Osteopontin expression in cardiovascular diseases.

abstract：:The lysosomal system has often been considered a prominent morphologic marker of distressed or dying neurons. Lysosomes or their constituent hydrolases have been viewed in different neuropathologic states as either initiators and direct agents of cell death, agents of cellular repair and recompensation, effectors of e...

journal_title：Annals of the New York Academy of Sciences

authors： Nixon RA,Cataldo AM

更新日期：1993-05-28 00:00:00

abstract：:Classic studies of the cerebellum before the middle of the twentieth century established the structural entity of the cerebellum and characterized its function as enabling animals and humans to carry out smooth and accurate movements, even at a high speed and without visual feedback. In the 1960s, neuronal circuit str...

journal_title：Annals of the New York Academy of Sciences

authors： Ito M

更新日期：2002-12-01 00:00:00

abstract：:Genes play a major role in behavioral adaptation to challenging environmental stimuli, but the complexity of their contribution remains unclear. There is growing evidence linking disease phenotypes with genes on the one hand, and the genesis of stress-related disorders like major depression, as a result of exposure to...

journal_title：Annals of the New York Academy of Sciences

authors： Jabbi M,Korf J,Ormel J,Kema IP,den Boer JA

更新日期：2008-12-01 00:00:00

abstract：:Exposure of quail eggs 4 hr per day during the first 5 incubation days at 2450 MHz and in an exposure field of 30 mW/cm-2 and at an absorbed power of 14 mW/g does not cause any great change in body weight, observed gross malformations, rbc, wbc, hematocrit, hemoglobin, or differential wbc percentages. If small differe...

journal_title：Annals of the New York Academy of Sciences

authors： McRee DI,Hamrick PE,Zinkl J,Thaxton P,Parkhurst CR

更新日期：1975-02-28 00:00:00

abstract：:In this chapter, we have presented evidence for several potential levels of interaction of NT/N gene products with dopaminergic systems of the brain. We have focused on one manifestation of this interaction related to the effects of antipsychotic drugs on expression of the NT/N gene in two anatomically discrete popula...

journal_title：Annals of the New York Academy of Sciences

authors： Merchant KM,Dobie DJ,Dorsa DM

更新日期：1992-01-01 00:00:00

abstract：:Judicious selection of new animal models for the study of basic aging processes must combine feasibility and good use of the comparative method with evidence of antiaging adaptations, like the ability to combat oxidative damage to cells and tissues. A number of vertebrate species already in use or being developed as n...

journal_title：Annals of the New York Academy of Sciences

authors： Holmes DJ

更新日期：2004-06-01 00:00:00

abstract：:Estrogen synthesized in situ plays a more important role in breast cancer cell proliferation than does circulating estrogen. Aromatase is the enzyme that converts androgen to estrogen and is expressed at a higher level in breast cancer tissue than in surrounding noncancer tissue. A promising route of chemoprevention a...

journal_title：Annals of the New York Academy of Sciences

authors： Eng ET,Williams D,Mandava U,Kirma N,Tekmal RR,Chen S

更新日期：2002-06-01 00:00:00

abstract：:Obesity and Type 2 diabetes are now major public health issues in developed nations and have reached epidemic proportions in many developing nations, as well as disadvantaged groups in developed countries, e.g., Mexican-Americans, African-Americans, and Australian Aborigines. These groups all show hyperinsulinemia and...

journal_title：Annals of the New York Academy of Sciences

authors： Zimmet P,Boyko EJ,Collier GR,de Courten M

更新日期：1999-11-18 00:00:00

abstract：:Thymosin alpha 1, originally isolated as the compound responsible for reconstitution of immune function in thymectomized animal models, has enjoyed a wide-ranging clinical development program over the past decades, extending across multiple companies, indications, countries, and continents. This paper provides an over...

journal_title：Annals of the New York Academy of Sciences

authors： Tuthill C,Rios I,McBeath R

更新日期：2010-04-01 00:00:00

abstract：:Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...

journal_title：Annals of the New York Academy of Sciences

authors： Conticello SG

更新日期：2012-09-01 00:00:00

abstract：:This paper represents a unique effort to elucidate the dynamics of two major types of politically motivated hostage takers. The data presented are derived from an ongoing research project that is gathering extensive interview and psychological test materials from prisoners convicted of politically motivated crimes, bo...

journal_title：Annals of the New York Academy of Sciences

authors： Knutson JN

更新日期：1980-01-01 00:00:00

abstract：:Analyses of the RNA metabolism of hyperthermophilic archaea highlight the efficiency of regulatory RNAs and RNA-guided processes at extreme temperatures. These organisms must overcome the intrinsic thermolability of RNAs. Elevated levels of RNA modifications and structured GC-rich regions are observed for many univers...

journal_title：Annals of the New York Academy of Sciences

authors： Gomes-Filho JV,Randau L

更新日期：2019-07-01 00:00:00

abstract：:Jopock (Jpk), a transacting factor associated with the position-specific regulatory element of murine Hoxa-7, has shown to induce cell death in both prokaryotic and eukaryotic cells when introduced and overexpressed. Since Jpk protein harbors a transmembrane domain (TM) and a putative endoplasmic reticulum (ER) -reten...

journal_title：Annals of the New York Academy of Sciences

authors： Kim HS,Kong KA,Chung H,Park S,Kim MH

更新日期：2007-01-01 00:00:00

abstract：:Granulocytic anaplasmosis is a tick-borne, zoonotic disease caused by an obligate intracellular granulocytotropic bacterium, Anaplasma phagocytophilum. A. phagocytophilum and other Anaplasma and Ehrlichia spp. have been variably implicated with an associated hematologic alteration, platelet dysfunction, that can resul...

journal_title：Annals of the New York Academy of Sciences

authors： Borjesson DL,Brazzell JL,Feferman R

更新日期：2005-12-01 00:00:00

abstract：:There is a growing interest in the effectiveness of mindfulness meditation for sleep disturbed populations. Our study sought to evaluate the effect of mindfulness meditation interventions on sleep quality. To assess for relative efficacy, comparator groups were restricted to specific active controls (such as evidenced...

journal_title：Annals of the New York Academy of Sciences

authors： Rusch HL,Rosario M,Levison LM,Olivera A,Livingston WS,Wu T,Gill JM

更新日期：2019-06-01 00:00:00

abstract：:This has been an overview of fish health, a comparison of some aspects of fish husbandry with other animal husbandry, and comments concerning fish health research--especially where it is going. The 1972 disease survey identified current problems; it ranked the problems according to priority. More important, research e...

journal_title：Annals of the New York Academy of Sciences

authors： Wolf K

更新日期：1975-01-24 00:00:00

abstract：:Transcriptome analysis is a powerful tool to characterize changes in leukocyte gene expression patterns and reveal very early molecular abnormalities in tissue. Herein, we report on characterization of the very earliest abnormalities in the transcriptome of leukocytes from young "prepathologic" NOD and NON female mice...

journal_title：Annals of the New York Academy of Sciences

authors： Gerling IC,Ali C,Lenchik N

更新日期：2003-11-01 00:00:00

abstract：:We investigated Ca2+ clearance mechanisms (CCMs) at the axon terminals of mammalian central neurons: neurohypophysial (NHP) axon terminals and calyces of Held. Ca2+ transients were evoked by applying a short depolarization pulse via a patch pipette containing Ca2+ indicator dye. Quantitative analysis of the Ca2+ decay...

journal_title：Annals of the New York Academy of Sciences

authors： Lee SH,Kim MH,Lee JY,Lee SH,Lee D,Park KH,Ho WK

更新日期：2007-03-01 00:00:00

abstract：:The adaptation of the vestibulo-ocular reflex (VOR) was studied in 26 normal subjects and 26 patients with cerebellar lesions, using horizontal vision-reversal prisms. In normal subjects, the adaptation of gain after wearing prisms for one hour was approximately 50% of the VOR value in the dark. In contrast to this, p...

journal_title：Annals of the New York Academy of Sciences

authors： Yagi T,Shimizu M,Sekine S,Kamio T,Suzuki JI

更新日期：1981-01-01 00:00:00

abstract：:This paper reviews a series of my heat transfer studies of on the so-called "self-rewetting" fluids, in which the Marangoni effect due to concentration gradient and the thermocapillary flow cooperatively result in a strong liquid inflow at the nucleation sites in the course of boiling. First of all, the background of ...

journal_title：Annals of the New York Academy of Sciences

authors： Abe Y

更新日期：2006-09-01 00:00:00

abstract：:Though only a decade has elapsed since the default network (DN) was first defined as a large-scale brain system, recent years have brought great insight into the network's adaptive functions. A growing theme highlights the DN as playing a key role in internally directed or self-generated thought. Here, we synthesize r...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews-Hanna JR,Smallwood J,Spreng RN

更新日期：2014-05-01 00:00:00

abstract：:In many scientific and technical applications, a three-dimensional (3D) object must be reconstructed, either to assist in understanding the object's structure or to ease its automatic handling and analysis. Volume reconstruction has been used in health care to diagnose, simulate, facilitate surgical planning, develop ...

journal_title：Annals of the New York Academy of Sciences

authors： Masero V,León-Rojas JM,Moreno J

更新日期：2002-12-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a serious, chronic condition that, without early recognition and treatment, leads to progressive right heart failure and death. The dual endothelin receptor antagonist macitentan was designed through a deliberate discovery process to maximize endothelin-axis blockade while impr...

journal_title：Annals of the New York Academy of Sciences

authors： Selej M,Romero AJ,Channick RN,Clozel M

更新日期：2015-11-01 00:00:00

abstract：:The fourth component of complement (C4) occurs in human plasma as a protein with a three polypeptide chain structure. Lately a single-chain form of C4 has been purified from human plasma by sequential steps of immunoadsorbent chromatography, gel filtration in 6 M guanidine hydrochloride, and gel filtration in 6 M guan...

journal_title：Annals of the New York Academy of Sciences

authors： Gorski JP,Muller-Eberhard HJ

更新日期：1980-01-01 00:00:00

abstract：:Long-term exposure to cadmium (Cd) induces perturbation of kidney proximal tubular epithelial cells. Mitochondrial dysfunction in renal cortical cells may contribute to the pathogenesis of Cd-induced nephropathy. In this study, we examined the accumulation of mitochondrial DNA (mtDNA) with a large deletion and cellula...

journal_title：Annals of the New York Academy of Sciences

authors： Takaki A,Jimi S,Segawa M,Iwasaki H

更新日期：2004-04-01 00:00:00

abstract：:Antagonists of the NMDA glutamate receptor, including phencyclidine (PCP), ketamine, and CGS-19755, produce cognitive and behavioral changes in humans. In rodents these agents produce a myriad of histopathological and neurochemical changes. Several lines of evidence suggest that a large number of these drug-induced ef...

journal_title：Annals of the New York Academy of Sciences

authors： Farber NB

更新日期：2003-11-01 00:00:00

abstract：:Nerve agents (NAs) produce acute and long-term brain injury and dysfunction, as evident from the Japan and Syria incidents. Magnetic resonance imaging (MRI) is a versatile technique to examine such chronic anatomical, functional, and neuronal damage in the brain. The objective of this study was to investigate long-ter...

journal_title：Annals of the New York Academy of Sciences

authors： Reddy SD,Wu X,Kuruba R,Sridhar V,Reddy DS

更新日期：2020-11-01 00:00:00

abstract：:At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF-7) and leukemia (SKW-3, AR-230) cell lines as well as hypophosphorylation (K-562, CMLT-1, DOHH-2) and fragmentation of Rb (BV-173, SKW-3) in leukemia cell lines. ErPC3 exerts at lea...

journal_title：Annals of the New York Academy of Sciences

authors： Berger MR,Tsoneva I,Konstantinov SM,Eibl H

更新日期：2003-12-01 00:00:00

abstract：:The present study examined the effects of psychological stress on performance quality, autonomic responses, and upper extremity muscle activity in skilled pianists through comparisons between stressful (competition) and nonstressful (rehearsal) conditions. We observed increased levels of subjective anxiety, autonomic ...

journal_title：Annals of the New York Academy of Sciences

authors： Yoshie M,Kudo K,Ohtsuki T

更新日期：2009-07-01 00:00:00

abstract：:The obesity epidemic is a leading cause of health problems in the United States, increasing the risk of cardiovascular, endocrine, and psychiatric diseases. Although many people lose weight through changes in diet and lifestyle, keeping the weight off remains a challenge. Here, we discuss a hypothesis that seeks to ex...

journal_title：Annals of the New York Academy of Sciences

authors： Matikainen-Ankney BA,Kravitz AV

更新日期：2018-09-01 00:00:00