Role of animal and human pharmacology in antifungal drug design.

abstract：:Various biological activities of peptides have been found. In this study, the induction of apoptosis in a human lymphoma cell line (U937) by peptide fraction separated from anchovy sauce was studied using biochemical and flow cytometric methods. After U937 was treated with a hydrophobic peptide fraction of the anchovy...

journal_title：Annals of the New York Academy of Sciences

authors： Lee YG,Kim JY,Lee KW,Kim KH,Lee HJ

更新日期：2003-12-01 00:00:00

abstract：:Nicotinamide can protect the NOD mouse from diabetes if given early enough and in sufficient dose. The effect partly wanes with time. There is reduced islet inflammation. Similar protective effects can be demonstrated in quasi-experimental interventions in humans--both diabetes related and unrelated deemed at risk of ...

journal_title：Annals of the New York Academy of Sciences

authors： Elliott RB,Pilcher CC,Stewart A,Fergusson D,McGregor MA

更新日期：1993-11-30 00:00:00

abstract：:Despite new technological advances in the rehabilitation of audition in profoundly deaf children, auditory training remains a fundamental part of their education. Consequently, it is necessary to learn what kind of stimuli, what kind of auditory tasks, and what kind of learning procedures generate faster and more long...

journal_title：Annals of the New York Academy of Sciences

authors： Rochette F,Bigand E

更新日期：2009-07-01 00:00:00

abstract：:Our cumulative experience continues to validate the fetal nucleated erythrocyte as the target fetal cell type of choice, primarily because it reflects the cytogenetic status of the current pregnancy. Additional cell types, such as the granulocyte, await further study. Quantitative PCR is a sensitive and useful new met...

journal_title：Annals of the New York Academy of Sciences

authors： Bianchi DW

更新日期：1994-09-07 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are a rare population of circulating cells that selectively express Toll-like receptors (TLR)7 and TLR9 and have the capacity to produce large amounts of type I interferons (IFNs) in response to viruses or host-derived nucleic acid-containing complexes. Through the production of typ...

journal_title：Annals of the New York Academy of Sciences

authors： Lande R,Gilliet M

更新日期：2010-01-01 00:00:00

abstract：:Preliminary reports indicate the influence of oxidative stress and interleukins, particularly TGF-beta1, in maintenance of bone mass. This study was designed to determine any possible variations of cellular lipid peroxidation, the total antioxidant power, and concentration of TGF-beta1 in blood and saliva of osteoporo...

journal_title：Annals of the New York Academy of Sciences

authors： Yousefzadeh G,Larijani B,Mohammadirad A,Heshmat R,Dehghan G,Rahimi R,Abdollahi M

更新日期：2006-12-01 00:00:00

abstract：:The human organism is in a state of dynamic equilibrium, homeostasis. The stress system is activated when homeostasis is challenged by extrinsic or intrinsic forces, the stressors. This system, whose central component is the central nervous system (CNS) and includes corticotropin-releasing hormone (CRH) and noradrener...

journal_title：Annals of the New York Academy of Sciences

authors： Stratakis CA,Chrousos GP

更新日期：1995-12-29 00:00:00

abstract：:The striatum is the major input nucleus of the basal ganglia. It is thought to play a key role in learning on the basis of positive reinforcement and in action selection. One view of the striatum conceives it as comprising a reiterated matrix of processing units that perform common operations in different striatal reg...

journal_title：Annals of the New York Academy of Sciences

authors： Wickens JR,Budd CS,Hyland BI,Arbuthnott GW

更新日期：2007-05-01 00:00:00

abstract：:Especially since the (re-)discovery of T cell subpopulations with specialized regulatory activities, mechanisms of anti-inflammatory T cell regulation are studied very actively and are expected to lead to the development of novel immunotherapeutic approaches, especially in chronic inflammatory diseases. Heat shock pro...

journal_title：Annals of the New York Academy of Sciences

authors： Van Eden W,Wick G,Albani S,Cohen I

更新日期：2007-10-01 00:00:00

abstract：:The M1 antigens, associated with gastric fucomucin, the early oncofetal precancerous marker for the distal colon, were studied using the immunoperoxidase method in the distal colon. We compared human tumoral mucosa with that of rats during DMH-induced carcinogenesis. In both cases we examined histologically normal muc...

journal_title：Annals of the New York Academy of Sciences

authors： Bara J,Decaens C,Burtin P

更新日期：1983-01-01 00:00:00

abstract：:Chemical hypoxia produces depletion of ATP, intracellular Ca2+ overload, and cell death. The role of Na+/Ca2+ exchanger (NCX), the major plasma membrane Ca2+ extruding system, has been explored in chemical hypoxia using BHK cells stably transfected with the three mammalian NCX isoforms: NCX1, NCX2, and NCX3. Here we r...

journal_title：Annals of the New York Academy of Sciences

authors： Secondo A,Staiano IR,Scorziello A,Sirabella R,Boscia F,Adornetto A,Canzoniero LM,Di Renzo G,Annunziato L

更新日期：2007-03-01 00:00:00

abstract：:Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited ...

journal_title：Annals of the New York Academy of Sciences

authors： Soonpaa MH,Daud AI,Koh GY,Klug MG,Kim KK,Wang H,Field LJ

更新日期：1995-03-27 00:00:00

abstract：:Agonist interactions with release processes do not validate autoreceptor operation. Instead, the data suggests that autoreceptors function as homoreceptors. Declining efficacy of agonist inhibition of transmitter release with increasing stimulation "intensity" is not assignable to competition with endogenous transmitt...

journal_title：Annals of the New York Academy of Sciences

authors： Kalsner S

更新日期：1990-01-01 00:00:00

abstract：:The immunotherapeutic agent ipilimumab has helped address a significant unmet need in the treatment of advanced melanoma. Ipilimumab is a fully human monoclonal antibody that targets cytotoxic T-lymphocyte antigen-4 (CTLA-4), thereby augmenting antitumor immune responses. After decades in which a number of clinical tr...

journal_title：Annals of the New York Academy of Sciences

authors： Wolchok JD,Hodi FS,Weber JS,Allison JP,Urba WJ,Robert C,O'Day SJ,Hoos A,Humphrey R,Berman DM,Lonberg N,Korman AJ

更新日期：2013-07-01 00:00:00

abstract：:Cell transplantation therapy for diabetes and Parkinson's disease offers hope for long-term alleviation of symptoms. However, successful protocols remain elusive due to obstacles, including rejection and lack of tropic support for the graft. To enhance engraftment, testis-derived postmitotic Sertoli cells have been co...

journal_title：Annals of the New York Academy of Sciences

authors： Cameron DF,Hushen JJ,Nazian SJ,Willing A,Saporta S,Sanberg PR

更新日期：2001-11-01 00:00:00

abstract：:Certain livestock diseases in sub-Saharan Africa, such as foot-and-mouth disease are difficult to control because of the large numbers of infected wildlife hosts. These wildlife disease reservoirs form a continuous hazard of transmittal of the diseases to domestic livestock, which limits the access of livestock produc...

journal_title：Annals of the New York Academy of Sciences

authors： Sutmoller P

更新日期：2002-10-01 00:00:00

abstract：:The gene encoding thermostable alanine recemase from Bacillus stearothermophilus was cloned and expressed in E. coli. The enzyme was purified to homogeneity from cell extracts of E. coli carrying a plasmid designated pICR4. The alanine racemase gene sequenced was found to contain an open reading frame of 1158 nucleoti...

journal_title：Annals of the New York Academy of Sciences

authors： Soda K,Tanizawa K

更新日期：1990-01-01 00:00:00

abstract：:The cell nucleus is a prominent target of autoantibodies in systemic autoimmune disorders. Approximately 2% of the population in Europe and North America suffers from systemic rheumatic diseases, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), and scleroderma. The molecular mechanisms of systemic aut...

journal_title：Annals of the New York Academy of Sciences

authors： Chen M,von Mikecz A

更新日期：2005-06-01 00:00:00

abstract：:Influenza A virus infections result in approximately 500,000 human deaths per year and many more sublethal infections. Wild birds are recognized as the ancestral host of influenza A viruses, and avian viruses have contributed genetic material to most human viruses, including subtypes H5N1 and H1N1. Thus, influenza vir...

journal_title：Annals of the New York Academy of Sciences

authors： Vandegrift KJ,Sokolow SH,Daszak P,Kilpatrick AM

更新日期：2010-05-01 00:00:00

abstract：:Patients with renal impairment have an increased risk for cardiovascular disease, which may be the result of advanced glycation end products (AGEs). The aim of this study was to investigate the levels of AGE peptides in relation to kidney function and to study the relationship of AGE peptides with endothelial function...

journal_title：Annals of the New York Academy of Sciences

authors： Schalkwijk CG,Ter Wee PM,Stehouwer CD

更新日期：2005-06-01 00:00:00

abstract：:Rats inoculated once with nicotinic acetylcholine receptor and adjuvants had two episodes of weakness, the first being acute and transient, starting on day 8, and remitting in a few days, the second, chronic, progressive, and appearing after day 20. In the acute phase, the compound action potential and twitch evoked ...

journal_title：Annals of the New York Academy of Sciences

authors： Lambert EH,Lindstrom JM,Lennon VA

更新日期：1976-01-01 00:00:00

abstract：:In Bar Harbor 129 dystrophic mice, thymic development is abnormal. Before weaning, the thymus is slightly smaller than in phenotypically normal littermates; after weaning, however, the lymphoid elements undergo rapid atrophy. The epithelial elements, in contrast, display hyperlasia. Thymectomy has no influence on the ...

journal_title：Annals of the New York Academy of Sciences

authors： Horrobin DF,Morgan RO,Karmali RA,Ally AI,Manku MS,Karmazyn M,Cunnane SC

更新日期：1979-01-01 00:00:00

abstract：:The characterization of the molecular mechanisms involved in low-oxygen chemotransduction has been an active field of research since the first description of an oxygen-sensitive K(+) channel in rabbit carotid body (CB) chemoreceptor cells. As a result, a large number of components of the transduction cascade, from O(2...

journal_title：Annals of the New York Academy of Sciences

authors： Gonzalez C,Vaquero LM,López-López JR,Pérez-García MT

更新日期：2009-10-01 00:00:00

abstract：:Mammalian spermatogenesis is a complex developmental process. Spermatozoa, like ova, are uniquely capable of supporting embryonic development. Our approach to understanding this process is to identify genes whose developmental pattern of expression suggests that they may play a role in spermatogenesis. Experiments on ...

journal_title：Annals of the New York Academy of Sciences

authors： Duggal RN,Zakeri ZF,Ponzetto C,Wolgemuth DJ

更新日期：1987-01-01 00:00:00

abstract：:Few studies have evaluated the impact of nutritional supplementation among pregnant adolescents. We examined the effects of the Rang Din Nutrition Study (RDNS) interventions on children born to mothers <20 years of age. The RDNS was a cluster-randomized effectiveness trial with four arms: (1) women and children both r...

journal_title：Annals of the New York Academy of Sciences

authors： Dewey KG,Matias SL,Mridha MK,Arnold CD

更新日期：2020-05-01 00:00:00

abstract：:Recent immunologic studies have provided important new information about the nature of AHF deficiency diseases and the structure and synthesis of this protein. They provide, moreover, a considerably improved ability to identify the carrier state in hemophilia A. Additional progress may be possible in the identificatio...

journal_title：Annals of the New York Academy of Sciences

authors： Hoyer LW,Rick ME

更新日期：1975-01-20 00:00:00

abstract：:In 2014, there was an outbreak of beriberi on Kuria, a remote atoll in Kiribati, a small Pacific Island nation. A thiamine-poor diet consisting mainly of rice, sugar, and small amounts of fortified flour was likely to blame. We aimed to design a food fortification strategy to improve thiamine intakes in Kuria. We surv...

journal_title：Annals of the New York Academy of Sciences

authors： Green TJ,Whitfield KC,Daniels L,Brown RC,Houghton LA

更新日期：2021-01-12 00:00:00

abstract：:Coccidioides causes coccidioidomycosis in the southwestern United States. Its clinical manifestations range from the primary asymptomatic to progressive pulmonary and extrapulmonary disease. Because of endemicity, frequent relapse, and virulent nature of Coccidioides, there is an urgent need for the development of eff...

journal_title：Annals of the New York Academy of Sciences

authors： Awasthi S

更新日期：2007-09-01 00:00:00

abstract：:Indoor air pollution occurs as an undesirable consequence of urbanization, energy conservation, indoor bioaerosol contamination, and use of synthetic materials and new technologies, and has become a worldwide concern. It is important to comprehend not only the diversity of pollutant hazards but also to develop novel m...

journal_title：Annals of the New York Academy of Sciences

authors： Brooks BO,Aldrich FD,Utter GM,DeBroy JA,Schimke RD

更新日期：1992-04-30 00:00:00

abstract：:When an arbovirus enters an arthropod in an infected blood meal, several mechanisms may interact to affect its life cycle and ultimate transmissibility. Intrinsic absolute failure in the establishment of infection must be contrasted with infection that is successfully established but is variably modulated in its viral...

journal_title：Annals of the New York Academy of Sciences

authors： Murphy FA

更新日期：1975-01-01 00:00:00