Historical review of the significance of the cerebellum and the role of Purkinje cells in motor learning.

abstract：:Acetaldehyde covalently binds to purified tubulin in vitro to form both stable and unstable adducts. The formation of stable adducts can be greatly facilitated by the inclusion of the relatively gentle and Schiff base specific reducing agent, sodium cyanoborohydride. Although the tubulin molecule has multiple lysine r...

journal_title：Annals of the New York Academy of Sciences

authors： Tuma DJ,Jennett RB,Sorrell MF

更新日期：1987-01-01 00:00:00

abstract：:The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and no...

journal_title：Annals of the New York Academy of Sciences

authors： Cai D,Liu T

更新日期：2011-12-01 00:00:00

abstract：:In our study, we present a purely statistical observations-based model-free analysis that provides evidence about Granger causality (GC) from long-lived radiative forcings (LLRFs) to the climate trend (CT). This relies on having locally ordered breaks in the slopes of the trend functions of LLRF and the CT, with the b...

journal_title：Annals of the New York Academy of Sciences

authors： Estrada F,Perron P

更新日期：2019-01-01 00:00:00

abstract：:This paper describes the experimental results of a pilot-scale application of membrane technologies to textile wastewater advanced treatment, downstream of a biological activated sludge process, aimed at water reuse in textile technology processes. The chosen approach consisted of sand filtration as a pretreatment, a ...

journal_title：Annals of the New York Academy of Sciences

authors： Marcucci M,Ciabatti I,Matteucci A,Vernaglione G

更新日期：2003-03-01 00:00:00

abstract：:Patients with probable Alzheimer's disease were either stimulated with a continuous visual recognition task (n = 18) or with a continuous auditory recognition task during PET measurement with 18 FDG. The PET scanner was a Siemens CTI, ECAT EXACT with 5 mm transaxial and 6 mm axial resolution. The global stimulation ef...

journal_title：Annals of the New York Academy of Sciences

authors： Kessler J,Ghaemi M,Mielke R,Herholz K,Heiss WD

更新日期：1996-01-17 00:00:00

abstract：:The cell surface antigen recognized by monoclonal antibody W7C5 is expressed at low levels on human CD34(+) and CD34(-) bone marrow stem cell populations but at high levels on fetal liver CD34(+) cells. To identify the recognized antigen, we performed partial amino acid sequence and MALDI analysis of purified W7C5 ant...

journal_title：Annals of the New York Academy of Sciences

authors： Giesert C,Marxer A,Sutherland DR,Schuh AC,Kanz L,Buhring HJ

更新日期：2003-05-01 00:00:00

abstract：:An inactive form of erythrocyte CA I was found in patients with primary aldosteronism. The levels of CA I in the patients were within the normal range: however, the specific esterase activity of CA I from three patients was in the range of 0.12-0.26 u/mg CA I (normal control: 0.66 +/- 0.1 u/mg CA I). In one subject, w...

journal_title：Annals of the New York Academy of Sciences

authors： Kondo T,Taniguchi N,Hirano T,Kawakami Y

更新日期：1984-01-01 00:00:00

abstract：:In the present research, the relationship between various semantic memory functions and episodic odor memory across the adult life span is addressed. In contrast to earlier evidence that odors may be encoded and stored as unique, nonlinguistic whole percepts, the present work suggests that episodic odor information is...

journal_title：Annals of the New York Academy of Sciences

authors： Larsson M,Bäckman L

更新日期：1998-11-30 00:00:00

abstract：:Despite the global transition to overnutrition, stunting affected approximately 159 million children worldwide in 2014, while an estimated 50 million children were wasted. India is an important front in the fight against malnutrition and is grappling with the coexistence of undernutrition, overnutrition, and micronutr...

journal_title：Annals of the New York Academy of Sciences

authors： Shankar B,Agrawal S,Beaudreault AR,Avula L,Martorell R,Osendarp S,Prabhakaran D,Mclean MS

更新日期：2017-05-01 00:00:00

abstract：:Human platelets in sufficient numbers for a therapeutic transfusion can be collected for preservation either by pooling ABO- and Rh-compatible platelets or by apheresis procedures using mechanical cell-separating machines. Human platelets have been frozen successfully with 5 or 6% dimethyl sulfoxide (DMSO) and stored ...

journal_title：Annals of the New York Academy of Sciences

authors： Valeri CR

更新日期：1985-01-01 00:00:00

abstract：:The theme of this presentation has been to show that the control of transmitter release at the neuromuscular synapse is achieved by extracellular and intracellular calcium. For the fast information transfer represented by the end-plate potential, the electrochemical gradient for calcium across the presynaptic membrane...

journal_title：Annals of the New York Academy of Sciences

authors： Rahamimoff R,Erulkar SD,Lev-Tov A,Meiri H

更新日期：1978-04-28 00:00:00

abstract：:Mouse pheochromocytoma cells (MPCs) provide an excellent model system for investigating the effects of hypoxia on catecholamine enzyme genes and on transcription factors mediating stress responses. RT-PCR detects rapid, transient increases in PNMT mRNA in hypoxic MPC 712 cells. Additionally, elevation of mRNAs encodin...

journal_title：Annals of the New York Academy of Sciences

authors： Evinger MJ,Cikos S,Nwafor-Anene V,Powers JF,Tischler AS

更新日期：2002-10-01 00:00:00

abstract：:In hereditary HTG rats, basal systolic blood pressure using tail-cuff sphygmomanometry was significantly higher (122.1 +/- 2.1 mm Hg; n = 16) than that in NTG animals (107.1 +/- 1.52; n = 16). A low salt diet did not influence blood pressure in NTG rats during the consecutive 4 weekly periods. However, in the second w...

journal_title：Annals of the New York Academy of Sciences

authors： Lichardus B,Seböková E,Jezová D,Mitková A,Zemánková A,Földes O,Vrána A,Klimes I

更新日期：1993-06-14 00:00:00

abstract：:Environments are changing rapidly, and to cope with these changes, organisms have to adapt. Adaptation can take many shapes and occur at different speeds, depending on the type of response, the trait, the population, and the environmental conditions. The biodiversity crisis that we are currently facing illustrates tha...

journal_title：Annals of the New York Academy of Sciences

authors： Kristensen TN,Ketola T,Kronholm I

更新日期：2020-09-01 00:00:00

abstract：:The CCR6 chemokine receptor is expressed by most B cells and subsets of T cells and dendritic cells (DCs) found in the gut mucosal immune system. CCL20, the single chemokine ligand for CCR6, is selectively made by the follicle-associated epithelium (FAE) overlying Peyer's patches (PPs) and isolated lymphoid follicles ...

journal_title：Annals of the New York Academy of Sciences

authors： Williams IR

更新日期：2006-08-01 00:00:00

abstract：:The signal peptidases from both chicken oviduct and dog pancreas microsomes have been detected by a post-translational assay and, in the case of dog microsomes, by a cotranslational assay. This proteolytic activity is not sensitive to a variety of conventional protease inhibitors under the conditions used in these ass...

journal_title：Annals of the New York Academy of Sciences

authors： Thibodeau SN,Walsh KA

更新日期：1980-01-01 00:00:00

abstract：:Understanding the predictive relationships between climate variability and coccidioidomycosis is of great importance for the development of an effective public health decision-support system. Preliminary regression-based climate modeling studies have shown that about 80% of the variance in seasonal coccidioidomycosis ...

journal_title：Annals of the New York Academy of Sciences

authors： Comrie AC,Glueck MF

更新日期：2007-09-01 00:00:00

abstract：:Catecholamines (CAs) are significantly involved in the regulation of homeostasis of the organism at rest and especially during stressful situations. Stress induces increases in plasma CA (epinephrine and norepinephrine) levels and prolactin (PRL) release from the adenopituitary. We have recently observed that salsolin...

journal_title：Annals of the New York Academy of Sciences

authors： Bodnar I,Mravec B,Kubovcakova L,Fekete MI,Nagy GM,Kvetnansky R

更新日期：2004-06-01 00:00:00

abstract：:Diverse mutations in the gene encoding the copper transporter ATP7A lead to X-linked recessive Menkes disease or occipital horn syndrome. Recently, two unique ATP7A missense mutations, T994I and P1386S, were shown to cause isolated adult-onset distal motor neuropathy. These mutations induce subtle defects in ATP7A int...

journal_title：Annals of the New York Academy of Sciences

authors： Yi L,Kaler S

更新日期：2014-05-01 00:00:00

abstract：:The potential impact of atrazine (ATZ) on gonadal malformations in larval Xenopus laevis has been controversially discussed, and a hypothesis has been generated that ATZ might induce the estrogen-synthesizing enzyme aromatase, leading to feminization or demasculinization. Recently, extensive long-term studies clearly ...

journal_title：Annals of the New York Academy of Sciences

authors： Kloas W,Lutz I,Urbatzka R,Springer T,Krueger H,Wolf J,Holden L,Hosmer A

更新日期：2009-04-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE) have an increased incidence of vascular disease, and oxidative stress is recognized as an important feature in this condition, despite the underlying mechanisms not being fully understood. In these patients, an interaction between lipoproteins and the immune system has ...

journal_title：Annals of the New York Academy of Sciences

authors： Batuca JR,Ames PR,Isenberg DA,Alves JD

更新日期：2007-06-01 00:00:00

abstract：:The quasibiennial oscillation (QBO) dominates the variability of the equatorial stratosphere and also affects the circulation and temperature of the extratropical region. In this paper we review previous work showing that the mid- to high-latitude circulation is weaker (stronger) when QBO easterlies (westerlies) domin...

journal_title：Annals of the New York Academy of Sciences

authors： Peña-Ortiz C,García-Herrera R,Ribera P,Calvo N

更新日期：2008-12-01 00:00:00

abstract：:In a prospective investigation of perioperative cardiac edema formation requiring a delayed sternal closure, we identified thrombin increase combined with a simultaneous decrease of factor XIII as a probable cause. After experimental studies additionally revealed that factor XIII could protect endothelial barrier func...

journal_title：Annals of the New York Academy of Sciences

authors： Wozniak G,Noll T,Akintürk H,Thul J,Müller M

更新日期：2001-01-01 00:00:00

abstract：:In the inflammatory synovium production of collagenase is probably responsible for the degradation of collagen in the extracellular matrix and distortion of the architecture and function of the joints. Major collagenase-producing cells are mesenchymal cells such as fibroblasts and chondrocytes, which synthesize and se...

journal_title：Annals of the New York Academy of Sciences

authors： Krane SM,Conca W,Stephenson ML,Amento EP,Goldring MB

更新日期：1990-01-01 00:00:00

abstract：:The innervation of muscles in patients with the post-polio syndrome (PPS) may differ from limb to limb or even within the same limb because of the segmental nature of the initial involvement and the varying degree of subsequent recovery. Consequently, the compensatory effort of the neighboring muscles varies even in t...

journal_title：Annals of the New York Academy of Sciences

authors： Dalakas MC

更新日期：1995-05-25 00:00:00

abstract：:The recent identification of tumor-associated antigens (TAA) and TAA-derived peptides presented by MHC molecules to T cells has provided the tools to design and test clinical vaccines for treating human malignancies, such as melanoma. While the most effective adjuvant for use in vaccine formulation remains unclear, au...

journal_title：Annals of the New York Academy of Sciences

authors： Zitvogel L,Couderc B,Mayordomo JI,Robbins PD,Lotze MT,Storkus WJ

更新日期：1996-10-31 00:00:00

abstract：:Three distinct anion exchangers are described that directly or indirectly mediate Cl- transport across the luminal membrane of the proximal tubule cell. Studies on the intact proximal tubule indicate that the Cl(-)-formate exchanger is a major mechanism for Cl- transport under physiologic conditions. As just discussed...

journal_title：Annals of the New York Academy of Sciences

authors： Aronson PS,Kuo SM

更新日期：1989-01-01 00:00:00

abstract：:Delayed type hypersensitivity (DTH) reactions represent cell-mediated immune responses that exert important immunoprotective (resistance to viruses, bacteria, and fungi) or immunopathologic (allergic or autoimmune hypersensitivity) effects. We have used the skin DTH response as an in vivo model to study neuro-endocrin...

journal_title：Annals of the New York Academy of Sciences

authors： Dhabhar FS

更新日期：2003-05-01 00:00:00

abstract：:The extreme toxicity of organophosphorous-based compounds has been known since the late 1930s. Starting in the mid-1940s, many nations throughout the world have been producing large quantities of organophosphorous (OP) nerve agents. Huge stockpiles of nerve agents have since developed. There are reportedly more than 2...

journal_title：Annals of the New York Academy of Sciences

authors： LeJeune KE,Dravis BC,Yang F,Hetro AD,Doctor BP,Russell AJ

更新日期：1998-12-13 00:00:00

abstract：:Nephroblastoma overexpressed (Nov), a member of the CCN family of proteins, is expressed by osteoblasts and its transcription is regulated by transforming growth factor (TGF)-beta and bone morphogenetic proteins (BMP). CCN proteins can interact with TGF-beta, BMPs, and Wnt. We explored the function of Nov in skeletal ...

journal_title：Annals of the New York Academy of Sciences

authors： Canalis E

更新日期：2007-11-01 00:00:00