Dietary and pharmacological control of estradiol metabolism in humans.

Abstract:

:Clinical research has demonstrated that increased or decreased estradiol 2-hydroxylation can easily be achieved with a number of experimental approaches. In contrast, estradiol 16 alpha-hydroxylation, which may have potentially deleterious effects in estrogen-dependent tissues, cannot be readily altered. Predictable hormonal consequences have thus far been found in response to the modification of 2-hydroxylation. This approach offers promise as a method for specifically altering the risk for diseases associated with either too little estrogen (osteoporosis) or too much estrogen (breast and uterine cancer).

journal_name

Ann N Y Acad Sci

authors

Michnovicz JJ,Bradlow HL

doi

10.1111/j.1749-6632.1990.tb34303.x

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

291-9

eissn

0077-8923

issn

1749-6632

journal_volume

595

pub_type

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