Human placental nucleoside kinase activities.

abstract：:Tight junction (TJ) properties are determined by membrane protein complexes of neighboring cells that form both a barrier and a selective pathway for paracellular substrate transport. Our previous work supports the view that paracellular permeability changes in the thick ascending limb (TAL) may underlie the mechanism...

journal_title：Annals of the New York Academy of Sciences

authors： Shan Q,Himmerkus N,Hou J,Goodenough DA,Bleich M

更新日期：2009-05-01 00:00:00

abstract：:Studies of the ability of the EPR spin trap DEPMPO to detect both superoxide and hydroxyl radicals produced by systems in vitro and in vivo are presented. Experiments using free radical-generating systems confirmed the suitability of the EPR spin trapping technique but also revealed the existence of an undesirable con...

journal_title：Annals of the New York Academy of Sciences

authors： Mojović M,Vuletić M,Bacić GG

更新日期：2005-06-01 00:00:00

abstract：:Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (ApoE)-epsilon 4 allele. Insulin has also been implicated in processing of beta-amyloid and amyloid precur...

journal_title：Annals of the New York Academy of Sciences

authors： Craft S,Asthana S,Schellenberg G,Baker L,Cherrier M,Boyt AA,Martins RN,Raskind M,Peskind E,Plymate S

更新日期：2000-04-01 00:00:00

abstract：:Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved extremely useful for binding and autoradiographic studies. More recently we have synthesized a ...

journal_title：Annals of the New York Academy of Sciences

authors： Hudson AL,Gough R,Tyacke R,Lione L,Lalies M,Lewis J,Husbands S,Knight P,Murray F,Hutson P,Nutt DJ

更新日期：1999-06-21 00:00:00

abstract：:Although Lyme disease (LD) is the most common tick-borne disease in the United States, little is known about the frequency of and risk factors for infection with Borrelia burgdorferi in occupational groups. In 1986, we recruited primarily outdoor workers from six employee groups in southeastern New York where LD is en...

journal_title：Annals of the New York Academy of Sciences

authors： Smith PF,Benach JL,White DJ,Stroup DF,Morse DL

更新日期：1988-01-01 00:00:00

abstract：:Newly molted Boophilus microplus females obtained in a laboratory at 30 degrees C and environmental relative humidity (RH) were employed. An original device was used to hold ticks during feeding. Three groups of 15 ticks each were created: unfed, fed with heparinized blood, and fed with defibrinated blood. Ticks were ...

journal_title：Annals of the New York Academy of Sciences

authors： de la Vega R,Díaz G,Finlay L

更新日期：2000-01-01 00:00:00

abstract：:Vaccinia virus encodes secretory proteins termed virokines. One of the major virokines encoded by the N1L open reading frame is the 13.8 kDa protein. A recombinant virus, termed vGK5, lacking this protein when injected intracranially into mice, has one of the highest levels of in vivo attenuation achieved by deletion ...

journal_title：Annals of the New York Academy of Sciences

authors： Billings B,Smith SA,Zhang Z,Lahiri DK,Kotwal GJ

更新日期：2004-12-01 00:00:00

abstract：:Over seventy percent of unexpected infant deaths are registered as SIDS. Over 85,000 infants have been screened at birth and one month of age for risk of unexpected death using the Sheffield Score system. Scores range from below 400 to over 800 points. Infants with scores over 800 are at more than 16 times greater ris...

journal_title：Annals of the New York Academy of Sciences

authors： Carpenter RG,Gardner A,Harris J,Judd M,Lewry J,Maddock CR,Powell J,Taylor EM

更新日期：1988-01-01 00:00:00

abstract：:Leukoplakia in the oral cavity has been used as a putative surrogate marker of head and neck cancer development. A class of chemoprevention compounds, called protease inhibitors, has been shown in vitro and in animal models to effectively suppress premalignant lesions. Bowman-Birk inhibitor (BBI) is a protease inhibit...

journal_title：Annals of the New York Academy of Sciences

authors： Meyskens FL

更新日期：2001-12-01 00:00:00

abstract：:Adhesive interactions are recognized requirements for cellular proliferation, migration and differentiation during normal morphogenesis as well as disease. By differential cloning, osteopontin was identified as an adhesive protein upregulated during vascular remodeling and neointima formation in both rat models and hu...

journal_title：Annals of the New York Academy of Sciences

authors： Giachelli CM,Liaw L,Murry CE,Schwartz SM,Almeida M

更新日期：1995-04-21 00:00:00

abstract：:In the present study, the ability of high-dose androgens, namely AAS, administered during adolescence to facilitate aggressive behavior in experimental animals was examined. Data from these studies show clearly that exposure to high doses of multiple AAS during adolescent development can predispose animals to intense ...

journal_title：Annals of the New York Academy of Sciences

authors： Melloni RH Jr,Ferris CF

更新日期：1996-09-20 00:00:00

abstract：:The article describes the process of planning the Memorial of Disappeared Detained Citizens in the City of Montevideo, Uruguay, the construction of which was completed in January 2003. It explores the role that memory, planning, and reconciliation carried out in the public realm can play in the context of an urban env...

journal_title：Annals of the New York Academy of Sciences

authors： Kohen M

更新日期：2004-06-01 00:00:00

abstract：:The available evidence suggests that plasma leakage in dengue hemorrhagic fever is caused by the action of circulating mediators on the vascular endothelium, and that the host immune response is a critical determinant of this response. We have been exploring the role of dengue virus-specific T lymphocytes in the immun...

journal_title：Annals of the New York Academy of Sciences

authors： Rothman AL

更新日期：2009-09-01 00:00:00

abstract：:The present study was aimed at finding neural correlates of aesthetic versus descriptive listening of the same musical cadences. Results showed that aesthetic listening generated greater right frontocentral negativities than did descriptive listening, indicating distinct cortical mechanisms for aesthetic versus descri...

journal_title：Annals of the New York Academy of Sciences

authors： Brattico E,Jacobsen T,De Baene W,Nakai N,Tervaniemi M

更新日期：2003-11-01 00:00:00

abstract：:At a given cytosolic domain of a chromaffin cell, the rate and amplitude of the Ca(2+) concentration, [Ca(2+)](c), depend on at least three efficient regulatory mechanisms: (1) the plasmalemmal Ca(2+) channels; (2) the endoplasmic reticulum (ER); and (3) the mitochondria. High-voltage activated Ca(2+) channels of the ...

journal_title：Annals of the New York Academy of Sciences

authors： Cuchillo-Ibanez I,Albillos A,Aldea M,Arroyo G,Fuentealba J,Garcia AG

更新日期：2002-10-01 00:00:00

abstract：:The availability of improved peptide synthesis procedures, convenient and sensitive assays for receptor binding and activation, together with advances in methods for structural characterization, has enabled the key structural features of the relaxin family of peptides responsible for biological activity to be defined....

journal_title：Annals of the New York Academy of Sciences

authors： Tregear GW,Bathgate RA,Hossain MA,Lin F,Zhang S,Shabanpoor F,Scott DJ,Ma S,Gundlach AL,Samuel CS,Wade JD

更新日期：2009-04-01 00:00:00

abstract：:Experimental and observational findings suggest that calcium intake may protect against colorectal neoplasia. To investigate this hypothesis, we conducted a randomized, double-blind trial of colorectal adenoma recurrence. Nine hundred thirty patients with a recent history of colorectal adenomas were randomly given cal...

journal_title：Annals of the New York Academy of Sciences

authors： Baron JA,Beach M,Mandel JS,van Stolk RU,Haile RW,Sandler RS,Rothstein R,Summers RW,Snover DC,Beck GJ,Frankl H,Pearson L,Bond JH,Greenberg ER

更新日期：1999-01-01 00:00:00

abstract：:The SERMs currently in clinical practice or in late stages of clinical development have been studied primarily for their effects on the breast, cardiovascular, bone, and reproductive systems. The effect of SERMs on the hypothalamic-pituitary-gonadal (HPG) axis has not been the primary focus of the studies conducted th...

journal_title：Annals of the New York Academy of Sciences

authors： Plouffe L Jr,Siddhanti S

更新日期：2001-12-01 00:00:00

abstract：:RAS interacts with multiple targets in the cell and controls at least two signaling pathways, one regulating extracellular signal-regulated kinase (ERK) activation and the other controlling membrane ruffling formation. These two pathways appear to act synergistically to cause transformation. Human smooth muscle alpha-...

journal_title：Annals of the New York Academy of Sciences

authors： Kumar CC,Ohashi K,Nagata K,Walsh A,Bar-Sagi D,Mizuno K

更新日期：1999-01-01 00:00:00

abstract：:Recent studies demonstrate major effects of adrenal medullary and catecholaminergic pathways on a wide variety of normal physiologic and regulatory events. Alterations in these pathways, involving changes in catecholamines or in proteins and peptides costored and coreleased with catecholamines, may lead to profound ch...

journal_title：Annals of the New York Academy of Sciences

authors： Parmer RJ,Zinder O

更新日期：2002-10-01 00:00:00

abstract：:Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) frequently develop and progress in settings in which sympathoadrenomedullary and gonadal hormone levels are changing, e.g., during pregnancy, postpartum period, menopause, estrogen administration. This paper addresses the view that adrenal and gonadal ho...

journal_title：Annals of the New York Academy of Sciences

authors： Wilder RL,Elenkov IJ

更新日期：1999-06-22 00:00:00

abstract：:Since the first detection of highly pathogenic H5N1 avian influenza virus from sick goose in Guangdong province in China in 1996, scientists in China started to develop vaccines for avian influenza pandemic preparedness. An H5N2 inactivated vaccine was produced from a low pathogenic virus, A/turkey/England/N-28/73, an...

journal_title：Annals of the New York Academy of Sciences

authors： Qiao C,Tian G,Jiang Y,Li Y,Shi J,Yu K,Chen H

更新日期：2006-10-01 00:00:00

abstract：:Eight children with congenital adrenal hyperplasia and late initiation of corticosteroid treatment are included in the present study. Four of them received LHRHa treatment for the arrest of central precocious puberty, while the other four served as controls. The administration of LHRHa was effective in arresting the m...

journal_title：Annals of the New York Academy of Sciences

authors： Dacou-Voutetakis C,Karidis N

更新日期：1993-05-28 00:00:00

abstract：:The role of gamma-glutamyl-carboxylated growth arrest-specific 6 (cGas6) in mediating the beneficial effect of vitamin K (VK) on regulating glucose metabolism remains elusive. We took a three-pronged approach-evaluating human type 2 diabetes (T2D), high-fat diet (HFD)-fed mice, and in vitro cultured myotubes-to addres...

journal_title：Annals of the New York Academy of Sciences

authors： Dihingia A,Ozah D,Borah T,Kalita J,Manna P

更新日期：2020-02-01 00:00:00

abstract：:Data have been presented to document that the human newborn is a conditionable organism. Babies in the first days of life possess sensitivity to stimulation in all sensory modalities, an unconditioned repertoire of responses to some of these sensory stimuli, and a capacity for associating simultaneously presented stim...

journal_title：Annals of the New York Academy of Sciences

authors： Lipsitt LP

更新日期：1990-01-01 00:00:00

abstract：:The clinical, epidemiological, and therapeutic aspects of 15 patients with Mediterranean spotted fever (MSF), admitted to the Internal Medicine Department of the General Hospital of Sitia (southeastern Crete, Greece) between December 2000 and July 2003, were studied. Diagnosis was made on the basis of clinical signs a...

journal_title：Annals of the New York Academy of Sciences

authors： Germanakis A,Psaroulaki A,Gikas A,Tselentis Y

更新日期：2006-10-01 00:00:00

abstract：:The aim of the study was to investigate the effect of functional polymorphisms in promoters of the MMP-2 (-1306 C > T), MMP-3 (-1171 5A > 6A), MMP-9 (-1562 C > T), MMP-12 (-82 A > G), TIMP-1 (-372 C > T), and PAI-1 (-675 4G > 5G and -847 A > G) genes on the growth rate of small abdominal aortic aneurysms. The patients...

journal_title：Annals of the New York Academy of Sciences

authors： Powell JT

更新日期：2006-11-01 00:00:00

abstract：:The Cervico-ocular reflex (COR), which depends on proprioceptive afferents from neck muscles to the vestibular nucleus, makes little contribution to the stabilization of gaze in humans. If labyrinthine function is lost because of disease, however, the COR may increase in gain and assume greater importance in generatin...

journal_title：Annals of the New York Academy of Sciences

authors： Carmona S,Nieto D

更新日期：2005-04-01 00:00:00

abstract：:Social behavior in most human societies is characterized by the following of moral rules explicitly justified by religious belief systems. These systems constitute the diverse domain of human sacred values. Supernatural entities as founders or warranty of moral principles may be seen as a form of "conversation stopper...

journal_title：Annals of the New York Academy of Sciences

authors： Tófalvy T,Viciana H

更新日期：2009-06-01 00:00:00

abstract：:Membrane phospholipid metabolism is abnormal in Alzheimer's disease (AD) brain. Phosphatidylcholine and phosphatidylethanolamine levels are decreased as are choline and ethanolamine, while glycerophosphocholine (GPC) and glycerophosphoethanolamine are increased. To develop a rat model for these changes, we examined th...

journal_title：Annals of the New York Academy of Sciences

authors： Holmes TC,Nitsch RM,Erfurth A,Wurtman RJ

更新日期：1993-09-24 00:00:00