Abstract:
:Acanthamoeba castellanii (A. castellanii) is a common soil- or water-borne protozoon that feeds on bacteria by phagocytosis. A. castellanii can grow between 4 and 32 degrees C and has to adapt quickly to chilling in order to survive. We have identified a Delta12-fatty acid desaturase as key to low temperature adaptation. The activity of this enzyme is mainly increased through gene expression and new protein synthesis. Interestingly, the activity can also be altered independently by dissolved oxygen levels. In addition, we have identified a gene for the Delta12-desaturase, which, when expressed in yeast, catalyses Delta15-desaturation also. Moreover, it is also capable of producing very unusual n-1 polyunsaturated products.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Harwood JLdoi
10.1196/annals.1391.025subject
Has Abstractpub_date
2007-10-01 00:00:00pages
52-7eissn
0077-8923issn
1749-6632pii
annals.1391.025journal_volume
1113pub_type
杂志文章,评审abstract::One of the most studied effects of verbal working memory (WM) is the influence of the length of the words that compose the list to be remembered. This work aims to investigate the nature of musical WM by replicating the word length effect in the musical domain. Length and rate of presentation were manipulated in a rec...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2009.04787.x
更新日期:2009-07-01 00:00:00
abstract::Approximately 90% of all cancer deaths arise from metastasis formation. Hence, understanding the molecular mechanisms underlying tumor progression, local invasion, and the formation of tumor metastases represents one of the great challenges in exploratory cancer research. Recent experimental results indicate that chan...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1294.006
更新日期:2004-04-01 00:00:00
abstract::Continuous infusion (CI) of coagulation factor concentrates has been used since the early 1990s. Recent reports of the occurrence of an inhibitor after CI have raised concerns about this method of treatment. We conducted a retrospective study to investigate the development of inhibitors after CI of Factor VIII concent...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1361.094
更新日期:2005-06-01 00:00:00
abstract::SPAG-1, a sporozoite surface antigen of T. annulata, has previously been shown to elicit partial protection when used, as an hepatitis B core antigen fusion, to immunize cattle. The objective of this study was to try and improve the protective capacity of this antigen by enlisting different vaccine strategies. Cattle ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1998.tb11054.x
更新日期:1998-06-29 00:00:00
abstract::The first recognition of tolerance and partial tolerance to attempted sensitization with simple allergenic chemicals is described. A proper designation would be the Frei-Sulzbeger-Chase phenomenon. Coupling with self occurs in these experiments; there is not only resistance to developing contactant-type sensitivity bu...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1982.tb36110.x
更新日期:1982-01-01 00:00:00
abstract::Teaching primary care is an important, but as yet, incompletely fulfilled responsibility of medical schools. The current surge of interest will not provide the needed personnel if primary care is defined too broadly, and if it is made everybody's business, but nobody's in particular. Primary care must not neglect firs...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1978.tb22078.x
更新日期:1978-06-21 00:00:00
abstract::Conservation translocation of species varies from restoring historic populations to managing the relocation of imperiled species to new locations. We review the literature in three areas--translocation, managed relocation, and conservation decision making--to inform conservation translocation under changing climates. ...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/nyas.12050
更新日期:2013-05-01 00:00:00
abstract::There is growing literature on the subject of aneurysmal degeneration of arteries in patients who are infected with HIV. A patient recently seen at our medical center with an aneurysm of the carotid artery stimulated our interest in reviewing the mechanisms by which HIV may initiate or predispose to these pathologies....
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1383.018
更新日期:2006-11-01 00:00:00
abstract::After fertilization, the next major hurdle for human reproduction is trophoblast differentiation, which is required for implantation, followed in lockstep by rapid assembly of these embryonic cells into a functional placenta. During this process, cytotrophoblast stem cells invade the uterus, anchoring the conceptus to...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2003.tb03211.x
更新日期:2003-05-01 00:00:00
abstract::Research examining brain development during adolescence is escalating rapidly along multiple dimensions, as illustrated by the remarkable diversity of trans-disciplinary work shown in this symposium. Ontogenetic transitions characteristics of adolescence are common among mammalian species. Although no other species de...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1308.002
更新日期:2004-06-01 00:00:00
abstract::Imatinib is a selective tyrosine kinase inhibitor used for the treatment of Philadelphia chromosome-positive leukemias and other malignancies. An important clinical observation is that imatinib can affect the function of normal nonmalignant cells resulting in myelosuppression in treated patients. This observation is s...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1349.022
更新日期:2005-06-01 00:00:00
abstract::Our previous results demonstrate the gastroprotective but not ulcerogenic action of glucocorticoids released in response to ulcerogenic stress factors. The present study was undertaken to investigate the possible mechanisms underlying the gastroprotective action of glucocorticoids in rat stomachs. The effects of defic...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1296.034
更新日期:2004-06-01 00:00:00
abstract::To identify factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium (OE), and to determine the mechanisms by which these factors act, we have studied mouse OE using two major experimental paradigms: tissue culture of embryonic OE and cell types isolated from it; and ablation of the olfa...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1998.tb10571.x
更新日期:1998-11-30 00:00:00
abstract::The endometrium acquires the ability to implant the developing embryo within a specific time window, termed the "receptive phase." During this period, the endometrium undergoes pronounced structural and functional changes induced by the ovarian steroids, estrogen and progesterone, which prepare it to be receptive to i...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2001.tb03792.x
更新日期:2001-09-01 00:00:00
abstract::To evaluate the effect of Lactobacillus casei on the effectiveness of the Mexican bovine babesiosis mixed vaccine, 20 bovines were randomly allocated into four groups of five animals (I, II, III, and IV). At day -2 animals in groups I and II were inoculated with saline solution by intramuscular route (i.m.) and animal...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1428.071
更新日期:2008-12-01 00:00:00
abstract::An aqueous solution of L-glutamine (50 mmol/L) and methylglyoxal (100 mmol/L) was incubated at 120 degrees C for 3 h in a 200 mmol/L phosphate buffer (pH 7.4). Four major fluorophores were revealed on the HPLC chromatogram. The same four fluorophores were obtained from the heating of a mixture of ammonia and methylgly...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1196/annals.1433.025
更新日期:2008-04-01 00:00:00
abstract::Neuropsychiatric disorders (i.e., mood disorders and schizophrenia) and inflammation are closely intertwined, and possibly powering each other in a bidirectional loop. Depression facilitates inflammatory reactions and inflammation promotes depression and other neuropsychiatric disorders. Patients with neuropsychiatric...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/nyas.13712
更新日期:2019-02-01 00:00:00
abstract::The concentration of materials and energy within cities is an inevitable consequence of dense populations and their per capita requirements for food, fiber, and fuel. As the world population becomes increasingly urban over the coming decades, urban areas will dramatically affect the distribution of nutrients across th...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1196/annals.1439.014
更新日期:2008-01-01 00:00:00
abstract::Some characteristics of the effects of brief and prolonged stress on tail-flick latency are described. The pharmacological profiles of the latency responses to 30 sec and 30 min footshock are strikingly different. Thus, the increase of tail-flick latency after 30 sec shock is unaffected by naloxone and enhanced by dru...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1986.tb14621.x
更新日期:1986-01-01 00:00:00
abstract::Disorientation may draw attention from other activities and its impact on cognition may cause pilot error and problems of concentration in dizzy patients. Tasks used to study the impact of disorientation include number processing, intelligence scales and Brookes matrices (reproduction of 2xD patterns of numbers vs. no...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2008.03744.x
更新日期:2009-05-01 00:00:00
abstract::In this chapter, we have presented evidence for several potential levels of interaction of NT/N gene products with dopaminergic systems of the brain. We have focused on one manifestation of this interaction related to the effects of antipsychotic drugs on expression of the NT/N gene in two anatomically discrete popula...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.1992.tb27339.x
更新日期:1992-01-01 00:00:00
abstract::Statistical learning is a set of cognitive mechanisms allowing for extracting regularities from the environment and segmenting continuous sensory input into discrete units. The current study used functional magnetic resonance imaging (fMRI) (N = 25) in conjunction with an artificial language learning paradigm to provi...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/nyas.14299
更新日期:2020-05-01 00:00:00
abstract::Developmental robustness, the capacity to stay "on track" despite the myriad vicissitudes that inevitably plague a developing organism, is, I argue, a prerequisite for natural selection and key to our understanding of the evolution of developmental processes. But how is such robustness achieved? And how can we reconci...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2002.tb04918.x
更新日期:2002-12-01 00:00:00
abstract::Monoclonal antibodies reactive with desmin (D3 and D76) have been generated and their specificities validated by immunoblots, RIAs, and immunocytochemistry. No cross-reaction with other IFPs has been observed. The McAbs recognized different epitopes but both reside in the amino-terminal rod domain of desmin. Whereas M...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.1985.tb50411.x
更新日期:1985-01-01 00:00:00
abstract::Influenza A virus infections result in approximately 500,000 human deaths per year and many more sublethal infections. Wild birds are recognized as the ancestral host of influenza A viruses, and avian viruses have contributed genetic material to most human viruses, including subtypes H5N1 and H1N1. Thus, influenza vir...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/j.1749-6632.2010.05451.x
更新日期:2010-05-01 00:00:00
abstract::Measles infection remains a serious threat to child survival in the developing world despite vaccination and treatment with vitamin A. This report reviews the epidemiology of measles in HIV-infected children in Africa. In hospitalized infants, the rate of malnutrition before measles and the rate of death after measles...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/j.1749-6632.2000.tb05511.x
更新日期:2000-11-01 00:00:00
abstract::Extracellular stress proteins including heat shock proteins (Hsps) and glucose-regulated proteins (Grps) are emerging as important mediators of intercellular signaling and transport. Release of such proteins from cells is triggered by physical trauma and behavioral stress as well as exposure to immunological "danger s...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,收录出版,评审
doi:10.1196/annals.1391.019
更新日期:2007-10-01 00:00:00
abstract::Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bon...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章
doi:10.1111/nyas.14380
更新日期:2020-08-01 00:00:00
abstract::With the demographic aging of populations worldwide, diseases associated with aging are becoming more prevalent and costly to individuals, families, and healthcare systems. Among aging-related impairments, a decline in cognitive function is of particular concern, as it erodes memory and processing abilities and eventu...
journal_title:Annals of the New York Academy of Sciences
pub_type: 杂志文章,评审
doi:10.1111/nyas.13062
更新日期:2016-03-01 00:00:00
abstract::This paper explores aspects of the role that laboratory instruments have played in establishing psychology as a science. Comparisons of earlier instruments with their more modern counterparts indicate that many problems and methods still of interest today were explored in the laboratories of psychology's pioneers. Suc...
journal_title:Annals of the New York Academy of Sciences
pub_type: 历史文章,杂志文章
doi:10.1111/j.1749-6632.1983.tb47336.x
更新日期:1983-01-01 00:00:00