The interaction of acetaldehyde with tubulin.

abstract：:Insulin-like factor 3 (INSL3), previously known as the relaxin-like factor (RLF), is a major peptide hormone secreted from the testicular Leydig cells of adult men and circulating in the blood at a concentration of approximately 1 ng/mL. Women also produce INSL3 in the theca interna cells of ovarian follicles, but cir...

journal_title：Annals of the New York Academy of Sciences

authors： Ivell R,Hartung S,Anand-Ivell R

更新日期：2005-05-01 00:00:00

abstract：:Research in the area of adolescent alcohol use is progressing rapidly, as exemplified by the chapters in this section. Basic animal research in rodents has revealed adolescents to be more sensitive than adults to ethanol-induced disruptions in brain plasticity, although adolescents conversely are relatively insensitiv...

journal_title：Annals of the New York Academy of Sciences

authors： Spear LP

更新日期：2004-06-01 00:00:00

abstract：:The vast majority of what is known about the neural underpinnings of human cognition comes from studies limited to racially, ethnically, and socioeconomically homogeneous samples. Furthermore, although most studies include both males and females in their samples, sex differences in patterns of brain activity and perfo...

journal_title：Annals of the New York Academy of Sciences

authors： Dotson VM,Duarte A

更新日期：2020-03-01 00:00:00

abstract：:Beta-carotene acts as an antioxidant or a pro-oxidant depending on the concentrations that cells are treated with. Oxidative DNA damage is related to apoptosis of various cells. Ataxia-telangiectasia-mutated (ATM), a sensor for DNA-damaging agents, activates a variety of effectors in multiple signaling pathways, such ...

journal_title：Annals of the New York Academy of Sciences

authors： Jang SH,Lim JW,Kim H

更新日期：2009-08-01 00:00:00

abstract：:The Ca2+-pump ATPase of human RBC membranes appears to be exquisitely sensitive to a variety of amphipathic molecules. The acidic protein calmodulin (CaM) activates the enzyme some three- to fivefold with an apparent Kd of approximately 1-5 nM. A variety of other amphipathic anions, such as acidic phospholipids, free ...

journal_title：Annals of the New York Academy of Sciences

authors： Vincenzi FF

更新日期：1982-01-01 00:00:00

abstract：:The adrenergic system has long been known to be activated in a situation of stress and thus during opiate withdrawal. A method for detoxification that decreases the stimulation of the sympathetic nervous system will prevent changes of catecholamine levels. Some of such methods have been developed. One of them uses dir...

journal_title：Annals of the New York Academy of Sciences

authors： Macedo TR,Relvas J,Fontes Ribeiro CA,Pacheco F,Morgadinho MT,Pinto CM,Gomes PC,Ventura M,Henriques V,Nunes SV,Ruis GR,Ramalheira C,Boto I,Vale LL

更新日期：2000-09-01 00:00:00

abstract：:The validity of waist circumference and sagittal diameter as surrogate measures of visceral fat were assessed using preliminary cross-sectional data from the Health, Aging and Body Composition Study, a cohort of 3,075 men and women aged 70-79. Weight, body mass index, waist circumference, waist/thigh ratio, and sagitt...

journal_title：Annals of the New York Academy of Sciences

authors： Harris TB,Visser M,Everhart J,Cauley J,Tylavsky F,Fuerst T,Zamboni M,Taaffe D,Resnick HE,Scherzinger A,Nevitt M

更新日期：2000-05-01 00:00:00

abstract：:The superior soft tissue contrast and multiplanar capability of magnetic resonance imaging has contributed to earlier diagnosis and implementation of effective treatment for a variety of arthropathies. Owing to overlapping clinical signs and symptoms, MRI plays a role in delineating the features and stages of these co...

journal_title：Annals of the New York Academy of Sciences

authors： Momeni M,Brindle K

更新日期：2009-02-01 00:00:00

abstract：:The proto-oncogene c-myc is involved in multiple cell pathways with opposite effects on cell outcome of death or proliferation. It has been proposed that these different roles depend on the sequestration of c-Myc protein in cellular compartments and/or its phosphorylation. We speculated that subcellular localization o...

journal_title：Annals of the New York Academy of Sciences

authors： Supino R,Favini E,Cuccuru G,Zunino F,Scovassi AI

更新日期：2007-01-01 00:00:00

abstract：:This article reviews the implementation processes for interventions that integrate nutrition and psychosocial stimulation for children under 5 years of age in low- and middle-income countries. We examine the content of these programs, the delivery strategy, intensity and duration, personnel training and supervision, c...

journal_title：Annals of the New York Academy of Sciences

authors： Yousafzai AK,Aboud F

更新日期：2014-01-01 00:00:00

abstract：:Mesothelium is the simple squamous epithelium covering all abdominal organs and the coeloms in which those organs reside. While the structural characteristics of this cell type were documented a century ago, its potential in development, disease, and wound healing is only now becoming apparent. In the embryo, mesothel...

journal_title：Annals of the New York Academy of Sciences

authors： Shelton EL,Bader DM

更新日期：2012-10-01 00:00:00

abstract：:The role of acid-base interactions during coordinated acinar and duct cell secretion in the exocrine pancreas is described. The sequence of acid-base events may be summarized as follows: (1) Sorting of secretory proteins and membrane components into the regulated secretory pathway of pancreatic acinar cells is trigger...

journal_title：Annals of the New York Academy of Sciences

authors： Freedman SD,Scheele GA

更新日期：1994-03-23 00:00:00

abstract：:One of the richest reservoirs of antibiotic-resistant bacteria and genes, animal intestinal microbiota contributes to the spread of antibiotic resistance in the environment and, potentially, to human pathogens. Both culture-based genomic technology and culture-independent metagenomics have been developed to investigat...

journal_title：Annals of the New York Academy of Sciences

authors： Su JQ,Cui L,Chen QL,An XL,Zhu YG

更新日期：2017-01-01 00:00:00

abstract：:In the present study we analyzed the morphology of testes and efferent ducts as well as the localization of androgen receptors (AR) in the tissues of XY, YY, and XX male rainbow trout Oncorhynchus mykiss Walbaum. Testes of the XX trout differed distinctly from those of XY and YY males; the interstitial space was very ...

journal_title：Annals of the New York Academy of Sciences

authors： Galas JF,Hejmej A,Glogowski J,Bilińska B

更新日期：2009-04-01 00:00:00

abstract：:Organisms minimize genetic damage through complex pathways of DNA repair. Yet a gene family--the AID/APOBECs--has evolved in vertebrates with the sole purpose of producing targeted damage in DNA/RNA molecules through cytosine deamination. They likely originated from deaminases involved in A>I editing in tRNAs. AID, th...

journal_title：Annals of the New York Academy of Sciences

authors： Conticello SG

更新日期：2012-09-01 00:00:00

abstract：:Melatonin is a hormone secreted by the pineal gland, mostly in the dark period of the light/dark cycle, with corresponding fluctuations reflected in the plasma melatonin levels. This hormone plays a critical role in the regulation of various neural and endocrine processes that are synchronized with daily change in pho...

journal_title：Annals of the New York Academy of Sciences

authors： Lahiri DK,Chen D,Lahiri P,Rogers JT,Greig NH,Bondy S

更新日期：2004-12-01 00:00:00

abstract：:The contemporary world faces an unprecedented environmental challenge. Past international research has amply shown that we cannot afford to wait for a "development path" that automatically takes us on a sustainable future. Whether we look at global or local problems, the international debate increasingly points to the...

journal_title：Annals of the New York Academy of Sciences

authors： Magnani E

更新日期：2011-02-01 00:00:00

abstract：:The following on molecular mechanisms of Barrett's esophagus and adenocarcinoma contains commentaries on the mechanism of bile and gastric acid induced damage; the roles of BMP-4 and CDX-2 in the development of intestinal metaplasia; the transcription factors driving intestinalization in Barrett's esophagus; the contr...

journal_title：Annals of the New York Academy of Sciences

authors： Dvorak K,Goldman A,Kong J,Lynch JP,Hutchinson L,Houghton JM,Chen H,Chen X,Krishnadath KK,Westra WM

更新日期：2011-09-01 00:00:00

abstract：:Valproic acid (VA), a histone deacetylase inhibitor (HDACI), in vitro induces differentiation of promyelocyte leukemia cell (HL-60) and proliferation arrest and apoptosis of various leukemia cell lines. In MOLT-4 cells (human T lymphocyte leukemia) the cell cycle arrest is caused by 2 mM VA, while 4 mM VA induces main...

journal_title：Annals of the New York Academy of Sciences

authors： Záskodová D,Rezácová M,Vávrová J,Vokurková D,Tichy A

更新日期：2006-12-01 00:00:00

abstract：:By virtue of the progress in proteomics, the involvement of posttranslational modifications in aging has been more clearly demonstrated in recent years. We describe here that (1) carbonylation, a hallmark of protein oxidation in general, is paradoxically decreased in histone with aging and increased by calorie restric...

journal_title：Annals of the New York Academy of Sciences

authors： Nakamura A,Kawakami K,Kametani F,Nakamoto H,Goto S

更新日期：2010-06-01 00:00:00

abstract：:Calpain, an inactive proenzyme, translocates from the cytosol to the membrane upon binding calcium, and is activated at the membrane in the presence of calcium and PIP2. Activated calpain is very unstable and presumably used only once. Thus the primary targets of calpain are considered to be membrane or membrane-assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Suzuki K,Saido TC,Hirai S

更新日期：1992-12-31 00:00:00

abstract：:The emphasis on the effects of early olfactory restriction has been on the deleterious nature of the consequences of this abnormal early experience. While these effects are certainly present and dramatic, it is also the case that the olfactory system is left fairly intact by this experimental manipulation. If one asks...

journal_title：Annals of the New York Academy of Sciences

authors： Leon M

更新日期：1998-11-30 00:00:00

abstract：:In recent years, different subphenotypes of obesity have been described, including metabolically healthy obesity (MHO), in which a proportion of obese individuals, despite excess body fat, remain free of metabolic abnormalities and increased cardiometabolic risk. In the absence of a universally accepted set of criteri...

journal_title：Annals of the New York Academy of Sciences

authors： Phillips CM

更新日期：2017-03-01 00:00:00

abstract：:The human moral nature has perplexed laymen and academics for millennia. Recent developments in cognitive neuroscience are opening new venues for unveiling the complex psychological and neurobiological mechanisms underling human morality and its impairments. Here we review these lines of evidence and key topics of deb...

journal_title：Annals of the New York Academy of Sciences

authors： Moll J,De Oliveira-Souza R,Zahn R

更新日期：2008-03-01 00:00:00

abstract：:Our recently developed method, TranSIESTA, enables modelling of molecular electronic devices under operation conditions. The method is based on density functional theory, and calculates the self-consistent electronic structure of a nanostructure coupled to three-dimensional electrodes with different electrochemical po...

journal_title：Annals of the New York Academy of Sciences

authors： Stokbro K,Taylor J,Brandbyge M,Ordejón P

更新日期：2003-12-01 00:00:00

abstract：:Indoor air pollution occurs as an undesirable consequence of urbanization, energy conservation, indoor bioaerosol contamination, and use of synthetic materials and new technologies, and has become a worldwide concern. It is important to comprehend not only the diversity of pollutant hazards but also to develop novel m...

journal_title：Annals of the New York Academy of Sciences

authors： Brooks BO,Aldrich FD,Utter GM,DeBroy JA,Schimke RD

更新日期：1992-04-30 00:00:00

abstract：:The term intrauterine growth restriction (IUGR) is assigned to newborns with a birth weight and/or birth length below the 10th percentile for their gestational age and whose abdominal circumference is below the 2.5th percentile with pathologic restriction of fetal growth. IUGR is usually due to maternal, fetal, or pla...

journal_title：Annals of the New York Academy of Sciences

authors： Valsamakis G,Kanaka-Gantenbein C,Malamitsi-Puchner A,Mastorakos G

更新日期：2006-12-01 00:00:00

abstract：:The life expectancy of patients with thalassemia major has significantly increased in recent years, as reported by several groups in different countries. However, complications are still frequent and affect the patients' quality of life. In a recent study from the United Kingdom, it was found that 50% of the patients ...

journal_title：Annals of the New York Academy of Sciences

authors： Borgna-Pignatti C,Cappellini MD,De Stefano P,Del Vecchio GC,Forni GL,Gamberini MR,Ghilardi R,Origa R,Piga A,Romeo MA,Zhao H,Cnaan A

更新日期：2005-01-01 00:00:00

abstract：:The rapid, inexpensive transmission of words and data, brought about by the internet and cheap computers, is changing the world faster than anything mankind has ever experienced, reaching into nearly every aspect of our lives, public and private, commercial and governmental. We are in an Information Age with an essent...

journal_title：Annals of the New York Academy of Sciences

authors： Hugh-Jones M

更新日期：2000-01-01 00:00:00

abstract：:Depressive disorders are associated with significant psychosocial impairment and disability. Depression should be thoroughly evaluated, as should current and past suicidality and potential risk factors for suicide. Mortality by suicide characterizes the course of major affective disorders in approximately 15% of those...

journal_title：Annals of the New York Academy of Sciences

authors： Nemeroff CB,Compton MT,Berger J

更新日期：2001-04-01 00:00:00