Adolescence and the trajectory of alcohol use: introduction to part VI.

abstract：:Genomic sequence data provide evidence for a common origin of life and for its evolution by genetic variation via mutation and recombination. This paper discusses the fundamental dialectic paradigm of evolution--stability versus variability--at the crossroads of molecular genetics, population genetics, ecology, and th...

journal_title：Annals of the New York Academy of Sciences

authors： Radman M,Matic I,Taddei F

更新日期：1999-05-18 00:00:00

abstract：:Animal trials of many pharmacological neuroprotective agents have been quite successful, whereas trials in humans have been uniformly disappointing. A major difference between laboratory research in animals and clinical research in humans is the amount and/or quality of data obtained. The goal of this presentation is ...

journal_title：Annals of the New York Academy of Sciences

authors： Andrews RJ

更新日期：2005-08-01 00:00:00

abstract：:Epidemiological studies have suggested that excess body weight gain may be a major risk factor for colon and breast cancer. A positive energy balance creates metabolic stresses, including the excess production of reactive oxygen species (ROS), hyperinsulinemia, the elevated adipokine secretion, and increased gut perme...

journal_title：Annals of the New York Academy of Sciences

authors： Sung MK,Yeon JY,Park SY,Park JH,Choi MS

更新日期：2011-07-01 00:00:00

abstract：:In this paper, I have introduced and solved a simple deterministic model of eye tracking that produces rich dynamical behavior. Some of its main features, notably the existence of a chaotic regime, are reminiscent of the anomalies reported in smooth pursuit eye tracking experiments with schizophrenia patients. By obta...

journal_title：Annals of the New York Academy of Sciences

authors： Huberman BA

更新日期：1987-01-01 00:00:00

abstract：:The alteration of oligosaccharide structures through genetic manipulation of glycosyltransferase activities is now a reality. It is apparent that this technique has greater consequences on oligosaccharide structure when an exogenous enzyme is introduced into cells, and in particular when this enzyme is responsible for...

journal_title：Annals of the New York Academy of Sciences

authors： Youakim A,Shur BD

更新日期：1994-11-30 00:00:00

abstract：:First we remind general considerations concerning biodiversity on earth and particularly the loss of genetic biodiversity that seems irreversible whether its origin is directly or indirectly linked to human activities. Urgent and considerable efforts must be made from now on to cataloge, understand, preserve, and enha...

journal_title：Annals of the New York Academy of Sciences

authors： Maillard JC,Gonzalez JP

更新日期：2006-10-01 00:00:00

abstract：:Tight junction (TJ) properties are determined by membrane protein complexes of neighboring cells that form both a barrier and a selective pathway for paracellular substrate transport. Our previous work supports the view that paracellular permeability changes in the thick ascending limb (TAL) may underlie the mechanism...

journal_title：Annals of the New York Academy of Sciences

authors： Shan Q,Himmerkus N,Hou J,Goodenough DA,Bleich M

更新日期：2009-05-01 00:00:00

abstract：:These findings support the hypothesis that a frontal-subcortical abnormality is necessary to produce symptoms of depression (e.g., mood-related signs, behavioral disturbances, neurovegetative signs) in dementia. Behavioral disturbances (e.g., disinhibition, agitation, social withdrawal) were more likely to occur in FL...

journal_title：Annals of the New York Academy of Sciences

authors： Lopez OL,Gonzalez MP,Becker JT,Reynolds CF 3rd,Sudilovsky A,DeKosky ST

更新日期：1995-12-15 00:00:00

abstract：:It is known that red wines have antioxidant properties owing to the presence of polyphenols and hydroxycinnamates. It has been reported that these compounds are efficient scavengers of peroxynitrite (ONOO(-)). We assayed the ONOO(-)-scavenging activity of plant polyphenols, hydroxycinnamates, and red wines using a flu...

journal_title：Annals of the New York Academy of Sciences

authors： Valdez LB,Actis-Goretta L,Boveris A

更新日期：2002-05-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTL) play a central role in successful control of HIV. Induction of effective CTL responses may therefore be an essential requirement of HIV vaccines. Knowledge of CTL epitopes targeted either in natural infection or following vaccination will be critical to understanding the anti-HIV immune r...

journal_title：Annals of the New York Academy of Sciences

authors： Goulder PJ

更新日期：2000-11-01 00:00:00

abstract：:Positron emission tomography allows for the study of human brain physiology and chemistry including cerebral blood flow, oxygen or glucose metabolism. We applied PET to study glucose metabolism using aphasia as a model of neurobehavior. The most striking observation was that the extent of cerebral glucose metabolic ch...

journal_title：Annals of the New York Academy of Sciences

authors： Metter EJ

更新日期：1991-01-01 00:00:00

abstract：:Exposure of LLC-PK1 epithelial cell cultures to phorbol ester tumor promoters causes immediate translocation of protein kinase C-alpha (PKC-alpha) from cytosolic to membrane-associated compartments. With a very similar time course, a dramatic and sustained increase in tight junctional (paracellular) permeability occur...

journal_title：Annals of the New York Academy of Sciences

authors： Mullin JM,Laughlin KV,Ginanni N,Marano CW,Clarke HM,Peralta Soler A

更新日期：2000-01-01 00:00:00

abstract：:Basal phagocytosis of neutrophils, a crucial component of non-specific immunity, is an eminently circadian parameter. In mice and rats, rates of phagocytosis peak in the second half of the dark span. A lipopolysaccharide-induced phagocytic response challenged in this period appears the most significant in amplitude an...

journal_title：Annals of the New York Academy of Sciences

authors： Hriscu ML

更新日期：2005-12-01 00:00:00

abstract：:Endometriosis is a common gynecologic disorder that affects approximately 14% of all women and 30% to 50% of infertile women. Since the most common symptoms of endometriosis--progressive dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility--are also symptoms of multiple disorders, a diagnosis of endometrios...

journal_title：Annals of the New York Academy of Sciences

authors： Rice VM

更新日期：2002-03-01 00:00:00

abstract：:Taking into account that methamphetamine (MA) is a popular recreational drug among young adult women, i.e., in gestational age, the present model aims to assess the effects of its exposure during development. In this experimental model, MA effects are assessed in the rat during the first month of life, regarding both ...

journal_title：Annals of the New York Academy of Sciences

authors： Gomes-DA-Silva J,Silva MC,Tavares MA

更新日期：1998-05-01 00:00:00

abstract：:The discovery of cell-free nucleic acids in plasma has opened up new possibilities for noninvasive clinical diagnosis. We demonstrate the presence of cell-free fetal RNA in maternal plasma, indicating that plasma fetal RNA might be used as a marker for noninvasive prenatal diagnosis. ...

journal_title：Annals of the New York Academy of Sciences

authors： Poon LL,Leung TN,Lau TK,Lo YM

更新日期：2001-09-01 00:00:00

abstract：:After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found. In this review, basic and clinical evidence is presented that assembles and hypothetically explains most of the key pathologic events associated with the development of AD. These pathologic events are triggered in AD by impai...

journal_title：Annals of the New York Academy of Sciences

authors： de la Torre JC

更新日期：2000-01-01 00:00:00

abstract：:Air particulate activity over all of the Northern Hemisphere reached its highest levels since the termination of nuclear weapons testing--sometimes up to 1 million times higher than before the Chernobyl contamination. There were essential changes in the ionic, aerosol, and gas structure of the surface air in the heavi...

journal_title：Annals of the New York Academy of Sciences

authors： Yablokov AV,Nesterenko VB,Nesterenko AV

更新日期：2009-11-01 00:00:00

abstract：:Semi-conservative replication ensures that the DNA sequence of sister chromatids is identical except for replication errors and variation in the length of telomere repeats resulting from replicative losses and variable end processing. What happens with the various epigenetic marks during DNA replication is less clear....

journal_title：Annals of the New York Academy of Sciences

authors： Lansdorp PM,Falconer E,Tao J,Brind'Amour J,Naumann U

更新日期：2012-08-01 00:00:00

abstract：:The general aim of this experiment was to investigate the processes involved in reading musical notation and to study the relationship between written music and its auditory representation. Our main interest was to determine if musicians can develop expectancies for plausible or implausible auditory events on the sole...

journal_title：Annals of the New York Academy of Sciences

authors： Schön D,Besson M

更新日期：2003-11-01 00:00:00

abstract：:The prevalence of obesity is rapidly increasing in the United States, particularly among women. Approximately 60-70% of hypertension in adults may be directly attributed to obesity. In addition, maternal obesity is a major risk factor for hypertensive disorders during pregnancy. The underlying mechanisms for the assoc...

journal_title：Annals of the New York Academy of Sciences

authors： Fu Q

更新日期：2019-10-01 00:00:00

abstract：:The scientific investigation of brains of different vertebrates, both extant and extinct, is of interest for several reasons: for translating medical research on rodent models into practice, for understanding the animals investigated in order to improve conservation and management strategies, and for understanding the...

journal_title：Annals of the New York Academy of Sciences

authors： Manger PR

更新日期：2011-05-01 00:00:00

abstract：:A number of important themes emerge from our compartmental analyses of Na,K-ATPase biosynthesis in response to ionic stimuli. The ubiquitous alpha 1 beta 1 type sodium pump evolved to generate and maintain transmembrane Na+ and K+ gradients, and there are cell-type specific mechanisms of increasing synthesis and decre...

journal_title：Annals of the New York Academy of Sciences

authors： McDonough AA,Azuma KK,Lescale-Matys L,Tang MJ,Nakhoul F,Hensley CB,Komatsu Y

更新日期：1992-11-30 00:00:00

abstract：:Modern neurostimulation approaches in humans provide controlled inputs into the operations of cortical regions, with highly specific behavioral consequences. This enables causal structure-function inferences, and in combination with neuroimaging, has provided novel insights into the basic mechanisms of action of neuro...

journal_title：Annals of the New York Academy of Sciences

authors： Bestmann S,Feredoes E

更新日期：2013-08-01 00:00:00

abstract：:Nonpathogenic enteric bacterial species initiate and perpetuate experimental colitis in interleukin-10 geneeficient mice (IL-10(-/-)). Bacteria-specific effects on the epithelium are difficult to distinguish because of the complex nature of the gut microflora. We showed that IL-10(-/-) mice compared to wild-type mice ...

journal_title：Annals of the New York Academy of Sciences

authors： Ruiz PA,Shkoda A,Kim SC,Sartor RB,Haller D

更新日期：2006-08-01 00:00:00

abstract：:Child maltreatment (CM) not only has detrimental and lifelong psychological consequences, but also can lead to lasting alterations in core physiological systems--a biological memory of CM. Furthermore, some of these alterations might even be transmitted to the next generation. This article describes current knowledge ...

journal_title：Annals of the New York Academy of Sciences

authors： Schury K,Kolassa IT

更新日期：2012-07-01 00:00:00

abstract：:Homozygous beta thalassemia affects thousands of people around the world. Current management of this condition includes regular transfusion of red cells, which leads to transfusional iron overload requiring chelation therapy: increasing hemoglobin levels while decreasing or eliminating iron overload is therefore a maj...

journal_title：Annals of the New York Academy of Sciences

authors： Dover GJ

更新日期：1998-06-30 00:00:00

abstract：:Most measurement devices for bioimpedance spectroscopy are coupled to the measured object (tissue) via electrodes. At frequencies > 500 kHz, they suffer from artifacts due to stray capacitances between electrode leads as well as between the ground and object. The noninvasive measurement of the brain conductivity is ha...

journal_title：Annals of the New York Academy of Sciences

authors： Scharfetter H,Ninaus W,Puswald B,Petrova GI,Kovachev D,Hutten H

更新日期：1999-04-20 00:00:00

abstract：:The discovery of AQP4-IgG (a pathogenic antibody that targets the astrocytic water channel aquaporin-4), as the first sensitive and specific biomarker for any inflammatory central nervous system demyelinating disease (IDD), has shifted emphasis from the oligodendrocyte and myelin to the astrocyte as a central immunopa...

journal_title：Annals of the New York Academy of Sciences

authors： Pittock SJ,Lucchinetti CF

更新日期：2016-02-01 00:00:00

abstract：:Interleukin (IL)-11 is a member of the gp130 family of cytokines. Comparison of IL-11 with another gp130 family member, IL-6, indicates that these two cytokines share many overlapping signal transduction mechanisms. However, unlike IL-6, treatment of patients with a recombinant human form of IL-11 (rhIL-11) does not i...

journal_title：Annals of the New York Academy of Sciences

authors： Trepicchio WL,Dorner AJ

更新日期：1998-09-29 00:00:00