Abstract:
:The M1 antigens, associated with gastric fucomucin, the early oncofetal precancerous marker for the distal colon, were studied using the immunoperoxidase method in the distal colon. We compared human tumoral mucosa with that of rats during DMH-induced carcinogenesis. In both cases we examined histologically normal mucosa, mucinous hyperplasia, glands with serrated epithelium and hypermature goblet cells like those observed in human hyperplastic polyps, dysplasia, and transitional mucosa. We were able to assess similarities between these rat and human mucosae in terms of the tissue and cell location of these M1 antigens as well as the frequency of occurrence in the different comparative lesions. Thus, we demonstrated that such similarities can be observed not only at a histologic level, but also on a molecular level. The presence of M1 antigens in the human distal colon is comparable to mucous modifications induced by a chemical carcinogen, as observed during DMH-induced carcinogenesis in the rat.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Bara J,Decaens C,Burtin Pdoi
10.1111/j.1749-6632.1983.tb32862.xsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
182-94eissn
0077-8923issn
1749-6632journal_volume
417pub_type
杂志文章abstract::Acute viral infection of humans induces virus-specific serum antibody production that often persists for decades. To better understand the nature of this long-term antiviral antibody response, we studied antiviral antibody production of mice acutely infected with lymphocytic choriomeningitis virus (LCMV). Although thi...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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journal_title:Annals of the New York Academy of Sciences
pub_type: 历史文章,杂志文章
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2010-08-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1988.tb40412.x
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,多中心研究
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更新日期:1997-06-17 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2012-04-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2008-01-01 00:00:00
abstract::Decreased postural stability is observed in most astronauts immediately following spaceflight. Because ataxia may present postflight operational hazards, it is important to determine the incidence of postural instability immediately following landing and the dynamics of recovery of normal postural equilibrium control....
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1992.tb25253.x
更新日期:1992-05-22 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2016-10-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
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更新日期:2006-08-01 00:00:00
abstract::The present study was aimed at finding neural correlates of aesthetic versus descriptive listening of the same musical cadences. Results showed that aesthetic listening generated greater right frontocentral negativities than did descriptive listening, indicating distinct cortical mechanisms for aesthetic versus descri...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
abstract::Nerve agents (NAs) produce acute and long-term brain injury and dysfunction, as evident from the Japan and Syria incidents. Magnetic resonance imaging (MRI) is a versatile technique to examine such chronic anatomical, functional, and neuronal damage in the brain. The objective of this study was to investigate long-ter...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/nyas.14431
更新日期:2020-11-01 00:00:00
abstract::Estrogens are represented by a diverse group of compounds. Within this large family of molecules are tissue-selective estrogens that have been classified as selective estrogen receptor modulators (SERMs). These compounds are characterized by the fact that they exhibit both estrogen agonist and antagonist activity depe...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2001.tb04039.x
更新日期:2001-12-01 00:00:00
abstract::A majority of incidentally found adrenal tumors derive from the adrenal cortex. The aim of our study was evaluation of the incidence of chromaffin tumors in a group of 1,111 patients with adrenal incidentalomas. In this group there were 803 women and 308 men, aged 10-87 years. Clinical examination, imaging studies (ul...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1353.004
更新日期:2006-08-01 00:00:00