Novel selective compounds for the investigation of imidazoline receptors.

abstract：:The HLA DQB1*0302 allele on DR4 haplotypes is a well-known marker for T1D susceptibility. The contribution of this DQ molecule to overall disease susceptibility may be genotype dependent. On Asian DR4 haplotypes, not only DQB1*0302, but also DQB1*0401 confer susceptibility to T1D, which is mediated by DRB1*0405 on the...

journal_title：Annals of the New York Academy of Sciences

authors： Park Y,Tait BD,Kawasaki E,Rowley M,Mackay IR

更新日期：2004-12-01 00:00:00

abstract：:Cardiac muscle relies highly on aerobic metabolism. Heart muscle has a high oxygen uptake at resting conditions, which increases many fold during exhaustive physical exercise. Such a high rate of oxidative metabolism is often associated with enhanced production of reactive oxygen metabolites. A single bout of strenuou...

journal_title：Annals of the New York Academy of Sciences

authors： Atalay M,Sen CK

更新日期：1999-06-30 00:00:00

abstract：:Hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis is often observed in association with and even prior to the onset of major depression. It is presently unclear (1) which molecular and cellular processes contribute to hyperactivity of parvocellular hypothalamic neurons (key regulators of the HPA system) an...

journal_title：Annals of the New York Academy of Sciences

authors： Joëls M,Verkuyl JM,Van Riel E

更新日期：2003-12-01 00:00:00

abstract：:We isolated a eugenol-degrading bacterium, Pseudomonas fluorescens E118. This strain produced a novel enzyme, eugenol dehydrogenase, which catalyzes the conversion of eugenol into coniferyl alcohol. The enzyme was purified from the eugenol-induced cells of P. fluorescens E118. The purified enzyme appeared to be homoge...

journal_title：Annals of the New York Academy of Sciences

authors： Furukawa H,Nagasawa T

更新日期：1998-12-13 00:00:00

abstract：:Unfortunately, all of the problems of the hemophiliac have not been solved by the availability of concentrated factor VIII products. Patients still are faced with the crippling effects of arthritis, problems with employment, problems with ignorance (both medical and lay), and an increased risk of premature death even ...

journal_title：Annals of the New York Academy of Sciences

authors： Breckenridge RT

更新日期：1975-01-20 00:00:00

abstract：:Most anticancer treatments such as chemo- and radiotherapy induce DNA damage and apoptosis in normal cells. The aim of this study was to assess the induction of single and double DNA strand breaks (ssb and dsb, respectively) and apoptosis in normal human lymphocytes and rat thymocytes subjected to the action of H2O2, ...

journal_title：Annals of the New York Academy of Sciences

authors： Benítez-Bribiesca L,Sánchez-Suárez P

更新日期：1999-01-01 00:00:00

abstract：:The immunotherapeutic agent ipilimumab has helped address a significant unmet need in the treatment of advanced melanoma. Ipilimumab is a fully human monoclonal antibody that targets cytotoxic T-lymphocyte antigen-4 (CTLA-4), thereby augmenting antitumor immune responses. After decades in which a number of clinical tr...

journal_title：Annals of the New York Academy of Sciences

authors： Wolchok JD,Hodi FS,Weber JS,Allison JP,Urba WJ,Robert C,O'Day SJ,Hoos A,Humphrey R,Berman DM,Lonberg N,Korman AJ

更新日期：2013-07-01 00:00:00

abstract：:Higher fasting plasma insulin levels and reduced CSF-to-plasma insulin ratios, suggestive of insulin resistance, have been observed in patients with Alzheimer's disease (AD) who do not possess an apolipoprotein E (ApoE)-epsilon 4 allele. Insulin has also been implicated in processing of beta-amyloid and amyloid precur...

journal_title：Annals of the New York Academy of Sciences

authors： Craft S,Asthana S,Schellenberg G,Baker L,Cherrier M,Boyt AA,Martins RN,Raskind M,Peskind E,Plymate S

更新日期：2000-04-01 00:00:00

abstract：:To test whether the development of emotional resilience is a function of sensitive caregiving and child negative affect, we tested the joint contributions of 7-month maternal sensitivity and infant negative affect to the prediction of 33-month emotional resilience across the first 3 years of life. The aims of this stu...

journal_title：Annals of the New York Academy of Sciences

authors： Conway AM,McDonough SC

更新日期：2006-12-01 00:00:00

abstract：:The M1 antigens, associated with gastric fucomucin, the early oncofetal precancerous marker for the distal colon, were studied using the immunoperoxidase method in the distal colon. We compared human tumoral mucosa with that of rats during DMH-induced carcinogenesis. In both cases we examined histologically normal muc...

journal_title：Annals of the New York Academy of Sciences

authors： Bara J,Decaens C,Burtin P

更新日期：1983-01-01 00:00:00

abstract：:Our previous results demonstrate the gastroprotective but not ulcerogenic action of glucocorticoids released in response to ulcerogenic stress factors. The present study was undertaken to investigate the possible mechanisms underlying the gastroprotective action of glucocorticoids in rat stomachs. The effects of defic...

journal_title：Annals of the New York Academy of Sciences

authors： Filaretova LP,Podvigina TT,Bagaeva TR,Tanaka A,Takeuchi K

更新日期：2004-06-01 00:00:00

abstract：:Alexithymia has been associated with both posttraumatic stress disorder and neuroendocrine responses to stress. This study examined the relationship of alexithymia to salivary cortisol and 3-methoxy-4-hydroxy-phenylglycol (MHPG) in a sample of police academy recruits exposed to a video stress challenge. Alexithymia sc...

journal_title：Annals of the New York Academy of Sciences

authors： McCaslin SE,Inslicht SS,Neylan TC,Metzler TJ,Otte C,Lenoci M,Henn-Haase C,Best S,Yehuda R,Marmar CR

更新日期：2006-07-01 00:00:00

abstract：:It is well established for both rat and man that the total testosterone concentration within the testis is far higher than that in serum. We know for the rat that intratesticular testosterone can be reduced by 50-60% without an adverse effect on spermatogenesis but that the required intratesticular testosterone concen...

journal_title：Annals of the New York Academy of Sciences

authors： Jarow JP,Zirkin BR

更新日期：2005-12-01 00:00:00

abstract：:We review here evidence that a large portion of the caudomedial telencephalon of songbirds, distinct from the song control circuit, is involved in the perceptual processing of birdsong. When songbirds hear song, a number of caudomedial pallial areas are activated, as revealed by expression of the activity-dependent ge...

journal_title：Annals of the New York Academy of Sciences

authors： Mello CV,Velho TA,Pinaud R

更新日期：2004-06-01 00:00:00

abstract：:Manifest pre-eclampsia is associated with activation of peripheral neutrophils as well as elevations in maternal cell-free DNA. For this reason, we were very intrigued by recent reports indicating that activated circulatory neutrophils secrete nuclear DNA to generate extracellular DNA lattices, termed NETs (neutrophil...

journal_title：Annals of the New York Academy of Sciences

authors： Gupta A,Hasler P,Gebhardt S,Holzgreve W,Hahn S

更新日期：2006-09-01 00:00:00

abstract：:Acanthamoeba castellanii (A. castellanii) is a common soil- or water-borne protozoon that feeds on bacteria by phagocytosis. A. castellanii can grow between 4 and 32 degrees C and has to adapt quickly to chilling in order to survive. We have identified a Delta12-fatty acid desaturase as key to low temperature adaptati...

journal_title：Annals of the New York Academy of Sciences

authors： Harwood JL

更新日期：2007-10-01 00:00:00

abstract：:The most common ototoxic compounds in clinical practice are aminoglycoside antibiotics, cisplatin, and loop diuretics (ethacrynic acid and furosemide). These agents also have substantial renal effects in the form of nephrotoxicity or diuresis. The understanding of these renal effects may provide insight into ototoxic ...

journal_title：Annals of the New York Academy of Sciences

authors： Humes HD

更新日期：1999-11-28 00:00:00

abstract：:The public health implications of reducing or preventing the excess increase in blood pressure and the acquisition of obesity during childhood years are important. Many children with high blood pressure, particularly those who are initially obese or become obese as young adults and those with excess left ventricular m...

journal_title：Annals of the New York Academy of Sciences

authors： Mahoney LT,Lauer RM,Lee J,Clarke WR

更新日期：1991-01-01 00:00:00

abstract：:There is an urgent need for surrogate biomarkers in clinical diagnostics but also preclinical in toxicology of chemicals and efficacy testing of pharmaceuticals. On the background of the emerging fields of systems biology and theranostics, the importance of time scales and the synchronization of complex biological rea...

journal_title：Annals of the New York Academy of Sciences

authors： Schrattenholz A,Soskić V,Groebe K

更新日期：2010-06-01 00:00:00

abstract：:We studied 13 patients with unilateral peripheral vestibular lesions following removal of acoustic neurinomas. The time constant of the VOR after surgery was 6.4 +/- 2.6 seconds (normal is 18.5 +/- 7.7 seconds). The time constant of OKAN after surgery was 7.2 +/- 1.8 seconds (normal is 11.3 +/- 3.2 seconds). The mean ...

journal_title：Annals of the New York Academy of Sciences

authors： Hain TC,Zee DS

更新日期：1992-05-22 00:00:00

abstract：:Insulin-like growth factor (IGF) and its receptor (IGF-IR) play an important role in mitogenesis, apoptosis, growth, and proliferation of several types of cancers. Overexpression of IGF-IR in colorectal cancer is associated with increase of cancer cell proliferation and migration as well as inhibition of apoptosis. In...

journal_title：Annals of the New York Academy of Sciences

authors： Sulkowski S,Kanczuga-Koda L,Koda M,Wincewicz A,Sulkowska M

更新日期：2006-12-01 00:00:00

abstract：:Hypoxia is a common physiologic and pathophysiologic stimulus that activates the expression of genes through oxygen-sensitive transcription factors including the hypoxia-inducible factor (HIF) and nuclear factor-kappaB (NF-kappaB). Hypoxia-dependent gene expression can have important physiologic or pathophysiologic co...

journal_title：Annals of the New York Academy of Sciences

authors： Taylor CT,Cummins EP

更新日期：2009-10-01 00:00:00

abstract：:We found a novel genetic abnormality, heterozygous C-->T nucleotide substitution at position -1138 bp in the 5'-flanking region of the fibrinogen A alpha gene, in patients with hypofibrinogenemia. Luciferase reporter assay using the pGL3-basic vector and CHO cells indicates that the transcriptional activity of a vecto...

journal_title：Annals of the New York Academy of Sciences

authors： Okumura N,Terasawa F,Yonekawa O,Hamada E,Kaneko H

更新日期：2001-01-01 00:00:00

abstract：:Older age is associated with functional declines throughout the body, including some aspects of cognitive performance. While dementia develops in only some elderly individuals, declines in cognitive functioning have an impact on daily living for many others. There are individual differences in age-related cognitive ch...

journal_title：Annals of the New York Academy of Sciences

authors： Moffat SD

更新日期：2005-12-01 00:00:00

abstract：:Using a newly developed algorithm in conjunction with the front tracking scheme, we have evaluated the transport associated with a deformable bubble moving in a tube in the presence of a soluble or an insoluble surfactant. Such evaluations are useful to the understanding of gas embolism--a common syndrome for decompre...

journal_title：Annals of the New York Academy of Sciences

authors： Ayyaswamy PS,Zhang J,Eckmann DM

更新日期：2006-09-01 00:00:00

abstract：:Phospholemman (PLM) is the first sequenced member of the FXYD family of regulators of ion transport. The mature protein has 72 amino acids and consists of an extracellular N terminus containing the signature FXYD motif, a single transmembrane (TM) domain, and a cytoplasmic C-terminal domain containing four potential s...

journal_title：Annals of the New York Academy of Sciences

authors： Cheung JY,Rothblum LI,Moorman JR,Tucker AL,Song J,Ahlers BA,Carl LL,Wang J,Zhang XQ

更新日期：2007-03-01 00:00:00

abstract：:Several orphan G-protein-coupled receptors (GPCRs), LGR7 and LGR8, GPCR135 and GPCR142, were recently identified as putative, native receptors for different relaxin-family peptides, and their cell signaling mechanisms were elucidated in stably transfected cell lines. Anatomic studies have demonstrated that discrete po...

journal_title：Annals of the New York Academy of Sciences

authors： Ortinau S,Lin F,Wade JD,Tregear GW,Bathgate RA,Gundlach AL

更新日期：2005-05-01 00:00:00

abstract：:When conceptualized within a developmental systems theoretical framework, resilience involves mutually beneficial, reciprocally influential relations between a person and his or her context. The key features of developmental systems theory, which stress the plasticity of these relations, lead to an optimistic view of ...

journal_title：Annals of the New York Academy of Sciences

authors： Lerner RM

更新日期：2006-12-01 00:00:00

abstract：:Full-grown amphibian oocytes, arrested in prophase I or meiosis, respond in vitro to progesterone and certain other steroids. They undergo an apparently normal sequence of nuclear maturation and cytoplasmic differentiation, which are necessary precedents for fertilization and embryogenesis. Individual oocytes or popul...

journal_title：Annals of the New York Academy of Sciences

authors： Schuetz AW

更新日期：1977-03-11 00:00:00

abstract：:Tight junction (TJ) properties are determined by membrane protein complexes of neighboring cells that form both a barrier and a selective pathway for paracellular substrate transport. Our previous work supports the view that paracellular permeability changes in the thick ascending limb (TAL) may underlie the mechanism...

journal_title：Annals of the New York Academy of Sciences

authors： Shan Q,Himmerkus N,Hou J,Goodenough DA,Bleich M

更新日期：2009-05-01 00:00:00