Causes of intrauterine growth restriction and the postnatal development of the metabolic syndrome.

Abstract:

:The term intrauterine growth restriction (IUGR) is assigned to newborns with a birth weight and/or birth length below the 10th percentile for their gestational age and whose abdominal circumference is below the 2.5th percentile with pathologic restriction of fetal growth. IUGR is usually due to maternal, fetal, or placental factors. However, many IUGR cases have unknown underlying cause. Recent studies focus on new factors that can influence fetal development and birth outcome like the timing and the type of fetal nutrition, maternal psychosocial stress and personality variables, 11beta-hydroxysteroid dehydrogenase type 2 placental activity, the activity of the neuroendocrine system that mediates the effects of psychosocial stress, and the role of proinflammatory cytokines and of oxidative stress. Data have shown that IUGR is associated with a late life increased prevalence of metabolic syndrome, a condition associating obesity with hypertension, type 2 diabetes mellitus (DM2), and cardiovascular disease. Recent data demonstrated that the diabetes-associated mortality appears to be disproportionately concentrated among individuals of abnormal birth weight.

journal_name

Ann N Y Acad Sci

authors

Valsamakis G,Kanaka-Gantenbein C,Malamitsi-Puchner A,Mastorakos G

doi

10.1196/annals.1365.012

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

138-47

eissn

0077-8923

issn

1749-6632

pii

1092/1/138

journal_volume

1092

pub_type

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