Semantic mediation of age-related deficits in episodic recognition of common odors.

abstract：:We have previously shown that increased dosage of the mouse protein zero gene (Mpz) causes a dysmyelinating neuropathy in transgenic (Tg80) mice. To ask whether the dysmyelination is dose dependent, we inbred one of the Tg80 lines and compared the resulting phenotype in homozygous and heterozygous mice. Whereas hetero...

journal_title：Annals of the New York Academy of Sciences

authors： Quattrini A,Feltri ML,Previtali S,Fasolini M,Messing A,Wrabetz L

更新日期：1999-10-01 00:00:00

abstract：:Adrenocortical androgens, including dehydroepiandrosterone (DHEA), are produced in the inner zone of the adrenal cortex that is in direct contact with the neural crest-derived catecholamine-producing chromaffin cells. DHEA has recently been identified as a crucial regulator of neuronal stem cell proliferation. Thus, D...

journal_title：Annals of the New York Academy of Sciences

authors： Ziegler CG,Sicard F,Sperber S,Ehrhart-Bornstein M,Bornstein SR,Krug AW

更新日期：2006-08-01 00:00:00

abstract：:Anticardiolipin antibodies (aCLAs) and antibodies to oxidized-low density lipoproteins (oxLDL) are associated with two distinct diseases: the antiphospholipid syndrome and atherosclerosis. Because both diseases may be apparent in patients with systemic lupus erythematosus (SLE), it is important to establish the relati...

journal_title：Annals of the New York Academy of Sciences

authors： Damoiseaux J,Jeyasekharan AD,Theunissen R,Tervaert JW

更新日期：2005-06-01 00:00:00

abstract：:Uncertainty in exposure assessment and uncertainty in kinetic models of early effects after exposure to a toxin are addressed in this paper. Sources of uncertainty in the determination of exposure of workers in chemical industry exposed to dioxins are exhibited and a simple kinetic model for biomonitor measurements of...

journal_title：Annals of the New York Academy of Sciences

authors： Edler L

更新日期：1999-01-01 00:00:00

abstract：:Intracellular foreign protein (beta-galactosidase) expression in recombinant CHO cell lines in continuous culture was analyzed by developing a mathematical model that includes the effects of metabolic burden and cell cycle dependence of intracellular foreign protein expression. This combined growth kinetic and cell cy...

journal_title：Annals of the New York Academy of Sciences

authors： Gu MB,Todd P,Kompala DS

更新日期：1994-05-02 00:00:00

abstract：:More effective therapies have improved survival times of HIV+ patients, resulting in a higher prevalence of long-term complications of the disease. This review focuses on HIV-associated cardiovascular pathology, correlating the morphologic findings to clinical syndromes of HIV disease/AIDS. ...

journal_title：Annals of the New York Academy of Sciences

authors： d'Amati G,di Gioia CR,Gallo P

更新日期：2001-11-01 00:00:00

abstract：:A primary impairment of the kidney sodium excretion has been documented both in hypertensive patients (EH) and genetic animal models (Milan hypertensive rat [MHS]) carrying mutations of the cytoskeletal protein adducin and/or increased plasma levels of endogenous ouabain (EO). Ouabain (OU) itself induces hypertension ...

journal_title：Annals of the New York Academy of Sciences

authors： Ferrari P,Ferrandi M,Torielli L,Barassi P,Tripodi G,Minotti E,Molinari I,Melloni P,Bianchi G

更新日期：2003-04-01 00:00:00

abstract：:Comparative studies of in vivo and in vitro reactivities to Kveim preparations have been carried out in 45 sarcoid and 30 normal subjects. Lymphocytes of 14 of 45 sarcoids and 4 of 30 normals proliferated significantly in response to at least 1 of the 4 Kveim suspensions used for in vitro studies. The prevalence of po...

journal_title：Annals of the New York Academy of Sciences

authors： Zweiman B,Israel HL

更新日期：1976-01-01 00:00:00

abstract：:Mitochondrial dysfunction is implicated in many forms of cell death, particularly in the central nervous system. The mitochondria are required at the same time to generate adenosine 5'-triphosphate (ATP) for the cell, sequester excess cytoplasmic Ca(2+), and both produce and detoxify superoxide free radicals. The elec...

journal_title：Annals of the New York Academy of Sciences

authors： Nicholls DG

更新日期：2008-12-01 00:00:00

abstract：:Anaplasma phagocytophilum (A. phagocytophilum, formerly Ehrlichia phagocytophila) is a tick-borne pathogen responsible for tick-borne fever in ruminants, equine granulocytic ehrlichiosis (EGE) in horses, canine granulocytic ehrlichiosis (CGE) in dogs, and for human granulocytic ehrlichiosis (HGE). Human cases have bee...

journal_title：Annals of the New York Academy of Sciences

authors： Alberti A,Sparagano OA

更新日期：2006-10-01 00:00:00

abstract：:In order to identify rate and stability of remission induced by low-dose prednisone comedication in early rheumatoid arthritis (RA), we evaluated patients with early RA (<1 year) who were randomized to receive (P) or not (non-P) low-dose prednisone in association with step-up disease-modifying antirheumatic drug thera...

journal_title：Annals of the New York Academy of Sciences

authors： Todoerti M,Scirè CA,Boffini N,Bugatti S,Montecucco C,Caporali R

更新日期：2010-04-01 00:00:00

abstract：:Primary hyperparathyroidism (PHPT) results from excessive secretion of parathyroid hormone (PTH), and catabolic and anabolic effects of PTH on bone may lead to overall deleterious effects on skeleton. The aim of this study was to analyze the changes in lumbar spine bone mineral density (BMD) in patients with PHPT who ...

journal_title：Annals of the New York Academy of Sciences

authors： Lumachi F,Camozzi V,Ermani M,Nardi A,Luisetto G

更新日期：2007-11-01 00:00:00

abstract：:Twin and family studies have demonstrated that most cognitive traits are moderately to highly heritable. Neurodevelopmental disorders such as dyslexia, autism, and specific language impairment (SLI) also show strong genetic influence. Nevertheless, it has proved difficult for researchers to identify genes that would e...

journal_title：Annals of the New York Academy of Sciences

authors： Bishop DV

更新日期：2009-03-01 00:00:00

abstract：:Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...

journal_title：Annals of the New York Academy of Sciences

authors： Slifka MK,Ahmed R

更新日期：1996-10-25 00:00:00

abstract：:I(2) site-selective compounds are known to interact with and inhibit monoamine oxidase (MAO), but it remains unclear as to whether this interaction occurs through an allosteric or competitive interaction. This study used the new selective, irreversible I(2) ligand BU99006, to clarify the relationship between MAO and t...

journal_title：Annals of the New York Academy of Sciences

authors： Paterson LM,Tyacke RJ,Nutt DJ,Hudson AL

更新日期：2003-12-01 00:00:00

abstract：:Ibogaine, an alkaloid extracted from Tabemanthe iboga, is being studied as a potential long-acting treatment for oploid and stimulant abuse as well as for alcoholism and smoking. Studies in this laboratory have used animal models to characterize ibogaine's interactions with drugs of abuse, and to investigate the mecha...

journal_title：Annals of the New York Academy of Sciences

authors： Glick SD,Maisonneuve IS

更新日期：1998-05-30 00:00:00

abstract：:An MRI-pathological correlation study was performed to determine the pathological background of white matter lesions depicted on MR images. The pathological findings were various combinations of myelin loss, axonal loss, scattered microinfarcts, astrogliosis, dilatation of perivascular space, and relative preservation...

journal_title：Annals of the New York Academy of Sciences

authors： Udaka F,Sawada H,Kameyama M

更新日期：2002-11-01 00:00:00

abstract：:There has been renewed interest in the role of strategies in sensorimotor learning. The combination of new behavioral methods and computational methods has begun to unravel the interaction between processes related to strategic control and processes related to motor adaptation. These processes may operate on very diff...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor JA,Ivry RB

更新日期：2012-03-01 00:00:00

abstract：:Twenty-month-old Swiss mice were allocated into three groups: (A) control; (B) infected group; and (C) infected but treated with 5 mg of the phytocompound MMT. Mice were infected intranasally with 30 microL of 75 HA viral units. MMT markedly blunted the nasal signs of virus infection and the febrile response. Formazan...

journal_title：Annals of the New York Academy of Sciences

authors： Cervi J,Marotta F,Bater C,Masulair K,Minelli E,Harada M,Marandola P

更新日期：2006-05-01 00:00:00

abstract：:It is now generally accepted that it is not possible to design iron(III)-selective hexadentate chelators with high oral bioavailability. In order to achieve suitable levels of oral activity for the treatment of systemic iron overload either tridentate or bidentate molecules need to be investigated. There are a number ...

journal_title：Annals of the New York Academy of Sciences

authors： Hider RC,Zhou T

更新日期：2005-01-01 00:00:00

abstract：:A brief overview of the different techniques used to estimate the probable maximum precipitation (PMP) is presented. As a particular case, the 1-day PMP over Catalonia has been calculated and mapped with a high spatial resolution. For this purpose, the annual maximum daily rainfall series from 145 pluviometric station...

journal_title：Annals of the New York Academy of Sciences

authors： Casas MC,Rodríguez R,Nieto R,Redaño A

更新日期：2008-12-01 00:00:00

abstract：:Obesity has various deleterious effects on health largely associated with metabolic abnormalities including abnormal glucose and lipid homeostasis that are associated with vascular injury and known cardiac, renal, and cerebrovascular complications. Advanced age is also associated with increased adiposity, decreased le...

journal_title：Annals of the New York Academy of Sciences

authors： Lee EB

更新日期：2011-12-01 00:00:00

abstract：:Though several studies show that genetic factors influence individual differences in musical engagement, aptitude, and achievement, no study to date has investigated whether specialization among musically active individuals in terms of choice of instrument and genre is heritable. Using a large twin cohort, we explored...

journal_title：Annals of the New York Academy of Sciences

authors： Mosing MA,Ullén F

更新日期：2018-05-09 00:00:00

abstract：:Experimental and observational findings suggest that calcium intake may protect against colorectal neoplasia. To investigate this hypothesis, we conducted a randomized, double-blind trial of colorectal adenoma recurrence. Nine hundred thirty patients with a recent history of colorectal adenomas were randomly given cal...

journal_title：Annals of the New York Academy of Sciences

authors： Baron JA,Beach M,Mandel JS,van Stolk RU,Haile RW,Sandler RS,Rothstein R,Summers RW,Snover DC,Beck GJ,Frankl H,Pearson L,Bond JH,Greenberg ER

更新日期：1999-01-01 00:00:00

abstract：:A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold LE

更新日期：2001-06-01 00:00:00

abstract：:Post-polio syndrome (PPS) describes the clinical onset of progressive muscular weakness many years after survival of acute paralytic poliomyelitis, often in muscle groups clinically unaffected by the original disease process. Prior pathologic descriptions of this often disabling, but not usually fatal, syndrome have b...

journal_title：Annals of the New York Academy of Sciences

authors： Miller DC

更新日期：1995-05-25 00:00:00

abstract：:Analysis of fetal DNA in maternal plasma has recently been introduced as a new method for noninvasive prenatal diagnosis. In the majority of cases, the Y chromosome-specific sequences are commonly used as a fetus-specific marker with a high risk of false-negative cases. We attempted to develop a sensitive and reliable...

journal_title：Annals of the New York Academy of Sciences

authors： Vecchione G,Tomaiuolo M,Sarno M,Colaizzo D,Petraroli R,Matteo M,Greco P,Grandone E,Margaglione M

更新日期：2008-08-01 00:00:00

abstract：:In the present study, we examined the potential impact of a T-to-C substitution at nucleotide 1519 of the GABA(A)alpha6 receptor subunit gene (GABRA6) on obesity and obesity-related phenotypes as well as circulating hormones, including salivary cortisol, in 284 unrelated Swedish men born in 1944. The subjects were gen...

journal_title：Annals of the New York Academy of Sciences

authors： Rosmond R,Bouchard C,Björntorp P

更新日期：2002-06-01 00:00:00

abstract：:We studied the GABAergic control of the spinal locomotor network using an isolated brain stem/spinal cord from newborn rats, in which locomotor-like activity was recorded. We demonstrate that endogenously released GABA controls the locomotor network, by decreasing or completely abolishing all locomotor-like activity. ...

journal_title：Annals of the New York Academy of Sciences

authors： Cazalets JR,Bertrand S,Sqalli-Houssaini Y,Clarac F

更新日期：1998-11-16 00:00:00

abstract：:The aim of this study was to evaluate the possible neuroprotective effects of thymosin beta(4) in different models of excitotoxicity. The application of thymosin beta(4) significantly attenuated glutamate-induced toxicity both in primary cultures of cortical neurons and in rat hippocampal slices. In in vivo experiment...

journal_title：Annals of the New York Academy of Sciences

authors： Popoli P,Pepponi R,Martire A,Armida M,Pèzzola A,Galluzzo M,Domenici MR,Potenza RL,Tebano MT,Mollinari C,Merlo D,Garaci E

更新日期：2007-09-01 00:00:00