Abstract：
:Some characteristics of the effects of brief and prolonged stress on tail-flick latency are described. The pharmacological profiles of the latency responses to 30 sec and 30 min footshock are strikingly different. Thus, the increase of tail-flick latency after 30 sec shock is unaffected by naloxone and enhanced by drugs which decrease 5HT or DA-dependent transmission, while the increase after 30 min shock is blocked by naloxone and also by the above drugs. The increased tail-flick latency after 30 sec shock only occurs if tail-flick latency is also determined before shock. This finding, together with the attenuation or enhancement of the post-shock response by drugs that similarly affect conditioned avoidance behavior, suggests that the increased latency after brief shock occurs through a mechanism that is related to passive avoidance learning. Finally, a new approach to the investigation of stress-induced analgesia is described in which neurochemical changes during prolonged immobilization stress are repeatedly monitored using cisternal CSF samples taken in parallel with tail-flick latency measurements.
journal_name
Ann N Y Acad Scijournal_title
Annals of the New York Academy of Sciencesauthors
Curzon G,Hutson PH,Kennett GA,Marcou M,Gower A,Tricklebank MDdoi
10.1111/j.1749-6632.1986.tb14621.xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
93-103eissn
0077-8923issn
1749-6632journal_volume
467pub_type
杂志文章,评审abstract：:The current status of gene transfer experiments indicates that it is possible to provide (1) safe and efficient retroviral packaging lines for gene transfer; and (2) vectors containing the human beta-globin genes and selectable marker genes which can be transmitted into erythroid cells and are appropriately expressed....
journal_title：Annals of the New York Academy of Sciences
pub_type： 杂志文章,评审
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abstract：:Aromatase cytochrome P450, the key enzyme of estrogen biosynthesis from androgens, is encoded by CYP19. Its structure shows some peculiarities: exons II to X encode the protein, while multiple alternative exons I encode unique 5'-untranslated regions of the aromatase mRNA transcripts. Immunohistochemistry studies in t...
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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更新日期：1994-08-15 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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更新日期：1987-01-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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更新日期：1984-01-01 00:00:00
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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更新日期：1995-09-07 00:00:00
abstract：:One hundred years after Santiago Ramon y Cajal provided critical evidence for the "neuron doctrine," his cellular view of the brain remains the basis of modern neural science. This article begins with a review of how the early work of Ramon y Cajal, Charles Sherrington, and John Eccles and their contemporaries laid ...
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journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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abstract：:Reproduction usually is characterized by a mean-population fecundity pattern. Such a pattern has a maximum at earlier ages and a subsequent gradual decline in egg production. It is shown that individual fecundity trajectories do not follow such a pattern. In particular, the regular individual fecundity pattern has no ...
journal_title：Annals of the New York Academy of Sciences
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journal_title：Annals of the New York Academy of Sciences
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更新日期：2003-05-01 00:00:00
