Potential approaches for myocardial regeneration.

Abstract:

:Cardiomyocytes in the adult mammal retain little or none of their developmental capacity for hyperplastic growth. As a consequence of this differentiated, nonproliferative phenotype, cardiomyocyte loss due to injury or disease is irreversible. Therapeutic intervention in end-stage diseased hearts is currently limited to cardiac transplantation. An increase in cardiomyocyte number in diseased hearts could improve function. Augmentation of the cardiomyocyte population may be achievable by the expression of regulatory proteins in the myocardium, or by intracardiac grafting of exogenous cardiomyocytes.

journal_name

Ann N Y Acad Sci

authors

Soonpaa MH,Daud AI,Koh GY,Klug MG,Kim KK,Wang H,Field LJ

doi

10.1111/j.1749-6632.1995.tb17454.x

subject

Has Abstract

pub_date

1995-03-27 00:00:00

pages

446-54

eissn

0077-8923

issn

1749-6632

journal_volume

752

pub_type

杂志文章,评审
  • Micronutrient status and human immunodeficiency virus (HIV) infection.

    abstract::This study surveyed serum concentrations of vitamins, electrolytes, and trace elements in subjects seropositive for HIV-1 by ELISA and confirmatory Western blot. Thirty subjects (26 males, 4 females) were recruited at a hospital clinic. Seventeen were classified as having mild or severe ARC (AIDS-related complex), 7 h...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1990.tb00146.x

    authors: Bogden JD,Baker H,Frank O,Perez G,Kemp F,Bruening K,Louria D

    更新日期:1990-01-01 00:00:00

  • Origins of pathogenic anti-DNA idiotypes in the NZB X SWR model of lupus nephritis.

    abstract::The investigations with the NZB X SWR model show that the development of systemic autoimmune disease is a multistep, multigene process. Severe lupus nephritis in the NZB X SWR hybrids results from the interaction of genes inherited from both the autoimmune NZB and the normal SWR parents. A similar genetic interaction ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1986.tb20855.x

    authors: Datta SK,Gavalchin J

    更新日期:1986-01-01 00:00:00

  • Decreased catecholamine-induced cell death in B lymphocytes from patients with rheumatoid arthritis.

    abstract::The expression of beta2-adrenergic receptors (beta2-R) on B lymphocytes and agonist-induced cAMP production is reduced in patients with rheumatoid arthritis (RA). To further study functional consequences of the diminished beta2-R density on B lymphocytes in RA patients, agonist-induced cell death was evaluated and com...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04243.x

    authors: Wahle M,Pierer M,Krause A,Kolker S,Baerwald CG

    更新日期:2002-06-01 00:00:00

  • Systemic neutralization of TGF-β attenuates osteoarthritis.

    abstract::Osteoarthritis (OA) is a major source of pain and disability worldwide with no effective medical therapy due to poor understanding of its pathogenesis. Transforming growth factor β (TGF-β) has been reported to play a role in subchondral bone pathology and articular cartilage degeneration during the progression of OA. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.13000

    authors: Xie L,Tintani F,Wang X,Li F,Zhen G,Qiu T,Wan M,Crane J,Chen Q,Cao X

    更新日期:2016-07-01 00:00:00

  • Reproductive aging: theoretical perspectives, mechanisms, nonhuman models, and health correlates.

    abstract::Every 365.2421999 days--more or less--the earth rotates, revolves, wobbles, and precesses along an elliptical path around the sun. Those of us who survive the journey are a year older: we have aged one solar year. Some years we seem to age faster than other years; some people seem to age faster than other people; some...

    journal_title:Annals of the New York Academy of Sciences

    pub_type:

    doi:10.1111/j.1749-6632.2010.05700.x

    authors: Haaga J,O'Connor K,Weinstein M,Wise P

    更新日期:2010-08-01 00:00:00

  • Closure, function, emergence, semiosis, and life: the same idea? Reflections on the concrete and the abstract in theoretical biology.

    abstract::In this note epistemological problems in general theories about living systems are considered; in particular, the question of hidden connections between different areas of experience, such as folk biology and scientific biology, and hidden connections between central concepts of theoretical biology, such as function, ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2000.tb06278.x

    authors: Emmeche C

    更新日期:2000-01-01 00:00:00

  • Prolactin and neuroimmunomodulation: in vitro and in vivo observations.

    abstract::Prolactin (PL) is a mammotropic neuropeptide produced by the pituitary and extrapituitary cells existing as several isoforms and belongs to the growth and lactogenic hormone family, which includes growth hormone and placental lactogens. The secretion of pituitary PL is under hypothalamic control. The cytokines IL-1, I...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb07629.x

    authors: Chikanza IC

    更新日期:1999-06-22 00:00:00

  • Occurrence of Bartonella henselae and Bartonella quintana among human immunodeficiency virus-infected patients.

    abstract::The purpose of this study was to determine the seroprevalence against Bartonella henselae and Bartonella quintana among a risk group, patients with HIV infection, and to identify the epidemiological factors involved. Our data indicate that the prevalence of Bartonella infection among HIV-infected patients is much grea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1355.047

    authors: Pape M,Kollaras P,Mandraveli K,Tsona A,Metallidis S,Nikolaidis P,Alexiou-Daniel S

    更新日期:2005-12-01 00:00:00

  • Lewy body pathology in fetal grafts.

    abstract::Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [(18)F]6-fluroro-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understa...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2009.05229.x

    authors: Chu Y,Kordower JH

    更新日期:2010-01-01 00:00:00

  • Interactions between psychiatric and physical disorders and their effects on the risks of suicide: a nested case-control study.

    abstract::Previous studies, which included predominantly Caucasian populations, examined psychiatric and physical illness and associated suicide risk. We used a nationwide database to reassess the findings in an Asian population, and also analyzed the influence of different onset timing of psychiatric and physical illness and t...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14216

    authors: Chang CF,Yeh MK,Chien WC,Chung CH,Li TT,Lai EC

    更新日期:2020-02-01 00:00:00

  • Transplantation of pancreatic islets contained in minimal volume microcapsules in diabetic high mammalians.

    abstract::To minimize technical problems relating to excessive size (600-800 mu in diameter) of standard alginate microcapsules (CSM) for pancreatic islet graft immunoisolation, we have developed two novel minimal volume, chemically identical, capsule prototypes (MVC): 1) coherent microcapsules (CM), and 2) medium-size microcap...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1999.tb08506.x

    authors: Calafiore R,Basta G,Luca G,Boselli C,Bufalari A,Bufalari A,Cassarani MP,Giustozzi GM,Brunetti P

    更新日期:1999-06-18 00:00:00

  • Prenatal cocaine exposure: long-term deficits in learning and motor performance.

    abstract::We have developed a rabbit model of in utero exposure to intravenous injections of cocaine given twice daily to dams from gestational days 8-29. At the doses employed (4 mg/kg, injected twice daily), no differences were found in the body weight gain of dams, time to delivery, litter size, and body weight or other phys...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:

    authors: Romano AG,Harvey JA

    更新日期:1998-06-21 00:00:00

  • Fertility drugs and gynecologic cancer.

    abstract::Fertility drugs (FD) are spreading worldwide fast and therefore many studies have reviewed the possible association between the use of these drugs and cancer. Since the drugs used for ovulation induction during in vitro fertilization (IVF) like hCG, hMG, rFSH increase the levels of gonadal hormones, concerns have grow...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1196/annals.1365.022

    authors: Kanakas N,Mantzavinos T

    更新日期:2006-12-01 00:00:00

  • Structure/function studies of the gamma subunit of the Na,K-ATPase.

    abstract::The Na,K-ATPase gamma subunit is present primarily in kidney as two splice variants, gammaa and gammab, which differ only at their extracellular N-termini. Two distinct effects of gamma are seen in biochemical Na,K-ATPase assays of mammalian (HeLa) cells transfected with gammaa or gammab, namely, (i) a decrease in K'(...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.2003.tb07224.x

    authors: Blostein R,Pu HX,Scanzano R,Zouzoulas A

    更新日期:2003-04-01 00:00:00

  • Ontogeny of neurokinin-1 receptor mediation of methamphetamine neurotoxicity in the striatum of the mouse brain.

    abstract::We studied the role of the peptide substance P, signaling through the neurokinin-1 (NK-1) receptor, on methamphetamine-induced loss of dopamine transporter sites, a well-documented marker of toxicity in the striatum of the mouse brain, because this peptide is under dynamic regulation by the neurotransmitter dopamine. ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb04166.x

    authors: Yu J,Allison S,Ibrahim D,Cadet JL,Angulo JA

    更新日期:2002-06-01 00:00:00

  • Immunomodulating activity of myelopeptides: clinical trials.

    abstract::Bone marrow cells of various animal species and the human produce a group of bioregulatory peptides called myelopeptides (MPs). A highly purified myelopeptide (MP) fraction and some individual molecules have been isolated from the supernatant of the porcine bone marrow cell culture by successive gel chromatography and...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1993.tb35888.x

    authors: Petrov RV

    更新日期:1993-06-23 00:00:00

  • The stress concept and neuroimmunoregulation in modern biology.

    abstract::Sixty years ago Hans Selye discovered that the neuroendocrine and immune systems interact during stress. The pathophysiological significance of neuroendocrine-immune interaction during injury has only been recognized recently. Today it is rapidly emerging that, in addition to defense against exogenous pathogenic agent...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb08969.x

    authors: Berczi I

    更新日期:1998-06-30 00:00:00

  • Fetal sex identification in maternal plasma by means of short tandem repeats on chromosome x.

    abstract::Analysis of fetal DNA in maternal plasma has recently been introduced as a new method for noninvasive prenatal diagnosis. In the majority of cases, the Y chromosome-specific sequences are commonly used as a fetus-specific marker with a high risk of false-negative cases. We attempted to develop a sensitive and reliable...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1448.038

    authors: Vecchione G,Tomaiuolo M,Sarno M,Colaizzo D,Petraroli R,Matteo M,Greco P,Grandone E,Margaglione M

    更新日期:2008-08-01 00:00:00

  • Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.

    abstract::Curcumin (diferuloylmethane) is a nontoxic dietary pigment in tumeric and curry and a potent inhibitor of the common transcription factor Nuclear Factor kappaB (NF-kappaB) in several cell types. It is well established that some of the catabolic effects of the proinflammatory cytokines interleukin-1beta (IL-1beta) and ...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1329.067

    authors: Schulze-Tanzil G,Mobasheri A,Sendzik J,John T,Shakibaei M

    更新日期:2004-12-01 00:00:00

  • Neuroimaging, neuromodulation, and population health: the neuroscience of chronic disease prevention.

    abstract::Preventable chronic diseases are the leading cause of death in the majority of countries throughout the world, and this trend will continue for the foreseeable future. The potential to offset the social, economic, and personal burdens associated with such conditions depends on our ability to influence people's thought...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/nyas.13868

    authors: Hall PA,Bickel WK,Erickson KI,Wagner DD

    更新日期:2018-09-01 00:00:00

  • Oxidation, lipoxygenase, and atherogenesis.

    abstract::Mounting evidence suggests that oxidative processes contribute to the pathogenesis of atherosclerosis and that antioxidants may represent a strategy to complement the lowering of lipids in the therapy of this disease. Although multiple molecular events have been identified in vitro and although it is tempting to ascri...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1994.tb12046.x

    authors: Sigal E,Laughton CW,Mulkins MA

    更新日期:1994-04-18 00:00:00

  • Prologue: mind over molecule: activating biological demons.

    abstract::The new vogue for systems biology is an important development. It is time to complement reductionist molecular biology by integrative approaches. But this welcome development is in danger of losing its way. Many of the early implementations of the approach are very low level, in some cases hardly more than an extensio...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1420.000

    authors: Noble D

    更新日期:2008-03-01 00:00:00

  • The viral eukaryogenesis hypothesis: a key role for viruses in the emergence of eukaryotes from a prokaryotic world environment.

    abstract::Understanding how the gulf between prokaryotic and eukaryotic cellular design arose is a major challenge. The viral eukaryogenesis (VE) hypothesis addresses the challenge of eukaryotic origins by suggesting the first eukaryotic cell was a multimember consortium consisting of a viral ancestor of the nucleus, an archaea...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2009.04994.x

    authors: Bell PJ

    更新日期:2009-10-01 00:00:00

  • Low frequency of autoantibodies to islet cell, glutamic acid decarboxylase, and second-islet antigen in patients with gestational diabetes mellitus: a follow-up study.

    abstract::The aim of the study was to determine the frequency of patients with gestational diabetes mellitus (GDM) who have serological markers typical of autoimmune type 1 DM. The specific pancreatic markers, ICAs, glutamic decarboxylase (GADAbs), and second islet antigen (IA2Abs), were measured in 70 women with GDM during the...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.2002.tb02983.x

    authors: Lapolla A,Fedele D,Pedini B,Dal Fra MG,Sanzari M,Masin M,Zanchetta R,Betterle C

    更新日期:2002-04-01 00:00:00

  • Spatialization in working memory: can individuals reverse the cultural direction of their thoughts?

    abstract::A recent study based on the SPoARC effect (spatial position association response codes) showed that culture heavily shapes cognition and more specifically the way thought is organized; when Western adults are asked to keep in mind a sequence of colors, they mentally organize them from left to right, whereas right-to-l...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/nyas.14499

    authors: Guida A,Mosinski F,Cipora K,Mathy F,Noël Y

    更新日期:2020-10-01 00:00:00

  • A natural toxic defense system: cardenolides in butterflies versus birds.

    abstract::We have verified that wild birds can become conditioned to reject naturally toxic insects either visually (experiment 1) or by taste (experiment 2). We have also verified, however, that unconditioned taste rejection of noxious chemicals by wild birds also occurs (experiment 3). Such unconditioned responses to the apos...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1985.tb27072.x

    authors: Brower LP,Fink LS

    更新日期:1985-01-01 00:00:00

  • LHRH and sexual dimorphism.

    abstract::An increasing amount of evidences suggests that galanin plays an important role in the regulation of reproduction in the rat. Galanin is colocalized with luteinizing hormone-releasing hormone (LHRH) in a subset of LHRH neurons, and the pattern of coexpression is sexually dimorphic, with a higher incidence of colocaliz...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb10694.x

    authors: Merchenthaler I

    更新日期:1998-12-21 00:00:00

  • Growth activation of resting cells: induction of balanced and imbalanced growth.

    abstract::Little is known about how mitogenic factors generate growth regulatory signals and how these are mediated within the cell. We have developed three different types of mitogenic stimuli in order to identify the possible existence of common denominators in a complex and perhaps pleiotypic signal-response system. 3T3 cell...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1111/j.1749-6632.1982.tb43423.x

    authors: Zetterberg A,Engström W,Larsson O

    更新日期:1982-12-10 00:00:00

  • Studies of eccentric gaze stability: effects of pitch head position on horizontal gaze-holding in patients with cerebellar disease.

    abstract::We studied the effects of change of head position in the pitch plane on the ability to hold horizontal eccentric gaze in five patients with cerebellar disorders. All patient showed a change in the time constant of horizontal centripetal drift when the head was pitched forward or back. This result suggests that otolith...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章

    doi:10.1196/annals.1325.075

    authors: Wilson E,Sng K,Somers JT,Reschke MF,Leigh RJ

    更新日期:2005-04-01 00:00:00

  • Sarcoplasmic reticulum proteins in heart failure.

    abstract::Altered calcium homeostasis may play a key role in the pathophysiology of human heart failure. Levels of sarcoplasmic reticulum (SR) proteins and sarcolemmal Na(+)-Ca2+ exchanger were analyzed by Western blot in failing and nonfailing human myocardium and related to myocardial function. Levels of the SR calcium releas...

    journal_title:Annals of the New York Academy of Sciences

    pub_type: 杂志文章,评审

    doi:10.1111/j.1749-6632.1998.tb08270.x

    authors: Lehnart SE,Schillinger W,Pieske B,Prestle J,Just H,Hasenfuss G

    更新日期:1998-09-16 00:00:00