Abstract:
:The new vogue for systems biology is an important development. It is time to complement reductionist molecular biology by integrative approaches. But this welcome development is in danger of losing its way. Many of the early implementations of the approach are very low level, in some cases hardly more than an extension of genomics and bioinformatics. In this paper, I outline some general principles that could form the basis of systems biology as a truly multilevel approach. We need the insights obtained from a higher level analysis in order to succeed at the lower levels. Higher levels in biological systems impose boundary conditions on the lower levels. Without understanding those conditions and their effects, we will be seriously restricted in understanding the logic of living systems. Sydney Brenner has insisted that "the cell is the correct level of abstraction." I would go further and insist on the value of abstraction at even higher levels than the cell, while recognizing the cell as a landmark level of biological organization. The principles outlined are illustrated with examples from cardiac and other aspects of physiology and biochemistry.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Noble Ddoi
10.1196/annals.1420.000subject
Has Abstractpub_date
2008-03-01 00:00:00pages
xi-xixeissn
0077-8923issn
1749-6632pii
1123/1/xijournal_volume
1123pub_type
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
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journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
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