Steroid biosynthesis within the frog brain: a model of neuroendocrine regulation.

abstract：:During relapses in relapsing-remitting multiple sclerosis (RRMS), serum soluble HLA class I surface antigen (sHLA-I) levels are reported to either decrease or remain unchanged, whereas serum sHLA-II levels increase. Interferon-beta1b therapy was recently reported to increase serum sHLA-I in RRMS. In the present prospe...

journal_title：Annals of the New York Academy of Sciences

authors： Minagar A,Adamashvilli I,Jaffe SL,Glabus MF,Gonzalez-Toledo E,Kelley RE

更新日期：2005-06-01 00:00:00

abstract：:This paper discusses experimental research aimed at defining a base drag reduction device based on splitter plates. The unsteady three-dimensional nature of the flow is studied by Schlieren photography, particle image velocimetry, and measurement of the total unsteady lift and drag loads. ...

journal_title：Annals of the New York Academy of Sciences

authors： Neau L,Pruvost J,Rodriguez O,Loc TP

更新日期：2002-10-01 00:00:00

abstract：:Esophageal symptoms are common, and can arise from mucosal, motor, functional, and neoplastic processes, among others. Judicious use of diagnostic testing can help define the etiology of symptoms and can direct management. Endoscopy, esophageal high-resolution manometry (HRM), ambulatory pH or pH-impedance manometry, ...

journal_title：Annals of the New York Academy of Sciences

authors： Gyawali CP,de Bortoli N,Clarke J,Marinelli C,Tolone S,Roman S,Savarino E

更新日期：2018-12-01 00:00:00

abstract：:This paper is intended to serve as a traditional Tibetan medical response to advancements in basic longevity research, with particular attention to current models of caloric restriction. This is a complicated task, as Tibetan medicine traditionally approaches dietary modification from a radically different perspective...

journal_title：Annals of the New York Academy of Sciences

authors： Dakpa T,Dodson-Lavelle B

更新日期：2009-08-01 00:00:00

abstract：:Clinical research has demonstrated that increased or decreased estradiol 2-hydroxylation can easily be achieved with a number of experimental approaches. In contrast, estradiol 16 alpha-hydroxylation, which may have potentially deleterious effects in estrogen-dependent tissues, cannot be readily altered. Predictable h...

journal_title：Annals of the New York Academy of Sciences

authors： Michnovicz JJ,Bradlow HL

更新日期：1990-01-01 00:00:00

abstract：:The objective of this double-blind, placebo-controlled, dose-escalation study is to evaluate safety, tolerability, and enhancement on healing of thymosin beta-4 (Tbeta-4) administered topically in patients with venous ulcers. Three groups of patients, coming from 10 sites, 5 from Italy and 5 from Poland, will be enrol...

journal_title：Annals of the New York Academy of Sciences

authors： Guarnera G,DE Rosa A,Camerini R

更新日期：2007-09-01 00:00:00

abstract：:A complete amino acid sequence for rat testis P-450 17 alpha was deduced from nucleotide analysis of a cDNA clone isolated from a rat Leydig cell library. This cDNA expressed in COS-1 cells both 17 alpha-hydroxylase and 17,20 lyase activities. Rat P-450 17 alpha exhibited significant similarity to the nucleotide and d...

journal_title：Annals of the New York Academy of Sciences

authors： Dufau ML,Minegishi T,Buczko E,Kitamura M,Delgado C,Namiki M

更新日期：1989-01-01 00:00:00

abstract：:Current tuberculosis (TB) therapies take too long and the regimens are complex and subject to adverse effects and drug-drug interactions with concomitant medications. The emergence of drug-resistant TB strains exacerbates the situation. Drug discovery for TB has resurged in recent years, generating compounds (hits) wi...

journal_title：Annals of the New York Academy of Sciences

authors： Mdluli K,Kaneko T,Upton A

更新日期：2014-09-01 00:00:00

abstract：:The disturbances in the balance of pro- and antifibrinolytic activity, as observed in AAA and obesity, respectively, have considerable potential for influencing both intra- and extravascular fibrinolytic events and may be causally related to the development of vascular disease. For example, the wall of the aortic athe...

journal_title：Annals of the New York Academy of Sciences

authors： Samad F,Schneiderman J,Loskutoff D

更新日期：1997-04-15 00:00:00

abstract：:Studies on host responses in sheep artificially infected with Theileria sp. (China) were discussed and summarized mainly on typical high fever periods, merozoits and schizoon observation, antibody response. ...

journal_title：Annals of the New York Academy of Sciences

authors： Wu JS,Yu JM,Wang ZL,Song CP,Yuan JF,Yao BA

更新日期：2006-10-01 00:00:00

abstract：:Clinically potent skeletal muscle relaxants are used primarily for their effects on the central nervous system. But they also have direct effects on muscle contraction that possibly involve Ca2+ channels. We compared the effects of dantrolene, an agent known to have a direct action on vertebrate skeletal muscle, with ...

journal_title：Annals of the New York Academy of Sciences

authors： Helland LA,Lopez JR,Taylor SR,Trube G,Wanek LA

更新日期：1988-01-01 00:00:00

abstract：:The discovery of RNA interference (RNAi) in C. elegans and in plants has revolutionized current approaches to biology and medicine. RNAi silences genes in a sequence-specific manner through the actions of small pieces of double-stranded RNAs (siRNAs and miRNAs). RNAi has been found as a widespread natural phenomenon i...

journal_title：Annals of the New York Academy of Sciences

authors： Zheng ZM,Tang S,Tao M

更新日期：2005-11-01 00:00:00

abstract：:In this article, we have presented an overview of fundamental issues involved in mediphotonic imaging, and reviewed some of the emerging techniques for early-light transillumination imaging of body organs. The results on human breast tissues presented here, together with the data accumulated and advances made by resea...

journal_title：Annals of the New York Academy of Sciences

authors： Alfano RR,Demos SG,Gayen SK

更新日期：1997-05-30 00:00:00

abstract：:Visual motion is sensed by low-level (energy-based) and high-level (feature-based) mechanisms. Our interest is in the motion detectors underlying the initial ocular following responses (OFR) that are elicited at ultrashort latencies by sudden motions of large images. OFR were elicited in humans by applying horizontal ...

journal_title：Annals of the New York Academy of Sciences

authors： Chen KJ,Sheliga BM,Fitzgibbon EJ,Miles FA

更新日期：2005-04-01 00:00:00

abstract：:The receptive field of a direction-selective unit of any type consists of an excitatory center 3 degrees -5 degrees in size, a near inhibitory surround and a far surround upon which illumination exerts an influence for both spontaneous activity and specific cell response. ...

journal_title：Annals of the New York Academy of Sciences

authors： Golovkin M,Gorbunov V,Maximova E,Maximov V

更新日期：2005-06-01 00:00:00

abstract：:Disorders of sexual differentiation (DSDs) presenting during adolescence are discussed, and molecular explanations are given for some. DSD conditions are often discovered during early adolescence, an age well known to predispose to high risk for adjustment problems. Presentation may be with lack of or minimal pubertal...

journal_title：Annals of the New York Academy of Sciences

authors： Lee PA,Houk CP

更新日期：2008-01-01 00:00:00

abstract：:About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, and several types of...

journal_title：Annals of the New York Academy of Sciences

authors： Pistollato F,Masias M,Agudo P,Giampieri F,Battino M

更新日期：2019-05-01 00:00:00

abstract：:Vitamin E and essential fatty acid status were examined in two groups of patients, one receiving fat-free total parenteral nutrition (TPN) with intravenous all-rac-alpha-tocopherol for vitamin E deficiency and the other receiving routine intravenous fat (Intralipid, 10%) emulsions with TPN to supply both fatty acid an...

journal_title：Annals of the New York Academy of Sciences

authors： Thurlow PM,Grant JP

更新日期：1982-01-01 00:00:00

abstract：:Adhesive interactions are recognized requirements for cellular proliferation, migration and differentiation during normal morphogenesis as well as disease. By differential cloning, osteopontin was identified as an adhesive protein upregulated during vascular remodeling and neointima formation in both rat models and hu...

journal_title：Annals of the New York Academy of Sciences

authors： Giachelli CM,Liaw L,Murry CE,Schwartz SM,Almeida M

更新日期：1995-04-21 00:00:00

abstract：:We and others recently showed that fever induced by intravenously or intraperitoneally injected lipopolysaccharide (LPS) may involve brain signaling via hepatic vagal afferents. This suggests that LPS fever may be initiated by mediators released mainly by cells in the liver, presumably macrophages (Kupffer cells, Kc)....

journal_title：Annals of the New York Academy of Sciences

authors： Blatteis CM,Sehic E,Li S

更新日期：1998-09-29 00:00:00

abstract：:I(2) site-selective compounds are known to interact with and inhibit monoamine oxidase (MAO), but it remains unclear as to whether this interaction occurs through an allosteric or competitive interaction. This study used the new selective, irreversible I(2) ligand BU99006, to clarify the relationship between MAO and t...

journal_title：Annals of the New York Academy of Sciences

authors： Paterson LM,Tyacke RJ,Nutt DJ,Hudson AL

更新日期：2003-12-01 00:00:00

abstract：:We have developed an assay to detect mucosally delivered antibody to Cryptosporidium parvum sporozoite antigens. We absorbed a recombinant 23-kD sporozoite protein to polystyrene microspheres, and used flow cytometry to detect, titer, and determine the isotype of antibody to p23 that was shed in the feces of experimen...

journal_title：Annals of the New York Academy of Sciences

authors： Wyatt CR,Perryman LE

更新日期：2000-01-01 00:00:00

abstract：:The development of animal and mathematical models for several forms of acquired nystagmus has led to more comprehensive knowledge of these disorders. In the best understood forms, such as periodic alternating nystagmus, our range of knowledge includes an animal model, the neurotransmitters involved, and effective trea...

journal_title：Annals of the New York Academy of Sciences

authors： Leigh RJ,Das VE,Seidman SH

更新日期：2002-04-01 00:00:00

abstract：:Cardiac development is characterized by a complex interplay of chemical, mechanical, and electrical forces, which together contribute to the proper formation of the heart muscle. In adult myocardium, cardiomyocytes are elongated, well-coupled by gap junctions, and organized in spatially well-defined muscle fibers. Thi...

journal_title：Annals of the New York Academy of Sciences

authors： Pijnappels DA,Gregoire S,Wu SM

更新日期：2010-02-01 00:00:00

abstract：:A variety of chemical compounds are currently being discussed as novel drug delivery strategies. One promising strategy is to selectively open the paracellular pathway of epithelia for the passage of macromolecules. A prerequisite for this effect is a rapid and reversible action of these compounds, to allow a marked t...

journal_title：Annals of the New York Academy of Sciences

authors： Rosenthal R,Heydt MS,Amasheh M,Stein C,Fromm M,Amasheh S

更新日期：2012-07-01 00:00:00

abstract：:We have previously shown that bone marrow will seed and proliferate in normal recipients. Transfusion of 50 million cells on each of 4 or 5 consecutive days, a total of 200-250 million cells, resulted in the recipient's marrow being 20-40% of donor origin. The present paper reported on the marked enhancement of prolif...

journal_title：Annals of the New York Academy of Sciences

authors： Brecher G,Mulcahy K,Tjio JH,Raveché E

更新日期：1985-01-01 00:00:00

abstract：:Macrolide and polyether biosynthesis in actinomycetes is regulated at the level of precursor supply by effects of nutrients on the sources of the low-molecular-weight fatty acids used to build the carbon framework of these antibiotics. Ammonium ion appears to suppress the first enzymes of valine and threonine cataboli...

journal_title：Annals of the New York Academy of Sciences

authors： Tang L,Zhang YX,Hutchinson CR

更新日期：1994-05-02 00:00:00

abstract：:The rostral nucleus of the solitary tract (rNST) plays a key role in modulating, organizing and distributing the sensory information arriving at the central nervous system from gustatory receptors. However, except for some anatomical studies of rNST synapses, the neural circuits responsible for this first stage in syn...

journal_title：Annals of the New York Academy of Sciences

authors： Bradley RM,Grabauskas G

更新日期：1998-11-30 00:00:00

abstract：:On the basis of evidence just reviewed, the hormonal requirements during IVM of mammalian oocytes for fertilization and developmental competence may be summarized as follows: 1. Nuclear maturation occurs "spontaneously," without follicular factors or hormones, in all mammalian species. 2. Cumulus cells are necessary d...

journal_title：Annals of the New York Academy of Sciences

authors： Armstrong DT,Zhang X,Vanderhyden BC,Khamsi F

更新日期：1991-01-01 00:00:00

abstract：:The mechanism by which neurons and neurosecretory cells govern the expression and the exocytic discharge of their clear and dense-core vesicles had remained unclear until recently when studies in the neurosecretory cell model PC12 revealed these processes to be orchestrated by the transcriptional repressor neuron rest...

journal_title：Annals of the New York Academy of Sciences

authors： D'Alessandro R,Klajn A,Meldolesi J

更新日期：2009-01-01 00:00:00