HP is multifaceted and may mimic almost any interstitial lung disease, some infectious diseases,and even bronchiolar disorders. In the absence of a diagnostic ...

journal_title：Clinics in chest medicine

authors： Selman M

更新日期：2004-09-01 00:00:00

abstract：:Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and a...

journal_title：Clinics in chest medicine

authors： Lee JC,Christie JD

更新日期：2011-06-01 00:00:00

abstract：:Massive hemoptysis accounts for a minority of all patients with hemoptysis but poses a major challenge for the acute and long-term treatment. Massive hemoptysis can lead to asphyxiation and airway obstruction, shock, and exsanguination. Bronchoscopy plays an integral part in managing massive hemoptysis in diagnosis an...

journal_title：Clinics in chest medicine

authors： Dweik RA,Stoller JK

更新日期：1999-03-01 00:00:00

abstract：:This article review available strategies for mechanically ventilating patients with the adult respiratory distress syndrome. The authors first present the conventional strategies of mechanical ventilation: volume-limited mechanical ventilation with positive end-expiratory pressure (PEEP) at normal inspiratory-expirato...

journal_title：Clinics in chest medicine

authors： Stoller JK,Kacmarek RM

更新日期：1990-12-01 00:00:00

abstract：:After half a century of clinical experience and research, management of pulmonary arterial hypertension remains a challenge. Currently, data to support the use of standard therapies for pulmonary arterial hypertension (oxygen supplementation, diuretics, digoxin, anticoagulation, and calcium channel blockers) are mostl...

journal_title：Clinics in chest medicine

authors： Alam S,Palevsky HI

更新日期：2007-03-01 00:00:00

abstract：:CT is a useful tool for identification of small airways diseases, and it can be used to classify these entities into inflammatory and constrictive bronchiolitis. Inflammatory forms of bronchiolitis include cellular bronchiolitis (usually caused by infection or aspiration), respiratory bronchiolitis, panbronchiolitis, ...

journal_title：Clinics in chest medicine

authors： Lynch DA

更新日期：2008-03-01 00:00:00

abstract：:This review focuses on the top ten causes of ventilator-associated pneumonia (VAP), updating an earlier study. These pathogens have specific risk factors, different patterns of clinical resolution, and a wide range of attributable mortality. The discussion herein analyzes these aspects, placing particular emphasis on ...

journal_title：Clinics in chest medicine

authors： Rello J,Díaz E,Rodríguez A

更新日期：2005-03-01 00:00:00

abstract：:Selected occupational populations are at the highest risk of lung cancer, because they smoke at increased rates and are concurrently exposed to workplace lung carcinogens. Low-dose computed tomography (CT)-based lung cancer screening has an enormous potential to reduce lung cancer mortality in these populations, as sh...

journal_title：Clinics in chest medicine

authors： Markowitz SB,Dickens B

更新日期：2020-12-01 00:00:00

abstract：:Chronic lung diseases, including chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH), are unusually prevalent among persons infected with human immunodeficiency virus (HIV). Often these disease states are identified at younger ages than would be expected in the general population. Recent epide...

journal_title：Clinics in chest medicine

authors： Fitzpatrick M,Crothers K,Morris A

更新日期：2013-06-01 00:00:00

abstract：:The combination of the unique pathologic features of usual interstitial pneumonia (UIP) on biopsy, the progressive clinical course, and resistance to anti-inflammatory therapy constitutes the cardinal manifestations of what is termed idiopathic pulmonary fibrosis (IFP)/usual interstitial pneumonia, and it has led to r...

journal_title：Clinics in chest medicine

authors： Noble PW,Homer RJ

更新日期：2004-12-01 00:00:00

abstract：:Several medications have been associated with the development of the BOOP lesion. Often, symptoms include nonproductive cough and shortness of breath with bilateral crackles by examination. Occasionally, there is fever and rash, and, rarely, eosinophilia. The chest radiograph usually shows bilateral patchy infiltrates...

journal_title：Clinics in chest medicine

authors： Epler GR

更新日期：2004-03-01 00:00:00

abstract：:Pseudomonas aeruginosa remains an important cause of pulmonary disease in patients who have cystic fibrosis. The development of antimicrobial therapy directed against this organism has resulted in the preservation of lung function and improved longevity. Efficacy has been demonstrated with agents administered via pare...

journal_title：Clinics in chest medicine

authors： Lahiri T

更新日期：2007-06-01 00:00:00

abstract：:This article reviews several important noninfectious pulmonary complications that threaten survival, pulmonary function, and quality of life after lung transplantation. Topics reviewed include primary graft dysfunction (PGD), native lung hyperinflation, anastomotic complications, phrenic nerve injury, pleural complica...

journal_title：Clinics in chest medicine

authors： Ahya VN,Kawut SM

更新日期：2005-12-01 00:00:00

abstract：:Pulmonary function testing (PFT) is used extensively by pulmonary specialists to address two common clinical questions: (1) What is the risk of a postoperative pulmonary complication in an individual with lung disease? and (2) Will the patient be able to tolerate lung resection surgery? Today, there are numerous tests...

journal_title：Clinics in chest medicine

authors： Powell CA,Caplan CE

更新日期：2001-12-01 00:00:00

abstract：:This article provides a systematic review of the literature on the application of noninvasive ventilation in various forms of hypercapnic and hypoxemic respiratory failures. A description of the underlying pathophysiology is followed by a review of physiologic data explaining the mechanisms of action of noninvasive ve...

journal_title：Clinics in chest medicine

authors： Meduri GU

更新日期：1996-09-01 00:00:00

abstract：:Sleep-related breathing disorder or sleep-disordered breathing (SDB) encompasses central sleep apnea (CSA), obstructive sleep apnea (OSA), and sleep-related hypoventilation or hypoxemic syndromes. SDB is common in neurologic conditions that affect the central and/or peripheral nervous systems. Patients with neurologic...

journal_title：Clinics in chest medicine

authors： Deak MC,Kirsch DB

更新日期：2014-09-01 00:00:00

abstract：:The term "steroid-resistant (SR) asthma" has been used to describe a group of asthmatics who demonstrate persistent airway obstruction and inflammation despite treatment with high doses of systemic glucocorticoids. There are at least two forms of SR asthma, that is, primary and acquired types. Type I SR asthma is acqu...

journal_title：Clinics in chest medicine

authors： Leung DY,Szefler SJ

更新日期：1997-09-01 00:00:00

abstract：:Nasal CPAP is and should be the first-line treatment for OSA. Any physician who uses nasal CPAP undoubtedly recognizes that this treatment modality has limitations, however. The authors believe that surgery offers a viable alternative to nasal CPAP in patients who are intolerant of nasal CPAP. Potential risks and comp...

journal_title：Clinics in chest medicine

authors： Li KK

更新日期：2003-06-01 00:00:00

abstract：:Pulmonary rehabilitation is an art of medical practice incorporating many therapeutic modalities with the goal of improving the patient's functional ability. The gains to be realized and the basis for improvement following pulmonary rehabilitation are detailed in this article. ...

journal_title：Clinics in chest medicine

authors： Make BJ

更新日期：1986-12-01 00:00:00

abstract：:This heterogeneous group of immunologic causes of pleural effusions includes connective tissue diseases, a syndrome related to tissue injury (postcardiac injury syndrome), a disease of unknown etiology (sarcoidosis), a malignancy, and adverse reactions to drugs. Except in rheumatoid pleurisy and lupus pleuritis, the p...

journal_title：Clinics in chest medicine

authors： Sahn SA

更新日期：1985-03-01 00:00:00

abstract：:Cough is a complex physiologic event that protects the lungs from mechanical, chemical, and thermal injury. It is a normal reflex and therefore helps humans to adapt to an ever-changing environment. Cough can also be a pathologic reflex in that it may be an important and often the only sign of serious disease, may sig...

journal_title：Clinics in chest medicine

authors： Braman SS,Corrao WM

更新日期：1987-06-01 00:00:00

abstract：:The use of nuclear magnetic resonance to produce diagnostic images of the human chest has just become possible. These images are computer-reconstructed maps of the distribution in tissue of protons and of some of their magnetic characteristics. The images are high resolution and anatomically accurate, are capable of d...

journal_title：Clinics in chest medicine

authors： Newhouse JH

更新日期：1984-06-01 00:00:00

abstract：:The types of pulmonary arterial hypertension described here all focus attention on the changes produced in the lung's microcirculation, particularly the precapillary unit. Although one senses intuitively that obliteration of resistance arteries is an effective cause of hypertension, we emphasize that cell metaplasia a...

journal_title：Clinics in chest medicine

authors： Meyrick B,Reid L

更新日期：1983-05-01 00:00:00

abstract：:Early detection and surgical resection are essential for the treatment of lung cancer. It would be ideal to be able to detect and treat preinvasive bronchial lesions, defined as dysplasia and carcinoma in situ before progressing to invasive cancer. Advanced airway-assessment techniques have opened an avenue for early ...

journal_title：Clinics in chest medicine

authors： Nakajima T,Yasufuku K

更新日期：2013-09-01 00:00:00