Geometrical factors in conductance through molecular films.

abstract：:Alcohol suppresses reproduction in humans, monkeys, and small rodents by suppressing release of luteinizing hormone (LH). The major action is on the hypothalamus to decrease release of LH-releasing hormone (LHRH). The release of LHRH is controlled by nitric oxide (NO) as determined by in vivo and in vitro experiments....

journal_title：Annals of the New York Academy of Sciences

authors： Rettori V,McCann SM

更新日期：1998-05-01 00:00:00

abstract：:Two major methodological problems that impact clinical research in endometriosis are the absence of a low-cost, highly reliable method for diagnosing endometriosis and the possibility that endometriosis is actually multiple different diseases that we have not yet been able to differentiate. Animal models of endometrio...

journal_title：Annals of the New York Academy of Sciences

authors： Barbieri RL,Missmer S

更新日期：2002-03-01 00:00:00

abstract：:Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the past decade, somatic...

journal_title：Annals of the New York Academy of Sciences

authors： Kaipparettu BA,Ma Y,Wong LJ

更新日期：2010-07-01 00:00:00

abstract：:The term intrauterine growth restriction (IUGR) is assigned to newborns with a birth weight and/or birth length below the 10th percentile for their gestational age and whose abdominal circumference is below the 2.5th percentile with pathologic restriction of fetal growth. IUGR is usually due to maternal, fetal, or pla...

journal_title：Annals of the New York Academy of Sciences

authors： Valsamakis G,Kanaka-Gantenbein C,Malamitsi-Puchner A,Mastorakos G

更新日期：2006-12-01 00:00:00

abstract：:This review outlines the scientific rationale supporting the potential use of deep-brain electrical stimulation (DBS) in the central thalamus as a method to improve behavioral responsiveness following severe brain injury. Neurons within the central thalamus are selectively vulnerable to disconnection and dysfunction f...

journal_title：Annals of the New York Academy of Sciences

authors： Schiff ND

更新日期：2009-03-01 00:00:00

abstract：:The objectives of ExoMars are to inject an orbiter around Mars and to land a rover on the surface to look for possible traces of life. During the first stages of the feasibility analysis, the mass margin of the orbiter was very small for a direct transfer in the Soyuz/Fregat scenario. An analysis of the combined use o...

journal_title：Annals of the New York Academy of Sciences

authors： Gil-Fernández J,Van Damme CC,Graziano M,Amata GB,Cogo F,Perino MA

更新日期：2005-12-01 00:00:00

abstract：:Natural systems harbor complex interactions that are fundamental parts of ecology and evolution. These interactions challenge our inclinations and training to seek the simplest explanations of patterns in nature. Not least is the likelihood that some complex processes might be missed when their patterns look similar t...

journal_title：Annals of the New York Academy of Sciences

authors： Kinnison MT,Hairston NG Jr,Hendry AP

更新日期：2015-12-01 00:00:00

abstract：:The objective of this double-blind, placebo-controlled, dose-escalation study is to evaluate safety, tolerability, and enhancement on healing of thymosin beta-4 (Tbeta-4) administered topically in patients with venous ulcers. Three groups of patients, coming from 10 sites, 5 from Italy and 5 from Poland, will be enrol...

journal_title：Annals of the New York Academy of Sciences

authors： Guarnera G,DE Rosa A,Camerini R

更新日期：2007-09-01 00:00:00

abstract：:The emphasis on the effects of early olfactory restriction has been on the deleterious nature of the consequences of this abnormal early experience. While these effects are certainly present and dramatic, it is also the case that the olfactory system is left fairly intact by this experimental manipulation. If one asks...

journal_title：Annals of the New York Academy of Sciences

authors： Leon M

更新日期：1998-11-30 00:00:00

abstract：:The emission factors for indoor straw combustion are a major data gap for estimating the polycyclic aromatic hydrocarbon (PAH) emissions in China. The emission factors for open-fire straw burning were borrowed from our previous study and a rough estimate was developed. As one of the most important emission sources in ...

journal_title：Annals of the New York Academy of Sciences

authors： Zhang Y,Dou H,Chang B,Wei Z,Qiu W,Liu S,Liu W,Tao S

更新日期：2008-10-01 00:00:00

abstract：:It is now generally accepted that it is not possible to design iron(III)-selective hexadentate chelators with high oral bioavailability. In order to achieve suitable levels of oral activity for the treatment of systemic iron overload either tridentate or bidentate molecules need to be investigated. There are a number ...

journal_title：Annals of the New York Academy of Sciences

authors： Hider RC,Zhou T

更新日期：2005-01-01 00:00:00

abstract：:Mitochondrial dysfunction is implicated in many forms of cell death, particularly in the central nervous system. The mitochondria are required at the same time to generate adenosine 5'-triphosphate (ATP) for the cell, sequester excess cytoplasmic Ca(2+), and both produce and detoxify superoxide free radicals. The elec...

journal_title：Annals of the New York Academy of Sciences

authors： Nicholls DG

更新日期：2008-12-01 00:00:00

abstract：:How can people adaptively analyze and "work through" negative feelings without ruminating? This paper will briefly review findings from an integrative program of research, which suggests that a critical factor determining whether people's attempts to adaptively reason about negative experiences succeed or fail is the ...

journal_title：Annals of the New York Academy of Sciences

authors： Kross E

更新日期：2009-06-01 00:00:00

abstract：:Here we describe the AddNeuroMed multicenter magnetic resonance imaging (MRI) study for longitudinal assessment in Alzheimer's disease (AD). The study is similar to a faux clinical trial and has been established to assess longitudinal MRI changes in AD, mild cognitive impairment (MCI), and healthy control subjects usi...

journal_title：Annals of the New York Academy of Sciences

authors： Simmons A,Westman E,Muehlboeck S,Mecocci P,Vellas B,Tsolaki M,Kłoszewska I,Wahlund LO,Soininen H,Lovestone S,Evans A,Spenger C,AddNeuroMed Consortium.

更新日期：2009-10-01 00:00:00

abstract：:Dietary and human factors have been found to be the major factors influencing the bioavailability of micronutrients, such as provitamin A carotenoid (pVAC), iron, and zinc, in biofortified crops. Dietary factors are related to food matrix structure and composition. Processing can improve pVAC bioavailability by disrup...

journal_title：Annals of the New York Academy of Sciences

authors： Bechoff A,Dhuique-Mayer C

更新日期：2017-02-01 00:00:00

abstract：:Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically "seal" the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial...

journal_title：Annals of the New York Academy of Sciences

authors： Schulzke JD,Fromm M

更新日期：2009-05-01 00:00:00

abstract：:There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes...

journal_title：Annals of the New York Academy of Sciences

authors： Do Rego JL,Seong JY,Burel D,Luu-The V,Larhammar D,Tsutsui K,Pelletier G,Tonon MC,Vaudry H

更新日期：2009-04-01 00:00:00

abstract：:New data on the organization of the intra-amygdaloid circuit is reviewed, beginning with the basolateral (BL) complex, the main input station of the amygdala for sensory afferents, and concluding with the central (CE) nucleus, an important source of projections to brain-stem structures mediating fear responses. The BL...

journal_title：Annals of the New York Academy of Sciences

authors： Paré D,Royer S,Smith Y,Lang EJ

更新日期：2003-04-01 00:00:00

abstract：:The Women's Health Initiative (WHI) hormone trials have been widely interpreted as demonstrating that combined menopausal hormone therapy (HT) fails to protect against-and may increase-cardiovascular disease (CVD), stroke, and dementia in menopausal women, regardless of whether initiated early in the menopause or late...

journal_title：Annals of the New York Academy of Sciences

authors： Harman SM,Naftolin F,Brinton EA,Judelson DR

更新日期：2005-06-01 00:00:00

abstract：:The potential impact of atrazine (ATZ) on gonadal malformations in larval Xenopus laevis has been controversially discussed, and a hypothesis has been generated that ATZ might induce the estrogen-synthesizing enzyme aromatase, leading to feminization or demasculinization. Recently, extensive long-term studies clearly ...

journal_title：Annals of the New York Academy of Sciences

authors： Kloas W,Lutz I,Urbatzka R,Springer T,Krueger H,Wolf J,Holden L,Hosmer A

更新日期：2009-04-01 00:00:00

abstract：:The xynA gene encoding a major xylanase of Clostridium stercorarium F-9 was sequenced. The structural gene consists of an open reading frame of 1533 bp encoding a protein of 511 amino acids with an M(r) of 56,519. XynA consists of a catalytic domain belonging to family G at the NH2-terminus and two direct repeats of a...

journal_title：Annals of the New York Academy of Sciences

authors： Sakka K,Takada G,Karita S,Ohmiya K

更新日期：1996-05-15 00:00:00

abstract：:The gain of function phenotypes exhibited by the heterozygous Tr, Tr-J, and CMT1A mutations indicate that these mutations interfere with more than the function of a single PMP22 allele. The identification of proteins that interact with PMP22 and that are sensitive both to stoichiometry and the effects of the mutations...

journal_title：Annals of the New York Academy of Sciences

authors： Snipes GJ,Orfali W,Fraser A,Dickson K,Colby J

更新日期：1999-09-14 00:00:00

abstract：:Most anticancer treatments such as chemo- and radiotherapy induce DNA damage and apoptosis in normal cells. The aim of this study was to assess the induction of single and double DNA strand breaks (ssb and dsb, respectively) and apoptosis in normal human lymphocytes and rat thymocytes subjected to the action of H2O2, ...

journal_title：Annals of the New York Academy of Sciences

authors： Benítez-Bribiesca L,Sánchez-Suárez P

更新日期：1999-01-01 00:00:00

abstract：:During relapses in relapsing-remitting multiple sclerosis (RRMS), serum soluble HLA class I surface antigen (sHLA-I) levels are reported to either decrease or remain unchanged, whereas serum sHLA-II levels increase. Interferon-beta1b therapy was recently reported to increase serum sHLA-I in RRMS. In the present prospe...

journal_title：Annals of the New York Academy of Sciences

authors： Minagar A,Adamashvilli I,Jaffe SL,Glabus MF,Gonzalez-Toledo E,Kelley RE

更新日期：2005-06-01 00:00:00

abstract：:The complex dielectric properties of canine skeletal muscles were measured at 25 degrees C during ischemia in the frequency range from 50 Hz to 200 MHz. The dielectric spectrum of skeletal muscle shows an alpha-dispersion below 1 kHz and a beta-dispersion with a relaxation frequency of about 100 kHz. The alpha-dispers...

journal_title：Annals of the New York Academy of Sciences

authors： Schäfer M,Kirlum HJ,Schlegel C,Gebhard MM

更新日期：1999-04-20 00:00:00

abstract：:Early in oral tolerance induction, IL-10-producing CD4(+) T cells were increased, and adoptive transfer of IL-10-deficient CD4(+) T cells failed induction of oral tolerance, suggesting a key role of IL-10 production in such a process. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cong Y,Liu C,Weaver CT,Elson CO

更新日期：2004-12-01 00:00:00

abstract：:Cognitive enhancement, the amplification or extension of core capacities of the mind, has become a major topic in bioethics. But cognitive enhancement is a prime example of a converging technology where individual disciplines merge and issues transcend particular local discourses. This article reviews currently availa...

journal_title：Annals of the New York Academy of Sciences

authors： Sandberg A,Bostrom N

更新日期：2006-12-01 00:00:00

abstract：:Members of the steroid receptor superfamily, like other transcription factors, can function as transcriptional inducers as well as repressors of transcription. The mechanisms by which repression is achieved seem to be specific for the factors and [table: see text] regulatory sequences involved. Many and perhaps all of...

journal_title：Annals of the New York Academy of Sciences

authors： Renkawitz R

更新日期：1993-06-11 00:00:00

abstract：:Cognitive neuroscience research has traditionally overlooked half of the population. Arguing that variability in ovarian hormones confounds empirical findings, girls and women have been excluded from research for decades. But times are changing. This review summarizes historical trends that have led to a knowledge gap...

journal_title：Annals of the New York Academy of Sciences

authors： Beltz AM,Moser JS

更新日期：2020-03-01 00:00:00

abstract：:Enhanced levels of plasminogen activator inhibitor-1 (PAI-1) are considered to be a risk factor for pathological conditions associated with hypoxia or hyperinsulinemia. The expression of the PAI-1 gene is increased by insulin in different cells, although, the molecular mechanisms behind insulin-induced PAI-1 expressio...

journal_title：Annals of the New York Academy of Sciences

authors： Dimova EY,Kietzmann T

更新日期：2006-12-01 00:00:00