Adolescence and the trajectory of alcohol use: introduction to part VI.

Abstract:

:Research in the area of adolescent alcohol use is progressing rapidly, as exemplified by the chapters in this section. Basic animal research in rodents has revealed adolescents to be more sensitive than adults to ethanol-induced disruptions in brain plasticity, although adolescents conversely are relatively insensitive to ethanol cues that serve to moderate intake. Risks for excessive alcohol consumption due to genetic background have been shown in primate research to be exacerbated by adverse early life experiences. Studies in clinical populations have revealed neurocognitive deficits evident years following adolescent alcohol abuse, along with evidence that some neural changes may predate adolescent alcohol abuse, whereas others appear to be a consequence of this abuse. Further research is needed to detail determinants and consequences of adolescent alcohol abuse and to identify potential protective factors to diminish the propensity for excessive use of alcohol during this critical developmental period.

journal_name

Ann N Y Acad Sci

authors

Spear LP

doi

10.1196/annals.1308.025

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

202-5

eissn

0077-8923

issn

1749-6632

pii

1021/1/202

journal_volume

1021

pub_type

杂志文章,评审
  • SNAP-25 in neuropsychiatric disorders.

    abstract::SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates dif...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2008.03995.x

    authors: Corradini I,Verderio C,Sala M,Wilson MC,Matteoli M

    更新日期:2009-01-01 00:00:00

  • M1 muscarinic agonists as potential disease-modifying agents in Alzheimer's disease. Rationale and perspectives.

    abstract::A cholinergic hypofunction in Alzheimer's disease (AD) may lead to formation of beta-amyloids that might impair the coupling of M1 muscarinic ACh receptors (mAChRs) with G proteins. This disruption in coupling can lead to decreased signal transduction, to a reduction in levels of trophic amyloid precursor proteins (AP...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06941.x

    authors: Fisher A,Michaelson DM,Brandeis R,Haring R,Chapman S,Pittel Z

    更新日期:2000-01-01 00:00:00

  • Molecular diagnosis of granulocytic anaplasmosis and infectious cyclic thrombocytopenia by PCR-RFLP.

    abstract::Anaplasma phagocytophilum (A. phagocytophilum, formerly Ehrlichia phagocytophila) is a tick-borne pathogen responsible for tick-borne fever in ruminants, equine granulocytic ehrlichiosis (EGE) in horses, canine granulocytic ehrlichiosis (CGE) in dogs, and for human granulocytic ehrlichiosis (HGE). Human cases have bee...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1373.055

    authors: Alberti A,Sparagano OA

    更新日期:2006-10-01 00:00:00

  • Interaction between microglia and oligodendrocyte cell progenitors involves Golli proteins.

    abstract::Multiple sclerosis (MS) is an autoimmune and chronic inflammatory disease characterized by plaques, areas of destroyed myelin sheaths in the CNS, which results in multiple disabilities for patients. In addition to demyelinated plaques, pathophysiological studies have shown "shadow plaques" that represent areas of part...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1342.015

    authors: Filipović R,Zecević N

    更新日期:2005-06-01 00:00:00

  • Regulation of the metastatic process by E-selectin and stress-activated protein kinase-2/p38.

    abstract::The formation of metastasis is a dreadful complication of cancer that is associated with a poor prognosis. Several clinical observations and experimental findings indicate that the metastatic process is nonrandom and involves a sequence of multistep events that may all be targeted for therapy. This includes angiogenes...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2002.tb04702.x

    authors: Laferriere J,Houle F,Huot J

    更新日期:2002-11-01 00:00:00

  • MHC class I chain-related gene alleles 5 and 5.1 are transmitted more frequently to type 1 diabetes offspring in HBDI families.

    abstract::Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by autoimmune destruction of pancreatic beta cells. Genetic and environmental factors contribute in this disease. There is evidence that MHC class I chain-related gene (MIC-A) plays a role in the susceptibility to this and other autoimmune diseases...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb02993.x

    authors: Zake LN,Ghaderi M,Park YS,Babu S,Eisenbarth G,Sanjeevi CB

    更新日期:2002-04-01 00:00:00

  • Transfer factor in immunodeficiency diseases.

    abstract::Results of therapeutic trials of transfer factor in a number of laboratories suggest clinical benefit and enhancement of immunological reactivity in patients with primary or secondary immunodeficiency diseases. Long term follow-up of 32 patients with the Wiskott-Aldrich syndrome suggested that transfer factor caused c...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1979.tb47116.x

    authors: Spitler LE

    更新日期:1979-01-01 00:00:00

  • Potential contribution of VH gene replacement in immunity and disease.

    abstract::VH replacement occurs through RAG-mediated recombination between a cryptic recombination signal sequence (cRSS) presented in a rearranged VH gene and a 23-bp RSS from an upstream VH gene. VH replacement renews the entire VH coding region and extends the immunoglobulin heavy-chain (IgH) CDR3 regions preferentially with...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1358.020

    authors: Liu Y,Fan R,Zhou S,Yu Z,Zhang Z

    更新日期:2005-12-01 00:00:00

  • Visual skills and cross-modal plasticity in deaf readers: possible implications for acquiring meaning from print.

    abstract::Most research on reading skill acquisition in deaf individuals has been conducted from the perspective of a hearing child learning to read. This approach may limit our understanding of how a deaf child approaches the task of learning to read and successfully acquires reading skills. An alternative approach is to consi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1416.013

    authors: Dye MW,Hauser PC,Bavelier D

    更新日期:2008-12-01 00:00:00

  • The emergence of collaborative brain function: FMRI studies of the development of response inhibition.

    abstract::Adolescence marks the beginning of adult-level cognitive control of behavior supported by the brain maturation processes of synaptic pruning and myelination. Cognitive development studies on adolescence indicate that this period is characterized by improvements in the performance of existing abilities including speed ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1308.035

    authors: Luna B,Sweeney JA

    更新日期:2004-06-01 00:00:00

  • Hemispheric asymmetries in the quasibiennial oscillation signature on the mid- to high-latitude circulation of the stratosphere.

    abstract::The quasibiennial oscillation (QBO) dominates the variability of the equatorial stratosphere and also affects the circulation and temperature of the extratropical region. In this paper we review previous work showing that the mid- to high-latitude circulation is weaker (stronger) when QBO easterlies (westerlies) domin...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1446.007

    authors: Peña-Ortiz C,García-Herrera R,Ribera P,Calvo N

    更新日期:2008-12-01 00:00:00

  • Estrogen mediation of breast tumor formation involves estrogen receptor-dependent, as well as independent, genotoxic effects.

    abstract::Long-term exposure to estrogens influences the development of breast cancer in women, but the precise mechanisms involved are not clearly defined. Our working hypothesis is that estrogen modulates this process by two separate processes. One involves the binding of estradiol to estrogen receptor (ER) alpha with stimula...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2008.03685.x

    authors: Santen R,Cavalieri E,Rogan E,Russo J,Guttenplan J,Ingle J,Yue W

    更新日期:2009-02-01 00:00:00

  • Involvement of glial glutamate transporters in morphine dependence.

    abstract::There are several lines of evidence implying the involvement of the central glutamatergic system in morphine dependence. Extracellular glutamate released from nerve terminals is counterbalanced by glutamate transporters in neurons (EAAC1 and EAAT4) and glial cells (GLT-1 and GLAST), thereby modulating the glutamatergi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1307.047

    authors: Nakagawa T,Satoh M

    更新日期:2004-10-01 00:00:00

  • On the true role of oxygen free radicals in the living state, aging, and degenerative disorders.

    abstract::Oxyradicals are generally considered harmful byproducts of oxidative metabolism, causing molecular damage in living systems. They are implicated in various processes such as mutagenesis, aging, and series of pathological events. Although all this may be justified, evidence is accumulating that it is an oversimplified ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05649.x

    authors: Nagy IZ

    更新日期:2001-04-01 00:00:00

  • Proteome and proteomics for the research on protein alterations in aging.

    abstract::Functional decline of tissues in aged animals is a result of cellular aging. Though any process of somatic cell aging basically depends on genomic instructions, phenotypes of aged cells are expressed in a given internal environment of each cell type that was made with translated proteins and post-translationally modif...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb05637.x

    authors: Toda T

    更新日期:2001-04-01 00:00:00

  • Cisplatin-induced apoptosis in melanoma cells: role of caspase-3 and caspase-7 in Apaf-1 proteolytic cleavage and in execution of the degradative phases.

    abstract::Apoptosis protease-activating factor-1 (Apaf-1), which plays a central role in the formation of the apoptosome, is absent or poorly expressed (because of a transcriptional silencing by methylation) in a substantial percentage of metastatic melanomas and melanoma cell lines, which are unable to activate caspase-9 and e...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1299.034

    authors: Del Bello B,Valentini MA,Comporti M,Maellaro E

    更新日期:2003-12-01 00:00:00

  • Handling anticancer drugs: from hazard identification to risk management?

    abstract::The potential health hazards involved with antineoplastic agents have been known for decades. Many anticancer drugs are recognized as carcinogens and genotoxins in experimental assays. Second cancers have been recorded in follow-up studies with treated patients. The first findings on occupational exposures among hospi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1371.008

    authors: Sorsa M,Hämeilä M,Järviluoma E

    更新日期:2006-09-01 00:00:00

  • The molecular cross talk of the dystrophin-glycoprotein complex.

    abstract::The proper function of skeletal muscles relies on their ability to process signals derived from motor neurons, transmit stimuli along the muscle fibers, contract, and regenerate efficiently after injury. The dystrophin-glycoprotein complex (DGC; also called the dystrophin-associated protein complex) plays a central ro...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13500

    authors: Gawor M,Prószyński TJ

    更新日期:2018-01-01 00:00:00

  • Is PR3-ANCA formation initiated in Wegener's granulomatosis lesions? Granulomas as potential lymphoid tissue maintaining autoantibody production.

    abstract::In Wegener's granulomatosis (WG), antiproteinase 3 (PR3) autoantibodies (PR3-ANCA) are crucial in the development of generalized vasculitis. Wegener's pathognomonic lesion, a granulomatous inflammation of the upper and lower respiratory tract, contains abundant lymphocytes and macrophages. Lymphocyte clusters in germi...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1361.042

    authors: Voswinkel J,Müller A,Lamprecht P

    更新日期:2005-06-01 00:00:00

  • Mandated empowerment: handing antipoverty policy back to the poor?

    abstract::The current trend in antipoverty policy emphasizes mandated empowerment: the poor are being handed the responsibility for making things better for themselves, largely without being asked whether this is what they want. Beneficiary control is now being built into public service delivery, while microcredit and small bus...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1425.019

    authors: Banerjee AV,Duflo E

    更新日期:2008-01-01 00:00:00

  • A systematic-heuristic approach for space trajectory design.

    abstract::In this paper a novel algorithm is proposed for space trajectory design that combines a systematic and a heuristic method for global optimization. For the systematic part of the algorithm a branching technique is used, whereas a particular implementation of evolution programming forms the core of the heuristic part. T...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1311.014

    authors: Vasile M

    更新日期:2004-05-01 00:00:00

  • Curcumin inhibits the classical and the alternate pathways of complement activation.

    abstract::Curcumin (Cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. In the current investigation, Cur dissolved using sodium hydroxide solution (CurNa) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (RA) and quercetin (Qur) dissolved ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1352.007

    authors: Kulkarni AP,Ghebremariam YT,Kotwal GJ

    更新日期:2005-11-01 00:00:00

  • Assessment of carotenoid intakes in humans.

    abstract::The availability of new food composition carotenoid values for fruits and vegetables increases our ability to test hypotheses concerning the role of antioxidant nutrients and cancer risk. To estimate the usual carotenoid intakes, a quantitative diet history covering a one-year period is recommended for epidemiologic s...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb26158.x

    authors: Hankin JH,Le Marchand L,Kolonel LN,Wilkens LR

    更新日期:1993-12-31 00:00:00

  • Xenozoonoses and the xenotransplant recipient.

    abstract::The use of animal cells, tissues, or organs for humans is being investigated as an alternative to allotransplantation and as therapy for a broad range of disease states including diabetes, Parkinson's disease, and neurologic pain control. The risk of transmitting novel infections with these tissues, xenozoonoses, has ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1998.tb09121.x

    authors: Michaels M

    更新日期:1998-12-30 00:00:00

  • Human sexual selection, good genes, and special design.

    abstract::Evolutionary psychology seeks to understand the functional design underlying psychological processes and behavior. Theories of selection pressures developed within evolutionary biology are key components of this understanding. Because past selection pressures responsible for current design cannot be directly observed,...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06615.x

    authors: Gangestad SW

    更新日期:2000-04-01 00:00:00

  • Concanavalin-A-affinity molecular heterogeneity of human hepatoma AFP and cord-serum AFP.

    abstract::Glycosylation of alpha-fetoprotein (AFP) by human primary hepatocellular carcinoma (PHC) is abnormal. Concanavalin A (Con A)-affinity molecular variant patterns of serum AFP from patients with PHC are different from those of cord-serum AFP. Different patients with PHC exhibit different Con-A-affinity AFP molecular var...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1983.tb32850.x

    authors: Smith CJ,Ajdukiewicz A,Kelleher PC

    更新日期:1983-01-01 00:00:00

  • Structure and activity in the relaxin family of peptides.

    abstract::The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, together with advances in methods for structural characterization, has enabled the key structural features of the relaxin family of peptides responsible for biological activity to be defined....

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.03955.x

    authors: Tregear GW,Bathgate RA,Hossain MA,Lin F,Zhang S,Shabanpoor F,Scott DJ,Ma S,Gundlach AL,Samuel CS,Wade JD

    更新日期:2009-04-01 00:00:00

  • Development of a hybrid liver support system.

    abstract::Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2001.tb03843.x

    authors: Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

    更新日期:2001-11-01 00:00:00

  • Oxidative damage, bleomycin, and gamma radiation induce different types of DNA strand breaks in normal lymphocytes and thymocytes. A comet assay study.

    abstract::Most anticancer treatments such as chemo- and radiotherapy induce DNA damage and apoptosis in normal cells. The aim of this study was to assess the induction of single and double DNA strand breaks (ssb and dsb, respectively) and apoptosis in normal human lymphocytes and rat thymocytes subjected to the action of H2O2, ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1999.tb07928.x

    authors: Benítez-Bribiesca L,Sánchez-Suárez P

    更新日期:1999-01-01 00:00:00

  • Comparative effects of NO-synthase inhibitor and NMDA antagonist on generation of nitric oxide and release of amino acids and acetylcholine in the rat brain elicited by amphetamine neurotoxicity.

    abstract::The aim of this study was to clarify the role of nitric oxide (NO) and lipid peroxidation (LPO) processes as well as the contribution of various neurotransmitters in pathophysiological mechanisms of neurotoxicity induced by amphetamine (AMPH). NO level was determined directly in brain tissues using electron paramagnet...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1316.027

    authors: Bashkatova V,Kraus MM,Vanin A,Hornick A,Prast H

    更新日期:2004-10-01 00:00:00